Click here to switch to the map view.

The map label for this gene is moeA [H]

Identifier: 51894336

GI number: 51894336

Start: 3414057

End: 3415304

Strand: Reverse

Name: moeA [H]

Synonym: STH3201

Alternate gene names: 51894336

Gene position: 3415304-3414057 (Counterclockwise)

Preceding gene: 51894337

Following gene: 51894335

Centisome position: 95.77

GC content: 73.56

Gene sequence:

>1248_bases
ATGCTTCGGGTTGAGGAGGCCTGTGAGCTTCTGCTGCACCGCGCGCCGCCCCGGCGCGTGGAGCGGGTACCGTTGGAGGA
CGCGCTGGGGCTGGTCCTGGCCGAGGATGTGCACGCGCCCGAGCCGCTGCCCGCCTTCGCCCGATCGGGCATGGACGGGT
ACGCCGTCCGCTCCGCGGACACCCTGGGGGCAACCCGGGAGCAGCCCGTGGTCCTCCGGCCGGTCGGGGTGATTCCTGCC
GGGCATCCCCGGGAGGCGGAACTGGCGCCGGGCACGGCGGTGGCCATCATGACCGGCGGCGCGGTGCCGCCGGGCGCCGA
CGCGGTGATCCGGCTGGAGGAGGTGCGGGTGACCCCGGAGGGCGTGCTGGTGTTCCGCCCCGTCCCGCCGATGGAGAACG
TCGCGCCCGTGGGCGAGGACGTGCGGGAGGGCGAGCTGATCCTCGAGGCCGGTCATCTGATCCGCCCCCAGGAGATCAAC
CTGCTTGCGGCCCTCGGCATCCTGGAGGTCCCGGTTTTCGCCCGGCCCCGGGTGGGGATCCTGAGCACCGGGGACGAGTT
GGTGCCGGCGCACCAGACGCCGGGACCGGGGCAGATCCGCAACTCCAACAGCCCCGGCGTGGCCGCGCTGGTGCGGGCCG
CAGGGGGCGTCCCCATCGTGCTGGGGGTCGCCCGCGATGTGACCGAGGTCATCGCCGGCATGCTGCGGGAGGCGGCGGGG
TGCGACCTGATTCTCACCACGGGCGGCGTTTCCGTGGGCCGGTTTGACGTGGTGCGGGAGGCGCTGACGATCCTGGGTGC
CGAACAGCTCTTCTGGCGGGTCAGCATCAAGCCCGGCACGCCGGTGTGTGCGAGCGTGTTGGAAGGCCGCCTCGTCATCG
GGCTGTCGGGCAACCCTGCGGCGGCGATTACGGACTTCGACCTGCTGGTGCGCCCGTTGCTGGACCACCTGCTGGGCCGG
CGCCGCCTGGGCCTCAGGGCCGCGGAGGGGGTGCTGGACCAGCCGGTGCTGAAAACGGCGGGCGTCACCCGGTACCTCCG
GGCGCGGGCGTACAATGGTCCGGACGGCGAGATCCGGCTTGACACCAGCATGGCCCAGCGGGCGGGCGTGCTCAGCTCGA
TGAGCCATGCCAACGCCTACGCGGTGGTTCCGGCCCACGCGGGCCCGCTCCCGGCCGGTGCGCGGGTGCGCGCCCTTCTG
CTGGACGACGCGGACGTCTTCGTGCCGCCCCCGAGGGGCGACGTGTGA

Upstream 100 bases:

>100_bases
CCCTTCCCCGGTTTGACTGGAACGACATCGTCGCCATCGCGGACTTCGTGGAGATGCGGTTGCTCAGGGACGCACAGACG
AGGAGCTAGGGGGGAGCGGC

Downstream 100 bases:

>100_bases
TCCGGAAGCCGCTGGAATCGGTTGACTACTTGACGCCGTGCCGCAATCTTTGATAAGCTAAGTGAGCCTCAGGATGACGA
CCCCATCGTCTAGAGGCCTA

Product: molybdenum cofactor biosynthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MLRVEEACELLLHRAPPRRVERVPLEDALGLVLAEDVHAPEPLPAFARSGMDGYAVRSADTLGATREQPVVLRPVGVIPA
GHPREAELAPGTAVAIMTGGAVPPGADAVIRLEEVRVTPEGVLVFRPVPPMENVAPVGEDVREGELILEAGHLIRPQEIN
LLAALGILEVPVFARPRVGILSTGDELVPAHQTPGPGQIRNSNSPGVAALVRAAGGVPIVLGVARDVTEVIAGMLREAAG
CDLILTTGGVSVGRFDVVREALTILGAEQLFWRVSIKPGTPVCASVLEGRLVIGLSGNPAAAITDFDLLVRPLLDHLLGR
RRLGLRAAEGVLDQPVLKTAGVTRYLRARAYNGPDGEIRLDTSMAQRAGVLSSMSHANAYAVVPAHAGPLPAGARVRALL
LDDADVFVPPPRGDV

Sequences:

>Translated_415_residues
MLRVEEACELLLHRAPPRRVERVPLEDALGLVLAEDVHAPEPLPAFARSGMDGYAVRSADTLGATREQPVVLRPVGVIPA
GHPREAELAPGTAVAIMTGGAVPPGADAVIRLEEVRVTPEGVLVFRPVPPMENVAPVGEDVREGELILEAGHLIRPQEIN
LLAALGILEVPVFARPRVGILSTGDELVPAHQTPGPGQIRNSNSPGVAALVRAAGGVPIVLGVARDVTEVIAGMLREAAG
CDLILTTGGVSVGRFDVVREALTILGAEQLFWRVSIKPGTPVCASVLEGRLVIGLSGNPAAAITDFDLLVRPLLDHLLGR
RRLGLRAAEGVLDQPVLKTAGVTRYLRARAYNGPDGEIRLDTSMAQRAGVLSSMSHANAYAVVPAHAGPLPAGARVRALL
LDDADVFVPPPRGDV
>Mature_415_residues
MLRVEEACELLLHRAPPRRVERVPLEDALGLVLAEDVHAPEPLPAFARSGMDGYAVRSADTLGATREQPVVLRPVGVIPA
GHPREAELAPGTAVAIMTGGAVPPGADAVIRLEEVRVTPEGVLVFRPVPPMENVAPVGEDVREGELILEAGHLIRPQEIN
LLAALGILEVPVFARPRVGILSTGDELVPAHQTPGPGQIRNSNSPGVAALVRAAGGVPIVLGVARDVTEVIAGMLREAAG
CDLILTTGGVSVGRFDVVREALTILGAEQLFWRVSIKPGTPVCASVLEGRLVIGLSGNPAAAITDFDLLVRPLLDHLLGR
RRLGLRAAEGVLDQPVLKTAGVTRYLRARAYNGPDGEIRLDTSMAQRAGVLSSMSHANAYAVVPAHAGPLPAGARVRALL
LDDADVFVPPPRGDV

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=347, Percent_Identity=32.8530259365994, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI10880983, Length=347, Percent_Identity=32.8530259365994, Blast_Score=161, Evalue=1e-39,
Organism=Escherichia coli, GI1787049, Length=387, Percent_Identity=36.4341085271318, Blast_Score=196, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI25147659, Length=324, Percent_Identity=35.4938271604938, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17562606, Length=353, Percent_Identity=29.4617563739377, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17136978, Length=371, Percent_Identity=28.0323450134771, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24638841, Length=371, Percent_Identity=28.0323450134771, Blast_Score=102, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43499; Mature: 43499

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRVEEACELLLHRAPPRRVERVPLEDALGLVLAEDVHAPEPLPAFARSGMDGYAVRSAD
CCCHHHHHHHHHHCCCHHHHHCCCHHHHHHHEEECCCCCCCCCCHHHHCCCCCEEEECCH
TLGATREQPVVLRPVGVIPAGHPREAELAPGTAVAIMTGGAVPPGADAVIRLEEVRVTPE
HCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEEEECCC
GVLVFRPVPPMENVAPVGEDVREGELILEAGHLIRPQEINLLAALGILEVPVFARPRVGI
CEEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCE
LSTGDELVPAHQTPGPGQIRNSNSPGVAALVRAAGGVPIVLGVARDVTEVIAGMLREAAG
EECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHCC
CDLILTTGGVSVGRFDVVREALTILGAEQLFWRVSIKPGTPVCASVLEGRLVIGLSGNPA
CCEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHCCEEEEEECCCCC
AAITDFDLLVRPLLDHLLGRRRLGLRAAEGVLDQPVLKTAGVTRYLRARAYNGPDGEIRL
EEEHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEE
DTSMAQRAGVLSSMSHANAYAVVPAHAGPLPAGARVRALLLDDADVFVPPPRGDV
CHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEEECCCCEEECCCCCCC
>Mature Secondary Structure
MLRVEEACELLLHRAPPRRVERVPLEDALGLVLAEDVHAPEPLPAFARSGMDGYAVRSAD
CCCHHHHHHHHHHCCCHHHHHCCCHHHHHHHEEECCCCCCCCCCHHHHCCCCCEEEECCH
TLGATREQPVVLRPVGVIPAGHPREAELAPGTAVAIMTGGAVPPGADAVIRLEEVRVTPE
HCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEEEECCC
GVLVFRPVPPMENVAPVGEDVREGELILEAGHLIRPQEINLLAALGILEVPVFARPRVGI
CEEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCE
LSTGDELVPAHQTPGPGQIRNSNSPGVAALVRAAGGVPIVLGVARDVTEVIAGMLREAAG
EECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHCC
CDLILTTGGVSVGRFDVVREALTILGAEQLFWRVSIKPGTPVCASVLEGRLVIGLSGNPA
CCEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHCCEEEEEECCCCC
AAITDFDLLVRPLLDHLLGRRRLGLRAAEGVLDQPVLKTAGVTRYLRARAYNGPDGEIRL
EEEHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEE
DTSMAQRAGVLSSMSHANAYAVVPAHAGPLPAGARVRALLLDDADVFVPPPRGDV
CHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEEECCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]