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The map label for this gene is apt

Identifier: 51893576

GI number: 51893576

Start: 2622666

End: 2623178

Strand: Reverse

Name: apt

Synonym: STH2438

Alternate gene names: 51893576

Gene position: 2623178-2622666 (Counterclockwise)

Preceding gene: 51893577

Following gene: 51893575

Centisome position: 73.56

GC content: 63.16

Gene sequence:

>513_bases
ATGGATTTCAAGTCGAAGATCCGCACCGTAGACGATTTCCCCAAGCCCGGGATCTCGTTCAAGGATATCACGACCCTGCT
GAAGGACGGCGAGGCGTTCCACGCCGCGATCGAGACCATGGCCGCGCACTTCGAGCCGCTGGGCATCAACATGGTGACGG
GCCCAGAGGCTCGTGGCTATATCTTTGCGTCCGCCCTGGCTTTCCGGCTGCGGGCCGGCTTCGTGCCCATCCGCAAGCCG
GGCAAGCTGCCGTGGAAGACCCGCAGCATCTCGTATCAACTGGAGTACGGCGAGGATAGGCTGGAGGTACACGAGGACGC
CTTCCAACCCGGACAGAAGGTGCTCGTGGTCGACGACCTGCTCGCTACGGGCGGCACGATTCGGGCCACCATTGACCTGG
TGGAGTCGCTGGGCGCCAAGGTGGTCGGTGTCGCCGTGCTGATCGAGCTCTCGGACCTCGGCGGCAGGAAGCGGTTGGAA
GGCCACGATGTGATTTCGCTGGTCCAGTTCTGA

Upstream 100 bases:

>100_bases
CGCACGGCAGACGTTTCCGGGTTCTGCATCGGCCTGAGTCACAAGTGTTGGCCGACGGCGAACCAGGCAATATAATTGAT
GTATGAGGGGGCTAAGATTG

Downstream 100 bases:

>100_bases
GAACCGACGACAGGCGGGACAGGGGGGTGACAGCCGTGATCGATATCCAACCGCTCTTGGATAAGGTGCGCTCGTACAAC
CCGACCGCGGATGTCGCCCT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MDFKSKIRTVDDFPKPGISFKDITTLLKDGEAFHAAIETMAAHFEPLGINMVTGPEARGYIFASALAFRLRAGFVPIRKP
GKLPWKTRSISYQLEYGEDRLEVHEDAFQPGQKVLVVDDLLATGGTIRATIDLVESLGAKVVGVAVLIELSDLGGRKRLE
GHDVISLVQF

Sequences:

>Translated_170_residues
MDFKSKIRTVDDFPKPGISFKDITTLLKDGEAFHAAIETMAAHFEPLGINMVTGPEARGYIFASALAFRLRAGFVPIRKP
GKLPWKTRSISYQLEYGEDRLEVHEDAFQPGQKVLVVDDLLATGGTIRATIDLVESLGAKVVGVAVLIELSDLGGRKRLE
GHDVISLVQF
>Mature_170_residues
MDFKSKIRTVDDFPKPGISFKDITTLLKDGEAFHAAIETMAAHFEPLGINMVTGPEARGYIFASALAFRLRAGFVPIRKP
GKLPWKTRSISYQLEYGEDRLEVHEDAFQPGQKVLVVDDLLATGGTIRATIDLVESLGAKVVGVAVLIELSDLGGRKRLE
GHDVISLVQF

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=170, Percent_Identity=45.2941176470588, Blast_Score=144, Evalue=3e-35,
Organism=Homo sapiens, GI71773201, Length=124, Percent_Identity=48.3870967741936, Blast_Score=115, Evalue=2e-26,
Organism=Escherichia coli, GI1786675, Length=170, Percent_Identity=51.7647058823529, Blast_Score=177, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17509087, Length=170, Percent_Identity=44.7058823529412, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6323619, Length=164, Percent_Identity=35.3658536585366, Blast_Score=100, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320649, Length=162, Percent_Identity=35.1851851851852, Blast_Score=83, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17136334, Length=173, Percent_Identity=42.1965317919075, Blast_Score=120, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_SYMTH (Q67LM3)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_076267.1
- ProteinModelPortal:   Q67LM3
- SMR:   Q67LM3
- GeneID:   2979261
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH2438
- NMPDR:   fig|292459.1.peg.2334
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BioCyc:   STHE292459:STH2438-MONOMER
- BRENDA:   2.4.2.7
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 18653; Mature: 18653

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFKSKIRTVDDFPKPGISFKDITTLLKDGEAFHAAIETMAAHFEPLGINMVTGPEARGY
CCHHHHCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCH
IFASALAFRLRAGFVPIRKPGKLPWKTRSISYQLEYGEDRLEVHEDAFQPGQKVLVVDDL
HHHHHHHHHHHHCCCCCCCCCCCCCEECEEEEEEECCCCHHHHHHHHCCCCCEEEEEEHH
LATGGTIRATIDLVESLGAKVVGVAVLIELSDLGGRKRLEGHDVISLVQF
HHCCCCHHHHHHHHHHHCCHHEEHEEEEEECCCCCCCCCCCCCCEEEECC
>Mature Secondary Structure
MDFKSKIRTVDDFPKPGISFKDITTLLKDGEAFHAAIETMAAHFEPLGINMVTGPEARGY
CCHHHHCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCH
IFASALAFRLRAGFVPIRKPGKLPWKTRSISYQLEYGEDRLEVHEDAFQPGQKVLVVDDL
HHHHHHHHHHHHCCCCCCCCCCCCCEECEEEEEEECCCCHHHHHHHHCCCCCEEEEEEHH
LATGGTIRATIDLVESLGAKVVGVAVLIELSDLGGRKRLEGHDVISLVQF
HHCCCCHHHHHHHHHHHCCHHEEHEEEEEECCCCCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA