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The map label for this gene is hisS1

Identifier: 51893560

GI number: 51893560

Start: 2606263

End: 2607561

Strand: Reverse

Name: hisS1

Synonym: STH2422

Alternate gene names: 51893560

Gene position: 2607561-2606263 (Counterclockwise)

Preceding gene: 51893561

Following gene: 51893559

Centisome position: 73.12

GC content: 69.67

Gene sequence:

>1299_bases
GTGAGCATCCAGGCGCCGCGGGGATTCAACGACATCCTCCCGGGCGAGCAGTACGGTTGGCGGGACTCCTACCGCTGGCA
GCGGCTGGAGGAGATCTTCCGGGAGGTCGCGCGGCTGTACGGCTACCAGGAGCTCCGGCCGCCGATGGTGGAGTACGTGG
ACCTGTTCATCCACGGCGTCGGGGCGACCACCGACATCGTGACCAAGGAGATGTTCAACATCACGCCCCGGGGCGACGAC
CCGGACGCCCGCCGGATGGCGATGCGGCCGGAGTTCACGGCCGGGCTGGTGCGGGCCTGGCTCGAGAACGGCCTGTACAA
CAACCCGCAGCCGACCAAGATCTTCGCCTACGGTCCGGCGTTCCGGTACGAGAACGTGCAGAAGGGCCGGTTCCGGGGCT
TCCACCAGCTGGACGTGGAGGTCTTCGGCGCCCAGGATCCGGCGGTGGACGCCGAGGTGATCAAGCTGGGGCTGGACGTG
GTGGCCCGGCTGGGGCTCACGGGCCTCGTGGTCTCGGTCAACTCCATCGGCTGTCCCCAGTGCCGGCCCCGCTACCGGCA
GGCCCTGCAGGACCACTTCCGGCCGCACCTGGGCGAGCTGTGCGAGGACTGCAACACGCGCTTTGAGAAGAACCCGCTCC
GGCTCCTGGACTGCAAGCGGGACGCCGACCACCCGGCGCAGCGGACCGCCCCGGTGACGCTGGACTACCTCTGCGACGAC
TGCCGGCGCCACTGGGAGGGCCTGCTGAGCCACCTGGCGGCCATGGGGATCCCCTACCAGATCGACACCCGCATCGTGCG
GGGGCTGGACTACTACACCAAGACCGTGTTCGAGGTGCTGCACCCGAAGCTGGGGGCGCAGTCGGCCCTCTGGGGCGGCG
GCCGCTACGACGGGCTGATCGAGATCGTCGGCGGCAAGCCCACGCCGGGCGTCGGCTTCGGCATGGGAATGGAGCGGGTG
CTGATGGTCCTGGAGGAGGAGGGGCTGACGGCCCCGTTCGCCGACCGGCCCCGGCTGGACGTCTTCGTGGCCACCCTGGG
CGAGGCGGCCCGGCCCGTGGGGCTGAAGCTGCTCTACGCGCTGCGGGACGCCGGCCTCTCGGCCGACATCGACTACCTGG
GGCGCAGCCTGAAGGCGCAGATGAAGTACGCCGGCAAGCAGAACAGCCGGTACGTCGTCATCCTGGGCGAGGACGAGGTG
CGCCAGGGCGTCGCATCGGTGAAGCACATGGACGAGGGCACGCAGGAGTCGGTGCCGCTCGATCAGATCATCTCGCACTT
GCGGAGGGCTGAGGCATGA

Upstream 100 bases:

>100_bases
TCTACGCCGTAAACGGCGAGGTGCGGGAGGAGCCGATCGACCCGGTCTACCTCGGGGAGAGCGAGCCCCTCACAACAACC
GGACGAGGAGAGGATCGAGC

Downstream 100 bases:

>100_bases
GCGAGTCGATTCAGGGCATGAAGCGTACGGTCTACTGCGGCGAGGTCACCGACGCCCTGGTGGGGCAGGAGGTCACCGTC
AACGGCTGGGTGCAGCGCAG

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MSIQAPRGFNDILPGEQYGWRDSYRWQRLEEIFREVARLYGYQELRPPMVEYVDLFIHGVGATTDIVTKEMFNITPRGDD
PDARRMAMRPEFTAGLVRAWLENGLYNNPQPTKIFAYGPAFRYENVQKGRFRGFHQLDVEVFGAQDPAVDAEVIKLGLDV
VARLGLTGLVVSVNSIGCPQCRPRYRQALQDHFRPHLGELCEDCNTRFEKNPLRLLDCKRDADHPAQRTAPVTLDYLCDD
CRRHWEGLLSHLAAMGIPYQIDTRIVRGLDYYTKTVFEVLHPKLGAQSALWGGGRYDGLIEIVGGKPTPGVGFGMGMERV
LMVLEEEGLTAPFADRPRLDVFVATLGEAARPVGLKLLYALRDAGLSADIDYLGRSLKAQMKYAGKQNSRYVVILGEDEV
RQGVASVKHMDEGTQESVPLDQIISHLRRAEA

Sequences:

>Translated_432_residues
MSIQAPRGFNDILPGEQYGWRDSYRWQRLEEIFREVARLYGYQELRPPMVEYVDLFIHGVGATTDIVTKEMFNITPRGDD
PDARRMAMRPEFTAGLVRAWLENGLYNNPQPTKIFAYGPAFRYENVQKGRFRGFHQLDVEVFGAQDPAVDAEVIKLGLDV
VARLGLTGLVVSVNSIGCPQCRPRYRQALQDHFRPHLGELCEDCNTRFEKNPLRLLDCKRDADHPAQRTAPVTLDYLCDD
CRRHWEGLLSHLAAMGIPYQIDTRIVRGLDYYTKTVFEVLHPKLGAQSALWGGGRYDGLIEIVGGKPTPGVGFGMGMERV
LMVLEEEGLTAPFADRPRLDVFVATLGEAARPVGLKLLYALRDAGLSADIDYLGRSLKAQMKYAGKQNSRYVVILGEDEV
RQGVASVKHMDEGTQESVPLDQIISHLRRAEA
>Mature_431_residues
SIQAPRGFNDILPGEQYGWRDSYRWQRLEEIFREVARLYGYQELRPPMVEYVDLFIHGVGATTDIVTKEMFNITPRGDDP
DARRMAMRPEFTAGLVRAWLENGLYNNPQPTKIFAYGPAFRYENVQKGRFRGFHQLDVEVFGAQDPAVDAEVIKLGLDVV
ARLGLTGLVVSVNSIGCPQCRPRYRQALQDHFRPHLGELCEDCNTRFEKNPLRLLDCKRDADHPAQRTAPVTLDYLCDDC
RRHWEGLLSHLAAMGIPYQIDTRIVRGLDYYTKTVFEVLHPKLGAQSALWGGGRYDGLIEIVGGKPTPGVGFGMGMERVL
MVLEEEGLTAPFADRPRLDVFVATLGEAARPVGLKLLYALRDAGLSADIDYLGRSLKAQMKYAGKQNSRYVVILGEDEVR
QGVASVKHMDEGTQESVPLDQIISHLRRAEA

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI6996014, Length=464, Percent_Identity=23.2758620689655, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI15029520, Length=468, Percent_Identity=22.6495726495727, Blast_Score=92, Evalue=8e-19,
Organism=Escherichia coli, GI1788861, Length=430, Percent_Identity=41.1627906976744, Blast_Score=312, Evalue=3e-86,
Organism=Caenorhabditis elegans, GI71993693, Length=483, Percent_Identity=21.7391304347826, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71993686, Length=483, Percent_Identity=21.7391304347826, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24643061, Length=489, Percent_Identity=23.3128834355828, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24643059, Length=404, Percent_Identity=25, Blast_Score=96, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYH_SYMTH (Q67LN9)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_076251.1
- ProteinModelPortal:   Q67LN9
- SMR:   Q67LN9
- GeneID:   2979790
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH2422
- NMPDR:   fig|292459.1.peg.2318
- HOGENOM:   HBG616575
- OMA:   VFEWVTT
- BioCyc:   STHE292459:STH2422-MONOMER
- BRENDA:   6.1.1.21
- GO:   GO:0005737
- HAMAP:   MF_00127
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516
- Gene3D:   G3DSA:3.40.50.800
- PANTHER:   PTHR11476
- PIRSF:   PIRSF001549
- TIGRFAMs:   TIGR00442

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; SSF52954 Anticodon_bd

EC number: =6.1.1.21

Molecular weight: Translated: 48655; Mature: 48524

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIQAPRGFNDILPGEQYGWRDSYRWQRLEEIFREVARLYGYQELRPPMVEYVDLFIHGV
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHCC
GATTDIVTKEMFNITPRGDDPDARRMAMRPEFTAGLVRAWLENGLYNNPQPTKIFAYGPA
CCHHHHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCC
FRYENVQKGRFRGFHQLDVEVFGAQDPAVDAEVIKLGLDVVARLGLTGLVVSVNSIGCPQ
CCCCCCCHHHHCCCEEECEEEECCCCCCCCHHHHHHHHHHHHHHCHHHEEEEECCCCCCC
CRPRYRQALQDHFRPHLGELCEDCNTRFEKNPLRLLDCKRDADHPAQRTAPVTLDYLCDD
CCHHHHHHHHHHHCHHHHHHHHHHCCHHCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHH
CRRHWEGLLSHLAAMGIPYQIDTRIVRGLDYYTKTVFEVLHPKLGAQSALWGGGRYDGLI
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEE
EIVGGKPTPGVGFGMGMERVLMVLEEEGLTAPFADRPRLDVFVATLGEAARPVGLKLLYA
EEECCCCCCCCCCHHCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHH
LRDAGLSADIDYLGRSLKAQMKYAGKQNSRYVVILGEDEVRQGVASVKHMDEGTQESVPL
HHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCH
DQIISHLRRAEA
HHHHHHHHHCCC
>Mature Secondary Structure 
SIQAPRGFNDILPGEQYGWRDSYRWQRLEEIFREVARLYGYQELRPPMVEYVDLFIHGV
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHCC
GATTDIVTKEMFNITPRGDDPDARRMAMRPEFTAGLVRAWLENGLYNNPQPTKIFAYGPA
CCHHHHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCC
FRYENVQKGRFRGFHQLDVEVFGAQDPAVDAEVIKLGLDVVARLGLTGLVVSVNSIGCPQ
CCCCCCCHHHHCCCEEECEEEECCCCCCCCHHHHHHHHHHHHHHCHHHEEEEECCCCCCC
CRPRYRQALQDHFRPHLGELCEDCNTRFEKNPLRLLDCKRDADHPAQRTAPVTLDYLCDD
CCHHHHHHHHHHHCHHHHHHHHHHCCHHCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHH
CRRHWEGLLSHLAAMGIPYQIDTRIVRGLDYYTKTVFEVLHPKLGAQSALWGGGRYDGLI
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEE
EIVGGKPTPGVGFGMGMERVLMVLEEEGLTAPFADRPRLDVFVATLGEAARPVGLKLLYA
EEECCCCCCCCCCHHCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHH
LRDAGLSADIDYLGRSLKAQMKYAGKQNSRYVVILGEDEVRQGVASVKHMDEGTQESVPL
HHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCH
DQIISHLRRAEA
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA