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The map label for this gene is prs [H]

Identifier: 51894374

GI number: 51894374

Start: 3454311

End: 3455276

Strand: Reverse

Name: prs [H]

Synonym: STH3239

Alternate gene names: 51894374

Gene position: 3455276-3454311 (Counterclockwise)

Preceding gene: 51894375

Following gene: 51894373

Centisome position: 96.89

GC content: 66.67

Gene sequence:

>966_bases
GTGGTACCTTACCAGGATCGCAAGCTGAAAATCTTTTCCGGGAACGCGAACCTCCCCCTGGCCAGGGCGATTGCGGACCA
CATGGGGATCAGCCTCGGCAACATGAACGTCGGCCGCTTCTCCAACGGGGAGATCCGGGTCGACATCAACGAATCGGTGC
GGGGCACCGACTGCTTTGTCATCCAGTCGGGGGTCCATCCGGTCAACGAGAACGTCATGGAGCTGCTGGTCATCGGCGAC
GCTCTCCGGCGGGCGAGCGCCCGCCGGATCACCGCGGTGGTGCCTCATTTTCCCTACGCCCGGCAGGATCGCAAGGCCAG
GGGGCGCGAGCCCATCACGGCCAAGCTGCTGGCGAACCTGATCACGACCGCCGGCTTCCGGCGCCTCCTCACCATCGACC
TGCACGCGGCGCAGATCCAGGGCTTCTTCGACACGCCGGTGGACCACCTGCACGCCGGCCCCCTGATCGCGAACTACTTC
CGGCAGAAGGGGCTGCAGAACGCGGTGGTCGTGTCGCCGGATACGGGCGGCGTGCCCCGCGCCCGGGACCTGGCGGAGCG
GCTGGGGGTCGGGCTGGCGATCATCGACAAGCGGCGGCCGGAGCCCAATGTCGCCGAGGTGATGAACATCATCGGTGACG
TGGAGGGAAAGACGGCGATCCTGGTGGACGACCTCATCGACACCGCCGGAACGATCGTGAAGGGCGCCGAGGCGCTGCTG
GAACGGGGGGCCACCGAGGTCTACGCCGCCTGTACGCACCCCGTGTTCAGCGGGCCGGCGTACGAGCGGCTGGCGGCCAG
CCCCATCAAGGAGATTGTCGTGACCGATACCATCCCGGTGGACGCCGACAAGATGGGCGGCAAGCTGCGCGTGGTGTCGG
TGGCGCCGCTCCTCGGCAAGGCCATCATCCGCATTCACGAAGACCTCTCCGTCTCAAAGATCTTTGAAGAGGAGCCCAGG
CTCTGA

Upstream 100 bases:

>100_bases
TGGTGGTGGAACGGGCGCAGGCGGTCATCAAGGAAGGCCGTGCCGCCAGCCTCAAAGAGGCATGGCGTCAGCGCAAGATG
AACAGGGAGGGCACCTAGCC

Downstream 100 bases:

>100_bases
GACCCGGCCCTCCGCGGCATCCCGGCGCGTTCCGGGGTGCCGCTGCGTTCTGGTCCGCCGTTTTCCGCGGTCCGGGACTA
TGGTAAAGTAGACCCTGTCG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MVPYQDRKLKIFSGNANLPLARAIADHMGISLGNMNVGRFSNGEIRVDINESVRGTDCFVIQSGVHPVNENVMELLVIGD
ALRRASARRITAVVPHFPYARQDRKARGREPITAKLLANLITTAGFRRLLTIDLHAAQIQGFFDTPVDHLHAGPLIANYF
RQKGLQNAVVVSPDTGGVPRARDLAERLGVGLAIIDKRRPEPNVAEVMNIIGDVEGKTAILVDDLIDTAGTIVKGAEALL
ERGATEVYAACTHPVFSGPAYERLAASPIKEIVVTDTIPVDADKMGGKLRVVSVAPLLGKAIIRIHEDLSVSKIFEEEPR
L

Sequences:

>Translated_321_residues
MVPYQDRKLKIFSGNANLPLARAIADHMGISLGNMNVGRFSNGEIRVDINESVRGTDCFVIQSGVHPVNENVMELLVIGD
ALRRASARRITAVVPHFPYARQDRKARGREPITAKLLANLITTAGFRRLLTIDLHAAQIQGFFDTPVDHLHAGPLIANYF
RQKGLQNAVVVSPDTGGVPRARDLAERLGVGLAIIDKRRPEPNVAEVMNIIGDVEGKTAILVDDLIDTAGTIVKGAEALL
ERGATEVYAACTHPVFSGPAYERLAASPIKEIVVTDTIPVDADKMGGKLRVVSVAPLLGKAIIRIHEDLSVSKIFEEEPR
L
>Mature_321_residues
MVPYQDRKLKIFSGNANLPLARAIADHMGISLGNMNVGRFSNGEIRVDINESVRGTDCFVIQSGVHPVNENVMELLVIGD
ALRRASARRITAVVPHFPYARQDRKARGREPITAKLLANLITTAGFRRLLTIDLHAAQIQGFFDTPVDHLHAGPLIANYF
RQKGLQNAVVVSPDTGGVPRARDLAERLGVGLAIIDKRRPEPNVAEVMNIIGDVEGKTAILVDDLIDTAGTIVKGAEALL
ERGATEVYAACTHPVFSGPAYERLAASPIKEIVVTDTIPVDADKMGGKLRVVSVAPLLGKAIIRIHEDLSVSKIFEEEPR
L

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=315, Percent_Identity=47.3015873015873, Blast_Score=300, Evalue=1e-81,
Organism=Homo sapiens, GI28557709, Length=314, Percent_Identity=46.1783439490446, Blast_Score=297, Evalue=1e-80,
Organism=Homo sapiens, GI4506129, Length=313, Percent_Identity=46.6453674121406, Blast_Score=296, Evalue=1e-80,
Organism=Homo sapiens, GI84875539, Length=316, Percent_Identity=46.2025316455696, Blast_Score=291, Evalue=5e-79,
Organism=Homo sapiens, GI4506133, Length=344, Percent_Identity=37.5, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI194018537, Length=342, Percent_Identity=38.3040935672515, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI310128524, Length=146, Percent_Identity=32.8767123287671, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI310115209, Length=146, Percent_Identity=32.8767123287671, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI310118259, Length=146, Percent_Identity=32.8767123287671, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI310119946, Length=146, Percent_Identity=32.8767123287671, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1787458, Length=311, Percent_Identity=54.3408360128617, Blast_Score=322, Evalue=2e-89,
Organism=Caenorhabditis elegans, GI25149168, Length=314, Percent_Identity=46.1783439490446, Blast_Score=297, Evalue=5e-81,
Organism=Caenorhabditis elegans, GI17554702, Length=314, Percent_Identity=46.1783439490446, Blast_Score=296, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI17554704, Length=312, Percent_Identity=46.1538461538462, Blast_Score=295, Evalue=3e-80,
Organism=Caenorhabditis elegans, GI71989924, Length=314, Percent_Identity=46.1783439490446, Blast_Score=294, Evalue=5e-80,
Organism=Caenorhabditis elegans, GI17570245, Length=337, Percent_Identity=36.4985163204748, Blast_Score=215, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6320946, Length=314, Percent_Identity=45.859872611465, Blast_Score=284, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6319403, Length=315, Percent_Identity=45.3968253968254, Blast_Score=278, Evalue=1e-75,
Organism=Saccharomyces cerevisiae, GI6321776, Length=314, Percent_Identity=43.6305732484076, Blast_Score=261, Evalue=8e-71,
Organism=Saccharomyces cerevisiae, GI6322667, Length=199, Percent_Identity=44.2211055276382, Blast_Score=173, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6324511, Length=270, Percent_Identity=31.4814814814815, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21355239, Length=314, Percent_Identity=46.4968152866242, Blast_Score=292, Evalue=2e-79,
Organism=Drosophila melanogaster, GI45551540, Length=337, Percent_Identity=43.620178041543, Blast_Score=281, Evalue=3e-76,
Organism=Drosophila melanogaster, GI24651458, Length=351, Percent_Identity=37.3219373219373, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24651456, Length=351, Percent_Identity=37.3219373219373, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI281362873, Length=351, Percent_Identity=37.3219373219373, Blast_Score=225, Evalue=3e-59,
Organism=Drosophila melanogaster, GI24651454, Length=351, Percent_Identity=37.3219373219373, Blast_Score=225, Evalue=3e-59,
Organism=Drosophila melanogaster, GI24651462, Length=199, Percent_Identity=41.7085427135678, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24651464, Length=199, Percent_Identity=41.7085427135678, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI45552010, Length=199, Percent_Identity=41.7085427135678, Blast_Score=161, Evalue=5e-40,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34821; Mature: 34821

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVPYQDRKLKIFSGNANLPLARAIADHMGISLGNMNVGRFSNGEIRVDINESVRGTDCFV
CCCCCCCEEEEEECCCCCHHHHHHHHHHCEEECCCCCCCCCCCEEEEEECCCCCCCEEEE
IQSGVHPVNENVMELLVIGDALRRASARRITAVVPHFPYARQDRKARGREPITAKLLANL
EECCCCCCHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCHHHHCCCCCHHHHHHHHH
ITTAGFRRLLTIDLHAAQIQGFFDTPVDHLHAGPLIANYFRQKGLQNAVVVSPDTGGVPR
HHHHHHHEEEEEEEEHHHHCCCCCCCHHHHCCCHHHHHHHHHCCCCCCEEECCCCCCCCC
ARDLAERLGVGLAIIDKRRPEPNVAEVMNIIGDVEGKTAILVDDLIDTAGTIVKGAEALL
HHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHH
ERGATEVYAACTHPVFSGPAYERLAASPIKEIVVTDTIPVDADKMGGKLRVVSVAPLLGK
HCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHEEEECCCCCCHHHCCCEEEEEEECHHHHH
AIIRIHEDLSVSKIFEEEPRL
HHHHHHCCCHHHHHHHCCCCC
>Mature Secondary Structure
MVPYQDRKLKIFSGNANLPLARAIADHMGISLGNMNVGRFSNGEIRVDINESVRGTDCFV
CCCCCCCEEEEEECCCCCHHHHHHHHHHCEEECCCCCCCCCCCEEEEEECCCCCCCEEEE
IQSGVHPVNENVMELLVIGDALRRASARRITAVVPHFPYARQDRKARGREPITAKLLANL
EECCCCCCHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCHHHHCCCCCHHHHHHHHH
ITTAGFRRLLTIDLHAAQIQGFFDTPVDHLHAGPLIANYFRQKGLQNAVVVSPDTGGVPR
HHHHHHHEEEEEEEEHHHHCCCCCCCHHHHCCCHHHHHHHHHCCCCCCEEECCCCCCCCC
ARDLAERLGVGLAIIDKRRPEPNVAEVMNIIGDVEGKTAILVDDLIDTAGTIVKGAEALL
HHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHH
ERGATEVYAACTHPVFSGPAYERLAASPIKEIVVTDTIPVDADKMGGKLRVVSVAPLLGK
HCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHEEEECCCCCCHHHCCCEEEEEEECHHHHH
AIIRIHEDLSVSKIFEEEPRL
HHHHHHCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]