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The map label for this gene is glpA [H]

Identifier: 51893124

GI number: 51893124

Start: 2124359

End: 2125996

Strand: Reverse

Name: glpA [H]

Synonym: STH1986

Alternate gene names: 51893124

Gene position: 2125996-2124359 (Counterclockwise)

Preceding gene: 51893125

Following gene: 51893123

Centisome position: 59.62

GC content: 76.07

Gene sequence:

>1638_bases
GTGCTGCAAGCCATCGTCATCGGCGGGGGGGCTACCGGCGCAGGCATCCTGCGCGACCTGGCCCTGCGGAGCGTGCGCGC
CGCGCTGGTGGAGCAGGGGGACCTGGTCCACGGTACCTCCAGCCGCTACCACGGCCTGCTGCACAGCGGCGGCCGGTACG
CGGTGAAGGACCCGGAGTCGGCGCGGGAGTGCGCCGTCGAGAACCAGATCGTGCGCCGGATCGCGCCGTTTGCGGTGGAG
CCCTGCGGCGGCCTGTTCGTGCGGCTGGAGCAGGACGACCCCGCCTACGCCCGGCGGTGGGTCGCCGCCTGCCGGGAGGC
GGGCATCCCGGTGGAGGAGGTGGACCCGGACCGGCTGCGCCGGGAGGAGCCGCTGCTGGCCGGGTCCGTGTGCGAGGCCT
GGGCCGTGCCGGACGCGGCGGTGGACGGCTGGCGGCTGGTCCGGGGGAACGTGGCCGCGGCCGAGGCCCGTGGCGCCCGG
GTGTTCACCTACCGGCGGGTCGTGGGGTTGCTGATGGACGGCCGCCGGGTGGCCGGGGTGCGCCTCCTGAACCTGGCCAC
CGGCGAGGAGGAGCGGCTGGAGGCGGAACTGGTGATCAACGCCGCGGGGGCCTGGGCCGGGCAGATCGCGGCGATGGCCG
GGGCGCCGCTGGACGTGGTGGCCGACCGCGGCGTCCTGCTGGTCTACCACGGCCGGCTCACCAGCCGGGTCGTCAACAGG
TTGCGCAAGCCCGGCAACGGCGACATCTTCGTGCCCGCGGGCAGCGTCACCCTCCTGGGCACGACGGCGACGCCGGTACC
CGACCCGGACGACATCTCCGTGCCGCCCGAGGAGGTCGAGGAACTGAAGCGGCTCGGGGCGGAGATGCTGCCGATGGCGG
CCACGGCCCGCATCCTGCGGGCCTTTGCCGGCGTGCGGCCGCTGTTCGGATCGGGCCCTGGCGGAAACACCCGGGAGATC
TCCCGGGGCTTCGCGGTGATCGACCACGAGGTCGAGCACGGCGTGCCCGGGCTCCTCTCGGTGGTCGGGGGCAAGCTCAC
CACCTACCGGATGATGGCCGAGAAGGCGGTGGACGTGGCAGCGGCCCGCCTGGGGGTGACGGTCCCGTGCCGCACGGCGG
AAGAGCCGATCCTGCCGCCGCCCGACCCGGACGCCGTCCGGCGGCTGGTCCACCTGGTGGGCCGGGACCTGGCGCAGGCC
GTGGCCGACCGGCACCCGGCGACGCTGCCGCAGATCGCCGAGGCCATCGCCCGGCCAGGCGGCCGGCAGGTGGTGTGCGA
GTGCGAGCAGGTGACCGCCGGCGAGCTGGTGGGCACCGCCCGGGAGCTGGGCGCACCGTCCCTGGGCGACCTCCGGCGCC
GGACCCGGCTGGGCATGGGCACCTGCCAGGGCGGCTTCTGCGGCTACCGCGCCGCCCTCCTGCTGGCACGGGAGGGGATC
GTGGCGCCGGAGCAGGTTCCTGCGCTGCTGGCCCGGTTCCAGGCGGAGCGGTGGCGCGGGGTCCGGGGCGGCCTGGGCGG
GCTGGAGCTCCGGGCGGCCGAGCTCAACTACGCGCTGGCCCGGGCCCAGCTGGCCATGGAGCCCGCTGCCGGCACGGCGG
ACGCAGTGGCGCAGATGGGGGGTGCGGGCCATGACTGA

Upstream 100 bases:

>100_bases
GGCCGGAACGAGGGCGCTGAGACGTGGAGAGACGCCCCGCCGGGGCACGCCGCACAGGCGTGTCCCCGGCGGGGCTTTGC
GCGAAAGGGGGAGCGGAACC

Downstream 100 bases:

>100_bases
AGTCATCATGGGGACGCCCCGTTTCCGCGGCCGGGTGCGCCGGCCGCAGGTGCTGGTGATCGGCGGCGGGCTGGCGGGCA
TGGCCGCCGCCCTGGCCGCG

Product: anaerobic sn-glycerol-3-phosphate dehydrogenase subunit A

Products: NA

Alternate protein names: G-3-P dehydrogenase [H]

Number of amino acids: Translated: 545; Mature: 545

Protein sequence:

>545_residues
MLQAIVIGGGATGAGILRDLALRSVRAALVEQGDLVHGTSSRYHGLLHSGGRYAVKDPESARECAVENQIVRRIAPFAVE
PCGGLFVRLEQDDPAYARRWVAACREAGIPVEEVDPDRLRREEPLLAGSVCEAWAVPDAAVDGWRLVRGNVAAAEARGAR
VFTYRRVVGLLMDGRRVAGVRLLNLATGEEERLEAELVINAAGAWAGQIAAMAGAPLDVVADRGVLLVYHGRLTSRVVNR
LRKPGNGDIFVPAGSVTLLGTTATPVPDPDDISVPPEEVEELKRLGAEMLPMAATARILRAFAGVRPLFGSGPGGNTREI
SRGFAVIDHEVEHGVPGLLSVVGGKLTTYRMMAEKAVDVAAARLGVTVPCRTAEEPILPPPDPDAVRRLVHLVGRDLAQA
VADRHPATLPQIAEAIARPGGRQVVCECEQVTAGELVGTARELGAPSLGDLRRRTRLGMGTCQGGFCGYRAALLLAREGI
VAPEQVPALLARFQAERWRGVRGGLGGLELRAAELNYALARAQLAMEPAAGTADAVAQMGGAGHD

Sequences:

>Translated_545_residues
MLQAIVIGGGATGAGILRDLALRSVRAALVEQGDLVHGTSSRYHGLLHSGGRYAVKDPESARECAVENQIVRRIAPFAVE
PCGGLFVRLEQDDPAYARRWVAACREAGIPVEEVDPDRLRREEPLLAGSVCEAWAVPDAAVDGWRLVRGNVAAAEARGAR
VFTYRRVVGLLMDGRRVAGVRLLNLATGEEERLEAELVINAAGAWAGQIAAMAGAPLDVVADRGVLLVYHGRLTSRVVNR
LRKPGNGDIFVPAGSVTLLGTTATPVPDPDDISVPPEEVEELKRLGAEMLPMAATARILRAFAGVRPLFGSGPGGNTREI
SRGFAVIDHEVEHGVPGLLSVVGGKLTTYRMMAEKAVDVAAARLGVTVPCRTAEEPILPPPDPDAVRRLVHLVGRDLAQA
VADRHPATLPQIAEAIARPGGRQVVCECEQVTAGELVGTARELGAPSLGDLRRRTRLGMGTCQGGFCGYRAALLLAREGI
VAPEQVPALLARFQAERWRGVRGGLGGLELRAAELNYALARAQLAMEPAAGTADAVAQMGGAGHD
>Mature_545_residues
MLQAIVIGGGATGAGILRDLALRSVRAALVEQGDLVHGTSSRYHGLLHSGGRYAVKDPESARECAVENQIVRRIAPFAVE
PCGGLFVRLEQDDPAYARRWVAACREAGIPVEEVDPDRLRREEPLLAGSVCEAWAVPDAAVDGWRLVRGNVAAAEARGAR
VFTYRRVVGLLMDGRRVAGVRLLNLATGEEERLEAELVINAAGAWAGQIAAMAGAPLDVVADRGVLLVYHGRLTSRVVNR
LRKPGNGDIFVPAGSVTLLGTTATPVPDPDDISVPPEEVEELKRLGAEMLPMAATARILRAFAGVRPLFGSGPGGNTREI
SRGFAVIDHEVEHGVPGLLSVVGGKLTTYRMMAEKAVDVAAARLGVTVPCRTAEEPILPPPDPDAVRRLVHLVGRDLAQA
VADRHPATLPQIAEAIARPGGRQVVCECEQVTAGELVGTARELGAPSLGDLRRRTRLGMGTCQGGFCGYRAALLLAREGI
VAPEQVPALLARFQAERWRGVRGGLGGLELRAAELNYALARAQLAMEPAAGTADAVAQMGGAGHD

Specific function: Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor [H]

COG id: COG0578

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=Loosely bound to the cytoplasmic membrane often occurring in vesicles associated with fumarate reductase (By similarity) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI285002233, Length=514, Percent_Identity=27.431906614786, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI285002231, Length=514, Percent_Identity=27.431906614786, Blast_Score=115, Evalue=1e-25,
Organism=Escherichia coli, GI1788574, Length=506, Percent_Identity=43.4782608695652, Blast_Score=376, Evalue=1e-105,
Organism=Escherichia coli, GI2367226, Length=368, Percent_Identity=24.4565217391304, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17509253, Length=378, Percent_Identity=25.3968253968254, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI161077125, Length=391, Percent_Identity=28.3887468030691, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24653942, Length=391, Percent_Identity=28.3887468030691, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24653944, Length=391, Percent_Identity=28.3887468030691, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI20130025, Length=391, Percent_Identity=28.3887468030691, Blast_Score=89, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007419
- InterPro:   IPR006076
- InterPro:   IPR017752
- InterPro:   IPR000447 [H]

Pfam domain/function: PF01266 DAO; PF04324 Fer2_BFD [H]

EC number: =1.1.5.3 [H]

Molecular weight: Translated: 57552; Mature: 57552

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS00978 FAD_G3PDH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQAIVIGGGATGAGILRDLALRSVRAALVEQGDLVHGTSSRYHGLLHSGGRYAVKDPES
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHCCCEEEECCCHH
ARECAVENQIVRRIAPFAVEPCGGLFVRLEQDDPAYARRWVAACREAGIPVEEVDPDRLR
HHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCHHCCCHHHHH
REEPLLAGSVCEAWAVPDAAVDGWRLVRGNVAAAEARGARVFTYRRVVGLLMDGRRVAGV
HCCCCHHHHHHHHHCCCCCCCCCEEEEECCCHHHHCCCCCHHHHHHHHHHHHCCCEECCE
RLLNLATGEEERLEAELVINAAGAWAGQIAAMAGAPLDVVADRGVLLVYHGRLTSRVVNR
EEEEECCCCHHHEEEEEEEEECCCHHHHHHHHCCCCHHHCCCCCEEEEECCHHHHHHHHH
LRKPGNGDIFVPAGSVTLLGTTATPVPDPDDISVPPEEVEELKRLGAEMLPMAATARILR
HCCCCCCCEEEECCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AFAGVRPLFGSGPGGNTREISRGFAVIDHEVEHGVPGLLSVVGGKLTTYRMMAEKAVDVA
HHHCCCCCCCCCCCCCHHHHHCCHHEEECHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHH
AARLGVTVPCRTAEEPILPPPDPDAVRRLVHLVGRDLAQAVADRHPATLPQIAEAIARPG
HHHHCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
GRQVVCECEQVTAGELVGTARELGAPSLGDLRRRTRLGMGTCQGGFCGYRAALLLAREGI
CCEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCC
VAPEQVPALLARFQAERWRGVRGGLGGLELRAAELNYALARAQLAMEPAAGTADAVAQMG
CCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHCC
GAGHD
CCCCC
>Mature Secondary Structure
MLQAIVIGGGATGAGILRDLALRSVRAALVEQGDLVHGTSSRYHGLLHSGGRYAVKDPES
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHCCCEEEECCCHH
ARECAVENQIVRRIAPFAVEPCGGLFVRLEQDDPAYARRWVAACREAGIPVEEVDPDRLR
HHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCHHCCCHHHHH
REEPLLAGSVCEAWAVPDAAVDGWRLVRGNVAAAEARGARVFTYRRVVGLLMDGRRVAGV
HCCCCHHHHHHHHHCCCCCCCCCEEEEECCCHHHHCCCCCHHHHHHHHHHHHCCCEECCE
RLLNLATGEEERLEAELVINAAGAWAGQIAAMAGAPLDVVADRGVLLVYHGRLTSRVVNR
EEEEECCCCHHHEEEEEEEEECCCHHHHHHHHCCCCHHHCCCCCEEEEECCHHHHHHHHH
LRKPGNGDIFVPAGSVTLLGTTATPVPDPDDISVPPEEVEELKRLGAEMLPMAATARILR
HCCCCCCCEEEECCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AFAGVRPLFGSGPGGNTREISRGFAVIDHEVEHGVPGLLSVVGGKLTTYRMMAEKAVDVA
HHHCCCCCCCCCCCCCHHHHHCCHHEEECHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHH
AARLGVTVPCRTAEEPILPPPDPDAVRRLVHLVGRDLAQAVADRHPATLPQIAEAIARPG
HHHHCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
GRQVVCECEQVTAGELVGTARELGAPSLGDLRRRTRLGMGTCQGGFCGYRAALLLAREGI
CCEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCC
VAPEQVPALLARFQAERWRGVRGGLGGLELRAAELNYALARAQLAMEPAAGTADAVAQMG
CCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHCC
GAGHD
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]