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The map label for this gene is sbm [H]

Identifier: 51893603

GI number: 51893603

Start: 2651544

End: 2651951

Strand: Reverse

Name: sbm [H]

Synonym: STH2465

Alternate gene names: 51893603

Gene position: 2651951-2651544 (Counterclockwise)

Preceding gene: 51893604

Following gene: 51893602

Centisome position: 74.36

GC content: 70.1

Gene sequence:

>408_bases
GTGGAAGTGGCAACCGGACGCAGGATCAGGGTGCTTGTGGCCAAGCTGGGACTGGACGCCCACGACCGGGGGGCGAAGGT
CATCGCCCGGGCGTACCGGGACGCCGGGTTCGAGGTGATCTACACCGGCCTCTACCAGCGGCCGGAGGCGGTGGCCGCGG
CCGCGATCCAGGAGGACGTGGACGTCATCGCGATCTCGTCGCTGGCCGGGGCGCACGGCGTGCTGATCCCGCAGCTCATC
CAGCTGCTCCGGGAGCAGGGGGTGGACGACGTGCTCATCCTGGCGGGCGGGATCATCCCCGACGACGAGGTGCCCGCCCT
GCTGGAGGCCGGCGTCGCCCGGGTGTTCGGCCCGGGGTCGGACCTGGAGGAGATCATTCAGTACACGAGGGAGAACGTGA
AGCGATGA

Upstream 100 bases:

>100_bases
CTGCACCGTGGGGGAGATCTGCGGCGTCTGGCGCGAGCTGTGGGGCGAGTACCGGGAGGAGTCGGTGTACTAGACGCGGG
GCGACGGAGGGGAAGCGGAA

Downstream 100 bases:

>100_bases
GGCCAGAGGACCGGGCTGCTGAGCTGTTCGCCCGTCTCCGCTCCGGGGACCGGCGGGCCCTCGCGCGGGCGATCACCTGG
ATCGAGAACGGGGACGAGGA

Product: methylmalonyl-CoA mutase C-terminal domain-containing protein

Products: succinyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 135; Mature: 135

Protein sequence:

>135_residues
MEVATGRRIRVLVAKLGLDAHDRGAKVIARAYRDAGFEVIYTGLYQRPEAVAAAAIQEDVDVIAISSLAGAHGVLIPQLI
QLLREQGVDDVLILAGGIIPDDEVPALLEAGVARVFGPGSDLEEIIQYTRENVKR

Sequences:

>Translated_135_residues
MEVATGRRIRVLVAKLGLDAHDRGAKVIARAYRDAGFEVIYTGLYQRPEAVAAAAIQEDVDVIAISSLAGAHGVLIPQLI
QLLREQGVDDVLILAGGIIPDDEVPALLEAGVARVFGPGSDLEEIIQYTRENVKR
>Mature_135_residues
MEVATGRRIRVLVAKLGLDAHDRGAKVIARAYRDAGFEVIYTGLYQRPEAVAAAAIQEDVDVIAISSLAGAHGVLIPQLI
QLLREQGVDDVLILAGGIIPDDEVPALLEAGVARVFGPGSDLEEIIQYTRENVKR

Specific function: Unknown

COG id: COG2185

COG function: function code I; Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=139, Percent_Identity=43.1654676258993, Blast_Score=118, Evalue=2e-27,
Organism=Escherichia coli, GI1789284, Length=118, Percent_Identity=47.4576271186441, Blast_Score=122, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI25144500, Length=117, Percent_Identity=52.1367521367521, Blast_Score=115, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: 5.4.99.2

Molecular weight: Translated: 14483; Mature: 14483

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVATGRRIRVLVAKLGLDAHDRGAKVIARAYRDAGFEVIYTGLYQRPEAVAAAAIQEDV
CCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHCC
DVIAISSLAGAHGVLIPQLIQLLREQGVDDVLILAGGIIPDDEVPALLEAGVARVFGPGS
HHEEHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCC
DLEEIIQYTRENVKR
CHHHHHHHHHHHCCC
>Mature Secondary Structure
MEVATGRRIRVLVAKLGLDAHDRGAKVIARAYRDAGFEVIYTGLYQRPEAVAAAAIQEDV
CCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHCC
DVIAISSLAGAHGVLIPQLIQLLREQGVDDVLILAGGIIPDDEVPALLEAGVARVFGPGS
HHEEHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCC
DLEEIIQYTRENVKR
CHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-methylmalonyl-CoA

Specific reaction: (R)-methylmalonyl-CoA = succinyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1355087; 9278503 [H]