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The map label for this gene is mtnA

Identifier: 51893206

GI number: 51893206

Start: 2205746

End: 2206825

Strand: Reverse

Name: mtnA

Synonym: STH2068

Alternate gene names: 51893206

Gene position: 2206825-2205746 (Counterclockwise)

Preceding gene: 51893207

Following gene: 51893204

Centisome position: 61.88

GC content: 68.06

Gene sequence:

>1080_bases
ATGCCCAAGCAGATCGAGCCGGTGGCGCTGGATGACGCGGGCAGCGCCCTGGTGATTGTGGACCAGACCCTGATTCCCAA
CGAGACCCGGTACTTGCGGCTCACCACGCCGGAGGAGACGTGGGAGGCCATCCGGTCGCTGCGGGTGCGTGGGGCCCCCG
CCATCGGCATCGCCGCGGCCATGGGGCTTTACCTGGGGGTGAAGGGGTCAGAGGCGGCCGATTTCGAGGACTTCTACCAC
GAGTTCCGGCAGGTGAAGGCGTATCTCGCCTCCGCCCGCCCGACGGCGGTGAACCTCTTCTGGGCCCTGGACCGGATGGA
GGCGTGTCTCTTGCGCCATCGGGACCGGCCGATCCCGGAGATCAAGGAGGCCCTGCGGGCCGAGGCGGAGGCGATCCGGG
AGGAGGACGCCCGGGCCAACCGCACCATCGGCGAGTACGCCCTCTCGCTGCTGAAGCCCGGTATGGGGATTCTCACCCAC
TGCAACGCGGGCGCGCTGGCTACGGCAGCCTACGGCACCGCCCTGGCGCCGATCTACCTGGGCCAGGAGCGGGGGTACAA
CTTCCGGGTGTTCGCGGACGAGACGCGGCCCCTGCTGCAGGGCGCCCGGCTCACCGCCTACGAACTGATGCAGGCCGGGG
TCGACGTGACCCTGATCTGCGATAACATGGCCTCCGCGGTGATGAAGAACGGCTGGGTGGACGCGGTCTTCGTCGGCTGC
GACCGGGTGGCCGCCAACGGCGACACCGCTAACAAGATCGGCACCTCCGGCGTGGCGATCCTGGCCAGGCACTACGGCAT
CCCGTTCTACGTGTGCGCACCCACCTCGACGATCGACCTGAGATGCCCCACCGGCGCCGACATTGTCATCGAGGAGCGCC
GGCCTGAAGAGGTGACCGAACAGTGGTACGCGAAGCGGATGGCGCCGGAGGGCGTAAAGGTCTACAACCCGGCCTTCGAC
GTCACCGATGCCGACTTGATCACGGCGATCATCACCGAGTACGGAATCGCCCGGCCGCCGTACACCGAGTCCTTGAAGGA
GCTGTTCCGGCGGAAAGAGGAGGCGGAGCGCCGGGCGTGA

Upstream 100 bases:

>100_bases
ACACGGCCGGCGGGCGGCCCGGCCATGCGCCGGGCTGCCGCCCCCCGGAGGTGGCTGAACGGGGCGGCCGCGACGGAGAA
AGGGGAGAACTGGTGCGATG

Downstream 100 bases:

>100_bases
CCGGCGGCGGCCCGGTTCCCGGGCCGTGAAGGGGTCCGGGAGGCGGAAGGGGCGTTCCGAGACCACAAAGAAGCCGGCAA
AGGGATCGGCCCGCACTCCA

Product: methylthioribose-1-phosphate isomerase

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MPKQIEPVALDDAGSALVIVDQTLIPNETRYLRLTTPEETWEAIRSLRVRGAPAIGIAAAMGLYLGVKGSEAADFEDFYH
EFRQVKAYLASARPTAVNLFWALDRMEACLLRHRDRPIPEIKEALRAEAEAIREEDARANRTIGEYALSLLKPGMGILTH
CNAGALATAAYGTALAPIYLGQERGYNFRVFADETRPLLQGARLTAYELMQAGVDVTLICDNMASAVMKNGWVDAVFVGC
DRVAANGDTANKIGTSGVAILARHYGIPFYVCAPTSTIDLRCPTGADIVIEERRPEEVTEQWYAKRMAPEGVKVYNPAFD
VTDADLITAIITEYGIARPPYTESLKELFRRKEEAERRA

Sequences:

>Translated_359_residues
MPKQIEPVALDDAGSALVIVDQTLIPNETRYLRLTTPEETWEAIRSLRVRGAPAIGIAAAMGLYLGVKGSEAADFEDFYH
EFRQVKAYLASARPTAVNLFWALDRMEACLLRHRDRPIPEIKEALRAEAEAIREEDARANRTIGEYALSLLKPGMGILTH
CNAGALATAAYGTALAPIYLGQERGYNFRVFADETRPLLQGARLTAYELMQAGVDVTLICDNMASAVMKNGWVDAVFVGC
DRVAANGDTANKIGTSGVAILARHYGIPFYVCAPTSTIDLRCPTGADIVIEERRPEEVTEQWYAKRMAPEGVKVYNPAFD
VTDADLITAIITEYGIARPPYTESLKELFRRKEEAERRA
>Mature_358_residues
PKQIEPVALDDAGSALVIVDQTLIPNETRYLRLTTPEETWEAIRSLRVRGAPAIGIAAAMGLYLGVKGSEAADFEDFYHE
FRQVKAYLASARPTAVNLFWALDRMEACLLRHRDRPIPEIKEALRAEAEAIREEDARANRTIGEYALSLLKPGMGILTHC
NAGALATAAYGTALAPIYLGQERGYNFRVFADETRPLLQGARLTAYELMQAGVDVTLICDNMASAVMKNGWVDAVFVGCD
RVAANGDTANKIGTSGVAILARHYGIPFYVCAPTSTIDLRCPTGADIVIEERRPEEVTEQWYAKRMAPEGVKVYNPAFDV
TDADLITAIITEYGIARPPYTESLKELFRRKEEAERRA

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily

Homologues:

Organism=Homo sapiens, GI72534748, Length=337, Percent_Identity=44.8071216617211, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI23943880, Length=327, Percent_Identity=39.7553516819572, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI7657058, Length=158, Percent_Identity=32.2784810126582, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI78000158, Length=270, Percent_Identity=25.1851851851852, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI78000156, Length=270, Percent_Identity=25.1851851851852, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI187607323, Length=270, Percent_Identity=25.1851851851852, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17557462, Length=347, Percent_Identity=35.7348703170029, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17557123, Length=278, Percent_Identity=27.6978417266187, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6325375, Length=379, Percent_Identity=34.5646437994723, Blast_Score=182, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6322878, Length=153, Percent_Identity=35.2941176470588, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357667, Length=341, Percent_Identity=40.7624633431085, Blast_Score=244, Evalue=6e-65,
Organism=Drosophila melanogaster, GI24651647, Length=341, Percent_Identity=40.7624633431085, Blast_Score=244, Evalue=6e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNA_SYMTH (Q67MP0)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_075897.1
- HSSP:   Q9X013
- ProteinModelPortal:   Q67MP0
- SMR:   Q67MP0
- GeneID:   2979572
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH2068
- NMPDR:   fig|292459.1.peg.1997
- HOGENOM:   HBG682649
- OMA:   VELVCTD
- ProtClustDB:   PRK05720
- BioCyc:   STHE292459:STH2068-MONOMER
- HAMAP:   MF_01678
- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559
- PANTHER:   PTHR10233
- TIGRFAMs:   TIGR00524
- TIGRFAMs:   TIGR00512

Pfam domain/function: PF01008 IF-2B

EC number: =5.3.1.23

Molecular weight: Translated: 39605; Mature: 39473

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: ACT_SITE 241-241 BINDING 93-93 BINDING 200-200

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKQIEPVALDDAGSALVIVDQTLIPNETRYLRLTTPEETWEAIRSLRVRGAPAIGIAAA
CCCCCCCEEECCCCCEEEEEECEECCCCCEEEEEECCHHHHHHHHHHHCCCCCHHHHHHH
MGLYLGVKGSEAADFEDFYHEFRQVKAYLASARPTAVNLFWALDRMEACLLRHRDRPIPE
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHH
IKEALRAEAEAIREEDARANRTIGEYALSLLKPGMGILTHCNAGALATAAYGTALAPIYL
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHEEE
GQERGYNFRVFADETRPLLQGARLTAYELMQAGVDVTLICDNMASAVMKNGWVDAVFVGC
ECCCCCEEEEEECCCHHHHHCCCHHHHHHHHCCCCEEEEEHHHHHHHHHCCCEEEEEEEC
DRVAANGDTANKIGTSGVAILARHYGIPFYVCAPTSTIDLRCPTGADIVIEERRPEEVTE
CHHCCCCCCCHHCCCCHHHHHHHHCCCCEEEECCCCEEEEECCCCCCEEEECCCCHHHHH
QWYAKRMAPEGVKVYNPAFDVTDADLITAIITEYGIARPPYTESLKELFRRKEEAERRA
HHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PKQIEPVALDDAGSALVIVDQTLIPNETRYLRLTTPEETWEAIRSLRVRGAPAIGIAAA
CCCCCCEEECCCCCEEEEEECEECCCCCEEEEEECCHHHHHHHHHHHCCCCCHHHHHHH
MGLYLGVKGSEAADFEDFYHEFRQVKAYLASARPTAVNLFWALDRMEACLLRHRDRPIPE
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHH
IKEALRAEAEAIREEDARANRTIGEYALSLLKPGMGILTHCNAGALATAAYGTALAPIYL
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHEEE
GQERGYNFRVFADETRPLLQGARLTAYELMQAGVDVTLICDNMASAVMKNGWVDAVFVGC
ECCCCCEEEEEECCCHHHHHCCCHHHHHHHHCCCCEEEEEHHHHHHHHHCCCEEEEEEEC
DRVAANGDTANKIGTSGVAILARHYGIPFYVCAPTSTIDLRCPTGADIVIEERRPEEVTE
CHHCCCCCCCHHCCCCHHHHHHHHCCCCEEEECCCCEEEEECCCCCCEEEECCCCHHHHH
QWYAKRMAPEGVKVYNPAFDVTDADLITAIITEYGIARPPYTESLKELFRRKEEAERRA
HHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA