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The map label for this gene is hisC

Identifier: 51893969

GI number: 51893969

Start: 3052669

End: 3053754

Strand: Reverse

Name: hisC

Synonym: STH2831

Alternate gene names: 51893969

Gene position: 3053754-3052669 (Counterclockwise)

Preceding gene: 51893970

Following gene: 51893968

Centisome position: 85.63

GC content: 72.1

Gene sequence:

>1086_bases
ATGTCCAGCGTGCGCACAGCGGTCCGGCGGATGAAGCCCTACGTGCCGGGCAAGCCGGTGGAGGACGTCCAGCGGGAGCT
GGGGCTTCACGACCTCGTCAAGCTCAACCAGAACGAGAACCCCCTGGGCCCTTCGCCCCGGGCGGTGGCGGCCGCGCGCG
CGGCGATGGCCCAGGTCCACACCTATCCCGAGGGAACCGCCCGCCGGCTCCGGGAGCGGCTGGCGCAGATGTGGAACCTG
CCTGCGGACTGGTTCCTGATCGGCAACGGCTCCGACGAGGTCTTCCGGCTGCTGGCGGAGGTGTACCTGGAGCCGGGGGA
CCGGGTGGTCGTCCCTGAGCCGTCGTTCGCCGCCTACCGGTTCGTGGCGGAGCTGATGGGCGCCGAGGTGGTGGCGGTGC
CCCTGGCCGGCTGGACCATGGACCTGCCTGCGATGGCGGAGGCGGCGGCGCGGGGTGCGAAGCTGCTCTTCCTCTGCCGG
CCCAACAACCCCACCGGCACGGTGTTCGCCGAGGCCGACCTGCGGGCGGCCCTGGAGCGGGTGCCGCCGTCGACCCTGGT
GGTGGTGGATGAGGCCTACCGGGAGTTCGACGAGACCCCGTTCGACAGCCGGGCCCTGGTGCAGGACTACCCGAACGTGG
TCATCGCCCGGACGTTCAGCAAGATCTACGGCATGGCGGGCTTCCGGCTGGGCTACGGCGTCATGCGGCCGGAGGTGCTG
GCGCCGCTGTACACGGCCCGGGATCCCTTCAGCGTGAACGGCCTGGCGGTGGCGGCCGGGCTGGCGGCCCTGGACGACGT
GGAACACGTGGAGCGGACCCGGGCGCTCACCCGGGAGGGAAAGGCGTACCTCTACGCCGCCTTCCAGCGGCTGGGGCTCG
GGTACGTGCCCAGCGAGGCCAACTTCGTCCTGTTCGACGCGGGCAGGCCTGCGGCAGAGGTGTTCGACGCGCTGCTTCGG
CGCGGGGTGCTGGTGCGTCCGTGCGGCTCCTTCGGCCTGCCGGACCACCTGCGGGTGACGGTGGGGACGCCGGAGCAGAA
CCGACGGTTCGTGGAGGCGCTGAAGGCGGCGCTGGGCGAAGGGTGA

Upstream 100 bases:

>100_bases
TGGTGGCCCTGGTGGACCAGGGGCTGAGCCCCGCGGACGTGGCGGACCAGCTGGCCAGCCGGCGGGGGAGGAGGCGGGAG
CAGCAGAAGGAGGAGTAGCC

Downstream 100 bases:

>100_bases
TGGGACCGGGCGGGGCCCCGGAGGGCGCTCCCGCCCTTTCGCATCAGGGGGATCGCCGAGGGGCCGGAAGGGGTCGCGCA
TAGGCGCTGCAGGGAACCTG

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MSSVRTAVRRMKPYVPGKPVEDVQRELGLHDLVKLNQNENPLGPSPRAVAAARAAMAQVHTYPEGTARRLRERLAQMWNL
PADWFLIGNGSDEVFRLLAEVYLEPGDRVVVPEPSFAAYRFVAELMGAEVVAVPLAGWTMDLPAMAEAAARGAKLLFLCR
PNNPTGTVFAEADLRAALERVPPSTLVVVDEAYREFDETPFDSRALVQDYPNVVIARTFSKIYGMAGFRLGYGVMRPEVL
APLYTARDPFSVNGLAVAAGLAALDDVEHVERTRALTREGKAYLYAAFQRLGLGYVPSEANFVLFDAGRPAAEVFDALLR
RGVLVRPCGSFGLPDHLRVTVGTPEQNRRFVEALKAALGEG

Sequences:

>Translated_361_residues
MSSVRTAVRRMKPYVPGKPVEDVQRELGLHDLVKLNQNENPLGPSPRAVAAARAAMAQVHTYPEGTARRLRERLAQMWNL
PADWFLIGNGSDEVFRLLAEVYLEPGDRVVVPEPSFAAYRFVAELMGAEVVAVPLAGWTMDLPAMAEAAARGAKLLFLCR
PNNPTGTVFAEADLRAALERVPPSTLVVVDEAYREFDETPFDSRALVQDYPNVVIARTFSKIYGMAGFRLGYGVMRPEVL
APLYTARDPFSVNGLAVAAGLAALDDVEHVERTRALTREGKAYLYAAFQRLGLGYVPSEANFVLFDAGRPAAEVFDALLR
RGVLVRPCGSFGLPDHLRVTVGTPEQNRRFVEALKAALGEG
>Mature_360_residues
SSVRTAVRRMKPYVPGKPVEDVQRELGLHDLVKLNQNENPLGPSPRAVAAARAAMAQVHTYPEGTARRLRERLAQMWNLP
ADWFLIGNGSDEVFRLLAEVYLEPGDRVVVPEPSFAAYRFVAELMGAEVVAVPLAGWTMDLPAMAEAAARGAKLLFLCRP
NNPTGTVFAEADLRAALERVPPSTLVVVDEAYREFDETPFDSRALVQDYPNVVIARTFSKIYGMAGFRLGYGVMRPEVLA
PLYTARDPFSVNGLAVAAGLAALDDVEHVERTRALTREGKAYLYAAFQRLGLGYVPSEANFVLFDAGRPAAEVFDALLRR
GVLVRPCGSFGLPDHLRVTVGTPEQNRRFVEALKAALGEG

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=363, Percent_Identity=31.404958677686, Blast_Score=143, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6322075, Length=360, Percent_Identity=28.6111111111111, Blast_Score=120, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_SYMTH (Q67KI2)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_076660.1
- ProteinModelPortal:   Q67KI2
- SMR:   Q67KI2
- GeneID:   2979869
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH2831
- NMPDR:   fig|292459.1.peg.2706
- HOGENOM:   HBG646350
- OMA:   TEANFIF
- BioCyc:   STHE292459:STH2831-MONOMER
- BRENDA:   2.6.1.9
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 39539; Mature: 39408

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSVRTAVRRMKPYVPGKPVEDVQRELGLHDLVKLNQNENPLGPSPRAVAAARAAMAQVH
CCHHHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
TYPEGTARRLRERLAQMWNLPADWFLIGNGSDEVFRLLAEVYLEPGDRVVVPEPSFAAYR
CCCCHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCCCEEEECCCCHHHHH
FVAELMGAEVVAVPLAGWTMDLPAMAEAAARGAKLLFLCRPNNPTGTVFAEADLRAALER
HHHHHHCCCEEEEECCCCCCCCHHHHHHHCCCCEEEEEECCCCCCEEEEECHHHHHHHHH
VPPSTLVVVDEAYREFDETPFDSRALVQDYPNVVIARTFSKIYGMAGFRLGYGVMRPEVL
CCCCEEEEEEHHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCHHHHCCCCCCHHHH
APLYTARDPFSVNGLAVAAGLAALDDVEHVERTRALTREGKAYLYAAFQRLGLGYVPSEA
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCC
NFVLFDAGRPAAEVFDALLRRGVLVRPCGSFGLPDHLRVTVGTPEQNRRFVEALKAALGE
CEEEEECCCCHHHHHHHHHHCCEEEECCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCC
G
C
>Mature Secondary Structure 
SSVRTAVRRMKPYVPGKPVEDVQRELGLHDLVKLNQNENPLGPSPRAVAAARAAMAQVH
CHHHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
TYPEGTARRLRERLAQMWNLPADWFLIGNGSDEVFRLLAEVYLEPGDRVVVPEPSFAAYR
CCCCHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCCCEEEECCCCHHHHH
FVAELMGAEVVAVPLAGWTMDLPAMAEAAARGAKLLFLCRPNNPTGTVFAEADLRAALER
HHHHHHCCCEEEEECCCCCCCCHHHHHHHCCCCEEEEEECCCCCCEEEEECHHHHHHHHH
VPPSTLVVVDEAYREFDETPFDSRALVQDYPNVVIARTFSKIYGMAGFRLGYGVMRPEVL
CCCCEEEEEEHHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCHHHHCCCCCCHHHH
APLYTARDPFSVNGLAVAAGLAALDDVEHVERTRALTREGKAYLYAAFQRLGLGYVPSEA
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCC
NFVLFDAGRPAAEVFDALLRRGVLVRPCGSFGLPDHLRVTVGTPEQNRRFVEALKAALGE
CEEEEECCCCHHHHHHHHHHCCEEEECCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA