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The map label for this gene is hisI [H]

Identifier: 51893970

GI number: 51893970

Start: 3053757

End: 3054389

Strand: Reverse

Name: hisI [H]

Synonym: STH2832

Alternate gene names: 51893970

Gene position: 3054389-3053757 (Counterclockwise)

Preceding gene: 51893971

Following gene: 51893969

Centisome position: 85.65

GC content: 69.83

Gene sequence:

>633_bases
GTGCGGACCGGGCAGGTGCTGATGCAGGCGTACATGAACGAGGAGGCGCTCCGCCTCACGCTGGAGACCGGGTACGCCTG
GTACTGGTCCCGCAGCCGGCAGGAGCTGTGGCAGAAGGGCGGGACCTCGGGCCACGTGCAGCGGGTCCGGGAGATCCGCA
CCGACTGCGACGGGGACTCGCTGCTGCTCCTGGTGGAACAGGAGGGGGTGGCCTGCCACGAGGGCACCTACTCCTGCTTC
ACCCGCCGGGTGGACGGTTCGCCCAAGGCCCTGATCGACACCGCCTTCTGGCCCATCCAGCCGGACGACACGGTGCCCTA
CGACATCGGGTCCATCCTCCGGGAGCTCACCGCCGTTCTGGCGGAGCGGCGGGCGCATCCCGACCCGGAGAGCTACACGA
GCAGGCTCTTCCGGAGGGGACCCGACGCTTACTGCAAGAAGATCGGCGAGGAGGCCACCGAGGTGGTGCTCGCCGTCAAG
AACCGGGACCGGGAGAACCTGGCCTTCGAGGTGGCTGACCTCTGGTTTCACAGCCTGGTGGCCCTGGTGGACCAGGGGCT
GAGCCCCGCGGACGTGGCGGACCAGCTGGCCAGCCGGCGGGGGAGGAGGCGGGAGCAGCAGAAGGAGGAGTAG

Upstream 100 bases:

>100_bases
AGGCCTTCCTCCGGGAGAGGGGGGTGCTGGTACGGTCATGACGGAGACCTTGACGCTGAAGTGGGGCCCGGACGGGCTGA
TTCCGGCCGTCGTGCAGGAC

Downstream 100 bases:

>100_bases
CCATGTCCAGCGTGCGCACAGCGGTCCGGCGGATGAAGCCCTACGTGCCGGGCAAGCCGGTGGAGGACGTCCAGCGGGAG
CTGGGGCTTCACGACCTCGT

Product: histidine biosynthesis bifunctional protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MRTGQVLMQAYMNEEALRLTLETGYAWYWSRSRQELWQKGGTSGHVQRVREIRTDCDGDSLLLLVEQEGVACHEGTYSCF
TRRVDGSPKALIDTAFWPIQPDDTVPYDIGSILRELTAVLAERRAHPDPESYTSRLFRRGPDAYCKKIGEEATEVVLAVK
NRDRENLAFEVADLWFHSLVALVDQGLSPADVADQLASRRGRRREQQKEE

Sequences:

>Translated_210_residues
MRTGQVLMQAYMNEEALRLTLETGYAWYWSRSRQELWQKGGTSGHVQRVREIRTDCDGDSLLLLVEQEGVACHEGTYSCF
TRRVDGSPKALIDTAFWPIQPDDTVPYDIGSILRELTAVLAERRAHPDPESYTSRLFRRGPDAYCKKIGEEATEVVLAVK
NRDRENLAFEVADLWFHSLVALVDQGLSPADVADQLASRRGRRREQQKEE
>Mature_210_residues
MRTGQVLMQAYMNEEALRLTLETGYAWYWSRSRQELWQKGGTSGHVQRVREIRTDCDGDSLLLLVEQEGVACHEGTYSCF
TRRVDGSPKALIDTAFWPIQPDDTVPYDIGSILRELTAVLAERRAHPDPESYTSRLFRRGPDAYCKKIGEEATEVVLAVK
NRDRENLAFEVADLWFHSLVALVDQGLSPADVADQLASRRGRRREQQKEE

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=199, Percent_Identity=41.2060301507538, Blast_Score=132, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6319819, Length=189, Percent_Identity=33.8624338624339, Blast_Score=94, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 23974; Mature: 23974

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTGQVLMQAYMNEEALRLTLETGYAWYWSRSRQELWQKGGTSGHVQRVREIRTDCDGDS
CCHHHHHHHHHHCHHHEEEEHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCC
LLLLVEQEGVACHEGTYSCFTRRVDGSPKALIDTAFWPIQPDDTVPYDIGSILRELTAVL
EEEEEECCCCEECCCHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
AERRAHPDPESYTSRLFRRGPDAYCKKIGEEATEVVLAVKNRDRENLAFEVADLWFHSLV
HHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ALVDQGLSPADVADQLASRRGRRREQQKEE
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRTGQVLMQAYMNEEALRLTLETGYAWYWSRSRQELWQKGGTSGHVQRVREIRTDCDGDS
CCHHHHHHHHHHCHHHEEEEHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCC
LLLLVEQEGVACHEGTYSCFTRRVDGSPKALIDTAFWPIQPDDTVPYDIGSILRELTAVL
EEEEEECCCCEECCCHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
AERRAHPDPESYTSRLFRRGPDAYCKKIGEEATEVVLAVKNRDRENLAFEVADLWFHSLV
HHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ALVDQGLSPADVADQLASRRGRRREQQKEE
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292 [H]