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The map label for this gene is yusP [H]

Identifier: 51893204

GI number: 51893204

Start: 2203757

End: 2205277

Strand: Reverse

Name: yusP [H]

Synonym: STH2066

Alternate gene names: 51893204

Gene position: 2205277-2203757 (Counterclockwise)

Preceding gene: 51893206

Following gene: 51893203

Centisome position: 61.84

GC content: 70.28

Gene sequence:

>1521_bases
GTGCGTGACCGTCGGATGTTAACTGTGTTCGCCCTGATGCTGGCGAGCTTTCTTACCGCCGTCGACGTCACCATCGTCGA
CACGGCGATGCCCCGGATCGTCGGATCCCTGGGCGGCTTCTCGATGCTTACCTGGCTCGTTTCGGCCTACATGCTCACCT
CCACCGCGACGATGCCGGTCTACGGCAAGCTGGCGGACATCATTGGACGGAAGAGAACGTTCACCATCGGCGCGGTCATC
TTCGTGATCGGCTCGGCGCTCTGCGGCGCGGCACCGTCGATGGAGGCCCTGATCCTGTTCCGCGCCCTGCAGGGGTTGGG
GGCCGGCGCGATGCAACCCACCGTGCAGACGATCCTGGGCGACATCTTCACCCCGGCGGAGCGGGCGAAGGTGCAGGGGT
GGTTCTCCGCCGTCTGGGGCTTCTCCGCCCTGGCGGGACCGCTGGTGGGCGGGCTGATGGTCGACTACCTCTCGTGGCGC
TACCTCTTCTACATCAACCTGCCCCTGGGCGCCCTGGCCCTGTATATGGTCTGGCGCCACTTCGACGAGCGGGTCCAGCG
GCGGAAGGCCCGGGTCGACTACCTGGGAGCGGTGACGCTCACGGGCGGCATGACCCTGCTCCTGCTCGTGCTGCTCACCG
GTGGCAGCCAGCTGCCCTGGGGGTCGCCCCAGATCCTCGGGATGGCCGGCGGCGCCGCCGTGCTGCTCCTGCTCTTCCTC
TGGACGCAGGGGCGCGCCCTGGACCCGATCCTGCCCCTGCGGCTGTTCCGGATCCCCGTCATCGGCTGGGGGAACCTCTC
GTCGCTCATGGTGGGCGGCGTGATGTACGGCACCTCCGTCTACCTGCCCATCTGGGCGCAGGGGGTGCAGGGCTACTCCG
CCACCCGCTCCGGGGCCTCGCTGCTCTGGCTCTCCATCGGCTGGCCGCTGGCGGCCGTGCTGGGCAGCCGGCTGATCGTG
CGCATGGGTGTGCGCCCCTCGGCCCTGTTGGGGCTCGGCCTCAACGTCGCCGGCTCTGCCGCGCTGGTGGCCCTGGCGCG
GACCATGGCCGAGATCCCCGAGGTGTTGCTGGCCCTGGTGACGTTCGTGATCGGCGCCGGGATGGGCTTCTCCACCCTGG
CCTTCATCCTGGGGATCCAGTCCTCGGTCGACTGGGCTCAGCGGGGGGTCGCCACGGCCTCGTTCCAGTTCATCCGCACC
CTGGGCGGCATGATCTGGGTCTCGGCGATGGGCGGCGTGATGAACCTGGACCTGCTGGGCCGGCTGCAGCGGATCCCCGG
CGTGGCGGCGAGGACGGCCGCCGAGGCGGGCCAGTGGGCCAACCGGCTCCTGGATCCCGCGCAGCGCGCGGCCCTCGGCC
CGGAGCTGCAGGCGGCGATGCAGGAGGCGCTGGCGGACGCACTCCGCAACGTCCACCTGGTGATGCTCCTGGCCGCCGTG
CTCAGCCTGGCCGCGGCGTTGCTGCTGCCCAATCTGCGGTTTGCACCCGAGAAGGCGCCGCAGGCGAGCACGGCCGATTA
G

Upstream 100 bases:

>100_bases
ACGTGCCGACTCGGCTTGGATTGGAACCTGTGTCCCCAGGGGCGGCCGTAGCGCGCCGCCATCGCGGCACGTCCCAAAGG
GCAGGGGGAGGGGTGCCCGC

Downstream 100 bases:

>100_bases
GGGCGCCGAGCGGGCAGGCCGCGGGCATGAACCAGACGGAGCCTGCGCCCGCGCCCATGAGCCGCATGGGGCCGGAACCA
ACGTCTATCAGACGGGACAA

Product: efflux transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MRDRRMLTVFALMLASFLTAVDVTIVDTAMPRIVGSLGGFSMLTWLVSAYMLTSTATMPVYGKLADIIGRKRTFTIGAVI
FVIGSALCGAAPSMEALILFRALQGLGAGAMQPTVQTILGDIFTPAERAKVQGWFSAVWGFSALAGPLVGGLMVDYLSWR
YLFYINLPLGALALYMVWRHFDERVQRRKARVDYLGAVTLTGGMTLLLLVLLTGGSQLPWGSPQILGMAGGAAVLLLLFL
WTQGRALDPILPLRLFRIPVIGWGNLSSLMVGGVMYGTSVYLPIWAQGVQGYSATRSGASLLWLSIGWPLAAVLGSRLIV
RMGVRPSALLGLGLNVAGSAALVALARTMAEIPEVLLALVTFVIGAGMGFSTLAFILGIQSSVDWAQRGVATASFQFIRT
LGGMIWVSAMGGVMNLDLLGRLQRIPGVAARTAAEAGQWANRLLDPAQRAALGPELQAAMQEALADALRNVHLVMLLAAV
LSLAAALLLPNLRFAPEKAPQASTAD

Sequences:

>Translated_506_residues
MRDRRMLTVFALMLASFLTAVDVTIVDTAMPRIVGSLGGFSMLTWLVSAYMLTSTATMPVYGKLADIIGRKRTFTIGAVI
FVIGSALCGAAPSMEALILFRALQGLGAGAMQPTVQTILGDIFTPAERAKVQGWFSAVWGFSALAGPLVGGLMVDYLSWR
YLFYINLPLGALALYMVWRHFDERVQRRKARVDYLGAVTLTGGMTLLLLVLLTGGSQLPWGSPQILGMAGGAAVLLLLFL
WTQGRALDPILPLRLFRIPVIGWGNLSSLMVGGVMYGTSVYLPIWAQGVQGYSATRSGASLLWLSIGWPLAAVLGSRLIV
RMGVRPSALLGLGLNVAGSAALVALARTMAEIPEVLLALVTFVIGAGMGFSTLAFILGIQSSVDWAQRGVATASFQFIRT
LGGMIWVSAMGGVMNLDLLGRLQRIPGVAARTAAEAGQWANRLLDPAQRAALGPELQAAMQEALADALRNVHLVMLLAAV
LSLAAALLLPNLRFAPEKAPQASTAD
>Mature_506_residues
MRDRRMLTVFALMLASFLTAVDVTIVDTAMPRIVGSLGGFSMLTWLVSAYMLTSTATMPVYGKLADIIGRKRTFTIGAVI
FVIGSALCGAAPSMEALILFRALQGLGAGAMQPTVQTILGDIFTPAERAKVQGWFSAVWGFSALAGPLVGGLMVDYLSWR
YLFYINLPLGALALYMVWRHFDERVQRRKARVDYLGAVTLTGGMTLLLLVLLTGGSQLPWGSPQILGMAGGAAVLLLLFL
WTQGRALDPILPLRLFRIPVIGWGNLSSLMVGGVMYGTSVYLPIWAQGVQGYSATRSGASLLWLSIGWPLAAVLGSRLIV
RMGVRPSALLGLGLNVAGSAALVALARTMAEIPEVLLALVTFVIGAGMGFSTLAFILGIQSSVDWAQRGVATASFQFIRT
LGGMIWVSAMGGVMNLDLLGRLQRIPGVAARTAAEAGQWANRLLDPAQRAALGPELQAAMQEALADALRNVHLVMLLAAV
LSLAAALLLPNLRFAPEKAPQASTAD

Specific function: Translocase That Confers Resistance To Substances Of High Hydrophobicity. [C]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=291, Percent_Identity=31.2714776632302, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1790195, Length=326, Percent_Identity=28.5276073619632, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788710, Length=337, Percent_Identity=29.3768545994065, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI87081983, Length=343, Percent_Identity=28.5714285714286, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1788392, Length=206, Percent_Identity=32.0388349514563, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790146, Length=163, Percent_Identity=31.2883435582822, Blast_Score=63, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322958, Length=546, Percent_Identity=23.0769230769231, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6323735, Length=310, Percent_Identity=28.3870967741935, Blast_Score=117, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6319770, Length=481, Percent_Identity=24.5322245322245, Blast_Score=106, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6325455, Length=250, Percent_Identity=28, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6321663, Length=152, Percent_Identity=31.5789473684211, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6324954, Length=225, Percent_Identity=28, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 53729; Mature: 53729

Theoretical pI: Translated: 10.74; Mature: 10.74

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDRRMLTVFALMLASFLTAVDVTIVDTAMPRIVGSLGGFSMLTWLVSAYMLTSTATMPV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCH
YGKLADIIGRKRTFTIGAVIFVIGSALCGAAPSMEALILFRALQGLGAGAMQPTVQTILG
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHH
DIFTPAERAKVQGWFSAVWGFSALAGPLVGGLMVDYLSWRYLFYINLPLGALALYMVWRH
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHHHHH
FDERVQRRKARVDYLGAVTLTGGMTLLLLVLLTGGSQLPWGSPQILGMAGGAAVLLLLFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHH
WTQGRALDPILPLRLFRIPVIGWGNLSSLMVGGVMYGTSVYLPIWAQGVQGYSATRSGAS
HCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEEEHHHHCCCCCCCCCCCCCE
LLWLSIGWPLAAVLGSRLIVRMGVRPSALLGLGLNVAGSAALVALARTMAEIPEVLLALV
EEEEECCHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TFVIGAGMGFSTLAFILGIQSSVDWAQRGVATASFQFIRTLGGMIWVSAMGGVMNLDLLG
HHHHHCCCCHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
RLQRIPGVAARTAAEAGQWANRLLDPAQRAALGPELQAAMQEALADALRNVHLVMLLAAV
HHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSLAAALLLPNLRFAPEKAPQASTAD
HHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRDRRMLTVFALMLASFLTAVDVTIVDTAMPRIVGSLGGFSMLTWLVSAYMLTSTATMPV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCH
YGKLADIIGRKRTFTIGAVIFVIGSALCGAAPSMEALILFRALQGLGAGAMQPTVQTILG
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHH
DIFTPAERAKVQGWFSAVWGFSALAGPLVGGLMVDYLSWRYLFYINLPLGALALYMVWRH
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHHHHH
FDERVQRRKARVDYLGAVTLTGGMTLLLLVLLTGGSQLPWGSPQILGMAGGAAVLLLLFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHH
WTQGRALDPILPLRLFRIPVIGWGNLSSLMVGGVMYGTSVYLPIWAQGVQGYSATRSGAS
HCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEEEHHHHCCCCCCCCCCCCCE
LLWLSIGWPLAAVLGSRLIVRMGVRPSALLGLGLNVAGSAALVALARTMAEIPEVLLALV
EEEEECCHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TFVIGAGMGFSTLAFILGIQSSVDWAQRGVATASFQFIRTLGGMIWVSAMGGVMNLDLLG
HHHHHCCCCHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
RLQRIPGVAARTAAEAGQWANRLLDPAQRAALGPELQAAMQEALADALRNVHLVMLLAAV
HHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSLAAALLLPNLRFAPEKAPQASTAD
HHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]