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The map label for this gene is rnhA

Identifier: 51894058

GI number: 51894058

Start: 3150382

End: 3150825

Strand: Reverse

Name: rnhA

Synonym: STH2922

Alternate gene names: 51894058

Gene position: 3150825-3150382 (Counterclockwise)

Preceding gene: 51894059

Following gene: 51894057

Centisome position: 88.35

GC content: 68.24

Gene sequence:

>444_bases
GTGCGGGAGGTCATCATCTACACCGACGGCGCCTGCTCCGGAAACCCCGGGCCCGGCGGCTGGGGCGCGGTGCTCCTGTA
CGGTTCCCACCGCAAGGAGCTGTCGGGCTTCCACCCCCACACGACCAACAACCGCATGGAGATTCAGGCCGCCATCGAGG
CCCTGCGGGCCCTGAAGTATCCCTGCAAGGTCAAGCTGTACTCGGACAGCGCCTACCTGGTCAACGCCTTCCGGCAGAAC
TGGCTGCGGACCTGGCAGCGGAACGGCTGGGTCAACAGCAGGAAGCAGCCGGTGGAGAACCAGGACCTGTGGCAGGAGTT
GCTGGAGGCTGCCCGGCCGCACCAGGTGGAATGGCTGAAGGTGCAGGGGCACGCCGACGTGGCGGAGAACAACCGCTGTG
ACGAGCTGGCGCGCGCGGCGATCGCGGCCGGCACGCAGGGCTGA

Upstream 100 bases:

>100_bases
TCACCGAGCCCGGAGCGGTGCGCAAGGGCTACTACACGGACACCGGGGAAGACGCCATCATCATGTGGAAGGAACCGCTG
GTCGAGGAGGCGATCTGACC

Downstream 100 bases:

>100_bases
GAGGTGAAGGGGTTGTCGGAAGGGCTGATCCTCGGTATCGAGTCCTCCTGCGACGAGACGGCGGCGGCCGTCGTCGCGGG
CGGGCGCAGGGTGCTGTCCA

Product: ribonuclease H

Products: NA

Alternate protein names: RNase H

Number of amino acids: Translated: 147; Mature: 147

Protein sequence:

>147_residues
MREVIIYTDGACSGNPGPGGWGAVLLYGSHRKELSGFHPHTTNNRMEIQAAIEALRALKYPCKVKLYSDSAYLVNAFRQN
WLRTWQRNGWVNSRKQPVENQDLWQELLEAARPHQVEWLKVQGHADVAENNRCDELARAAIAAGTQG

Sequences:

>Translated_147_residues
MREVIIYTDGACSGNPGPGGWGAVLLYGSHRKELSGFHPHTTNNRMEIQAAIEALRALKYPCKVKLYSDSAYLVNAFRQN
WLRTWQRNGWVNSRKQPVENQDLWQELLEAARPHQVEWLKVQGHADVAENNRCDELARAAIAAGTQG
>Mature_147_residues
MREVIIYTDGACSGNPGPGGWGAVLLYGSHRKELSGFHPHTTNNRMEIQAAIEALRALKYPCKVKLYSDSAYLVNAFRQN
WLRTWQRNGWVNSRKQPVENQDLWQELLEAARPHQVEWLKVQGHADVAENNRCDELARAAIAAGTQG

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain

Homologues:

Organism=Homo sapiens, GI21359816, Length=146, Percent_Identity=34.2465753424658, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1786408, Length=140, Percent_Identity=52.1428571428571, Blast_Score=147, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI115532542, Length=140, Percent_Identity=36.4285714285714, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45552509, Length=146, Percent_Identity=33.5616438356164, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI17137476, Length=146, Percent_Identity=33.5616438356164, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNH_SYMTH (Q67K93)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_076749.1
- HSSP:   P0A7Y4
- ProteinModelPortal:   Q67K93
- GeneID:   2979439
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH2922
- NMPDR:   fig|292459.1.peg.2796
- HOGENOM:   HBG742437
- OMA:   NGWRTAD
- ProtClustDB:   PRK00203
- BioCyc:   STHE292459:STH2922-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00042
- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156

Pfam domain/function: PF00075 RnaseH; SSF53098 RNaseH_fold

EC number: =3.1.26.4

Molecular weight: Translated: 16584; Mature: 16584

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREVIIYTDGACSGNPGPGGWGAVLLYGSHRKELSGFHPHTTNNRMEIQAAIEALRALKY
CCEEEEEECCCCCCCCCCCCCEEEEEECCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHCC
PCKVKLYSDSAYLVNAFRQNWLRTWQRNGWVNSRKQPVENQDLWQELLEAARPHQVEWLK
CCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEE
VQGHADVAENNRCDELARAAIAAGTQG
ECCCCCCCCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MREVIIYTDGACSGNPGPGGWGAVLLYGSHRKELSGFHPHTTNNRMEIQAAIEALRALKY
CCEEEEEECCCCCCCCCCCCCEEEEEECCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHCC
PCKVKLYSDSAYLVNAFRQNWLRTWQRNGWVNSRKQPVENQDLWQELLEAARPHQVEWLK
CCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEE
VQGHADVAENNRCDELARAAIAAGTQG
ECCCCCCCCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA