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The map label for this gene is lepB2 [H]

Identifier: 51893583

GI number: 51893583

Start: 2633131

End: 2633703

Strand: Reverse

Name: lepB2 [H]

Synonym: STH2445

Alternate gene names: 51893583

Gene position: 2633703-2633131 (Counterclockwise)

Preceding gene: 51893584

Following gene: 51893582

Centisome position: 73.85

GC content: 74.69

Gene sequence:

>573_bases
ATGGCGCCTCCGCAGGAGGGCCCGGCGCCGGCCCGCAGGGGGCTGGTGCGGGAGATTCTGGAGACCGCCGCGCTGGCCCT
GGTGGTCGCGCTGGTGGTGCGCACCTTCGGGGTGCAGGTCTTCCGGGTGGAAGGCGAATCGATGCTGCCGACCCTGGCCC
ACGGCGACCGGCTCCTGGTGAACAAGCTGGTCTACCGGCTCCGGGAGCCGGCGCCCGGCGAGGTGGTCGTGATCGCGGAT
CCCGCCAATCCCCACCGCCACCTGGTGAAGCGGGTCATCGCCGTCGCCGGGGACGAGGTGGCGGTAGAGGGCGACGCCGT
GTGGGTGAACGGCCGGCTCCTCGACGAACCCTACGTCCACCCCGGCAGCCCGGGCACCTACCGGGCGGGACCGCTGACGG
TGCCGGAGGGGTACGTGTGGGTGATGGGCGACAACCGGGGCGCCTCGCTGGACTCGCGCCTTCTGGGGCCGATCCCGGTG
GCGCGGGTGGAGGGCCGGGCGGCCGCGCTGGTGTGGCCGCCGGTGCGGATCGGGGATCACGGACCGCTGGCGGCGGCGCG
GACGTACCGCTAG

Upstream 100 bases:

>100_bases
AATGCGACCTGTACCTGCCCACCGACGACCTGAGCATCGAGGACGTGCGCCAGCGGGTGCTGGCGTTTATCGAAACGTGG
AAGGAGAAGGAGCGAACGTG

Downstream 100 bases:

>100_bases
ACCCGCCGGGCCCATGGGGCCCAGGCGGCCGGGTGTTTCGCCGGCGACAGCGCGGCAGCCGGCAAGTTGCGGACGTGACG
GGAGGACCTGGATTGGGCAA

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I-2; Leader peptidase I-2 [H]

Number of amino acids: Translated: 190; Mature: 189

Protein sequence:

>190_residues
MAPPQEGPAPARRGLVREILETAALALVVALVVRTFGVQVFRVEGESMLPTLAHGDRLLVNKLVYRLREPAPGEVVVIAD
PANPHRHLVKRVIAVAGDEVAVEGDAVWVNGRLLDEPYVHPGSPGTYRAGPLTVPEGYVWVMGDNRGASLDSRLLGPIPV
ARVEGRAAALVWPPVRIGDHGPLAAARTYR

Sequences:

>Translated_190_residues
MAPPQEGPAPARRGLVREILETAALALVVALVVRTFGVQVFRVEGESMLPTLAHGDRLLVNKLVYRLREPAPGEVVVIAD
PANPHRHLVKRVIAVAGDEVAVEGDAVWVNGRLLDEPYVHPGSPGTYRAGPLTVPEGYVWVMGDNRGASLDSRLLGPIPV
ARVEGRAAALVWPPVRIGDHGPLAAARTYR
>Mature_189_residues
APPQEGPAPARRGLVREILETAALALVVALVVRTFGVQVFRVEGESMLPTLAHGDRLLVNKLVYRLREPAPGEVVVIADP
ANPHRHLVKRVIAVAGDEVAVEGDAVWVNGRLLDEPYVHPGSPGTYRAGPLTVPEGYVWVMGDNRGASLDSRLLGPIPVA
RVEGRAAALVWPPVRIGDHGPLAAARTYR

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Homo sapiens, GI14211845, Length=173, Percent_Identity=31.2138728323699, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI21450679, Length=147, Percent_Identity=29.9319727891156, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6323800, Length=155, Percent_Identity=32.9032258064516, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323678, Length=186, Percent_Identity=27.4193548387097, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24642241, Length=155, Percent_Identity=32.9032258064516, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24656387, Length=141, Percent_Identity=29.7872340425532, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 20368; Mature: 20237

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: PS00501 SPASE_I_1 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPPQEGPAPARRGLVREILETAALALVVALVVRTFGVQVFRVEGESMLPTLAHGDRLLV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCHHHCCCHHHH
NKLVYRLREPAPGEVVVIADPANPHRHLVKRVIAVAGDEVAVEGDAVWVNGRLLDEPYVH
HHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEECCCEEEECCEECCCCCCC
PGSPGTYRAGPLTVPEGYVWVMGDNRGASLDSRLLGPIPVARVEGRAAALVWPPVRIGDH
CCCCCCCCCCCEECCCCEEEEEECCCCCCCCCCCCCCCCCEEECCCEEEEEECCEEECCC
GPLAAARTYR
CCCCCCCCCC
>Mature Secondary Structure 
APPQEGPAPARRGLVREILETAALALVVALVVRTFGVQVFRVEGESMLPTLAHGDRLLV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCHHHCCCHHHH
NKLVYRLREPAPGEVVVIADPANPHRHLVKRVIAVAGDEVAVEGDAVWVNGRLLDEPYVH
HHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEECCCEEEECCEECCCCCCC
PGSPGTYRAGPLTVPEGYVWVMGDNRGASLDSRLLGPIPVARVEGRAAALVWPPVRIGDH
CCCCCCCCCCCEECCCCEEEEEECCCCCCCCCCCCCCCCCEEECCCEEEEEECCEEECCC
GPLAAARTYR
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]