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The map label for this gene is lss [H]

Identifier: 51894445

GI number: 51894445

Start: 3537196

End: 3538503

Strand: Reverse

Name: lss [H]

Synonym: STH3311

Alternate gene names: 51894445

Gene position: 3538503-3537196 (Counterclockwise)

Preceding gene: 51894446

Following gene: 51894444

Centisome position: 99.23

GC content: 67.28

Gene sequence:

>1308_bases
TTGCCACGCCGTCCCCTGTTGCTGGTGGTGCTCGCAGCGATCATCAGTCTAGGTCTCGCAGCCGACCTTGGCGTACGGAA
TCTGCAACGCTCACAGCCGGCAGCAGCGGCGGATGGGCAGGAGACGGGAACCGGCACGGCCGGCGCGGAGCCCGATCAGC
TGGCCAGTGCGGACACCACTGACCGGGAACGGCTGGACATCGCCTCGCGCCAGGCGCAGGGGCCCAGGACCGCGCGCGAT
CCGCTGGGCGAGCCCGCGGCGGCCCAGGTGGTCGAGATGAAGAAGGCCGCCGTCATCACCGTGAACGGCGAGCCCGTGGT
TGCCGTCGCAGACGAGGCGGCGGCCCGGGAGGTCGTGGACACCATCCTCAATTCGTACCGGGAGTCGTACCTGAGCGACG
CGACCGTCGTTGAAGAGCTCTCCTTCGCCGAAGCCGTCACCTGGGAGGAGGGTGAGGTGGCGGCGGACAGCATCAAGACG
GTGGAGGAGGCCATCAACGTCCTGCTCCTGGGTACGGACAAGGTGGCCACCTACACGGTGGCGTCCGGCGACACGGCCTG
GGACATCGCCCTGGAGTACGGCCTCACCACCGACCAGCTGGCCAAGGCCAATCCCGGCGTCGACATTGAGCTGTTGCAGA
TCGGTCAGCAGCTGACCATCACCTACAAAGAGCCCTACGTGCACCCCCAGTCGGTGTCACAGCGGGTGGTGTACGAGAGC
ATTCCATTCGCGGAGCAGCGGATCGAAGATGACACCTTGTGGCCGTGGGAGTCGGTGGTGGTCACGCCCGGCCGCTCGGG
GACACGGGAGAAGGTTATCCGCGAGCGCCGGCAGGACGGCCAGATCGTCAGCACCGAGGTCCTGTCGAGCCGCGTCACGG
CGGAGCCGGTGACGCAGGTGCGCCGGGTCGGCGTCAAGCAGGTGCCGGATCTGGGCAGCGGGTCGCTGATCCTGCCCGTG
GTCGGGGAGATCAGCTCGTACTACGGGCCGCGCTGGGGCACGTGGCACAACGGCATCGACATCGCCGTACCCCACGGCAC
GCCGGTGCGGGCGGCCGACAGCGGCATGGTCGTCTACCGGGGCTGGAACGGCAACTACGGCAACATGATCGAGATCGATC
ACGGCGGCGGGAAGATGGTCACCTGGTACGCCCACCTGTCGGGCTTCAACGTGTCGGTGGGCCAGCAGGTGAACAAGGGC
GACATCATCGGCTACGTCGGCAGCACCGGGTACTCCACCGGTCCCCACCTGCACTTCGAGATCCGCATCGACGGGGATCC
GGTGAACCCGCTGAACTACTATCCGTAA

Upstream 100 bases:

>100_bases
TGTCAGGCAGTGGTTCCGCGTTCTCCGGAAACCTGGCAGGAAATACACCATACAAAGCGAAACTATATACCTCGTCATGC
ATTGAGGAGGTGGACCCGCC

Downstream 100 bases:

>100_bases
CAGGGACAGGCCCGTTTCGGGCCGCCGGCACGTCCGCCGGCGGCCCCTTGGTTTGTGCGGGTCCCGGCTGCATGTGCTTC
AGGCTCCATGGGGACGATAG

Product: putative metalloendopeptidase

Products: NA

Alternate protein names: Glycyl-glycine endopeptidase [H]

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MPRRPLLLVVLAAIISLGLAADLGVRNLQRSQPAAAADGQETGTGTAGAEPDQLASADTTDRERLDIASRQAQGPRTARD
PLGEPAAAQVVEMKKAAVITVNGEPVVAVADEAAAREVVDTILNSYRESYLSDATVVEELSFAEAVTWEEGEVAADSIKT
VEEAINVLLLGTDKVATYTVASGDTAWDIALEYGLTTDQLAKANPGVDIELLQIGQQLTITYKEPYVHPQSVSQRVVYES
IPFAEQRIEDDTLWPWESVVVTPGRSGTREKVIRERRQDGQIVSTEVLSSRVTAEPVTQVRRVGVKQVPDLGSGSLILPV
VGEISSYYGPRWGTWHNGIDIAVPHGTPVRAADSGMVVYRGWNGNYGNMIEIDHGGGKMVTWYAHLSGFNVSVGQQVNKG
DIIGYVGSTGYSTGPHLHFEIRIDGDPVNPLNYYP

Sequences:

>Translated_435_residues
MPRRPLLLVVLAAIISLGLAADLGVRNLQRSQPAAAADGQETGTGTAGAEPDQLASADTTDRERLDIASRQAQGPRTARD
PLGEPAAAQVVEMKKAAVITVNGEPVVAVADEAAAREVVDTILNSYRESYLSDATVVEELSFAEAVTWEEGEVAADSIKT
VEEAINVLLLGTDKVATYTVASGDTAWDIALEYGLTTDQLAKANPGVDIELLQIGQQLTITYKEPYVHPQSVSQRVVYES
IPFAEQRIEDDTLWPWESVVVTPGRSGTREKVIRERRQDGQIVSTEVLSSRVTAEPVTQVRRVGVKQVPDLGSGSLILPV
VGEISSYYGPRWGTWHNGIDIAVPHGTPVRAADSGMVVYRGWNGNYGNMIEIDHGGGKMVTWYAHLSGFNVSVGQQVNKG
DIIGYVGSTGYSTGPHLHFEIRIDGDPVNPLNYYP
>Mature_434_residues
PRRPLLLVVLAAIISLGLAADLGVRNLQRSQPAAAADGQETGTGTAGAEPDQLASADTTDRERLDIASRQAQGPRTARDP
LGEPAAAQVVEMKKAAVITVNGEPVVAVADEAAAREVVDTILNSYRESYLSDATVVEELSFAEAVTWEEGEVAADSIKTV
EEAINVLLLGTDKVATYTVASGDTAWDIALEYGLTTDQLAKANPGVDIELLQIGQQLTITYKEPYVHPQSVSQRVVYESI
PFAEQRIEDDTLWPWESVVVTPGRSGTREKVIRERRQDGQIVSTEVLSSRVTAEPVTQVRRVGVKQVPDLGSGSLILPVV
GEISSYYGPRWGTWHNGIDIAVPHGTPVRAADSGMVVYRGWNGNYGNMIEIDHGGGKMVTWYAHLSGFNVSVGQQVNKGD
IIGYVGSTGYSTGPHLHFEIRIDGDPVNPLNYYP

Specific function: Lyses staphylococcal cells by hydrolyzing the polyglycine interpeptide bridges of the peptidoglycan [H]

COG id: COG0739

COG function: function code M; Membrane proteins related to metalloendopeptidases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M23B family [H]

Homologues:

Organism=Escherichia coli, GI87081989, Length=130, Percent_Identity=40.7692307692308, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082297, Length=123, Percent_Identity=37.3983739837398, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI87082174, Length=128, Percent_Identity=38.28125, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789099, Length=119, Percent_Identity=41.1764705882353, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011055
- InterPro:   IPR016047
- InterPro:   IPR002886
- InterPro:   IPR003646
- InterPro:   IPR013667 [H]

Pfam domain/function: PF01551 Peptidase_M23; PF08460 SH3_5 [H]

EC number: =3.4.24.75 [H]

Molecular weight: Translated: 46856; Mature: 46725

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: PS51109 G5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRRPLLLVVLAAIISLGLAADLGVRNLQRSQPAAAADGQETGTGTAGAEPDQLASADTT
CCCCHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHCCCCCC
DRERLDIASRQAQGPRTARDPLGEPAAAQVVEMKKAAVITVNGEPVVAVADEAAAREVVD
CHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCEEEEEECCCEEEEECCHHHHHHHHH
TILNSYRESYLSDATVVEELSFAEAVTWEEGEVAADSIKTVEEAINVLLLGTDKVATYTV
HHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEEECCCCEEEEEE
ASGDTAWDIALEYGLTTDQLAKANPGVDIELLQIGQQLTITYKEPYVHPQSVSQRVVYES
ECCCCEEEEEEEECCCHHHHHCCCCCCEEEHEECCCEEEEEECCCCCCHHHHHHHHHHHC
IPFAEQRIEDDTLWPWESVVVTPGRSGTREKVIRERRQDGQIVSTEVLSSRVTAEPVTQV
CCCHHHHCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHCCCEEEHHHHHHCCCHHHHHHH
RRVGVKQVPDLGSGSLILPVVGEISSYYGPRWGTWHNGIDIAVPHGTPVRAADSGMVVYR
HHCCHHHCCCCCCCCEEEEEHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEE
GWNGNYGNMIEIDHGGGKMVTWYAHLSGFNVSVGQQVNKGDIIGYVGSTGYSTGPHLHFE
CCCCCCCCEEEEECCCCEEEEEEEEECCCEECCCCCCCCCCEEEEECCCCCCCCCEEEEE
IRIDGDPVNPLNYYP
EEECCCCCCCCCCCC
>Mature Secondary Structure 
PRRPLLLVVLAAIISLGLAADLGVRNLQRSQPAAAADGQETGTGTAGAEPDQLASADTT
CCCHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHCCCCCC
DRERLDIASRQAQGPRTARDPLGEPAAAQVVEMKKAAVITVNGEPVVAVADEAAAREVVD
CHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCEEEEEECCCEEEEECCHHHHHHHHH
TILNSYRESYLSDATVVEELSFAEAVTWEEGEVAADSIKTVEEAINVLLLGTDKVATYTV
HHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEEECCCCEEEEEE
ASGDTAWDIALEYGLTTDQLAKANPGVDIELLQIGQQLTITYKEPYVHPQSVSQRVVYES
ECCCCEEEEEEEECCCHHHHHCCCCCCEEEHEECCCEEEEEECCCCCCHHHHHHHHHHHC
IPFAEQRIEDDTLWPWESVVVTPGRSGTREKVIRERRQDGQIVSTEVLSSRVTAEPVTQV
CCCHHHHCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHCCCEEEHHHHHHCCCHHHHHHH
RRVGVKQVPDLGSGSLILPVVGEISSYYGPRWGTWHNGIDIAVPHGTPVRAADSGMVVYR
HHCCHHHCCCCCCCCEEEEEHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEE
GWNGNYGNMIEIDHGGGKMVTWYAHLSGFNVSVGQQVNKGDIIGYVGSTGYSTGPHLHFE
CCCCCCCCEEEEECCCCEEEEEEEEECCCEECCCCCCCCCCEEEEECCCCCCCCCEEEEE
IRIDGDPVNPLNYYP
EEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3547405; 9106216 [H]