Click here to switch to the map view.

The map label for this gene is tpx [H]

Identifier: 51894101

GI number: 51894101

Start: 3186016

End: 3186669

Strand: Reverse

Name: tpx [H]

Synonym: STH2965

Alternate gene names: 51894101

Gene position: 3186669-3186016 (Counterclockwise)

Preceding gene: 51894103

Following gene: 51894097

Centisome position: 89.36

GC content: 66.51

Gene sequence:

>654_bases
GTGTGCTTACTTCAAGGTATTGACGCCGCCGCGCCCGCCGCCGTTACGGGGACTCTCCGGCGTGATCCGTCACGCCCTGT
CCGCCCGGAGCGTCCAAACACCGGGAAACCAACTACGCCGTTACTGGAGGGAAACGCCGTGGAGCGCGCTGGTGCTTTTC
AGTTCAAGGGCGAGGTGACGCTGGTCGGTCCGGAGCTGCGCGTGGGCGATCAGGCTCCGGCCTTCACCGCGATCGGCAAT
GATCTCTCGACGGTGGACTCCCGGACGTTCGCGGGCAAGGTGCGCATCATCTCTTCGGTGCCGTCCCTGGACACGGGCGT
CTGCGACACCCAGACCCGCAAGTTCAACGAAGCCGCGGCCAGCCTGGGGGACGAGGTCGTCGTGCTCACCATCTCGGCTG
ACCTTCCGTTTGCCCAGAAGCGGTGGTGCGGCAACGCGGGCGTCGACCGCGTCATCACCCTTTCGGATTACCGCGACCAC
GCCTTCAGCAAGGCCTACGGCACCTACATCAAGGAGTGGGCGCTCTGCTCCCGGGCGGTCTTCGTCGTGGACCGGAACGA
CCGCCTTGTCCACGTGGAGTACGTCCCGGTGGCCGGACAGGAGCCCAACTACGACGCGGCGCTGGAGGCCGCGCGGGCTG
CCTTGAAGGCGTAA

Upstream 100 bases:

>100_bases
GGCGTCGGACGGTCCACCTCATCCATGAAGCCCCTTTCTGATGAATGACTGCCGCAGGAAACCCGCAGCAAATTTCAAGC
AAGCCCAGTATAATGTTAAA

Downstream 100 bases:

>100_bases
CGCAGTACCGCCGGAAAACCAGAGGGCCGACCCGCAGCAGGGTCGGCCCCGTATTTCGCTGTCGGGCTTCACTTCGCCTG
CGCCACGACGTCCGGCTCCA

Product: thioredoxin peroxidase

Products: oxidized thioredoxin; H2O [C]

Alternate protein names: Superoxide-inducible protein 8; SOI8 [H]

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MCLLQGIDAAAPAAVTGTLRRDPSRPVRPERPNTGKPTTPLLEGNAVERAGAFQFKGEVTLVGPELRVGDQAPAFTAIGN
DLSTVDSRTFAGKVRIISSVPSLDTGVCDTQTRKFNEAAASLGDEVVVLTISADLPFAQKRWCGNAGVDRVITLSDYRDH
AFSKAYGTYIKEWALCSRAVFVVDRNDRLVHVEYVPVAGQEPNYDAALEAARAALKA

Sequences:

>Translated_217_residues
MCLLQGIDAAAPAAVTGTLRRDPSRPVRPERPNTGKPTTPLLEGNAVERAGAFQFKGEVTLVGPELRVGDQAPAFTAIGN
DLSTVDSRTFAGKVRIISSVPSLDTGVCDTQTRKFNEAAASLGDEVVVLTISADLPFAQKRWCGNAGVDRVITLSDYRDH
AFSKAYGTYIKEWALCSRAVFVVDRNDRLVHVEYVPVAGQEPNYDAALEAARAALKA
>Mature_217_residues
MCLLQGIDAAAPAAVTGTLRRDPSRPVRPERPNTGKPTTPLLEGNAVERAGAFQFKGEVTLVGPELRVGDQAPAFTAIGN
DLSTVDSRTFAGKVRIISSVPSLDTGVCDTQTRKFNEAAASLGDEVVVLTISADLPFAQKRWCGNAGVDRVITLSDYRDH
AFSKAYGTYIKEWALCSRAVFVVDRNDRLVHVEYVPVAGQEPNYDAALEAARAALKA

Specific function: Has antioxidant activity. Could remove peroxides or H(2)O(2) [H]

COG id: COG2077

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1787584, Length=164, Percent_Identity=43.9024390243902, Blast_Score=131, Evalue=3e-32,

Paralogues:

None

Copy number: 2480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018219
- InterPro:   IPR002065
- InterPro:   IPR013740
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF08534 Redoxin [H]

EC number: 1.11.1.- [C]

Molecular weight: Translated: 23275; Mature: 23275

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS01265 TPX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCLLQGIDAAAPAAVTGTLRRDPSRPVRPERPNTGKPTTPLLEGNAVERAGAFQFKGEVT
CCEECCCCCCCCCCEEEHHCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCEEECCEEE
LVGPELRVGDQAPAFTAIGNDLSTVDSRTFAGKVRIISSVPSLDTGVCDTQTRKFNEAAA
EECCCEEECCCCCCEEECCCCHHHHCCCHHCCEEEEEECCCCCCCCCCCCHHHHHHHHHH
SLGDEVVVLTISADLPFAQKRWCGNAGVDRVITLSDYRDHAFSKAYGTYIKEWALCSRAV
HCCCCEEEEEEECCCCHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCEEE
FVVDRNDRLVHVEYVPVAGQEPNYDAALEAARAALKA
EEEECCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MCLLQGIDAAAPAAVTGTLRRDPSRPVRPERPNTGKPTTPLLEGNAVERAGAFQFKGEVT
CCEECCCCCCCCCCEEEHHCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCEEECCEEE
LVGPELRVGDQAPAFTAIGNDLSTVDSRTFAGKVRIISSVPSLDTGVCDTQTRKFNEAAA
EECCCEEECCCCCCEEECCCCHHHHCCCHHCCEEEEEECCCCCCCCCCCCHHHHHHHHHH
SLGDEVVVLTISADLPFAQKRWCGNAGVDRVITLSDYRDHAFSKAYGTYIKEWALCSRAV
HCCCCEEEEEEECCCCHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCEEE
FVVDRNDRLVHVEYVPVAGQEPNYDAALEAARAALKA
EEEECCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: reduced thioredoxin; H2O2 [C]

Specific reaction: reduced thioredoxin + H2O2 = oxidized thioredoxin + H2O [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377; 9298659 [H]