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The map label for this gene is gcp

Identifier: 51894057

GI number: 51894057

Start: 3149353

End: 3150378

Strand: Reverse

Name: gcp

Synonym: STH2921

Alternate gene names: 51894057

Gene position: 3150378-3149353 (Counterclockwise)

Preceding gene: 51894058

Following gene: 51894056

Centisome position: 88.34

GC content: 71.93

Gene sequence:

>1026_bases
GTGAAGGGGTTGTCGGAAGGGCTGATCCTCGGTATCGAGTCCTCCTGCGACGAGACGGCGGCGGCCGTCGTCGCGGGCGG
GCGCAGGGTGCTGTCCAATACCGTCGCGAGTCAGGTGGACCTCTTCCGCAAGTACGGAGGGGTCGTGCCTGAGATCGCCT
CGCGCCGGCACCTGGAGCTGATCCTGCCCGTGATCCGGGAGGCGCTGCAGATGGCCGGCGTCACGTTGGAGCAGATCGAC
GCGGTCGCCGTCACCCACGGTCCCGGCCTGGTGGGCACGCTGCTGGTGGGGCTGTCAGCCGCGAAGGCCCTGGCCTTCGG
CCTGGACAAGCCCCTGATCGGCGTGAACCACCTGCAGGGCCATATCTACGCCAACTTCCTGGTGGAGCCCCCGCCTGAGT
TCCCGCTGGTCTGCCTGGTGGTCTCGGGCGGCCATACGGACCTGATCTACATGGCCGGCCACGGCCGGATGGAGCTGCTC
GGCCGCACCCTGGACGACGCGGCCGGCGAGGCTTTCGACAAGGTGGCCCGCTCCGTGGGGCTCGGTTACCCCGGCGGCCC
GCAGGTGGAGAAGCTGGCCCGGTCGGGCGACCCGGAGGCCGTGCCGCTGCCGCGCGCCCACACGGAGGGGCCTTACGACT
TCTCCTTCTCGGGCCTGAAGACCGCGGTGCTCCAGTACGTCCAGCGCACCGGTCCCCTGAACGATCAGCAGCGGGCGGAC
CTCGCGGCGTCGTTCCAGCGGGCGGTGACGTCGGTGCTGGTGGAGCGCACGGTGAAGGCGGCGGAGGCGAAGGGCGTTCG
GCAGGTGATCCTGGCCGGGGGCGTCGCCGCCAACGGCGCCCTGCGGGAGGAGATGCGCGCCGCACTGGAGCCCCGGGGGA
TCCGCCTCGGCTACCCGCCGCCGGTGCTCTGTACCGACAACGCGGCCATGATCGCCGCCGCCGGCTACTACCTCTGGCGG
GCCGGCGTCCGCCACGACCTGGACCTGAACGCCGTGCCCGGGCTGGGGCTCGGCATCGGCGGCTGA

Upstream 100 bases:

>100_bases
GGAATGGCTGAAGGTGCAGGGGCACGCCGACGTGGCGGAGAACAACCGCTGTGACGAGCTGGCGCGCGCGGCGATCGCGG
CCGGCACGCAGGGCTGAGAG

Downstream 100 bases:

>100_bases
GGGGGGATGGCGCCGTGACGCGCCGGCACGAGAGGCTCACCCGGCTGCCCGACTACGGGCCGCACAACCCGCTGCAGTAC
TGGTACCGGCATGTCCACCC

Product: O-sialoglycoprotein endopeptidase

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MKGLSEGLILGIESSCDETAAAVVAGGRRVLSNTVASQVDLFRKYGGVVPEIASRRHLELILPVIREALQMAGVTLEQID
AVAVTHGPGLVGTLLVGLSAAKALAFGLDKPLIGVNHLQGHIYANFLVEPPPEFPLVCLVVSGGHTDLIYMAGHGRMELL
GRTLDDAAGEAFDKVARSVGLGYPGGPQVEKLARSGDPEAVPLPRAHTEGPYDFSFSGLKTAVLQYVQRTGPLNDQQRAD
LAASFQRAVTSVLVERTVKAAEAKGVRQVILAGGVAANGALREEMRAALEPRGIRLGYPPPVLCTDNAAMIAAAGYYLWR
AGVRHDLDLNAVPGLGLGIGG

Sequences:

>Translated_341_residues
MKGLSEGLILGIESSCDETAAAVVAGGRRVLSNTVASQVDLFRKYGGVVPEIASRRHLELILPVIREALQMAGVTLEQID
AVAVTHGPGLVGTLLVGLSAAKALAFGLDKPLIGVNHLQGHIYANFLVEPPPEFPLVCLVVSGGHTDLIYMAGHGRMELL
GRTLDDAAGEAFDKVARSVGLGYPGGPQVEKLARSGDPEAVPLPRAHTEGPYDFSFSGLKTAVLQYVQRTGPLNDQQRAD
LAASFQRAVTSVLVERTVKAAEAKGVRQVILAGGVAANGALREEMRAALEPRGIRLGYPPPVLCTDNAAMIAAAGYYLWR
AGVRHDLDLNAVPGLGLGIGG
>Mature_341_residues
MKGLSEGLILGIESSCDETAAAVVAGGRRVLSNTVASQVDLFRKYGGVVPEIASRRHLELILPVIREALQMAGVTLEQID
AVAVTHGPGLVGTLLVGLSAAKALAFGLDKPLIGVNHLQGHIYANFLVEPPPEFPLVCLVVSGGHTDLIYMAGHGRMELL
GRTLDDAAGEAFDKVARSVGLGYPGGPQVEKLARSGDPEAVPLPRAHTEGPYDFSFSGLKTAVLQYVQRTGPLNDQQRAD
LAASFQRAVTSVLVERTVKAAEAKGVRQVILAGGVAANGALREEMRAALEPRGIRLGYPPPVLCTDNAAMIAAAGYYLWR
AGVRHDLDLNAVPGLGLGIGG

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=346, Percent_Identity=35.5491329479769, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI8923380, Length=326, Percent_Identity=34.6625766871166, Blast_Score=151, Evalue=7e-37,
Organism=Escherichia coli, GI1789445, Length=326, Percent_Identity=47.5460122699387, Blast_Score=292, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI17557464, Length=335, Percent_Identity=32.2388059701493, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71995670, Length=327, Percent_Identity=31.8042813455657, Blast_Score=126, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320099, Length=358, Percent_Identity=31.2849162011173, Blast_Score=142, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6322891, Length=296, Percent_Identity=29.7297297297297, Blast_Score=103, Evalue=4e-23,
Organism=Drosophila melanogaster, GI20129063, Length=352, Percent_Identity=34.9431818181818, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI21357207, Length=337, Percent_Identity=32.9376854599407, Blast_Score=144, Evalue=6e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_SYMTH (Q67K94)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_076748.1
- ProteinModelPortal:   Q67K94
- SMR:   Q67K94
- MEROPS:   M22.001
- GeneID:   2979438
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH2921
- NMPDR:   fig|292459.1.peg.2795
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- BioCyc:   STHE292459:STH2921-MONOMER
- BRENDA:   3.4.24.57
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017860
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 35729; Mature: 35729

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGLSEGLILGIESSCDETAAAVVAGGRRVLSNTVASQVDLFRKYGGVVPEIASRRHLEL
CCCCCCCEEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHH
ILPVIREALQMAGVTLEQIDAVAVTHGPGLVGTLLVGLSAAKALAFGLDKPLIGVNHLQG
HHHHHHHHHHHHCCCHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCC
HIYANFLVEPPPEFPLVCLVVSGGHTDLIYMAGHGRMELLGRTLDDAAGEAFDKVARSVG
EEEEEEEECCCCCCCEEEEEEECCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHC
LGYPGGPQVEKLARSGDPEAVPLPRAHTEGPYDFSFSGLKTAVLQYVQRTGPLNDQQRAD
CCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHH
LAASFQRAVTSVLVERTVKAAEAKGVRQVILAGGVAANGALREEMRAALEPRGIRLGYPP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEECCCCC
PVLCTDNAAMIAAAGYYLWRAGVRHDLDLNAVPGLGLGIGG
CEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKGLSEGLILGIESSCDETAAAVVAGGRRVLSNTVASQVDLFRKYGGVVPEIASRRHLEL
CCCCCCCEEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHH
ILPVIREALQMAGVTLEQIDAVAVTHGPGLVGTLLVGLSAAKALAFGLDKPLIGVNHLQG
HHHHHHHHHHHHCCCHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCC
HIYANFLVEPPPEFPLVCLVVSGGHTDLIYMAGHGRMELLGRTLDDAAGEAFDKVARSVG
EEEEEEEECCCCCCCEEEEEEECCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHC
LGYPGGPQVEKLARSGDPEAVPLPRAHTEGPYDFSFSGLKTAVLQYVQRTGPLNDQQRAD
CCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHH
LAASFQRAVTSVLVERTVKAAEAKGVRQVILAGGVAANGALREEMRAALEPRGIRLGYPP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEECCCCC
PVLCTDNAAMIAAAGYYLWRAGVRHDLDLNAVPGLGLGIGG
CEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA