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The map label for this gene is hutH

Identifier: 51894329

GI number: 51894329

Start: 3402759

End: 3404282

Strand: Reverse

Name: hutH

Synonym: STH3194

Alternate gene names: 51894329

Gene position: 3404282-3402759 (Counterclockwise)

Preceding gene: 51894330

Following gene: 51894328

Centisome position: 95.46

GC content: 71.13

Gene sequence:

>1524_bases
ATGGAAGCGGTAGAACTCGGTGCACATTTAACCCTCCCGGAAGTCGTGGCTGTCGCCAGGCACGGCGCGCGCGTCGTGCT
GACGCCGGAGGTGCGGCAGCGGGTAGCCAGAGCGAGCGAGATGGTGGAACGGCTGGTGCGGGAGCGCCGGCCGGTCTACG
GCATCACCACCGGTTTTGGCAAGTTCAGCGACGTCCCCATATCGGCAGAGCAGACAGAAGCACTGCAGCGCAATCTCCTG
ATGAGCCACGCCTGCGCCGTCGGAGAGCCGCTCGCGGCGGAAGTGGTGCGGGCGATGCTCCTTCTGCGCGCCCAGGCGCT
CTCCCGGGGCCACTCCGGCATCCGGGCGGAGACCCTGGAGATGCTCGTGGCGTTCCTCAATCTCGGCCTCACCCCCGTGG
TGCCGGAGCAGGGCTCCCTGGGCGCCAGCGGCGACCTCGCGCCGCTCGCCCACATGAGCCTTCCGCTGATCGGGTTGGGT
GAGGCCGTTGTCAATGGCGAGCGGCTGTCCGGCGCCGAGGCGCTGCAGCGGGTCGGCCTCCGGCCGCTGACGCTGACGGC
CAAGGAAGGGCTGGCCCTGATCAACGGCACCCAGGCGATGACCGCGCTGGGGTCCCTCGGCCTCCACGATGCTCAGGTGC
TGCTGAAAACCGCGGACATCGCGGCGGCCATGACGGCCGAGGCGCTGGGGGCGATCCCGGCGGCCTGGGACCCGCGGGTG
CAGGCCCTGCGGCTCCACACGGGGCAGCAGGCGGCTGCCAGGAACCTGCGCCGGCTGACCGAGGGGTCGCGCCTCACCAC
CCGACCGGGGCAGATGCGCACCCAGGATCCGTACACCCTGCGCTGCCTTCCGCAGGTGCACGGCGCCAGCCGGACCGCGA
TCGAGCACGTGGCGCAGGTGCTGGACTGGGAGATGAACGCCGTCACCGACAATCCCCTGCTCTTCCCGGACGACGACGAG
GTCATCTCCGGCGGCAACTTCCACGGTCAGCCGGTCGCGCTGGCGCTGGACTACTTGGCCATCGCCGTCGCGGAGCTCGG
CGACATCGCCGAGCGGCGCATCGAGCGACTGGTCAACCCACAGCTTTCGGGGCTGCCGGCCTTCCTCACCCGCAACGGCG
GGGTGCATTCGGGGCTGATGATCACCCAGTACACGGCGGCGTCGCTGGTGAGCGAGAACAAGGTGCTCGCTCACCCGGCC
AGCGTGGACTCCATTCCGTCCAGCGCCAACCAGGAGGACCACGTGTCGATGGGCACCACGGCCGCCCGCAAGGCGCGGCA
GGTGATCGCCAACGTCCGCCGGGTGCTGGCCATCGAGCTGCTGTGCGCCGCCCAGGCTCTGGAGTTCGTGGGCCCGGAGC
GGCTCGCCCCGGCCACGCGCGCCGCCTACGCGGCGATCCGGGAGCGGGTGGCGCCGCTGAGCGGCGACCGGGTGCTGGCG
CCGGACATTGAGGCCCTCGCCGAACTGGTGCACAACGGGGAACTGGTCGCCGCCGTCGAGGCAGTGGCCGGTCCCCTCGA
GTAG

Upstream 100 bases:

>100_bases
TATGCCGCCCTTGACTGGTTTAAAGCGACAGCGTAGTCGTTTGCCTCCCCGGTTTTTCGGTTCCTATAATGGGAGCAGGC
TAATGCGGGAGGTTCAGTCC

Downstream 100 bases:

>100_bases
CGCAGTCGTAACCGAAACGAGGGGGGTATGGAGATGACCCGGACGGTCCGCGCCCCGCGCGGCACGCAGCTCTCGTGCAA
GGGGTGGCAGCAGGAGGCCG

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MEAVELGAHLTLPEVVAVARHGARVVLTPEVRQRVARASEMVERLVRERRPVYGITTGFGKFSDVPISAEQTEALQRNLL
MSHACAVGEPLAAEVVRAMLLLRAQALSRGHSGIRAETLEMLVAFLNLGLTPVVPEQGSLGASGDLAPLAHMSLPLIGLG
EAVVNGERLSGAEALQRVGLRPLTLTAKEGLALINGTQAMTALGSLGLHDAQVLLKTADIAAAMTAEALGAIPAAWDPRV
QALRLHTGQQAAARNLRRLTEGSRLTTRPGQMRTQDPYTLRCLPQVHGASRTAIEHVAQVLDWEMNAVTDNPLLFPDDDE
VISGGNFHGQPVALALDYLAIAVAELGDIAERRIERLVNPQLSGLPAFLTRNGGVHSGLMITQYTAASLVSENKVLAHPA
SVDSIPSSANQEDHVSMGTTAARKARQVIANVRRVLAIELLCAAQALEFVGPERLAPATRAAYAAIRERVAPLSGDRVLA
PDIEALAELVHNGELVAAVEAVAGPLE

Sequences:

>Translated_507_residues
MEAVELGAHLTLPEVVAVARHGARVVLTPEVRQRVARASEMVERLVRERRPVYGITTGFGKFSDVPISAEQTEALQRNLL
MSHACAVGEPLAAEVVRAMLLLRAQALSRGHSGIRAETLEMLVAFLNLGLTPVVPEQGSLGASGDLAPLAHMSLPLIGLG
EAVVNGERLSGAEALQRVGLRPLTLTAKEGLALINGTQAMTALGSLGLHDAQVLLKTADIAAAMTAEALGAIPAAWDPRV
QALRLHTGQQAAARNLRRLTEGSRLTTRPGQMRTQDPYTLRCLPQVHGASRTAIEHVAQVLDWEMNAVTDNPLLFPDDDE
VISGGNFHGQPVALALDYLAIAVAELGDIAERRIERLVNPQLSGLPAFLTRNGGVHSGLMITQYTAASLVSENKVLAHPA
SVDSIPSSANQEDHVSMGTTAARKARQVIANVRRVLAIELLCAAQALEFVGPERLAPATRAAYAAIRERVAPLSGDRVLA
PDIEALAELVHNGELVAAVEAVAGPLE
>Mature_507_residues
MEAVELGAHLTLPEVVAVARHGARVVLTPEVRQRVARASEMVERLVRERRPVYGITTGFGKFSDVPISAEQTEALQRNLL
MSHACAVGEPLAAEVVRAMLLLRAQALSRGHSGIRAETLEMLVAFLNLGLTPVVPEQGSLGASGDLAPLAHMSLPLIGLG
EAVVNGERLSGAEALQRVGLRPLTLTAKEGLALINGTQAMTALGSLGLHDAQVLLKTADIAAAMTAEALGAIPAAWDPRV
QALRLHTGQQAAARNLRRLTEGSRLTTRPGQMRTQDPYTLRCLPQVHGASRTAIEHVAQVLDWEMNAVTDNPLLFPDDDE
VISGGNFHGQPVALALDYLAIAVAELGDIAERRIERLVNPQLSGLPAFLTRNGGVHSGLMITQYTAASLVSENKVLAHPA
SVDSIPSSANQEDHVSMGTTAARKARQVIANVRRVLAIELLCAAQALEFVGPERLAPATRAAYAAIRERVAPLSGDRVLA
PDIEALAELVHNGELVAAVEAVAGPLE

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family

Homologues:

Organism=Homo sapiens, GI4504333, Length=505, Percent_Identity=45.9405940594059, Blast_Score=425, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17567831, Length=515, Percent_Identity=45.0485436893204, Blast_Score=412, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTH_SYMTH (Q67JH4)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_077020.1
- ProteinModelPortal:   Q67JH4
- SMR:   Q67JH4
- GeneID:   2980678
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH3194
- NMPDR:   fig|292459.1.peg.3065
- HOGENOM:   HBG510887
- OMA:   HTGVRPE
- BioCyc:   STHE292459:STH3194-MONOMER
- BRENDA:   4.3.1.3
- GO:   GO:0005737
- HAMAP:   MF_00229
- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313
- TIGRFAMs:   TIGR01225

Pfam domain/function: PF00221 PAL; SSF48557 L-Aspartase-like

EC number: =4.3.1.3

Molecular weight: Translated: 53710; Mature: 53710

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00488 PAL_HISTIDASE; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAVELGAHLTLPEVVAVARHGARVVLTPEVRQRVARASEMVERLVRERRPVYGITTGFG
CCCHHCCCCCCHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
KFSDVPISAEQTEALQRNLLMSHACAVGEPLAAEVVRAMLLLRAQALSRGHSGIRAETLE
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
MLVAFLNLGLTPVVPEQGSLGASGDLAPLAHMSLPLIGLGEAVVNGERLSGAEALQRVGL
HHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEECCHHHHCCCCCCHHHHHHHCCC
RPLTLTAKEGLALINGTQAMTALGSLGLHDAQVLLKTADIAAAMTAEALGAIPAAWDPRV
CCEEEECCCCEEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
QALRLHTGQQAAARNLRRLTEGSRLTTRPGQMRTQDPYTLRCLPQVHGASRTAIEHVAQV
HHHEECCCHHHHHHHHHHHHCCCCEECCCCCCCCCCCCEEEEEHHHCCCHHHHHHHHHHH
LDWEMNAVTDNPLLFPDDDEVISGGNFHGQPVALALDYLAIAVAELGDIAERRIERLVNP
HCCHHHCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QLSGLPAFLTRNGGVHSGLMITQYTAASLVSENKVLAHPASVDSIPSSANQEDHVSMGTT
CCCCCCHHHHCCCCCCCCEEEEHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCHHCCHH
AARKARQVIANVRRVLAIELLCAAQALEFVGPERLAPATRAAYAAIRERVAPLSGDRVLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHCCCCCCEEEC
PDIEALAELVHNGELVAAVEAVAGPLE
CCHHHHHHHHHCCCHHHHHHHHCCCCC
>Mature Secondary Structure
MEAVELGAHLTLPEVVAVARHGARVVLTPEVRQRVARASEMVERLVRERRPVYGITTGFG
CCCHHCCCCCCHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
KFSDVPISAEQTEALQRNLLMSHACAVGEPLAAEVVRAMLLLRAQALSRGHSGIRAETLE
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
MLVAFLNLGLTPVVPEQGSLGASGDLAPLAHMSLPLIGLGEAVVNGERLSGAEALQRVGL
HHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEECCHHHHCCCCCCHHHHHHHCCC
RPLTLTAKEGLALINGTQAMTALGSLGLHDAQVLLKTADIAAAMTAEALGAIPAAWDPRV
CCEEEECCCCEEEECCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
QALRLHTGQQAAARNLRRLTEGSRLTTRPGQMRTQDPYTLRCLPQVHGASRTAIEHVAQV
HHHEECCCHHHHHHHHHHHHCCCCEECCCCCCCCCCCCEEEEEHHHCCCHHHHHHHHHHH
LDWEMNAVTDNPLLFPDDDEVISGGNFHGQPVALALDYLAIAVAELGDIAERRIERLVNP
HCCHHHCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QLSGLPAFLTRNGGVHSGLMITQYTAASLVSENKVLAHPASVDSIPSSANQEDHVSMGTT
CCCCCCHHHHCCCCCCCCEEEEHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCHHCCHH
AARKARQVIANVRRVLAIELLCAAQALEFVGPERLAPATRAAYAAIRERVAPLSGDRVLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHCCCCCCEEEC
PDIEALAELVHNGELVAAVEAVAGPLE
CCHHHHHHHHHCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA