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The map label for this gene is ubiE

Identifier: 51893653

GI number: 51893653

Start: 2700071

End: 2700826

Strand: Reverse

Name: ubiE

Synonym: STH2515

Alternate gene names: 51893653

Gene position: 2700826-2700071 (Counterclockwise)

Preceding gene: 51893654

Following gene: 51893652

Centisome position: 75.74

GC content: 65.87

Gene sequence:

>756_bases
ATGGCCCCTGGCTACCAGCCTCCGTCGCCGGAGGAGAAGGAGCAGTACGTCCGCGAGCTCTTCGACAAGATCGCCGAGAA
CTACGACGCGATGAACCAGGTCATGTCGGCCGGCCAGTGGGAGAAGTGGCACCGGGAGTTCGTCGCCCAGACCCATTTCC
GGCCCGGTGACCACATCCTGGACGTGGCCTGCGGCACCGGCGACCTCACGCTGCTGGACGCCGCGCAGGTCGCGCCGGAC
GGCAAGGTCATCGGGGTGGACATCTCCGAAGGCATGCTGGAGGTGGGCCGGCGCCGCGTCGCCGCTTCGCCGTACAAGGA
CCTGATCACCCTGCAGCTCGGCAACGCCATGGACCTGCCCTTCCCGGACAACACGTTCGATGGCGTGACCATGGGGTGGG
CGATGCGCAACGTCGCGTCGATCCCCCGGACCCTGTCCGAGATCTACCGGGTCCTGAAGCCCGGCGGCCGCTTCATCTGC
CTGGAGGCCTCCAAGCCCTTCAGCCGTTTCATCCGCTTCGGCTTCTTCGTGTACTGGAAGACCTTCCTGCCGCTCATCGA
CTGGTTCGTGGTGAAGGCCGGCCGCCAGGCCAAGGTGCGCCCGTACACGTACCTCTCCCGCTCACTGGACAACTACCCCT
TCCCGGACCAGCTGGAGGAGCTCTTCCGGGAGGCCGGGTTCGTGGAGACGGATTACCAGCTGCTGATGCTGGGGACGGTG
GCGATTCATGTGGGAACCAAGCGCCGAGAAGGATAG

Upstream 100 bases:

>100_bases
CCCTGGGCCGAGAAGCAGCGGTGAACGGCCGGTCGGGTCGCGCGGGGCGATGGGCGGCGGCACGGCCGTGCGAATGCAGA
TGAACTGAGGAGGCGTTCTG

Downstream 100 bases:

>100_bases
GGAGGTGGCCGAGGTCCGCATCCGCCCCTTCGACTACGTCACCGACACCGCAGAGATCCTCTCCTTCATGCCCGAACTGT
ACGAGTCGAACTTCCCCGGG

Product: 2-heptaprenyl-1,4-naphthoquinone methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 251; Mature: 250

Protein sequence:

>251_residues
MAPGYQPPSPEEKEQYVRELFDKIAENYDAMNQVMSAGQWEKWHREFVAQTHFRPGDHILDVACGTGDLTLLDAAQVAPD
GKVIGVDISEGMLEVGRRRVAASPYKDLITLQLGNAMDLPFPDNTFDGVTMGWAMRNVASIPRTLSEIYRVLKPGGRFIC
LEASKPFSRFIRFGFFVYWKTFLPLIDWFVVKAGRQAKVRPYTYLSRSLDNYPFPDQLEELFREAGFVETDYQLLMLGTV
AIHVGTKRREG

Sequences:

>Translated_251_residues
MAPGYQPPSPEEKEQYVRELFDKIAENYDAMNQVMSAGQWEKWHREFVAQTHFRPGDHILDVACGTGDLTLLDAAQVAPD
GKVIGVDISEGMLEVGRRRVAASPYKDLITLQLGNAMDLPFPDNTFDGVTMGWAMRNVASIPRTLSEIYRVLKPGGRFIC
LEASKPFSRFIRFGFFVYWKTFLPLIDWFVVKAGRQAKVRPYTYLSRSLDNYPFPDQLEELFREAGFVETDYQLLMLGTV
AIHVGTKRREG
>Mature_250_residues
APGYQPPSPEEKEQYVRELFDKIAENYDAMNQVMSAGQWEKWHREFVAQTHFRPGDHILDVACGTGDLTLLDAAQVAPDG
KVIGVDISEGMLEVGRRRVAASPYKDLITLQLGNAMDLPFPDNTFDGVTMGWAMRNVASIPRTLSEIYRVLKPGGRFICL
EASKPFSRFIRFGFFVYWKTFLPLIDWFVVKAGRQAKVRPYTYLSRSLDNYPFPDQLEELFREAGFVETDYQLLMLGTVA
IHVGTKRREG

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2)

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family

Homologues:

Organism=Homo sapiens, GI116063536, Length=277, Percent_Identity=31.4079422382672, Blast_Score=142, Evalue=2e-34,
Organism=Escherichia coli, GI48994983, Length=244, Percent_Identity=37.7049180327869, Blast_Score=160, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI17557039, Length=251, Percent_Identity=31.8725099601594, Blast_Score=120, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI25143945, Length=116, Percent_Identity=30.1724137931034, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6323526, Length=250, Percent_Identity=31.2, Blast_Score=103, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24641702, Length=260, Percent_Identity=34.2307692307692, Blast_Score=139, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIE_SYMTH (Q67LE6)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_076344.1
- ProteinModelPortal:   Q67LE6
- SMR:   Q67LE6
- GeneID:   2982351
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH2515
- NMPDR:   fig|292459.1.peg.2406
- HOGENOM:   HBG559580
- OMA:   LINAGCN
- BioCyc:   STHE292459:STH2515-MONOMER
- HAMAP:   MF_01813
- InterPro:   IPR004033
- PANTHER:   PTHR10108:SF24
- TIGRFAMs:   TIGR01934

Pfam domain/function: PF01209 Ubie_methyltran

EC number: 2.1.1.-

Molecular weight: Translated: 28582; Mature: 28451

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS01183 UBIE_1; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPGYQPPSPEEKEQYVRELFDKIAENYDAMNQVMSAGQWEKWHREFVAQTHFRPGDHIL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEE
DVACGTGDLTLLDAAQVAPDGKVIGVDISEGMLEVGRRRVAASPYKDLITLQLGNAMDLP
EEECCCCCEEEEHHHHCCCCCCEEEEEHHHHHHHHHHHHHCCCCHHHEEEEEECCEECCC
FPDNTFDGVTMGWAMRNVASIPRTLSEIYRVLKPGGRFICLEASKPFSRFIRFGFFVYWK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHH
TFLPLIDWFVVKAGRQAKVRPYTYLSRSLDNYPFPDQLEELFREAGFVETDYQLLMLGTV
HHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHH
AIHVGTKRREG
HHEECCCCCCC
>Mature Secondary Structure 
APGYQPPSPEEKEQYVRELFDKIAENYDAMNQVMSAGQWEKWHREFVAQTHFRPGDHIL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEE
DVACGTGDLTLLDAAQVAPDGKVIGVDISEGMLEVGRRRVAASPYKDLITLQLGNAMDLP
EEECCCCCEEEEHHHHCCCCCCEEEEEHHHHHHHHHHHHHCCCCHHHEEEEEECCEECCC
FPDNTFDGVTMGWAMRNVASIPRTLSEIYRVLKPGGRFICLEASKPFSRFIRFGFFVYWK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHH
TFLPLIDWFVVKAGRQAKVRPYTYLSRSLDNYPFPDQLEELFREAGFVETDYQLLMLGTV
HHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHH
AIHVGTKRREG
HHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA