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The map label for this gene is bhbA [H]

Identifier: 51893604

GI number: 51893604

Start: 2651979

End: 2653583

Strand: Reverse

Name: bhbA [H]

Synonym: STH2466

Alternate gene names: 51893604

Gene position: 2653583-2651979 (Counterclockwise)

Preceding gene: 51893605

Following gene: 51893603

Centisome position: 74.41

GC content: 67.6

Gene sequence:

>1605_bases
GTGGCCACAGCGGAGCGCAAGGAGCGGTTCGCCGGGGTATCCGGCCGGCCGGTGAAGCGGTTCTACGGACCCGAGGACAT
CGCGGGCATGGAGTACGAGCGGGACCTGGGGGATCCCGGCGAGTACCCCTTCACCCGGGGCATACACCCGACCATGTACC
GCGGAAAGCTCTGGACCATGCGGCAGTTCGCGGGCTTCGGCACGGCGGAGGAGACCAACGCCCGGTTCCGCTACCTGCTC
GAGCAGGGGCAGACGGGCCTCTCCACCGCCTTCGACATGCCGACCCTGCTGGGGTACGACTCCGATCACCCGTACGCCAA
CGGCGAGGTGGGCAAGCTGGGGGTCGCCATCGACTCCCTGAAGGACTTCGAGATCCTGTTCGAGGGCATCCCCCTGGACA
AGGTCTCCACCTCCATGACCATCAACCCGCCTGCCTCGATCATGCTGGCCATGTACCTGGTGGTGGCGGAGAAGCAGGGC
GTCTCCTGGGACCAGGTGAGCGGCACCATCCAGAACGACATCCTGAAGGACTATATCGCCCAGAAGACCTATATCTACCC
GCCCGCCCCCTCGATGCGGCTGATCACCGACGTCATGGCCTTCTGCGCCCGGCACGTGCCCAAGTGGAACACCATTTCCA
TCTCCGGTTACCACATCCGGGAGGCCGGGGCCACCGCGGCGCAGGAGTTGGCCTTCACCCTGGCCGACGGCATCGCCTAC
GTGGAGGCGGGCATCAAGGCGGGGCTGGACGTGGACGAGTTCGCCCCGCGCCTCTCCTTCTTCTTCGACGTGCACAACGA
CTTCTTCGAGGAGATCGCCAAGTTCCGGGCCGCCCGGCGCATCTGGGCCCGGGTGATGCGGGAGCGGTTCGGCGCCAGGA
ACCCCCGCTCCTGGATGCTGCGCACCCACGCCCAGACCGCGGGCGTCAGCCTCACCGCCCAGCAGCCGGAGAACAACATC
GTGCGGGTGACCCTGCAGGCCCTGGCTGCGGTGCTGGGCGGCACGCAGTCGCTGCACACCAACTCCTACGACGAGGCGCT
GGCGCTGCCCAGCGAGGAGGCGGTGCGCATCGCCCTGCGCACCCAGCAGATCATCGCCGAGGAGAGCGGCGTCGCTAACG
TGGTCGACCCGCTGGCCGGCTCCTACTACGTGGAGTACCTGACCAACAAGCTGGAGGAGGAGGCCTACGCCTACTTCGAG
CAGATCGAGGCCCAGGGCGGCGTGATCGCCGCGATCGAAAAGGGCTGGTTCCAGCAGCAGATCGCCGACTCCGCCTACCG
CTTTCAGCGGCGGGTGATGAACGGGGACTACAAGGTGGTGGGGGTCAACGCCTACGTGGACCCCAACGAGAAGCCCGTGA
CCAACATCCTGAAGGTCAACCCCGAGGTGCAGCGGCGGCAGATCGAGCGGGTGCGCGCCGTGCGCGCGGCCCGGGACCAG
AAGGCCGCCGAGGCCGCCCTGGCGGAGCTGCGCCGCGCTTCGCAGACCGACGAGAACCTGATGCCCTACATCCTCGAGTG
TGTGCGGCGCTACTGCACCGTGGGGGAGATCTGCGGCGTCTGGCGCGAGCTGTGGGGCGAGTACCGGGAGGAGTCGGTGT
ACTAG

Upstream 100 bases:

>100_bases
GTTTCGCGGCGACGGGCGCGCGTAAGCTGCATAGCAGGAGGAATAGGCAGAAAAGGCGAATGGGTGTGAAGCGACACTGA
ATTGGGAGGGAGGGTGGCCC

Downstream 100 bases:

>100_bases
ACGCGGGGCGACGGAGGGGAAGCGGAAGTGGAAGTGGCAACCGGACGCAGGATCAGGGTGCTTGTGGCCAAGCTGGGACT
GGACGCCCACGACCGGGGGG

Product: methylmalonyl-CoA mutase N-terminal domain-containing protein

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 534; Mature: 533

Protein sequence:

>534_residues
MATAERKERFAGVSGRPVKRFYGPEDIAGMEYERDLGDPGEYPFTRGIHPTMYRGKLWTMRQFAGFGTAEETNARFRYLL
EQGQTGLSTAFDMPTLLGYDSDHPYANGEVGKLGVAIDSLKDFEILFEGIPLDKVSTSMTINPPASIMLAMYLVVAEKQG
VSWDQVSGTIQNDILKDYIAQKTYIYPPAPSMRLITDVMAFCARHVPKWNTISISGYHIREAGATAAQELAFTLADGIAY
VEAGIKAGLDVDEFAPRLSFFFDVHNDFFEEIAKFRAARRIWARVMRERFGARNPRSWMLRTHAQTAGVSLTAQQPENNI
VRVTLQALAAVLGGTQSLHTNSYDEALALPSEEAVRIALRTQQIIAEESGVANVVDPLAGSYYVEYLTNKLEEEAYAYFE
QIEAQGGVIAAIEKGWFQQQIADSAYRFQRRVMNGDYKVVGVNAYVDPNEKPVTNILKVNPEVQRRQIERVRAVRAARDQ
KAAEAALAELRRASQTDENLMPYILECVRRYCTVGEICGVWRELWGEYREESVY

Sequences:

>Translated_534_residues
MATAERKERFAGVSGRPVKRFYGPEDIAGMEYERDLGDPGEYPFTRGIHPTMYRGKLWTMRQFAGFGTAEETNARFRYLL
EQGQTGLSTAFDMPTLLGYDSDHPYANGEVGKLGVAIDSLKDFEILFEGIPLDKVSTSMTINPPASIMLAMYLVVAEKQG
VSWDQVSGTIQNDILKDYIAQKTYIYPPAPSMRLITDVMAFCARHVPKWNTISISGYHIREAGATAAQELAFTLADGIAY
VEAGIKAGLDVDEFAPRLSFFFDVHNDFFEEIAKFRAARRIWARVMRERFGARNPRSWMLRTHAQTAGVSLTAQQPENNI
VRVTLQALAAVLGGTQSLHTNSYDEALALPSEEAVRIALRTQQIIAEESGVANVVDPLAGSYYVEYLTNKLEEEAYAYFE
QIEAQGGVIAAIEKGWFQQQIADSAYRFQRRVMNGDYKVVGVNAYVDPNEKPVTNILKVNPEVQRRQIERVRAVRAARDQ
KAAEAALAELRRASQTDENLMPYILECVRRYCTVGEICGVWRELWGEYREESVY
>Mature_533_residues
ATAERKERFAGVSGRPVKRFYGPEDIAGMEYERDLGDPGEYPFTRGIHPTMYRGKLWTMRQFAGFGTAEETNARFRYLLE
QGQTGLSTAFDMPTLLGYDSDHPYANGEVGKLGVAIDSLKDFEILFEGIPLDKVSTSMTINPPASIMLAMYLVVAEKQGV
SWDQVSGTIQNDILKDYIAQKTYIYPPAPSMRLITDVMAFCARHVPKWNTISISGYHIREAGATAAQELAFTLADGIAYV
EAGIKAGLDVDEFAPRLSFFFDVHNDFFEEIAKFRAARRIWARVMRERFGARNPRSWMLRTHAQTAGVSLTAQQPENNIV
RVTLQALAAVLGGTQSLHTNSYDEALALPSEEAVRIALRTQQIIAEESGVANVVDPLAGSYYVEYLTNKLEEEAYAYFEQ
IEAQGGVIAAIEKGWFQQQIADSAYRFQRRVMNGDYKVVGVNAYVDPNEKPVTNILKVNPEVQRRQIERVRAVRAARDQK
AAEAALAELRRASQTDENLMPYILECVRRYCTVGEICGVWRELWGEYREESVY

Specific function: Catalyzes the interconversion of succinyl-CoA and methylmalonyl-CoA during the polyhydroxyalkanoate degradation pathway [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=516, Percent_Identity=48.062015503876, Blast_Score=498, Evalue=1e-141,
Organism=Escherichia coli, GI1789284, Length=504, Percent_Identity=50.3968253968254, Blast_Score=489, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI25144500, Length=515, Percent_Identity=48.7378640776699, Blast_Score=505, Evalue=1e-143,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 60057; Mature: 59926

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATAERKERFAGVSGRPVKRFYGPEDIAGMEYERDLGDPGEYPFTRGIHPTMYRGKLWTM
CCCHHHHHHHCCCCCCCHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCHHHH
RQFAGFGTAEETNARFRYLLEQGQTGLSTAFDMPTLLGYDSDHPYANGEVGKLGVAIDSL
HHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHCCHHHHCCCCCCCCCCCCCCEEHHHHHHH
KDFEILFEGIPLDKVSTSMTINPPASIMLAMYLVVAEKQGVSWDQVSGTIQNDILKDYIA
HHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHH
QKTYIYPPAPSMRLITDVMAFCARHVPKWNTISISGYHIREAGATAAQELAFTLADGIAY
CCCEECCCCCHHHHHHHHHHHHHHCCCCCCEEEECCEEEHHHCHHHHHHHHHHHHHHHHH
VEAGIKAGLDVDEFAPRLSFFFDVHNDFFEEIAKFRAARRIWARVMRERFGARNPRSWML
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
RTHAQTAGVSLTAQQPENNIVRVTLQALAAVLGGTQSLHTNSYDEALALPSEEAVRIALR
EEHHHHCCEEEEECCCCCCEEEHHHHHHHHHHCCCCCCCCCCCHHHHCCCCHHHHHHHHH
TQQIIAEESGVANVVDPLAGSYYVEYLTNKLEEEAYAYFEQIEAQGGVIAAIEKGWFQQQ
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHH
IADSAYRFQRRVMNGDYKVVGVNAYVDPNEKPVTNILKVNPEVQRRQIERVRAVRAARDQ
HHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHH
KAAEAALAELRRASQTDENLMPYILECVRRYCTVGEICGVWRELWGEYREESVY
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ATAERKERFAGVSGRPVKRFYGPEDIAGMEYERDLGDPGEYPFTRGIHPTMYRGKLWTM
CCHHHHHHHCCCCCCCHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCHHHH
RQFAGFGTAEETNARFRYLLEQGQTGLSTAFDMPTLLGYDSDHPYANGEVGKLGVAIDSL
HHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHCCHHHHCCCCCCCCCCCCCCEEHHHHHHH
KDFEILFEGIPLDKVSTSMTINPPASIMLAMYLVVAEKQGVSWDQVSGTIQNDILKDYIA
HHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHH
QKTYIYPPAPSMRLITDVMAFCARHVPKWNTISISGYHIREAGATAAQELAFTLADGIAY
CCCEECCCCCHHHHHHHHHHHHHHCCCCCCEEEECCEEEHHHCHHHHHHHHHHHHHHHHH
VEAGIKAGLDVDEFAPRLSFFFDVHNDFFEEIAKFRAARRIWARVMRERFGARNPRSWML
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
RTHAQTAGVSLTAQQPENNIVRVTLQALAAVLGGTQSLHTNSYDEALALPSEEAVRIALR
EEHHHHCCEEEEECCCCCCEEEHHHHHHHHHHCCCCCCCCCCCHHHHCCCCHHHHHHHHH
TQQIIAEESGVANVVDPLAGSYYVEYLTNKLEEEAYAYFEQIEAQGGVIAAIEKGWFQQQ
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHH
IADSAYRFQRRVMNGDYKVVGVNAYVDPNEKPVTNILKVNPEVQRRQIERVRAVRAARDQ
HHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHH
KAAEAALAELRRASQTDENLMPYILECVRRYCTVGEICGVWRELWGEYREESVY
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9889346; 11481431 [H]