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The map label for this gene is fabI [H]

Identifier: 51894063

GI number: 51894063

Start: 3154485

End: 3155267

Strand: Reverse

Name: fabI [H]

Synonym: STH2927

Alternate gene names: 51894063

Gene position: 3155267-3154485 (Counterclockwise)

Preceding gene: 51894064

Following gene: 51894062

Centisome position: 88.48

GC content: 68.33

Gene sequence:

>783_bases
GTGGGACTGATGACGGGGAGAAAGTGCCTGGTGATGGGCGTCGCCAACAAGCGCTCCATCGCGTGGGGGATCGCCCGGGC
CCTGCACCGGGAGGGCGCGGAGCTGGCGTTCACTTACGTCAACGATCGGCTGAAGGAGAACGTGGAGGAGCTGGTCCGGA
CTCTGGACGGGCACGAGGAGATGCCGCTCCTGCCCTGCGACGTCATGGAGGACGGCCAGATCGAGGCGGCCTTCGCCGAA
CTGGGCAGGCGCTGGGGGAAGCTGGACGTGGTGGTCCACTCCATCGCCTACGCACGGACGGAGGACCTGCAGCGGGACTT
CGTGGACACCACCCGGGAGGGGTGGCGCATCGCCCAGGAGGTTTCGGCATGGTCCCTCATTGCCGTCGCCCGGGCGGCCA
AGCCGCTGATGGAAGCCGCCGGCGGCGGGTCCATCATGACGCTGACGTACCTGGCCTCCGAGCGGGTGGTGGACCGGTAC
AACATCATGGCGCCGGCCAAGGCGGCCCTGGAGTGCAACGTGCGCTACCTGGCCCACGAGCTGGGGCCCAGCAACATCCG
GGTGAACGCCATTTCCGCCGGGCCGCTGAAGACCCTGGCTGCCAGCGCCGTGAAGGGGCTCAGCACCATCCGGGACATCG
TGGAGGAGCGGGCGCCGCTTCGGCGCAACGTGACCCTGGAAGAGGTGGGCGACGTCGGCCTGTTCCTGGCCTCTCCCCTG
TCCCGGTGTATCACCGGCGAGACGATCTACGCCGACAACGGCTTCCACATCATGGGGGTGTGA

Upstream 100 bases:

>100_bases
CGTGCAGAAGCGGCCATAGGGCATGGTAAACTCCGATCTAATAGGCTATTATTAGTACCAGGTATTAATCCGGCCGACGG
GTAAGGGGGAGACGTGTGCC

Downstream 100 bases:

>100_bases
CCGGTCGGCTGCGGAGAAATCACGCCGGCGGGGGTTCCGCGCGGCACTTCCGCCCCGGGGCGCGCGGCGCGCCGGGGCTT
TTTTCTTGACCTGATGCAGC

Product: enoyl-(acyl-carrier protein) reductase

Products: NA

Alternate protein names: NADH-dependent enoyl-ACP reductase [H]

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MGLMTGRKCLVMGVANKRSIAWGIARALHREGAELAFTYVNDRLKENVEELVRTLDGHEEMPLLPCDVMEDGQIEAAFAE
LGRRWGKLDVVVHSIAYARTEDLQRDFVDTTREGWRIAQEVSAWSLIAVARAAKPLMEAAGGGSIMTLTYLASERVVDRY
NIMAPAKAALECNVRYLAHELGPSNIRVNAISAGPLKTLAASAVKGLSTIRDIVEERAPLRRNVTLEEVGDVGLFLASPL
SRCITGETIYADNGFHIMGV

Sequences:

>Translated_260_residues
MGLMTGRKCLVMGVANKRSIAWGIARALHREGAELAFTYVNDRLKENVEELVRTLDGHEEMPLLPCDVMEDGQIEAAFAE
LGRRWGKLDVVVHSIAYARTEDLQRDFVDTTREGWRIAQEVSAWSLIAVARAAKPLMEAAGGGSIMTLTYLASERVVDRY
NIMAPAKAALECNVRYLAHELGPSNIRVNAISAGPLKTLAASAVKGLSTIRDIVEERAPLRRNVTLEEVGDVGLFLASPL
SRCITGETIYADNGFHIMGV
>Mature_259_residues
GLMTGRKCLVMGVANKRSIAWGIARALHREGAELAFTYVNDRLKENVEELVRTLDGHEEMPLLPCDVMEDGQIEAAFAEL
GRRWGKLDVVVHSIAYARTEDLQRDFVDTTREGWRIAQEVSAWSLIAVARAAKPLMEAAGGGSIMTLTYLASERVVDRYN
IMAPAKAALECNVRYLAHELGPSNIRVNAISAGPLKTLAASAVKGLSTIRDIVEERAPLRRNVTLEEVGDVGLFLASPLS
RCITGETIYADNGFHIMGV

Specific function: Fatty acid biosynthesis pathway; second reduction step. [C]

COG id: COG0623

COG function: function code I; Enoyl-[acyl-carrier-protein] reductase (NADH)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily [H]

Homologues:

Organism=Homo sapiens, GI7705925, Length=254, Percent_Identity=28.740157480315, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI32483357, Length=241, Percent_Identity=27.3858921161826, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI126723750, Length=236, Percent_Identity=27.5423728813559, Blast_Score=71, Evalue=8e-13,
Organism=Escherichia coli, GI1787545, Length=258, Percent_Identity=49.2248062015504, Blast_Score=257, Evalue=6e-70,
Organism=Escherichia coli, GI87082100, Length=261, Percent_Identity=28.3524904214559, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1787905, Length=249, Percent_Identity=26.5060240963855, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790717, Length=254, Percent_Identity=24.8031496062992, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI2367365, Length=261, Percent_Identity=26.4367816091954, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1789378, Length=260, Percent_Identity=26.5384615384615, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR014358
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.9 [H]

Molecular weight: Translated: 28465; Mature: 28334

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLMTGRKCLVMGVANKRSIAWGIARALHREGAELAFTYVNDRLKENVEELVRTLDGHEE
CCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHCCCCC
MPLLPCDVMEDGQIEAAFAELGRRWGKLDVVVHSIAYARTEDLQRDFVDTTREGWRIAQE
CCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSAWSLIAVARAAKPLMEAAGGGSIMTLTYLASERVVDRYNIMAPAKAALECNVRYLAHE
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LGPSNIRVNAISAGPLKTLAASAVKGLSTIRDIVEERAPLRRNVTLEEVGDVGLFLASPL
CCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHCCHHHHHHHHH
SRCITGETIYADNGFHIMGV
HHHHCCCEEEECCCEEEEEC
>Mature Secondary Structure 
GLMTGRKCLVMGVANKRSIAWGIARALHREGAELAFTYVNDRLKENVEELVRTLDGHEE
CCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHCCCCC
MPLLPCDVMEDGQIEAAFAELGRRWGKLDVVVHSIAYARTEDLQRDFVDTTREGWRIAQE
CCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSAWSLIAVARAAKPLMEAAGGGSIMTLTYLASERVVDRYNIMAPAKAALECNVRYLAHE
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LGPSNIRVNAISAGPLKTLAASAVKGLSTIRDIVEERAPLRRNVTLEEVGDVGLFLASPL
CCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHCCHHHHHHHHH
SRCITGETIYADNGFHIMGV
HHHHCCCEEEECCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10464225; 10984043 [H]