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The map label for this gene is fdhA [H]

Identifier: 51893739

GI number: 51893739

Start: 2790296

End: 2792695

Strand: Reverse

Name: fdhA [H]

Synonym: STH2601

Alternate gene names: 51893739

Gene position: 2792695-2790296 (Counterclockwise)

Preceding gene: 51893740

Following gene: 51893738

Centisome position: 78.31

GC content: 67.21

Gene sequence:

>2400_bases
ATGACGAACCACTGGACTGATTACCAGAACACCGACGTGTTCATGGTGCTGGGCACCAACCCGGCGGAGAACCACCCCAT
CTCCATGCGCTGGATCGACCGGGCGCGGGAGACCCGGGGTGCGAAGCTGATCGTGGTTGACCCCAAGTTCAACCGCACGG
CCGCGAAGGCCGACCTGTACGTGCAGATCCGCCCGGGCACCGACATCGCCTTCCTGGGCGGGCTCATGAACTACGCCATG
ACCCACGGCCGGTACTTCCACGAGTACGTGGCCAAGTATACCAACGCCAGCTACCTCATCCACCCGGACTTCAAGTTCGA
GGAAGGCCTCTTCTCCGGCGCCCAGGTGGGCGAGGACGGCCAGGTGAAGTACGACACCGCCACCTGGCAGTACCAGGTGG
ACGAGGACGGCAACATCAAGAAGGATCCGACGCTGCAGCACCCGCAGTGCGTCTTCCAGCTCATGAAGAAGCACTACGCG
CGGTACACGCCCGAGATGGTCGCCGAGACCTGCGGCATGACGGTCGAGGAGTTCCTGGAGGTCGCGGAGCTCTTCACCTC
CACCGGCCGGCCCGACAAGGCGGGCAACATCATGTACGCCATGGGCATCACGCAGTCGTCCCACGGCTCGCAGAACGTGC
GGGCGGTGGCCATGCTGCAGCTCCTGCTGGGCAACATCGGCATCCCCGGCGGCGGCGTGAACGCCCACCGGGGCGAGTCC
AACGTGCAGGGTTCCACCGACATGGCGATGCTCTGGAATAACCTGCCCGGCTACATGCCCATGCCGTCTGCGGCGCAGCA
CCCGACCCTGGCGGCCTACCAGGCGTCGACGCCCAAGTCGGGCTACTGGACCAACCGGCCCAAGTTCATGGTTTCGCTGC
TGAAGGCCTGGTGGGGCGAGAACGCCACGGCGGAGAACGACTTCGCCTACGACTACCTGCCGAAGCTGGACCACCGGGAC
CACTCCCACATGTCCATCTTCGAGGCGATGGGCCGCGGCGAGCTGAAGGGCCTGTTTGCCTGGGGCCAGAACTTCGCCGT
GGGCGGGCCCAACGTCACGAAGGAGCGGTCGGCCCTGGCGAACCTGGACTGGCTGGTCGTGGTCGACCTCTTCGAGACCG
AGACGGCGGCCTTCTGGAAGGGCCCGGGCATGAATCCGGCCGAGATTCAGACCGAGGTCTTCCTGCTGCCCGCCGCCGCC
TCCTACGAGAAGTGCGGCACCGTCACCAACTCCGGCCGCTGGATCCAGTGGCGCGACAAGGCCGTGGAGCCCATGGGCGA
CTCCCGGGACGACCTCTGGATCGCGGACCGGCTCTTCAAGAAGCTGCGTGAGCTCTATGCCACCGAGGGCGGCGCCTTCC
CCGATCCCATCCTGCAGCTGCACTGGGACTACGACGACGGCGACCACCCCTCGGCGGAAAAGGTGGCCTTCGAGATCAAC
GGCTACACCTGGGCCGACCGGAAGGGGCTCACGACCTTCGGCAACCTGCAGGACGACGGTTCCACCGCCTGCGGCTGCTG
GATCTACGCCGGCTACTTCGACAACTTCGAGACCCCGAAGTGCCGGAGCCGGGTGAAGGACGAGCCGGGCACGACGCTGG
GCACCCACCTGGGCTGGGCCTGGGCCTGGCCGGTCAACCGTCGGATCCTGTACAACCGCTGCTCGATGGACGAGCACGGC
CAGCCGTGGGATCCGGAGCGGCCGCTCTTCCGGTGGGACGGCGAGAAGTTCATCGCGCAGGACGTGCCTGACTTCGTCGC
CACCAACCCGCCCGAGGTCTCGGCGCAGAACCCGTTCATCATGATGCAGGAGGGCGTGGGGGCGCTCTGGTCGCCCTCCG
GGATGAAGGACGGCCCCATCCCCGAGCACTATGAGCCGGTGGAGTCGCCGGTGTCCAACCGGTTCAACCGGCGGCAGTTC
AACCCCGTGGCCGTCATCTCCGGCAAGGGCGAGTTCGGCGCCCTCACCGAGGCCGAGAACCCCGAGTTCCCGTACATCTG
CACCACCTACCGGGTGACCGAGCACTGGCAGTCCGGCGCCATGACCCGGTCGCTGCCGTGGCTGGGCGAGATGATGCCCG
ACATGTTCGTCGAGATCTCCCCGACCCTGGCGGCCAAGCTGGGCGTGCAGTCGGGCGACCGGGTGGAGGTGACCACCGTC
CGCGGCTCGCTGGTCGCCCCGGCGATGGTCACGCCCCGCATGCGGCCGGTCCGGGTCCACGGCCGGGAGATCGAGATCGT
GGGCATGCCCTGGCACTGGGGCTTCATGGGCAAGTTCACCGGCGCCTCGGCCAACGTGCTCACGCCGCACGTGGGCGACG
CCAACACCCAGATCCCCGAGTACAAGGCGTTCCTGTGCAACGTGAAGAAGGCCGGCGGCTCCGGCCCGGTAAGGGGGTAA

Upstream 100 bases:

>100_bases
GCTGATGCGCGGCCTGGGGATTGTCCGCCTGGAACATCACGCCCGTCTCTGACACAGCTCCACGGTGGCCGGTCTGGCCC
CCACGTTTGGACGCGGCGCG

Downstream 100 bases:

>100_bases
GCTCATGACCTACGGGATGCTCATCGACCTGTCCAAGTGCATGGGCTGCCGGGGCTGCCAGGTGGCCTGCAAGCAGTGGA
ACGACCTCCCGGGTGAGGAC

Product: formate dehydrogenase alpha subunit

Products: NA

Alternate protein names: FDH subunit alpha; Formate dehydrogenase large subunit [H]

Number of amino acids: Translated: 799; Mature: 798

Protein sequence:

>799_residues
MTNHWTDYQNTDVFMVLGTNPAENHPISMRWIDRARETRGAKLIVVDPKFNRTAAKADLYVQIRPGTDIAFLGGLMNYAM
THGRYFHEYVAKYTNASYLIHPDFKFEEGLFSGAQVGEDGQVKYDTATWQYQVDEDGNIKKDPTLQHPQCVFQLMKKHYA
RYTPEMVAETCGMTVEEFLEVAELFTSTGRPDKAGNIMYAMGITQSSHGSQNVRAVAMLQLLLGNIGIPGGGVNAHRGES
NVQGSTDMAMLWNNLPGYMPMPSAAQHPTLAAYQASTPKSGYWTNRPKFMVSLLKAWWGENATAENDFAYDYLPKLDHRD
HSHMSIFEAMGRGELKGLFAWGQNFAVGGPNVTKERSALANLDWLVVVDLFETETAAFWKGPGMNPAEIQTEVFLLPAAA
SYEKCGTVTNSGRWIQWRDKAVEPMGDSRDDLWIADRLFKKLRELYATEGGAFPDPILQLHWDYDDGDHPSAEKVAFEIN
GYTWADRKGLTTFGNLQDDGSTACGCWIYAGYFDNFETPKCRSRVKDEPGTTLGTHLGWAWAWPVNRRILYNRCSMDEHG
QPWDPERPLFRWDGEKFIAQDVPDFVATNPPEVSAQNPFIMMQEGVGALWSPSGMKDGPIPEHYEPVESPVSNRFNRRQF
NPVAVISGKGEFGALTEAENPEFPYICTTYRVTEHWQSGAMTRSLPWLGEMMPDMFVEISPTLAAKLGVQSGDRVEVTTV
RGSLVAPAMVTPRMRPVRVHGREIEIVGMPWHWGFMGKFTGASANVLTPHVGDANTQIPEYKAFLCNVKKAGGSGPVRG

Sequences:

>Translated_799_residues
MTNHWTDYQNTDVFMVLGTNPAENHPISMRWIDRARETRGAKLIVVDPKFNRTAAKADLYVQIRPGTDIAFLGGLMNYAM
THGRYFHEYVAKYTNASYLIHPDFKFEEGLFSGAQVGEDGQVKYDTATWQYQVDEDGNIKKDPTLQHPQCVFQLMKKHYA
RYTPEMVAETCGMTVEEFLEVAELFTSTGRPDKAGNIMYAMGITQSSHGSQNVRAVAMLQLLLGNIGIPGGGVNAHRGES
NVQGSTDMAMLWNNLPGYMPMPSAAQHPTLAAYQASTPKSGYWTNRPKFMVSLLKAWWGENATAENDFAYDYLPKLDHRD
HSHMSIFEAMGRGELKGLFAWGQNFAVGGPNVTKERSALANLDWLVVVDLFETETAAFWKGPGMNPAEIQTEVFLLPAAA
SYEKCGTVTNSGRWIQWRDKAVEPMGDSRDDLWIADRLFKKLRELYATEGGAFPDPILQLHWDYDDGDHPSAEKVAFEIN
GYTWADRKGLTTFGNLQDDGSTACGCWIYAGYFDNFETPKCRSRVKDEPGTTLGTHLGWAWAWPVNRRILYNRCSMDEHG
QPWDPERPLFRWDGEKFIAQDVPDFVATNPPEVSAQNPFIMMQEGVGALWSPSGMKDGPIPEHYEPVESPVSNRFNRRQF
NPVAVISGKGEFGALTEAENPEFPYICTTYRVTEHWQSGAMTRSLPWLGEMMPDMFVEISPTLAAKLGVQSGDRVEVTTV
RGSLVAPAMVTPRMRPVRVHGREIEIVGMPWHWGFMGKFTGASANVLTPHVGDANTQIPEYKAFLCNVKKAGGSGPVRG
>Mature_798_residues
TNHWTDYQNTDVFMVLGTNPAENHPISMRWIDRARETRGAKLIVVDPKFNRTAAKADLYVQIRPGTDIAFLGGLMNYAMT
HGRYFHEYVAKYTNASYLIHPDFKFEEGLFSGAQVGEDGQVKYDTATWQYQVDEDGNIKKDPTLQHPQCVFQLMKKHYAR
YTPEMVAETCGMTVEEFLEVAELFTSTGRPDKAGNIMYAMGITQSSHGSQNVRAVAMLQLLLGNIGIPGGGVNAHRGESN
VQGSTDMAMLWNNLPGYMPMPSAAQHPTLAAYQASTPKSGYWTNRPKFMVSLLKAWWGENATAENDFAYDYLPKLDHRDH
SHMSIFEAMGRGELKGLFAWGQNFAVGGPNVTKERSALANLDWLVVVDLFETETAAFWKGPGMNPAEIQTEVFLLPAAAS
YEKCGTVTNSGRWIQWRDKAVEPMGDSRDDLWIADRLFKKLRELYATEGGAFPDPILQLHWDYDDGDHPSAEKVAFEING
YTWADRKGLTTFGNLQDDGSTACGCWIYAGYFDNFETPKCRSRVKDEPGTTLGTHLGWAWAWPVNRRILYNRCSMDEHGQ
PWDPERPLFRWDGEKFIAQDVPDFVATNPPEVSAQNPFIMMQEGVGALWSPSGMKDGPIPEHYEPVESPVSNRFNRRQFN
PVAVISGKGEFGALTEAENPEFPYICTTYRVTEHWQSGAMTRSLPWLGEMMPDMFVEISPTLAAKLGVQSGDRVEVTTVR
GSLVAPAMVTPRMRPVRVHGREIEIVGMPWHWGFMGKFTGASANVLTPHVGDANTQIPEYKAFLCNVKKAGGSGPVRG

Specific function: Alpha chain of the formate dehydrogenase (FDH) catalyze the reversible two-electron oxidation of formate to carbon dioxide. FDH loses activity in the presence of air, but this activity can be restored. The alpha subunit of formate dehydrogenase forms the

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI3868719, Length=819, Percent_Identity=45.0549450549451, Blast_Score=708, Evalue=0.0,
Organism=Escherichia coli, GI3868720, Length=819, Percent_Identity=45.4212454212454, Blast_Score=702, Evalue=0.0,
Organism=Escherichia coli, GI3868721, Length=442, Percent_Identity=26.9230769230769, Blast_Score=135, Evalue=7e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006443
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 89408; Mature: 89277

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNHWTDYQNTDVFMVLGTNPAENHPISMRWIDRARETRGAKLIVVDPKFNRTAAKADLY
CCCCCCCCCCCCEEEEECCCCCCCCCEEHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEE
VQIRPGTDIAFLGGLMNYAMTHGRYFHEYVAKYTNASYLIHPDFKFEEGLFSGAQVGEDG
EEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEECCCCCHHCCCCCCCCCCCCC
QVKYDTATWQYQVDEDGNIKKDPTLQHPQCVFQLMKKHYARYTPEMVAETCGMTVEEFLE
CEEEECEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHH
VAELFTSTGRPDKAGNIMYAMGITQSSHGSQNVRAVAMLQLLLGNIGIPGGGVNAHRGES
HHHHHHCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
NVQGSTDMAMLWNNLPGYMPMPSAAQHPTLAAYQASTPKSGYWTNRPKFMVSLLKAWWGE
CCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCC
NATAENDFAYDYLPKLDHRDHSHMSIFEAMGRGELKGLFAWGQNFAVGGPNVTKERSALA
CCCCCCCCCHHCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCEECCCCCCCHHHHHHC
NLDWLVVVDLFETETAAFWKGPGMNPAEIQTEVFLLPAAASYEKCGTVTNSGRWIQWRDK
CCCEEEEEEEECCCCHHEECCCCCCHHHEEEEEEEEECCCCHHHCCCCCCCCCEEEECCC
AVEPMGDSRDDLWIADRLFKKLRELYATEGGAFPDPILQLHWDYDDGDHPSAEKVAFEIN
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCEEEEEEC
GYTWADRKGLTTFGNLQDDGSTACGCWIYAGYFDNFETPKCRSRVKDEPGTTLGTHLGWA
CEEEECCCCCCEECCCCCCCCCEEEEEEEEEECCCCCCCHHHHHCCCCCCCCHHCCCCEE
WAWPVNRRILYNRCSMDEHGQPWDPERPLFRWDGEKFIAQDVPDFVATNPPEVSAQNPFI
EECCCCCEEEEEECCCCCCCCCCCCCCCCEEECCCHHHHHCCCHHHCCCCCCCCCCCCEE
MMQEGVGALWSPSGMKDGPIPEHYEPVESPVSNRFNRRQFNPVAVISGKGEFGALTEAEN
EEECCCCCEECCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCC
PEFPYICTTYRVTEHWQSGAMTRSLPWLGEMMPDMFVEISPTLAAKLGVQSGDRVEVTTV
CCCCEEEEEEEEHHHHHCCCCCCCCCHHHHHCCHHEEECCCHHHHHHCCCCCCEEEEEEE
RGSLVAPAMVTPRMRPVRVHGREIEIVGMPWHWGFMGKFTGASANVLTPHVGDANTQIPE
CCCEECCHHCCCCCCEEEECCCEEEEEECCCCCCCCEEECCCCCCEECCCCCCCCCCCCC
YKAFLCNVKKAGGSGPVRG
HHHHEEEHHHCCCCCCCCC
>Mature Secondary Structure 
TNHWTDYQNTDVFMVLGTNPAENHPISMRWIDRARETRGAKLIVVDPKFNRTAAKADLY
CCCCCCCCCCCEEEEECCCCCCCCCEEHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEE
VQIRPGTDIAFLGGLMNYAMTHGRYFHEYVAKYTNASYLIHPDFKFEEGLFSGAQVGEDG
EEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEECCCCCHHCCCCCCCCCCCCC
QVKYDTATWQYQVDEDGNIKKDPTLQHPQCVFQLMKKHYARYTPEMVAETCGMTVEEFLE
CEEEECEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHH
VAELFTSTGRPDKAGNIMYAMGITQSSHGSQNVRAVAMLQLLLGNIGIPGGGVNAHRGES
HHHHHHCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
NVQGSTDMAMLWNNLPGYMPMPSAAQHPTLAAYQASTPKSGYWTNRPKFMVSLLKAWWGE
CCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCC
NATAENDFAYDYLPKLDHRDHSHMSIFEAMGRGELKGLFAWGQNFAVGGPNVTKERSALA
CCCCCCCCCHHCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCEECCCCCCCHHHHHHC
NLDWLVVVDLFETETAAFWKGPGMNPAEIQTEVFLLPAAASYEKCGTVTNSGRWIQWRDK
CCCEEEEEEEECCCCHHEECCCCCCHHHEEEEEEEEECCCCHHHCCCCCCCCCEEEECCC
AVEPMGDSRDDLWIADRLFKKLRELYATEGGAFPDPILQLHWDYDDGDHPSAEKVAFEIN
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCEEEEEEC
GYTWADRKGLTTFGNLQDDGSTACGCWIYAGYFDNFETPKCRSRVKDEPGTTLGTHLGWA
CEEEECCCCCCEECCCCCCCCCEEEEEEEEEECCCCCCCHHHHHCCCCCCCCHHCCCCEE
WAWPVNRRILYNRCSMDEHGQPWDPERPLFRWDGEKFIAQDVPDFVATNPPEVSAQNPFI
EECCCCCEEEEEECCCCCCCCCCCCCCCCEEECCCHHHHHCCCHHHCCCCCCCCCCCCEE
MMQEGVGALWSPSGMKDGPIPEHYEPVESPVSNRFNRRQFNPVAVISGKGEFGALTEAEN
EEECCCCCEECCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCC
PEFPYICTTYRVTEHWQSGAMTRSLPWLGEMMPDMFVEISPTLAAKLGVQSGDRVEVTTV
CCCCEEEEEEEEHHHHHCCCCCCCCCHHHHHCCHHEEECCCHHHHHHCCCCCCEEEEEEE
RGSLVAPAMVTPRMRPVRVHGREIEIVGMPWHWGFMGKFTGASANVLTPHVGDANTQIPE
CCCEECCHHCCCCCCEEEECCCEEEEEECCCCCCCCEEECCCCCCEECCCCCCCCCCCCC
YKAFLCNVKKAGGSGPVRG
HHHHEEEHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA