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The map label for this gene is guaB [H]

Identifier: 51894052

GI number: 51894052

Start: 3144219

End: 3145679

Strand: Reverse

Name: guaB [H]

Synonym: STH2916

Alternate gene names: 51894052

Gene position: 3145679-3144219 (Counterclockwise)

Preceding gene: 51894054

Following gene: 51894051

Centisome position: 88.21

GC content: 67.62

Gene sequence:

>1461_bases
ATGGACGCCAAGTTCGGGCCGGAGGCTTTGACTTTCGATGACGTACTGCTGGTCCCGGCGCACTCGGAGGTGCTCCCCCG
GGACGTCGACGTCTCAACCCGGCTGACACGCAAGATACGGCTCAACATCCCCCTGGTGTCGGCAGCGATGGACACGGTGA
CGGAGGCCCGCATGGCGATCGCCATGGCGCGCGAGGGCGGCATCGGCATCATCCATAAGTCGATGTCCATCGAGCGGCAG
GCGGAGGAGGTCGACAAGGTCAAGCGTTCCGAACACGGCATCATCGTCGACCCGGTCTTCGTCCACCCCGACGACATGAT
CGAGACGGCCCTGCAGCTCATGGCCCGGTACCGCATTTCCGGCACGCCGGTGGTGGAGCGGGGCACGCACAAGCTGGTGG
GCATCCTCACCAACCGCGACCTGCGGTTCGAGGACAACTGGAATCAGCCCGTCGGCAACGTGATGACCCGGGAGAACCTG
ATCACCGCTCCGGTGGGCACCACCCTGGAGCAGGCCCGGGAGATTCTGCGCCACGCCAAGGTGGAGAAGCTGCCGCTGGT
GGACGAGCATGGGGTGCTGAAGGGGCTCATCACCATCAAGGACATCGAGAAGGCCAAGAAGTACCCCAACTCGGCCAAGG
ACGAGCACGGCCGCCTGCTCTGCGGCGCGGCCGTCGGCGTGTCCGACGATCTGATGGAGCGGGCTGGCGCCCTGGTCGAC
GCGGGCGTGGACGTCCTGGTGCTGGACTCCGCCCACGGCCACTCCCGGGGCATCATGGAGGCCCTTCGCAAGGTGAAGCG
GAACTTCCCGCAGGTCCAGGTGATCGCGGGCAACGTGGCCACCTACGAGGGCACCCGCGACCTGATCGAGGCCGGCGCCG
ACGCGGTGAAGGTGGGCATCGGGCCCGGGTCCATCTGCACCACCCGCGTGGTGGCGGGCATCGGCGTCCCGCAGATCACG
GCGATCTACGAGTCGGCCAGGGCGGCCGACGAGTACGACGTGCCCATCATCGCGGACGGCGGCATCAAGTACTCGGGCGA
CATCACCAAGGCCATTGCGGCCGGCGCCTCCGCCGTCATGATCGGCTCCCTCTTCGCCGGCACCGACGAGTCCCCCGGCG
AGATGGAGATCTACCAGGGCCGCTCCTTCAAGGTCTACCGCGGGATGGGCTCCCTCGGCGCCATGAAGCAGGGTTCAGGC
GACCGGTACTTCCAGGAGGGCGCGCCCAAGCTGGTGCCGGAGGGCATCGAGGGACGCGTGCCGTACCGGGGTCCCCTGGC
GGAGATGGTCTTCCAGCTGGTGGGCGGCCTGCGGGCCGGCATGGGGTACTGCGGCACCCGCACCATCGAGGAGCTGCGCA
AGAACGGGAAGTTCTGCCGCATCACCGCCGCGGGGCTGCGGGAGAGCCACCCGCACGACGTGATGATCACCAAGGAAGCG
CCCAACTACAGCGCTACATAA

Upstream 100 bases:

>100_bases
TCCACATGCAGAAACCCTGCGGGCGGCGGTTGCCGCCGGTTATACGCTATGGTATAATGCTTCAAATTCCGAGCACGAGG
CTCAGTCGGAGGTCTGGATC

Downstream 100 bases:

>100_bases
GAATGCAGGGCGAGGCGAAAACGGCGGCCCGGGCAGCGCAGCCCGGGCCCTTTGCTTGGGAATTGCGGGGGCTTCCTGGA
CGGGGGTTCGGCTTTCTGTT

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MDAKFGPEALTFDDVLLVPAHSEVLPRDVDVSTRLTRKIRLNIPLVSAAMDTVTEARMAIAMAREGGIGIIHKSMSIERQ
AEEVDKVKRSEHGIIVDPVFVHPDDMIETALQLMARYRISGTPVVERGTHKLVGILTNRDLRFEDNWNQPVGNVMTRENL
ITAPVGTTLEQAREILRHAKVEKLPLVDEHGVLKGLITIKDIEKAKKYPNSAKDEHGRLLCGAAVGVSDDLMERAGALVD
AGVDVLVLDSAHGHSRGIMEALRKVKRNFPQVQVIAGNVATYEGTRDLIEAGADAVKVGIGPGSICTTRVVAGIGVPQIT
AIYESARAADEYDVPIIADGGIKYSGDITKAIAAGASAVMIGSLFAGTDESPGEMEIYQGRSFKVYRGMGSLGAMKQGSG
DRYFQEGAPKLVPEGIEGRVPYRGPLAEMVFQLVGGLRAGMGYCGTRTIEELRKNGKFCRITAAGLRESHPHDVMITKEA
PNYSAT

Sequences:

>Translated_486_residues
MDAKFGPEALTFDDVLLVPAHSEVLPRDVDVSTRLTRKIRLNIPLVSAAMDTVTEARMAIAMAREGGIGIIHKSMSIERQ
AEEVDKVKRSEHGIIVDPVFVHPDDMIETALQLMARYRISGTPVVERGTHKLVGILTNRDLRFEDNWNQPVGNVMTRENL
ITAPVGTTLEQAREILRHAKVEKLPLVDEHGVLKGLITIKDIEKAKKYPNSAKDEHGRLLCGAAVGVSDDLMERAGALVD
AGVDVLVLDSAHGHSRGIMEALRKVKRNFPQVQVIAGNVATYEGTRDLIEAGADAVKVGIGPGSICTTRVVAGIGVPQIT
AIYESARAADEYDVPIIADGGIKYSGDITKAIAAGASAVMIGSLFAGTDESPGEMEIYQGRSFKVYRGMGSLGAMKQGSG
DRYFQEGAPKLVPEGIEGRVPYRGPLAEMVFQLVGGLRAGMGYCGTRTIEELRKNGKFCRITAAGLRESHPHDVMITKEA
PNYSAT
>Mature_486_residues
MDAKFGPEALTFDDVLLVPAHSEVLPRDVDVSTRLTRKIRLNIPLVSAAMDTVTEARMAIAMAREGGIGIIHKSMSIERQ
AEEVDKVKRSEHGIIVDPVFVHPDDMIETALQLMARYRISGTPVVERGTHKLVGILTNRDLRFEDNWNQPVGNVMTRENL
ITAPVGTTLEQAREILRHAKVEKLPLVDEHGVLKGLITIKDIEKAKKYPNSAKDEHGRLLCGAAVGVSDDLMERAGALVD
AGVDVLVLDSAHGHSRGIMEALRKVKRNFPQVQVIAGNVATYEGTRDLIEAGADAVKVGIGPGSICTTRVVAGIGVPQIT
AIYESARAADEYDVPIIADGGIKYSGDITKAIAAGASAVMIGSLFAGTDESPGEMEIYQGRSFKVYRGMGSLGAMKQGSG
DRYFQEGAPKLVPEGIEGRVPYRGPLAEMVFQLVGGLRAGMGYCGTRTIEELRKNGKFCRITAAGLRESHPHDVMITKEA
PNYSAT

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=453, Percent_Identity=44.8123620309051, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI34328928, Length=453, Percent_Identity=44.8123620309051, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI156616279, Length=453, Percent_Identity=44.8123620309051, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI34328930, Length=453, Percent_Identity=44.8123620309051, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI66933016, Length=453, Percent_Identity=43.4878587196468, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI217035152, Length=447, Percent_Identity=44.9664429530201, Blast_Score=359, Evalue=4e-99,
Organism=Homo sapiens, GI217035148, Length=453, Percent_Identity=43.9293598233996, Blast_Score=354, Evalue=8e-98,
Organism=Homo sapiens, GI217035150, Length=453, Percent_Identity=41.7218543046358, Blast_Score=330, Evalue=3e-90,
Organism=Homo sapiens, GI156104880, Length=239, Percent_Identity=37.6569037656904, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI50541956, Length=220, Percent_Identity=40.4545454545455, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI50541954, Length=220, Percent_Identity=40.4545454545455, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI50541952, Length=220, Percent_Identity=40.4545454545455, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI50541948, Length=220, Percent_Identity=40.4545454545455, Blast_Score=162, Evalue=7e-40,
Organism=Escherichia coli, GI1788855, Length=483, Percent_Identity=58.592132505176, Blast_Score=513, Evalue=1e-146,
Organism=Escherichia coli, GI1786293, Length=240, Percent_Identity=37.5, Blast_Score=156, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI71994385, Length=470, Percent_Identity=38.5106382978723, Blast_Score=294, Evalue=8e-80,
Organism=Caenorhabditis elegans, GI71994389, Length=419, Percent_Identity=40.5727923627685, Blast_Score=279, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI17560440, Length=301, Percent_Identity=34.8837209302326, Blast_Score=176, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6322012, Length=464, Percent_Identity=41.5948275862069, Blast_Score=344, Evalue=2e-95,
Organism=Saccharomyces cerevisiae, GI6323585, Length=455, Percent_Identity=41.0989010989011, Blast_Score=337, Evalue=2e-93,
Organism=Saccharomyces cerevisiae, GI6323464, Length=455, Percent_Identity=41.3186813186813, Blast_Score=332, Evalue=7e-92,
Organism=Saccharomyces cerevisiae, GI6319352, Length=346, Percent_Identity=40.7514450867052, Blast_Score=254, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6319353, Length=114, Percent_Identity=40.3508771929825, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24641071, Length=484, Percent_Identity=41.9421487603306, Blast_Score=352, Evalue=3e-97,
Organism=Drosophila melanogaster, GI24641073, Length=484, Percent_Identity=41.9421487603306, Blast_Score=352, Evalue=3e-97,
Organism=Drosophila melanogaster, GI28571163, Length=439, Percent_Identity=42.5968109339408, Blast_Score=316, Evalue=2e-86,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52429; Mature: 52429

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAKFGPEALTFDDVLLVPAHSEVLPRDVDVSTRLTRKIRLNIPLVSAAMDTVTEARMAI
CCCCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHEEEEEEECCCHHHHHHHHHHHHHHHH
AMAREGGIGIIHKSMSIERQAEEVDKVKRSEHGIIVDPVFVHPDDMIETALQLMARYRIS
HHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHHHHHCCC
GTPVVERGTHKLVGILTNRDLRFEDNWNQPVGNVMTRENLITAPVGTTLEQAREILRHAK
CCCEEECCCCEEEEEEECCCEEECCCCCCCHHHHHHHCCEEECCCCHHHHHHHHHHHHCC
VEKLPLVDEHGVLKGLITIKDIEKAKKYPNSAKDEHGRLLCGAAVGVSDDLMERAGALVD
HHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHCCCHHH
AGVDVLVLDSAHGHSRGIMEALRKVKRNFPQVQVIAGNVATYEGTRDLIEAGADAVKVGI
CCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEECCEEECCCHHHHHHCCCCEEEEEC
GPGSICTTRVVAGIGVPQITAIYESARAADEYDVPIIADGGIKYSGDITKAIAAGASAVM
CCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEECCCEEECCCHHHHHHCCCHHHH
IGSLFAGTDESPGEMEIYQGRSFKVYRGMGSLGAMKQGSGDRYFQEGAPKLVPEGIEGRV
HHHHHCCCCCCCCCEEEECCCCEEEEECCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCC
PYRGPLAEMVFQLVGGLRAGMGYCGTRTIEELRKNGKFCRITAAGLRESHPHDVMITKEA
CCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEECC
PNYSAT
CCCCCC
>Mature Secondary Structure
MDAKFGPEALTFDDVLLVPAHSEVLPRDVDVSTRLTRKIRLNIPLVSAAMDTVTEARMAI
CCCCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHEEEEEEECCCHHHHHHHHHHHHHHHH
AMAREGGIGIIHKSMSIERQAEEVDKVKRSEHGIIVDPVFVHPDDMIETALQLMARYRIS
HHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHHHHHCCC
GTPVVERGTHKLVGILTNRDLRFEDNWNQPVGNVMTRENLITAPVGTTLEQAREILRHAK
CCCEEECCCCEEEEEEECCCEEECCCCCCCHHHHHHHCCEEECCCCHHHHHHHHHHHHCC
VEKLPLVDEHGVLKGLITIKDIEKAKKYPNSAKDEHGRLLCGAAVGVSDDLMERAGALVD
HHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHCCCHHH
AGVDVLVLDSAHGHSRGIMEALRKVKRNFPQVQVIAGNVATYEGTRDLIEAGADAVKVGI
CCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEECCEEECCCHHHHHHCCCCEEEEEC
GPGSICTTRVVAGIGVPQITAIYESARAADEYDVPIIADGGIKYSGDITKAIAAGASAVM
CCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEECCCEEECCCHHHHHHCCCHHHH
IGSLFAGTDESPGEMEIYQGRSFKVYRGMGSLGAMKQGSGDRYFQEGAPKLVPEGIEGRV
HHHHHCCCCCCCCCEEEECCCCEEEEECCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCC
PYRGPLAEMVFQLVGGLRAGMGYCGTRTIEELRKNGKFCRITAAGLRESHPHDVMITKEA
CCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEECC
PNYSAT
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]