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The map label for this gene is glmU

Identifier: 51894375

GI number: 51894375

Start: 3455279

End: 3456694

Strand: Reverse

Name: glmU

Synonym: STH3240

Alternate gene names: 51894375

Gene position: 3456694-3455279 (Counterclockwise)

Preceding gene: 51894376

Following gene: 51894374

Centisome position: 96.93

GC content: 67.8

Gene sequence:

>1416_bases
ATGTCGGACATCACGGCCGTTCTGCTCGCTGCCGGCCACGGAACCCGCATGAAATCGGACCTGATCAAAGTCATGCATCC
CCTTGCCGGGAAGCCGATGATCGGTCACATCGTGGACAACGTGCGGCGGGCAGGCCTGGAGGACATCGTGGTCGTGGTGG
GGTATCAGCAGGAGCGGATCCGGGAATACCTCGGCGACCGCGTGCGTTATGCCGTGCAGTCCGAGCAACTGGGGACGGGC
CACGCGGTGCTTCAGGCGGCCGGCCTGATCGACGAGACCGAGGGCGGCCACGTGCTGGTGATGTACGGCGACAACCCCTT
CATCGGTCCGGAGTTGATTGAACGGCTGATCCGGGCCCACGTCGAGGCGGATGCCGCCGCGAGCCTGCTCACGGCGGAGC
TCGCCGACCCCGGGGCCCTCGGGCGGATCCTGCGGGATCCGGCGACGGGCGCCTTCCTGGGCAGCGTCGAGTACAAGGAC
GCGACCCCCGAGCAGCGGCGCATCCGGGAGATCTGGACCGGGGTGGCGGTGTTCCGGCGGGCGGGCTTCACCGCGCTCCT
GAACCGGCTCGACCGGAACAACGCCCAGGGCGAGTACTACCTCCCCCAGGTGTGGGAGATCCTGCTCCAGCGGGGCGAGA
AGGTGCAGGCGCTGCTGCTGGCCTCCGAGGAGGACGCGCTGGCGCCCAACGATCGGGTGGAACTGGCCCGGGCCGAGGCG
CGGCTGCGCCGGCAGATCAACGAGCGTCACATGAGGAACGGCGTCACCATCATCAACCCGGACGCGACCTACATCGATGA
GGACGTGGAGATCGGGCGCGACACGGTGATCTGGCCCTTCACCTTCATCCACGGCAAGACGGTGATCGGCCCTCACTGCA
AGATCGGGCCGATGACCACCATCGTCTCGTCCACGGTGGCCGAGGGCTGCGTCGTGGAGCAGTCGGTGGTCGAGGAGTCG
TATGTCGGCCCCGGGTGCCGCATCGGGCCCATGGCCCACCTGCGCCCGGGCTGCGAACTGGAGGGCGCCGCAGAGATCGG
CAACTACGCCGAGCTCAAGAAGGCGAAGGTGGGACGCGGCGTGAAGTGCCACCACCATTCCTATCTGGGAGATGCCACCA
TCGGCGCCGGAGCCAACATCGGTGCCGGCACGATAACCGCCAACTACAACGGCGTGGAGAAGTTCAGGACCGAGATCGGC
AGCGGTGCCTTCATCGGCACCAACGTCAACCTGATCGCGCCCATCACCGTCGGGGACGGCGCCCTGATCGCCGCCGGCTC
CACCGTGGGCCCCAGGCTCGAGATCCCGGCTGACGCGCTGGTGGTGGAACGGGCGCAGGCGGTCATCAAGGAAGGCCGTG
CCGCCAGCCTCAAAGAGGCATGGCGTCAGCGCAAGATGAACAGGGAGGGCACCTAG

Upstream 100 bases:

>100_bases
GCCCGGGCCCGGCGCACGGGGCTGTGCCGGGCCAATTTTCCTTGTTTCGCGTCTGTCCTGTGGTATAATGGCTCCGGATC
AAGACCGGGGAGGGAAACCC

Downstream 100 bases:

>100_bases
CCGTGGTACCTTACCAGGATCGCAAGCTGAAAATCTTTTCCGGGAACGCGAACCTCCCCCTGGCCAGGGCGATTGCGGAC
CACATGGGGATCAGCCTCGG

Product: UDP-N-acetylglucosamine pyrophosphorylase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MSDITAVLLAAGHGTRMKSDLIKVMHPLAGKPMIGHIVDNVRRAGLEDIVVVVGYQQERIREYLGDRVRYAVQSEQLGTG
HAVLQAAGLIDETEGGHVLVMYGDNPFIGPELIERLIRAHVEADAAASLLTAELADPGALGRILRDPATGAFLGSVEYKD
ATPEQRRIREIWTGVAVFRRAGFTALLNRLDRNNAQGEYYLPQVWEILLQRGEKVQALLLASEEDALAPNDRVELARAEA
RLRRQINERHMRNGVTIINPDATYIDEDVEIGRDTVIWPFTFIHGKTVIGPHCKIGPMTTIVSSTVAEGCVVEQSVVEES
YVGPGCRIGPMAHLRPGCELEGAAEIGNYAELKKAKVGRGVKCHHHSYLGDATIGAGANIGAGTITANYNGVEKFRTEIG
SGAFIGTNVNLIAPITVGDGALIAAGSTVGPRLEIPADALVVERAQAVIKEGRAASLKEAWRQRKMNREGT

Sequences:

>Translated_471_residues
MSDITAVLLAAGHGTRMKSDLIKVMHPLAGKPMIGHIVDNVRRAGLEDIVVVVGYQQERIREYLGDRVRYAVQSEQLGTG
HAVLQAAGLIDETEGGHVLVMYGDNPFIGPELIERLIRAHVEADAAASLLTAELADPGALGRILRDPATGAFLGSVEYKD
ATPEQRRIREIWTGVAVFRRAGFTALLNRLDRNNAQGEYYLPQVWEILLQRGEKVQALLLASEEDALAPNDRVELARAEA
RLRRQINERHMRNGVTIINPDATYIDEDVEIGRDTVIWPFTFIHGKTVIGPHCKIGPMTTIVSSTVAEGCVVEQSVVEES
YVGPGCRIGPMAHLRPGCELEGAAEIGNYAELKKAKVGRGVKCHHHSYLGDATIGAGANIGAGTITANYNGVEKFRTEIG
SGAFIGTNVNLIAPITVGDGALIAAGSTVGPRLEIPADALVVERAQAVIKEGRAASLKEAWRQRKMNREGT
>Mature_470_residues
SDITAVLLAAGHGTRMKSDLIKVMHPLAGKPMIGHIVDNVRRAGLEDIVVVVGYQQERIREYLGDRVRYAVQSEQLGTGH
AVLQAAGLIDETEGGHVLVMYGDNPFIGPELIERLIRAHVEADAAASLLTAELADPGALGRILRDPATGAFLGSVEYKDA
TPEQRRIREIWTGVAVFRRAGFTALLNRLDRNNAQGEYYLPQVWEILLQRGEKVQALLLASEEDALAPNDRVELARAEAR
LRRQINERHMRNGVTIINPDATYIDEDVEIGRDTVIWPFTFIHGKTVIGPHCKIGPMTTIVSSTVAEGCVVEQSVVEESY
VGPGCRIGPMAHLRPGCELEGAAEIGNYAELKKAKVGRGVKCHHHSYLGDATIGAGANIGAGTITANYNGVEKFRTEIGS
GAFIGTNVNLIAPITVGDGALIAAGSTVGPRLEIPADALVVERAQAVIKEGRAASLKEAWRQRKMNREGT

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=451, Percent_Identity=40.3547671840355, Blast_Score=311, Evalue=7e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_SYMTH (Q67JC8)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_077066.1
- ProteinModelPortal:   Q67JC8
- SMR:   Q67JC8
- GeneID:   2979635
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH3240
- NMPDR:   fig|292459.1.peg.3110
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- BioCyc:   STHE292459:STH3240-MONOMER
- BRENDA:   2.3.1.157
- BRENDA:   2.7.7.23
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 50886; Mature: 50755

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 365-365 BINDING 73-73 BINDING 141-141 BINDING 157-157 BINDING 389-389 BINDING 425-425 BINDING 444-444

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDITAVLLAAGHGTRMKSDLIKVMHPLAGKPMIGHIVDNVRRAGLEDIVVVVGYQQERI
CCCHHEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEEECCCHHHH
REYLGDRVRYAVQSEQLGTGHAVLQAAGLIDETEGGHVLVMYGDNPFIGPELIERLIRAH
HHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHH
VEADAAASLLTAELADPGALGRILRDPATGAFLGSVEYKDATPEQRRIREIWTGVAVFRR
HHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEECEECCCCCCHHHHHHHHHHHHHHHHH
AGFTALLNRLDRNNAQGEYYLPQVWEILLQRGEKVQALLLASEEDALAPNDRVELARAEA
CCHHHHHHHHHCCCCCCCEECHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHH
RLRRQINERHMRNGVTIINPDATYIDEDVEIGRDTVIWPFTFIHGKTVIGPHCKIGPMTT
HHHHHHHHHHHHCCCEEECCCCCEECCHHHCCCCEEEEEEEEECCCEEECCCCCCCCHHH
IVSSTVAEGCVVEQSVVEESYVGPGCRIGPMAHLRPGCELEGAAEIGNYAELKKAKVGRG
HHHHHHHHCHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCHHHCCCHHHHHHHHCCCC
VKCHHHSYLGDATIGAGANIGAGTITANYNGVEKFRTEIGSGAFIGTNVNLIAPITVGDG
EEEECCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHCCCEEEECCCEEEEEEEECCC
ALIAAGSTVGPRLEIPADALVVERAQAVIKEGRAASLKEAWRQRKMNREGT
CEEEECCCCCCCEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SDITAVLLAAGHGTRMKSDLIKVMHPLAGKPMIGHIVDNVRRAGLEDIVVVVGYQQERI
CCHHEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEEECCCHHHH
REYLGDRVRYAVQSEQLGTGHAVLQAAGLIDETEGGHVLVMYGDNPFIGPELIERLIRAH
HHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHH
VEADAAASLLTAELADPGALGRILRDPATGAFLGSVEYKDATPEQRRIREIWTGVAVFRR
HHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEECEECCCCCCHHHHHHHHHHHHHHHHH
AGFTALLNRLDRNNAQGEYYLPQVWEILLQRGEKVQALLLASEEDALAPNDRVELARAEA
CCHHHHHHHHHCCCCCCCEECHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHH
RLRRQINERHMRNGVTIINPDATYIDEDVEIGRDTVIWPFTFIHGKTVIGPHCKIGPMTT
HHHHHHHHHHHHCCCEEECCCCCEECCHHHCCCCEEEEEEEEECCCEEECCCCCCCCHHH
IVSSTVAEGCVVEQSVVEESYVGPGCRIGPMAHLRPGCELEGAAEIGNYAELKKAKVGRG
HHHHHHHHCHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCHHHCCCHHHHHHHHCCCC
VKCHHHSYLGDATIGAGANIGAGTITANYNGVEKFRTEIGSGAFIGTNVNLIAPITVGDG
EEEECCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHCCCEEEECCCEEEEEEEECCC
ALIAAGSTVGPRLEIPADALVVERAQAVIKEGRAASLKEAWRQRKMNREGT
CEEEECCCCCCCEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA