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The map label for this gene is phoR [H]

Identifier: 51893144

GI number: 51893144

Start: 2146385

End: 2147905

Strand: Reverse

Name: phoR [H]

Synonym: STH2006

Alternate gene names: 51893144

Gene position: 2147905-2146385 (Counterclockwise)

Preceding gene: 51893145

Following gene: 51893143

Centisome position: 60.23

GC content: 75.81

Gene sequence:

>1521_bases
GTGAGGCGGCCGGGTCAGTGGCCGCTGGCCGTCCAGCTGGCCCTGGCGTTTGCGCTGGTCACGGTCCTGGCCCTCGGCGG
CAGCGGGGCGCTCCTGCTGTACCAGACCACGGCCCGGCTGCTGGAGGAGCGGGAGGCGTCCGTCATGGCCTGGGGGCAGG
CTGCAGCGGGCCTGGCGGCCGAGTACTGGGCCGATCCGCAGGAAGGCCTGACGCTGGCCTTCTACCGCTTCCACCAGCAG
AGCGGGATGCGGCCGGTGGCCGTGGACGGACAGGGAGTTGTCGTCGCCGACATCACCTCGGAGACGGAGCTCCTGGGGCA
GCGGCTGACGCACCCGGAGGTCCGGGACGCCCTGGCCGGCCGGGCGACGGCAGGCACCCGCCGGCTCCCCGGCGGCGAGT
GGGTGATGTACGCCGGCGTGCCGGTGGTCGTGGGCGAGCGGCTGGTCGGGGCGGTGCTGGTGGCGGCGGACATCACCTCG
GTGCGGGAGGCCCGGGACGACCTGCTCCGGCAGCTGGCCTGGGTGGCCGGGGCGATGGCGCTCCTGGCCGTGGGGGCGGG
CGTGATGCTCGCACGCTACCTCACCCGGCCGCTGGTCCGGCTGCGGGAGGCGGTGTCGTGCCTGGCCCGCGGGCGGCTGG
AGACACGGGTGGTGCCGGGCGGCAGCAGCGAGCTGCTGGACCTCGGGCGGGGGTTCAACCGCATGGCCGAGGAGTTGGGA
AGGCTGGATCAGCAGCGGCGGGCGTTCGTCGCGGACGCCTCCCACGAGCTGCGCACGCCCATCGCGGCGATCCGGGCGCT
GGCCGAGCCGCTGCTCAGCGACCGGCCTGTGGATCCGGCGATCTACAAGGAGCACCTGCAGGACATCGTGCACGAGTGCG
ACCGGGCCGGCCGGCTGGTGAACGCGCTGCTGGAGCTGGCCCGCCTGGATATGCGGGCCGGGGCCCGCCGCGCGGCGGGC
GACCCGGTCGAGCTGCGCCGGCTGGTGGCGGAGGTGGTGCACGCCCTGGAGCCGCTCGCCGCCGAGCGGGGCGTGCGGCT
GGAGCTGCAGCCGGGTCTGCCGGTGACGGCGCCGGCCGACCCGCAGCTGCTGGAGGCGGTGGTGGGCAACCTGGTGGAGA
ACGGCATCAAGTACACCCCGCGGGGCGGTTCCGTGCAGGTGGCCGTAGGCATCGGGCCGGCGGAGCCCGCACCCGGGCCG
GGCGGAAGCGAGCCGGACAGCGGCGGATGGCACGGGACGGTGTCGGGGGGCGACGCGGGGGAGGCGACCCGCGGGGGTGC
GCAGCCGGGCCAGGTGGCCTGGGTGACGGTGGCGGACTCGGGCATCGGCATCCCGCCCGAGCACCTGCCGCACATCTTCG
ACCGCTTCTACCGGGTGGACAAGGCCCGGTCGCGCGCCACCGGCGGCGCGGGACTCGGCCTGGCCATCGCGGCGGAGGCC
GCAGCGCGCCTGGGCGGCCGGATCCACGTGGCGTCGAAGGTCGGCGAGGGCAGCCGGTTTACGCTGACGCTGCCGGTTTA
A

Upstream 100 bases:

>100_bases
TCCACGTCCGGCGCATCCGGGAGAAGCTGGAGGAGGATCCCTCCCGGCCCCGGTACCTGCGCACCAAGTGGGGCGTGGGC
TACTACCTGGAGGCCGAGCC

Downstream 100 bases:

>100_bases
CCGGCACGTCACACTTTCGTAAAACCTCGTCATCGGGGGGTCATACTTCACCGGTAGACTCGGTCGTGGAGATGAACCCG
CGAAAGGAGCAGATGTCGAT

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MRRPGQWPLAVQLALAFALVTVLALGGSGALLLYQTTARLLEEREASVMAWGQAAAGLAAEYWADPQEGLTLAFYRFHQQ
SGMRPVAVDGQGVVVADITSETELLGQRLTHPEVRDALAGRATAGTRRLPGGEWVMYAGVPVVVGERLVGAVLVAADITS
VREARDDLLRQLAWVAGAMALLAVGAGVMLARYLTRPLVRLREAVSCLARGRLETRVVPGGSSELLDLGRGFNRMAEELG
RLDQQRRAFVADASHELRTPIAAIRALAEPLLSDRPVDPAIYKEHLQDIVHECDRAGRLVNALLELARLDMRAGARRAAG
DPVELRRLVAEVVHALEPLAAERGVRLELQPGLPVTAPADPQLLEAVVGNLVENGIKYTPRGGSVQVAVGIGPAEPAPGP
GGSEPDSGGWHGTVSGGDAGEATRGGAQPGQVAWVTVADSGIGIPPEHLPHIFDRFYRVDKARSRATGGAGLGLAIAAEA
AARLGGRIHVASKVGEGSRFTLTLPV

Sequences:

>Translated_506_residues
MRRPGQWPLAVQLALAFALVTVLALGGSGALLLYQTTARLLEEREASVMAWGQAAAGLAAEYWADPQEGLTLAFYRFHQQ
SGMRPVAVDGQGVVVADITSETELLGQRLTHPEVRDALAGRATAGTRRLPGGEWVMYAGVPVVVGERLVGAVLVAADITS
VREARDDLLRQLAWVAGAMALLAVGAGVMLARYLTRPLVRLREAVSCLARGRLETRVVPGGSSELLDLGRGFNRMAEELG
RLDQQRRAFVADASHELRTPIAAIRALAEPLLSDRPVDPAIYKEHLQDIVHECDRAGRLVNALLELARLDMRAGARRAAG
DPVELRRLVAEVVHALEPLAAERGVRLELQPGLPVTAPADPQLLEAVVGNLVENGIKYTPRGGSVQVAVGIGPAEPAPGP
GGSEPDSGGWHGTVSGGDAGEATRGGAQPGQVAWVTVADSGIGIPPEHLPHIFDRFYRVDKARSRATGGAGLGLAIAAEA
AARLGGRIHVASKVGEGSRFTLTLPV
>Mature_506_residues
MRRPGQWPLAVQLALAFALVTVLALGGSGALLLYQTTARLLEEREASVMAWGQAAAGLAAEYWADPQEGLTLAFYRFHQQ
SGMRPVAVDGQGVVVADITSETELLGQRLTHPEVRDALAGRATAGTRRLPGGEWVMYAGVPVVVGERLVGAVLVAADITS
VREARDDLLRQLAWVAGAMALLAVGAGVMLARYLTRPLVRLREAVSCLARGRLETRVVPGGSSELLDLGRGFNRMAEELG
RLDQQRRAFVADASHELRTPIAAIRALAEPLLSDRPVDPAIYKEHLQDIVHECDRAGRLVNALLELARLDMRAGARRAAG
DPVELRRLVAEVVHALEPLAAERGVRLELQPGLPVTAPADPQLLEAVVGNLVENGIKYTPRGGSVQVAVGIGPAEPAPGP
GGSEPDSGGWHGTVSGGDAGEATRGGAQPGQVAWVTVADSGIGIPPEHLPHIFDRFYRVDKARSRATGGAGLGLAIAAEA
AARLGGRIHVASKVGEGSRFTLTLPV

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=301, Percent_Identity=30.5647840531561, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1788393, Length=371, Percent_Identity=31.8059299191375, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1786783, Length=385, Percent_Identity=26.7532467532467, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI1790861, Length=420, Percent_Identity=27.6190476190476, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI87082128, Length=337, Percent_Identity=26.4094955489614, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1790346, Length=314, Percent_Identity=27.0700636942675, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1789808, Length=329, Percent_Identity=27.6595744680851, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1787894, Length=310, Percent_Identity=26.7741935483871, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1788279, Length=399, Percent_Identity=23.5588972431078, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789403, Length=340, Percent_Identity=27.9411764705882, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1790551, Length=238, Percent_Identity=26.4705882352941, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53340; Mature: 53340

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRPGQWPLAVQLALAFALVTVLALGGSGALLLYQTTARLLEEREASVMAWGQAAAGLAA
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
EYWADPQEGLTLAFYRFHQQSGMRPVAVDGQGVVVADITSETELLGQRLTHPEVRDALAG
HHCCCCCCCCEEHHHHHHHHCCCCEEEECCCCEEEEECCHHHHHHHHHCCCHHHHHHHHC
RATAGTRRLPGGEWVMYAGVPVVVGERLVGAVLVAADITSVREARDDLLRQLAWVAGAMA
CCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLAVGAGVMLARYLTRPLVRLREAVSCLARGRLETRVVPGGSSELLDLGRGFNRMAEELG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHCCHHHHHHHHH
RLDQQRRAFVADASHELRTPIAAIRALAEPLLSDRPVDPAIYKEHLQDIVHECDRAGRLV
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
NALLELARLDMRAGARRAAGDPVELRRLVAEVVHALEPLAAERGVRLELQPGLPVTAPAD
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCC
PQLLEAVVGNLVENGIKYTPRGGSVQVAVGIGPAEPAPGPGGSEPDSGGWHGTVSGGDAG
HHHHHHHHHHHHHCCCEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCC
EATRGGAQPGQVAWVTVADSGIGIPPEHLPHIFDRFYRVDKARSRATGGAGLGLAIAAEA
CCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
AARLGGRIHVASKVGEGSRFTLTLPV
HHHCCCEEEEEEECCCCCEEEEEECC
>Mature Secondary Structure
MRRPGQWPLAVQLALAFALVTVLALGGSGALLLYQTTARLLEEREASVMAWGQAAAGLAA
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
EYWADPQEGLTLAFYRFHQQSGMRPVAVDGQGVVVADITSETELLGQRLTHPEVRDALAG
HHCCCCCCCCEEHHHHHHHHCCCCEEEECCCCEEEEECCHHHHHHHHHCCCHHHHHHHHC
RATAGTRRLPGGEWVMYAGVPVVVGERLVGAVLVAADITSVREARDDLLRQLAWVAGAMA
CCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLAVGAGVMLARYLTRPLVRLREAVSCLARGRLETRVVPGGSSELLDLGRGFNRMAEELG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHCCHHHHHHHHH
RLDQQRRAFVADASHELRTPIAAIRALAEPLLSDRPVDPAIYKEHLQDIVHECDRAGRLV
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
NALLELARLDMRAGARRAAGDPVELRRLVAEVVHALEPLAAERGVRLELQPGLPVTAPAD
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCC
PQLLEAVVGNLVENGIKYTPRGGSVQVAVGIGPAEPAPGPGGSEPDSGGWHGTVSGGDAG
HHHHHHHHHHHHHCCCEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCC
EATRGGAQPGQVAWVTVADSGIGIPPEHLPHIFDRFYRVDKARSRATGGAGLGLAIAAEA
CCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
AARLGGRIHVASKVGEGSRFTLTLPV
HHHCCCEEEEEEECCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]