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The map label for this gene is murC

Identifier: 51894054

GI number: 51894054

Start: 3146405

End: 3147853

Strand: Reverse

Name: murC

Synonym: STH2918

Alternate gene names: 51894054

Gene position: 3147853-3146405 (Counterclockwise)

Preceding gene: 51894055

Following gene: 51894052

Centisome position: 88.27

GC content: 70.88

Gene sequence:

>1449_bases
GTGCTGAAGGCCCGGAAGGTGCATTTCATCGGAGTCGGTGGCTACGGCATGAGCGCGCTGGCCATGGTGCTGAAGCAGCG
CGGCACGGCGGTGTCGGGTTCCGACGTGGCCGCCTCTGCCCGCACGCAGCGGCTCGCGGAGGCGGGGGTGGAGGTCCACA
TCGGCGCCCATGACGCCGCTCACATCGAGGGAGCGGACGTGGTCGTCTACTCGACGCAGGTTCCTGAAGACAATCCTGAG
CTGGCAGCCGCCCGGGCCCGGGGGCTGCGGGTGCTCCACCGCTCGGAGCTCCTGGCCGAGTTCCTGAACGGACGGTCCAT
CGCGGTGGCGGGCACGCACGGAAAGACCACCACCTCGTCGATGGTGGCCTGCCTGCTGGAGAAGGCGGGGCTCGATCCCA
CCATCCTTCTCGGCGGCGACCTGGAGGTCATCGGCGGCACCGGCAAGGCCGGCCGCGGCGACTGGGTGGTGGCCGAGGCG
GATGAGTCTGACCGTTCCTTCCTCCGCTACCATCCGCGGGTGGCGGTGGTGACCAACGTGGAGCCGGAGCACCTGGAGTT
CTGGGAGGGGTCCTTCGCCCGCATCCAGGAGGGGTTCCGCCAGTTCCTGCGCCAGGTGCAGCCCGGCGGGCTGGCCGCGC
TCTGCGCCGACGATCCGACGCTGCGCAGCATCGGGCAGGAGCTGCGTAACCAACCGGGAGTCGTGCACGTGGTCTTCTAC
GGCACCCATCCCGAGGCCGAGTGGCGCGCGGAGAACATCCGCCCGTGGGAGAAGGGAATCGTCTACGACTGCGTCCGGGA
CGGCCGGCTCCTGGGCGAGGTGCGGCTGCCCATCCCCGGGCGGCACAACGCCCTGAATTCCCTGGGGGCCCTCGTCGCCG
GGGATTATGCCGGCCTGTCGTTTAGGCAGATGCAGGAGACCCTGCTCTCCTTCGGCAACGCCCGCCGCCGCTTCGAGGTG
TGGGCCGACGTGGACGGGATCCGGGTCGTAGACGATTACGCCCACCACCCCACCGAGATCCGGGCCACCCTGGCGGCGGC
CCGGGAGCAGGCGGGGCGGCGGGTCGTCGCGGTGTTCCAGCCGCAGCGGTACTCCCGCACCCACTGGCTGATGGATGAGT
TCGCCACGGCCTTCCAGGACGCCGACGTGCTGGTGCTGACCCGGATCTACAGCCCGCCGGGTGAGCGACCGATTCCCGGC
GTCTCCGCCGAGGCCCTGGCCCGGCGCATCCAGGCCAACACCGGCCGGCCCGTCGCCGTCATCTCCGACCAGGAGGAGAT
CCTCCGCTTCCTGCTGGCGGAGGTGCGCCCCGGGGACACGGTGATCACCATGGGCGCCGGCGACATCTGGAAGGTGGCCC
GGGCGCTGGCCCAGGCGCTGCAGTCCCGGGCGGTTACGCGTACGGCGAGTAGTGGTTCGGGTCGACCAGCTCCCGGTAGC
GGGCGATGA

Upstream 100 bases:

>100_bases
GTGGCTCTTCGCGCGGTTCATTGCCCGGCCGCCGGCGGTGCAGTTGGAACAGAAGACGCATCACTTGTAGGAAACGTCGT
CCCACGAGGGGGAAGCCTGG

Downstream 100 bases:

>100_bases
CCTGCTTCATGTCGTTCCACACGTCCTTCTTCTTCGAGGGGTCCCGGAGCAGGGCGGCCGGGTGATAGGTGGGCATGAAG
TGGATGCCCTCCCGCTCGAT

Product: UDP-N-acetylmuramate-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MLKARKVHFIGVGGYGMSALAMVLKQRGTAVSGSDVAASARTQRLAEAGVEVHIGAHDAAHIEGADVVVYSTQVPEDNPE
LAAARARGLRVLHRSELLAEFLNGRSIAVAGTHGKTTTSSMVACLLEKAGLDPTILLGGDLEVIGGTGKAGRGDWVVAEA
DESDRSFLRYHPRVAVVTNVEPEHLEFWEGSFARIQEGFRQFLRQVQPGGLAALCADDPTLRSIGQELRNQPGVVHVVFY
GTHPEAEWRAENIRPWEKGIVYDCVRDGRLLGEVRLPIPGRHNALNSLGALVAGDYAGLSFRQMQETLLSFGNARRRFEV
WADVDGIRVVDDYAHHPTEIRATLAAAREQAGRRVVAVFQPQRYSRTHWLMDEFATAFQDADVLVLTRIYSPPGERPIPG
VSAEALARRIQANTGRPVAVISDQEEILRFLLAEVRPGDTVITMGAGDIWKVARALAQALQSRAVTRTASSGSGRPAPGS
GR

Sequences:

>Translated_482_residues
MLKARKVHFIGVGGYGMSALAMVLKQRGTAVSGSDVAASARTQRLAEAGVEVHIGAHDAAHIEGADVVVYSTQVPEDNPE
LAAARARGLRVLHRSELLAEFLNGRSIAVAGTHGKTTTSSMVACLLEKAGLDPTILLGGDLEVIGGTGKAGRGDWVVAEA
DESDRSFLRYHPRVAVVTNVEPEHLEFWEGSFARIQEGFRQFLRQVQPGGLAALCADDPTLRSIGQELRNQPGVVHVVFY
GTHPEAEWRAENIRPWEKGIVYDCVRDGRLLGEVRLPIPGRHNALNSLGALVAGDYAGLSFRQMQETLLSFGNARRRFEV
WADVDGIRVVDDYAHHPTEIRATLAAAREQAGRRVVAVFQPQRYSRTHWLMDEFATAFQDADVLVLTRIYSPPGERPIPG
VSAEALARRIQANTGRPVAVISDQEEILRFLLAEVRPGDTVITMGAGDIWKVARALAQALQSRAVTRTASSGSGRPAPGS
GR
>Mature_482_residues
MLKARKVHFIGVGGYGMSALAMVLKQRGTAVSGSDVAASARTQRLAEAGVEVHIGAHDAAHIEGADVVVYSTQVPEDNPE
LAAARARGLRVLHRSELLAEFLNGRSIAVAGTHGKTTTSSMVACLLEKAGLDPTILLGGDLEVIGGTGKAGRGDWVVAEA
DESDRSFLRYHPRVAVVTNVEPEHLEFWEGSFARIQEGFRQFLRQVQPGGLAALCADDPTLRSIGQELRNQPGVVHVVFY
GTHPEAEWRAENIRPWEKGIVYDCVRDGRLLGEVRLPIPGRHNALNSLGALVAGDYAGLSFRQMQETLLSFGNARRRFEV
WADVDGIRVVDDYAHHPTEIRATLAAAREQAGRRVVAVFQPQRYSRTHWLMDEFATAFQDADVLVLTRIYSPPGERPIPG
VSAEALARRIQANTGRPVAVISDQEEILRFLLAEVRPGDTVITMGAGDIWKVARALAQALQSRAVTRTASSGSGRPAPGS
GR

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=471, Percent_Identity=36.9426751592357, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1790680, Length=483, Percent_Identity=29.8136645962733, Blast_Score=174, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_SYMTH (Q67K97)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_076745.1
- ProteinModelPortal:   Q67K97
- SMR:   Q67K97
- GeneID:   2979873
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH2918
- NMPDR:   fig|292459.1.peg.2791
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- BioCyc:   STHE292459:STH2918-MONOMER
- BRENDA:   6.3.2.8
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 52228; Mature: 52228

Theoretical pI: Translated: 7.48; Mature: 7.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKARKVHFIGVGGYGMSALAMVLKQRGTAVSGSDVAASARTQRLAEAGVEVHIGAHDAA
CCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCC
HIEGADVVVYSTQVPEDNPELAAARARGLRVLHRSELLAEFLNGRSIAVAGTHGKTTTSS
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHH
MVACLLEKAGLDPTILLGGDLEVIGGTGKAGRGDWVVAEADESDRSFLRYHPRVAVVTNV
HHHHHHHHCCCCCEEEECCCEEEEECCCCCCCCCEEEEECCCCCCHHHHCCCEEEEEECC
EPEHLEFWEGSFARIQEGFRQFLRQVQPGGLAALCADDPTLRSIGQELRNQPGVVHVVFY
CHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEEEE
GTHPEAEWRAENIRPWEKGIVYDCVRDGRLLGEVRLPIPGRHNALNSLGALVAGDYAGLS
CCCCCCHHCCCCCCHHHHCCHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCH
FRQMQETLLSFGNARRRFEVWADVDGIRVVDDYAHHPTEIRATLAAAREQAGRRVVAVFQ
HHHHHHHHHHHCCCCCEEEEEECCCCEEEEHHHCCCCHHHHHHHHHHHHHCCCEEEEEEC
PQRYSRTHWLMDEFATAFQDADVLVLTRIYSPPGERPIPGVSAEALARRIQANTGRPVAV
CCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCEEEE
ISDQEEILRFLLAEVRPGDTVITMGAGDIWKVARALAQALQSRAVTRTASSGSGRPAPGS
ECCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
GR
CC
>Mature Secondary Structure
MLKARKVHFIGVGGYGMSALAMVLKQRGTAVSGSDVAASARTQRLAEAGVEVHIGAHDAA
CCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCC
HIEGADVVVYSTQVPEDNPELAAARARGLRVLHRSELLAEFLNGRSIAVAGTHGKTTTSS
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHH
MVACLLEKAGLDPTILLGGDLEVIGGTGKAGRGDWVVAEADESDRSFLRYHPRVAVVTNV
HHHHHHHHCCCCCEEEECCCEEEEECCCCCCCCCEEEEECCCCCCHHHHCCCEEEEEECC
EPEHLEFWEGSFARIQEGFRQFLRQVQPGGLAALCADDPTLRSIGQELRNQPGVVHVVFY
CHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEEEE
GTHPEAEWRAENIRPWEKGIVYDCVRDGRLLGEVRLPIPGRHNALNSLGALVAGDYAGLS
CCCCCCHHCCCCCCHHHHCCHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCH
FRQMQETLLSFGNARRRFEVWADVDGIRVVDDYAHHPTEIRATLAAAREQAGRRVVAVFQ
HHHHHHHHHHHCCCCCEEEEEECCCCEEEEHHHCCCCHHHHHHHHHHHHHCCCEEEEEEC
PQRYSRTHWLMDEFATAFQDADVLVLTRIYSPPGERPIPGVSAEALARRIQANTGRPVAV
CCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCEEEE
ISDQEEILRFLLAEVRPGDTVITMGAGDIWKVARALAQALQSRAVTRTASSGSGRPAPGS
ECCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
GR
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA