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The map label for this gene is fdhA [H]

Identifier: 51893740

GI number: 51893740

Start: 2792744

End: 2793391

Strand: Reverse

Name: fdhA [H]

Synonym: STH2602

Alternate gene names: 51893740

Gene position: 2793391-2792744 (Counterclockwise)

Preceding gene: 51893745

Following gene: 51893739

Centisome position: 78.33

GC content: 65.9

Gene sequence:

>648_bases
ATGGGCGCAATGTGCCCTGCGATCGGGCATACGGAGCTACGCATGGGGGTGGAAAGCTTGGCCCTGACCCGACGTGATCT
CTTGAAGAGCTCGTTGGCGGCGGGGGGTGCCCTCTCGCTTCTGGGGCTCGGCGGCAAGGCCGAGGCGAAGGAGCGGGATG
ATCTGAAGATCGAGGGCGCCAAAGACTACCGGACGATCTGCTGCTACTGTTCGGTGGGCTGCGGGATTCAGCTCTGGGTG
AAGGACGGGGAGGTCGTGCACGTGAACGGCGACCCCGACCACCCGATCAACGAGGGCACGCTCTGTCCCAAGGGCGCGTC
CATCGCCAACCTGCGCATCGTCGCCGACAAGAACAACCAGTACCAGCCCAACCCGCGGCGGCTCACCAAGGTCCTCTACC
GGGCCCCTGGCGCCACCGACTGGGAGGAGAAGGACTGGGACTGGGCGATTGAGCGCATCGCCCGGAACGTAAAGGCGGCC
CGCGACGCCACCTTCGAGCGGGTGGACGAAAACGGCGTCACCGTCAACCGCACCTTCGCGATGGCCCACATCGGCTCGGC
GGCCCTCGACAACGAGGAGAACTACGTCCTCGCCAAGCTGATGCGCGGCCTGGGGATTGTCCGCCTGGAACATCACGCCC
GTCTCTGA

Upstream 100 bases:

>100_bases
ACCCAGAGGCCAACTGTGCTATTGCGAAACCTCCATCCTGCGCTATTTCGGGGCGGCATAGCCAAAGGTATGATCTGAAG
TAAACCGTACGTCGTGCGCA

Downstream 100 bases:

>100_bases
CACAGCTCCACGGTGGCCGGTCTGGCCCCCACGTTTGGACGCGGCGCGATGACGAACCACTGGACTGATTACCAGAACAC
CGACGTGTTCATGGTGCTGG

Product: putative formate dehydrogenase subunit

Products: NA

Alternate protein names: FDH subunit alpha; Formate dehydrogenase large subunit [H]

Number of amino acids: Translated: 215; Mature: 214

Protein sequence:

>215_residues
MGAMCPAIGHTELRMGVESLALTRRDLLKSSLAAGGALSLLGLGGKAEAKERDDLKIEGAKDYRTICCYCSVGCGIQLWV
KDGEVVHVNGDPDHPINEGTLCPKGASIANLRIVADKNNQYQPNPRRLTKVLYRAPGATDWEEKDWDWAIERIARNVKAA
RDATFERVDENGVTVNRTFAMAHIGSAALDNEENYVLAKLMRGLGIVRLEHHARL

Sequences:

>Translated_215_residues
MGAMCPAIGHTELRMGVESLALTRRDLLKSSLAAGGALSLLGLGGKAEAKERDDLKIEGAKDYRTICCYCSVGCGIQLWV
KDGEVVHVNGDPDHPINEGTLCPKGASIANLRIVADKNNQYQPNPRRLTKVLYRAPGATDWEEKDWDWAIERIARNVKAA
RDATFERVDENGVTVNRTFAMAHIGSAALDNEENYVLAKLMRGLGIVRLEHHARL
>Mature_214_residues
GAMCPAIGHTELRMGVESLALTRRDLLKSSLAAGGALSLLGLGGKAEAKERDDLKIEGAKDYRTICCYCSVGCGIQLWVK
DGEVVHVNGDPDHPINEGTLCPKGASIANLRIVADKNNQYQPNPRRLTKVLYRAPGATDWEEKDWDWAIERIARNVKAAR
DATFERVDENGVTVNRTFAMAHIGSAALDNEENYVLAKLMRGLGIVRLEHHARL

Specific function: Alpha chain of the formate dehydrogenase (FDH) catalyze the reversible two-electron oxidation of formate to carbon dioxide. FDH loses activity in the presence of air, but this activity can be restored. The alpha subunit of formate dehydrogenase forms the

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI3868719, Length=205, Percent_Identity=35.609756097561, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI3868720, Length=205, Percent_Identity=33.1707317073171, Blast_Score=124, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006443
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 23591; Mature: 23460

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAMCPAIGHTELRMGVESLALTRRDLLKSSLAAGGALSLLGLGGKAEAKERDDLKIEGA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCEEEECC
KDYRTICCYCSVGCGIQLWVKDGEVVHVNGDPDHPINEGTLCPKGASIANLRIVADKNNQ
CCCEEEEEEEECCCCEEEEEECCEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEECCCCC
YQPNPRRLTKVLYRAPGATDWEEKDWDWAIERIARNVKAARDATFERVDENGVTVNRTFA
CCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEH
MAHIGSAALDNEENYVLAKLMRGLGIVRLEHHARL
HHHHCHHHCCCCCCHHHHHHHHCCCEEEECCCCCC
>Mature Secondary Structure 
GAMCPAIGHTELRMGVESLALTRRDLLKSSLAAGGALSLLGLGGKAEAKERDDLKIEGA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCEEEECC
KDYRTICCYCSVGCGIQLWVKDGEVVHVNGDPDHPINEGTLCPKGASIANLRIVADKNNQ
CCCEEEEEEEECCCCEEEEEECCEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEECCCCC
YQPNPRRLTKVLYRAPGATDWEEKDWDWAIERIARNVKAARDATFERVDENGVTVNRTFA
CCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEH
MAHIGSAALDNEENYVLAKLMRGLGIVRLEHHARL
HHHHCHHHCCCCCCHHHHHHHHCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA