Click here to switch to the map view.

The map label for this gene is dhaT [H]

Identifier: 51893371

GI number: 51893371

Start: 2398923

End: 2399891

Strand: Reverse

Name: dhaT [H]

Synonym: STH2233

Alternate gene names: 51893371

Gene position: 2399891-2398923 (Counterclockwise)

Preceding gene: 51893372

Following gene: 51893370

Centisome position: 67.3

GC content: 72.86

Gene sequence:

>969_bases
GTGCGCCGTCTACGCCGACGTGATGGCCGAGCCCAGCGCGGAGTGGCTGGACCCGGTCAGCAGGTGAAGGCCCACCAGGC
CGACCTTGTGGTGGCCGTGGGCGGCGGCAGCGCGATCGACGTGGCCAAGGCCACAGCCGTCCTGGCCGCCAACGGCGGCA
CGGCCTACGACTACTTCGGCGTCGACCGGGTGCCCCGGCCGGGGCTGCCCGTGATCGCCATGCCCACCACGGCCGGCACC
GGCGCCGAGGCCACGCCCAACGCCATCTTCACCAACACCCGGACGCAGGTGAAGGAGGGGATCGTCTCCCCGTACATGAT
GCCCGCGGTGGCCATCGTGGACCCCGAGCTGACCCTGACAGCGCCGCCCGGGGTGACCGCCGCCACCGGGATGGACGCCC
TGACCCACGCGGTGGAATCCTTCACCTCAGTCAAGGCCGCGCCCACCACGGACCTGTTCGCCGCCGAAGCCATCCGCCGG
ATCGGCCGGTCGATCCGCACCGCGGTCTTCCGCGGCGGGGACCTCGCGGCCCGGACCGATATGGCCCTCGGCAGCCTGTA
CGCCGGCATCGCCATCTGCAACGCCGGCACCGGCGCGGTCCACGCCATGGCCTACCCGCTGGGCGGCCAGTTCCGGGTGC
CCCACGGCATCGCCAACGCGTCGCTGCTGCCGCACGTGCTCCCGTGGAACCTGCAGGGCAGCGTGGAGAAGTTCGCGCAG
GTCGCCCGGCTGCTGGGTGAGCCCGTGGACGGGCTCAGCGCCCTGGCGGCGGCGGAGCGTGCGGTGGCGGCCATCCAGCG
GCTCTGCGCCGACCTCGGCATCCCCTCCCGGCTGTCGGCGTTCGGCGTCCGGGAGGAGCACATCCCCGCCATGGCGGCGG
CCGCGCACGCGACGCGACGGCTCATGGACAACAACCCCCGCAACCTGACGGTTGAAGAGGTAGAGGCAATCTATCGCTCG
GCCCTGTGA

Upstream 100 bases:

>100_bases
GGCTCGGTGCCACCCGGGCCCTGTTGGTCAGCGACCGCGGTCTCCTGGCGACCGGCACCCCGGAGCGGCTCCAGCGGATG
CTGGAGGGCGCCGGCGTGCG

Downstream 100 bases:

>100_bases
AGGAGGAGCAGCCGGGAGATGGCGGACAGGATCAAGGTGCTCATGCTGCAAGCGATCCACGAAGAAGGGATCCTGCTCTT
CGACGACCGGTTTGAGGTGA

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: 1,3-propanediol oxidoreductase; 3-hydroxypropionaldehyde reductase [H]

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MRRLRRRDGRAQRGVAGPGQQVKAHQADLVVAVGGGSAIDVAKATAVLAANGGTAYDYFGVDRVPRPGLPVIAMPTTAGT
GAEATPNAIFTNTRTQVKEGIVSPYMMPAVAIVDPELTLTAPPGVTAATGMDALTHAVESFTSVKAAPTTDLFAAEAIRR
IGRSIRTAVFRGGDLAARTDMALGSLYAGIAICNAGTGAVHAMAYPLGGQFRVPHGIANASLLPHVLPWNLQGSVEKFAQ
VARLLGEPVDGLSALAAAERAVAAIQRLCADLGIPSRLSAFGVREEHIPAMAAAAHATRRLMDNNPRNLTVEEVEAIYRS
AL

Sequences:

>Translated_322_residues
MRRLRRRDGRAQRGVAGPGQQVKAHQADLVVAVGGGSAIDVAKATAVLAANGGTAYDYFGVDRVPRPGLPVIAMPTTAGT
GAEATPNAIFTNTRTQVKEGIVSPYMMPAVAIVDPELTLTAPPGVTAATGMDALTHAVESFTSVKAAPTTDLFAAEAIRR
IGRSIRTAVFRGGDLAARTDMALGSLYAGIAICNAGTGAVHAMAYPLGGQFRVPHGIANASLLPHVLPWNLQGSVEKFAQ
VARLLGEPVDGLSALAAAERAVAAIQRLCADLGIPSRLSAFGVREEHIPAMAAAAHATRRLMDNNPRNLTVEEVEAIYRS
AL
>Mature_322_residues
MRRLRRRDGRAQRGVAGPGQQVKAHQADLVVAVGGGSAIDVAKATAVLAANGGTAYDYFGVDRVPRPGLPVIAMPTTAGT
GAEATPNAIFTNTRTQVKEGIVSPYMMPAVAIVDPELTLTAPPGVTAATGMDALTHAVESFTSVKAAPTTDLFAAEAIRR
IGRSIRTAVFRGGDLAARTDMALGSLYAGIAICNAGTGAVHAMAYPLGGQFRVPHGIANASLLPHVLPWNLQGSVEKFAQ
VARLLGEPVDGLSALAAAERAVAAIQRLCADLGIPSRLSAFGVREEHIPAMAAAAHATRRLMDNNPRNLTVEEVEAIYRS
AL

Specific function: Most active with substrates containing two primary alcohol groups separated by one or two carbon atoms. In the physiological direction, 3-hydroxypropionaldehyde is the preferred substrate [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=333, Percent_Identity=30.03003003003, Blast_Score=123, Evalue=2e-28,
Organism=Escherichia coli, GI48994951, Length=314, Percent_Identity=40.4458598726115, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1789163, Length=298, Percent_Identity=40.6040268456376, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI87082107, Length=302, Percent_Identity=39.7350993377483, Blast_Score=192, Evalue=2e-50,
Organism=Escherichia coli, GI1787493, Length=326, Percent_Identity=30.3680981595092, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1789386, Length=314, Percent_Identity=27.0700636942675, Blast_Score=82, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17537053, Length=339, Percent_Identity=29.4985250737463, Blast_Score=137, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6321181, Length=307, Percent_Identity=39.0879478827362, Blast_Score=204, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24657991, Length=338, Percent_Identity=28.4023668639053, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.202 [H]

Molecular weight: Translated: 33425; Mature: 33425

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRLRRRDGRAQRGVAGPGQQVKAHQADLVVAVGGGSAIDVAKATAVLAANGGTAYDYFG
CCCHHHHCCCCCCCCCCCCHHHHCCCCCEEEEECCCCCHHHHHHEEEEEECCCCEEEECC
VDRVPRPGLPVIAMPTTAGTGAEATPNAIFTNTRTQVKEGIVSPYMMPAVAIVDPELTLT
CCCCCCCCCCEEEECCCCCCCCCCCCCCEECCCHHHHHHHHCCCHHHCEEEEECCCEEEE
APPGVTAATGMDALTHAVESFTSVKAAPTTDLFAAEAIRRIGRSIRTAVFRGGDLAARTD
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
MALGSLYAGIAICNAGTGAVHAMAYPLGGQFRVPHGIANASLLPHVLPWNLQGSVEKFAQ
HHHHHHHHHHHEECCCCCCEEEEEECCCCCEECCCCCCCCHHCCCCCCCCCCCCHHHHHH
VARLLGEPVDGLSALAAAERAVAAIQRLCADLGIPSRLSAFGVREEHIPAMAAAAHATRR
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHH
LMDNNPRNLTVEEVEAIYRSAL
HHCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MRRLRRRDGRAQRGVAGPGQQVKAHQADLVVAVGGGSAIDVAKATAVLAANGGTAYDYFG
CCCHHHHCCCCCCCCCCCCHHHHCCCCCEEEEECCCCCHHHHHHEEEEEECCCCEEEECC
VDRVPRPGLPVIAMPTTAGTGAEATPNAIFTNTRTQVKEGIVSPYMMPAVAIVDPELTLT
CCCCCCCCCCEEEECCCCCCCCCCCCCCEECCCHHHHHHHHCCCHHHCEEEEECCCEEEE
APPGVTAATGMDALTHAVESFTSVKAAPTTDLFAAEAIRRIGRSIRTAVFRGGDLAARTD
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
MALGSLYAGIAICNAGTGAVHAMAYPLGGQFRVPHGIANASLLPHVLPWNLQGSVEKFAQ
HHHHHHHHHHHEECCCCCCEEEEEECCCCCEECCCCCCCCHHCCCCCCCCCCCCHHHHHH
VARLLGEPVDGLSALAAAERAVAAIQRLCADLGIPSRLSAFGVREEHIPAMAAAAHATRR
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHH
LMDNNPRNLTVEEVEAIYRSAL
HHCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721705 [H]