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The map label for this gene is dacC [H]

Identifier: 51893725

GI number: 51893725

Start: 2773486

End: 2774610

Strand: Reverse

Name: dacC [H]

Synonym: STH2587

Alternate gene names: 51893725

Gene position: 2774610-2773486 (Counterclockwise)

Preceding gene: 51893726

Following gene: 51893724

Centisome position: 77.8

GC content: 67.56

Gene sequence:

>1125_bases
GTGCTGCTGGACTTCGCGACGGGCCAGGTGCTGTACGAGAAGAACCCGGATGAGCCCATCGCACCGGCCTCGCTCACCAA
GCTGATGACCCTGCACCTGGCCTTCAAGCGCATCGAGGCCGGGCAGATGAGCTACGACGACCCGGTCGTCGTCAGCCGGA
ACGCGTGGGCGGCCAATTTCCCCGACTCGTCGCTGATGTTCCTGGAGCCCGGCGACAAGGTGACGGTGGGCGAGGTCATG
AAGGGCCTGGCCATCGTGTCGGGCAACGACGCCGCCGTGGCCCTGGCGGAGCACATCGGCGGTACGGTGGAGAACTTCGT
CAAGATGATGAACGACGAGGCGCAGGCCCTGGGGTTCAAGACCTTCCGCTTCGTCGACCCCCATGGCCTCTCGCCGCAGA
ACCAGGTGACGGCGGGCGAGTTCGCCCGGTTCGCCCGGCTCTACATCCAGCTCCACCCCGAGTCGCTGGAGATGCTCCAC
AGCCAGAAGGAGTACTCCTATCCCCAGTATGAGAACCTCTCCGACGCCCGCCAGGCCGTGACCTCCCCCGAGGCCCACGA
GCCGATCACGCAGATGAACCGCAACGGCCTGCTCTGGACCTACGAGGGCGTCGATGGTCTGAAGACCGGCTTCGTGGATG
AGGCCGGTTTCAACCTGGCGGTCACGGCCCAGCGGGGCGGCATGCGGCTGGTCGGCGTGCTGCTGGGCATCCAGGCCGAC
TCCATCCCCGAGGGCTCGGCCAAGCGGGAGGCCGAGGGCGCGGCTCTGCTGAGCTGGGGCTTCAACAACTTCGTCACCGT
GAAGCCGCAGATGCCCGAGGTCAAGCCCGTGCGGGTCTGGAAGGGCGCCGCCAATGAGGTGACCCTCCAGGCCGCCGGCG
GGACGCCGACCCTGGTGCTGGAGAAGGGGCTGGAGTCGTCGCTGACCGCCTCCGTGCGGCAGGAGGAGTCCGTCACCGCT
CCGGTCGCCAAGGGGCAGAAGCTGGGCGAGGTGATCTTCGCCGCGGACGGCCAGGAGGTCGCCCGGCTGGACCTGGTGGC
GGCGGAGGACGTGCCGCAGGGCGGCTTCTTCAAGCGGATCTGGGACTCGCTGAAACTCTGGATACACGGGTTCTTTAACC
GCTGA

Upstream 100 bases:

>100_bases
GGCCATTGCACTGGTGGCCCTGGTGGCCGTGCTGCTCACCGGAACGCTCACCGCACCCGCGCAGGCAGCACCCGCCCTGG
ACCTGGAGGCGCGGTCCGCG

Downstream 100 bases:

>100_bases
TACTGTAAGACACACGCAGGGCTGTCCCAATGCTTGGGACAGCCCCCAGGTTGAAGACAAAATCCGGGTAACCCCTCGCG
GGTGCCCGGATTTTGTTGTA

Product: D-alanyl-D-alanine carboxypeptidase

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 6; PBP-6 [H]

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MLLDFATGQVLYEKNPDEPIAPASLTKLMTLHLAFKRIEAGQMSYDDPVVVSRNAWAANFPDSSLMFLEPGDKVTVGEVM
KGLAIVSGNDAAVALAEHIGGTVENFVKMMNDEAQALGFKTFRFVDPHGLSPQNQVTAGEFARFARLYIQLHPESLEMLH
SQKEYSYPQYENLSDARQAVTSPEAHEPITQMNRNGLLWTYEGVDGLKTGFVDEAGFNLAVTAQRGGMRLVGVLLGIQAD
SIPEGSAKREAEGAALLSWGFNNFVTVKPQMPEVKPVRVWKGAANEVTLQAAGGTPTLVLEKGLESSLTASVRQEESVTA
PVAKGQKLGEVIFAADGQEVARLDLVAAEDVPQGGFFKRIWDSLKLWIHGFFNR

Sequences:

>Translated_374_residues
MLLDFATGQVLYEKNPDEPIAPASLTKLMTLHLAFKRIEAGQMSYDDPVVVSRNAWAANFPDSSLMFLEPGDKVTVGEVM
KGLAIVSGNDAAVALAEHIGGTVENFVKMMNDEAQALGFKTFRFVDPHGLSPQNQVTAGEFARFARLYIQLHPESLEMLH
SQKEYSYPQYENLSDARQAVTSPEAHEPITQMNRNGLLWTYEGVDGLKTGFVDEAGFNLAVTAQRGGMRLVGVLLGIQAD
SIPEGSAKREAEGAALLSWGFNNFVTVKPQMPEVKPVRVWKGAANEVTLQAAGGTPTLVLEKGLESSLTASVRQEESVTA
PVAKGQKLGEVIFAADGQEVARLDLVAAEDVPQGGFFKRIWDSLKLWIHGFFNR
>Mature_374_residues
MLLDFATGQVLYEKNPDEPIAPASLTKLMTLHLAFKRIEAGQMSYDDPVVVSRNAWAANFPDSSLMFLEPGDKVTVGEVM
KGLAIVSGNDAAVALAEHIGGTVENFVKMMNDEAQALGFKTFRFVDPHGLSPQNQVTAGEFARFARLYIQLHPESLEMLH
SQKEYSYPQYENLSDARQAVTSPEAHEPITQMNRNGLLWTYEGVDGLKTGFVDEAGFNLAVTAQRGGMRLVGVLLGIQAD
SIPEGSAKREAEGAALLSWGFNNFVTVKPQMPEVKPVRVWKGAANEVTLQAAGGTPTLVLEKGLESSLTASVRQEESVTA
PVAKGQKLGEVIFAADGQEVARLDLVAAEDVPQGGFFKRIWDSLKLWIHGFFNR

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors [H]

COG id: COG1686

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=N-terminal lies in the periplasmic space [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S11 family [H]

Homologues:

Organism=Escherichia coli, GI1787062, Length=380, Percent_Identity=38.1578947368421, Blast_Score=237, Evalue=7e-64,
Organism=Escherichia coli, GI1786851, Length=380, Percent_Identity=35, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI87082022, Length=373, Percent_Identity=37.5335120643432, Blast_Score=201, Evalue=8e-53,
Organism=Escherichia coli, GI87082054, Length=227, Percent_Identity=26.431718061674, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015956
- InterPro:   IPR018044
- InterPro:   IPR012907
- InterPro:   IPR001967 [H]

Pfam domain/function: PF07943 PBP5_C; PF00768 Peptidase_S11 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 40753; Mature: 40753

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLDFATGQVLYEKNPDEPIAPASLTKLMTLHLAFKRIEAGQMSYDDPVVVSRNAWAANF
CEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCEECCC
PDSSLMFLEPGDKVTVGEVMKGLAIVSGNDAAVALAEHIGGTVENFVKMMNDEAQALGFK
CCCCEEEECCCCCEEHHHHHHCEEEEECCCHHHHHHHHHCCHHHHHHHHHCCHHHHCCCE
TFRFVDPHGLSPQNQVTAGEFARFARLYIQLHPESLEMLHSQKEYSYPQYENLSDARQAV
EEEEECCCCCCCCCCCCHHHHHHHHEEHEEECHHHHHHHHHHHHCCCCCCCCHHHHHHHH
TSPEAHEPITQMNRNGLLWTYEGVDGLKTGFVDEAGFNLAVTAQRGGMRLVGVLLGIQAD
CCCCCCCCHHHHCCCCCEEEECCCCCHHHCCCCCCCCCEEEEECCCCEEEEHHHHHCCCC
SIPEGSAKREAEGAALLSWGFNNFVTVKPQMPEVKPVRVWKGAANEVTLQAAGGTPTLVL
CCCCCCCCCCCCCCEEEEECCCCEEEECCCCCCCCEEEEECCCCCEEEEEECCCCCEEEE
EKGLESSLTASVRQEESVTAPVAKGQKLGEVIFAADGQEVARLDLVAAEDVPQGGFFKRI
ECCCCHHHHHHHHHCCCCCCCHHCCCCCCCEEEECCCCHHHEEEEEECCCCCCCCHHHHH
WDSLKLWIHGFFNR
HHHHHHHHHHHCCC
>Mature Secondary Structure
MLLDFATGQVLYEKNPDEPIAPASLTKLMTLHLAFKRIEAGQMSYDDPVVVSRNAWAANF
CEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCEECCC
PDSSLMFLEPGDKVTVGEVMKGLAIVSGNDAAVALAEHIGGTVENFVKMMNDEAQALGFK
CCCCEEEECCCCCEEHHHHHHCEEEEECCCHHHHHHHHHCCHHHHHHHHHCCHHHHCCCE
TFRFVDPHGLSPQNQVTAGEFARFARLYIQLHPESLEMLHSQKEYSYPQYENLSDARQAV
EEEEECCCCCCCCCCCCHHHHHHHHEEHEEECHHHHHHHHHHHHCCCCCCCCHHHHHHHH
TSPEAHEPITQMNRNGLLWTYEGVDGLKTGFVDEAGFNLAVTAQRGGMRLVGVLLGIQAD
CCCCCCCCHHHHCCCCCEEEECCCCCHHHCCCCCCCCCEEEEECCCCEEEEHHHHHCCCC
SIPEGSAKREAEGAALLSWGFNNFVTVKPQMPEVKPVRVWKGAANEVTLQAAGGTPTLVL
CCCCCCCCCCCCCCEEEEECCCCEEEECCCCCCCCEEEEECCCCCEEEEEECCCCCEEEE
EKGLESSLTASVRQEESVTAPVAKGQKLGEVIFAADGQEVARLDLVAAEDVPQGGFFKRI
ECCCCHHHHHHHHHCCCCCCCHHCCCCCCCEEEECCCCHHHEEEEEECCCCCCCCHHHHH
WDSLKLWIHGFFNR
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3279397; 8905232; 9278503; 7042389 [H]