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The map label for this gene is vanR [H]

Identifier: 51893644

GI number: 51893644

Start: 2691403

End: 2692104

Strand: Reverse

Name: vanR [H]

Synonym: STH2506

Alternate gene names: 51893644

Gene position: 2692104-2691403 (Counterclockwise)

Preceding gene: 51893645

Following gene: 51893643

Centisome position: 75.49

GC content: 66.52

Gene sequence:

>702_bases
ATGGCGGAGCCGCTGATCCTGGTCGTGGACGACGAGCAGGCGATTGCCGACCTGATCGAGATCCACCTGTTGGCGGAGGG
CTACCGGGTGCGCAAGGCGGACAACGGTGCCGATGCCCTGCGCATCGTGGCCGAGGAGGATCCCGACCTGGTGGTGCTCG
ACATCATGATGCCCGGCATGGACGGCCTGGAGGTCTGCCGGGCGATCCGGCGCGAGCGCAACGTGCCGATCCTCATGCTC
AGCGCCAAGTCGGAGGACGTGGATAAGATCCTTGGCCTGAAGACCGGGGCCGACGACTACCTCACCAAGCCCTTCAACCC
GCTGGAGCTGGTGGCCCGGGTGAAGGCGCAATTGCGGCGCTACCTTTCCCTGAACCCGGCGTCGGCGGCGGCCCGGGAGC
CGGGGGTTCTCGCCGTGGGCGGGCTCCGGATCGACCCGCTAGGCCGGTCGGTGTTCAAGGACGGGCGCGAGATTGCCCTC
ACGCCGACGGAGTTCGACATCCTGCTGCTGCTGGCATCGCACCCGGGGCGGGTCTTCAGCTCGGAGGAGATCTTCGAGCG
GGTCTGGAAGGAGCACTACTTCCAGTCCAACAACACGGTGATGGTCCACATCCGCCGGCTGCGGGAGAAGGTGGAGGACG
ACCCCAGCCATCCCACGCTCATCCGGACCGTCTGGGGGGTCGGCTACAAGATTGAGAAGTAA

Upstream 100 bases:

>100_bases
AGCAGAGCCGGGACAGAATCGTAAAGAAGCCGTAAGGTTTGCGTTCCGCCTGCCGTAAGAACCGCGCGGTAGGCTGGCGT
ACAGGACGAGGTGACGGTGG

Downstream 100 bases:

>100_bases
CCTGGCGTTCAGCCTCCGCTGGCGGATGATCCTGACGTTCATGGCGAGCGGTTTCCTGGCGGCGGTGTCGACGGCGCTGA
TGCTGGCGGTGGCCGCCAAC

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 232

Protein sequence:

>233_residues
MAEPLILVVDDEQAIADLIEIHLLAEGYRVRKADNGADALRIVAEEDPDLVVLDIMMPGMDGLEVCRAIRRERNVPILML
SAKSEDVDKILGLKTGADDYLTKPFNPLELVARVKAQLRRYLSLNPASAAAREPGVLAVGGLRIDPLGRSVFKDGREIAL
TPTEFDILLLLASHPGRVFSSEEIFERVWKEHYFQSNNTVMVHIRRLREKVEDDPSHPTLIRTVWGVGYKIEK

Sequences:

>Translated_233_residues
MAEPLILVVDDEQAIADLIEIHLLAEGYRVRKADNGADALRIVAEEDPDLVVLDIMMPGMDGLEVCRAIRRERNVPILML
SAKSEDVDKILGLKTGADDYLTKPFNPLELVARVKAQLRRYLSLNPASAAAREPGVLAVGGLRIDPLGRSVFKDGREIAL
TPTEFDILLLLASHPGRVFSSEEIFERVWKEHYFQSNNTVMVHIRRLREKVEDDPSHPTLIRTVWGVGYKIEK
>Mature_232_residues
AEPLILVVDDEQAIADLIEIHLLAEGYRVRKADNGADALRIVAEEDPDLVVLDIMMPGMDGLEVCRAIRRERNVPILMLS
AKSEDVDKILGLKTGADDYLTKPFNPLELVARVKAQLRRYLSLNPASAAAREPGVLAVGGLRIDPLGRSVFKDGREIALT
PTEFDILLLLASHPGRVFSSEEIFERVWKEHYFQSNNTVMVHIRRLREKVEDDPSHPTLIRTVWGVGYKIEK

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=42.2222222222222, Blast_Score=183, Evalue=9e-48,
Organism=Escherichia coli, GI1786599, Length=229, Percent_Identity=38.4279475982533, Blast_Score=165, Evalue=3e-42,
Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=39.3013100436681, Blast_Score=162, Evalue=1e-41,
Organism=Escherichia coli, GI87082012, Length=226, Percent_Identity=38.9380530973451, Blast_Score=160, Evalue=6e-41,
Organism=Escherichia coli, GI1790863, Length=232, Percent_Identity=37.0689655172414, Blast_Score=157, Evalue=8e-40,
Organism=Escherichia coli, GI1786911, Length=226, Percent_Identity=34.9557522123894, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1786784, Length=228, Percent_Identity=36.4035087719298, Blast_Score=140, Evalue=9e-35,
Organism=Escherichia coli, GI1790860, Length=232, Percent_Identity=34.051724137931, Blast_Score=132, Evalue=1e-32,
Organism=Escherichia coli, GI2367329, Length=224, Percent_Identity=35.2678571428571, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=33.6170212765957, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1789402, Length=227, Percent_Identity=34.3612334801762, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=32.4444444444444, Blast_Score=111, Evalue=3e-26,
Organism=Escherichia coli, GI1790552, Length=227, Percent_Identity=34.3612334801762, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1787375, Length=229, Percent_Identity=30.1310043668122, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1790299, Length=122, Percent_Identity=35.2459016393443, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788550, Length=117, Percent_Identity=34.1880341880342, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790437, Length=176, Percent_Identity=32.9545454545455, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1787487, Length=114, Percent_Identity=35.9649122807018, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI145693157, Length=101, Percent_Identity=33.6633663366337, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26158; Mature: 26026

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEPLILVVDDEQAIADLIEIHLLAEGYRVRKADNGADALRIVAEEDPDLVVLDIMMPGM
CCCCEEEEECCHHHHHHHHHHHHHHCCEEEEECCCCCCEEEEEECCCCCEEEEEEECCCC
DGLEVCRAIRRERNVPILMLSAKSEDVDKILGLKTGADDYLTKPFNPLELVARVKAQLRR
CHHHHHHHHHHHCCCCEEEEECCCCCHHHHHCCCCCCCHHHCCCCCHHHHHHHHHHHHHH
YLSLNPASAAAREPGVLAVGGLRIDPLGRSVFKDGREIALTPTEFDILLLLASHPGRVFS
HHCCCCHHHHCCCCCEEEECCEEECCCCHHHHHCCCEEEECCCCEEEEEEEECCCCCCCC
SEEIFERVWKEHYFQSNNTVMVHIRRLREKVEDDPSHPTLIRTVWGVGYKIEK
HHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHCCCCCCHHHHHHHCCCEEECC
>Mature Secondary Structure 
AEPLILVVDDEQAIADLIEIHLLAEGYRVRKADNGADALRIVAEEDPDLVVLDIMMPGM
CCCEEEEECCHHHHHHHHHHHHHHCCEEEEECCCCCCEEEEEECCCCCEEEEEEECCCC
DGLEVCRAIRRERNVPILMLSAKSEDVDKILGLKTGADDYLTKPFNPLELVARVKAQLRR
CHHHHHHHHHHHCCCCEEEEECCCCCHHHHHCCCCCCCHHHCCCCCHHHHHHHHHHHHHH
YLSLNPASAAAREPGVLAVGGLRIDPLGRSVFKDGREIALTPTEFDILLLLASHPGRVFS
HHCCCCHHHHCCCCCEEEECCEEECCCCHHHHHCCCEEEECCCCEEEEEEEECCCCCCCC
SEEIFERVWKEHYFQSNNTVMVHIRRLREKVEDDPSHPTLIRTVWGVGYKIEK
HHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHCCCCCCHHHHHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]