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The map label for this gene is pepB [H]

Identifier: 51893125

GI number: 51893125

Start: 2126224

End: 2128023

Strand: Reverse

Name: pepB [H]

Synonym: STH1987

Alternate gene names: 51893125

Gene position: 2128023-2126224 (Counterclockwise)

Preceding gene: 51893129

Following gene: 51893124

Centisome position: 59.67

GC content: 69.72

Gene sequence:

>1800_bases
ATGGCGCAGCAGCCCCTGAACCAGACGTGGGACCTGGACGTTTTCTTCCCCGGGGGGAGCTCGTCCCCCGAGTTCAAGCG
GTTCCTGGATGCGCTGACCGAGGACGTGACAGCCTTCGGGCAGCGGCTGGAGGCGGCCGGCGTGCCCGGGACGGCGGCCG
ACCTGGACGGCTGGATGCCGCTCCTGGATACCTTCCAGGACCTGACTCAGCGGATCCGGCAGGCCGGCGCGTTCGTCTCC
TGCCTCACGGCCCAGGACATGGCCGATGAGGGGGCCAAGCTGCTCCAGGGCCGGGTGGCGCAGATCCGGGCGGCGCTCGG
GAATGCCACGACCCTGCTGGATCACCAGCTGAGCGCGATGCCCGAGGAGGTCTTCGCGGCGCTGGAGGCCCGCCCCGAAT
GCGAGGCCATCGCGTACCCGCTGCGGGAGCGCCGCCTGCGGGCCGCCATGCGGATGGATCCGCAGCGGGAGTCGCTGGCC
GGCGACCTCGCGGTGGACGGGTATCACGCCTGGGGGCAGCTGTACGGCGAGCTGGTCGCCCGGGTGCAGATCCCCTGGGA
GGCGGGGGGCCGAACGGTGCACCTCTCCGCCGGCCAGGCGGCGAACAAGCTCCTGGACCCCGACCGGGCGGTCCGGGTGC
GGCTGTGGGAGCGCTGGGAGAAGGCCTGGGCCGAGCAGGCGGACCTCATCGGTGCGGCCCTGAACCACCTGGCGGGCTTC
CGGATCCAGCTGTACAAGCACCGGGGGTGGGACTCGATCCTCTCCGAGCCGCTGGAGAACAACCGCATGAAGGCCGAGAC
GCTGGAGGTCATGTGGGACGTCATCGACCGGAACAAGGGGATCTTCGTCGAGTTCCTCAACCGCAAGGCCCGGCTGCTGG
GGCTCGACAAGCTGGCCTGGCACGACGTGGACGCCCCCCTGGGCGGCGCCGACACCAAGATGACCTACGATGAGGCTGCA
GAGTTCGTGGTCGAGCACTTCGGCCGCTTCTCGCCCGACATGGCGCGCTTTGCCCGGAAGGCGTTCGAGGAGCGGTGGAT
CGAGGCCGAGGACCGGCCCGGCAAGCGGCCCGGCGGCTTCTGCACCTCGTTCCCGCTGACCCGCCAGTCCCGCATCTTCA
TGACCTTTGGCGGCAACCTGGACAACGTCTCCACCCTGGCGCACGAGCTGGGCCACGCCTACCACCAGTCGGTGATGAAC
GACCTGCCGCAGCTGGCGCAGGGCTACGCCATGAACGTCGCCGAGACGGCGTCCACCTTTGCCGAGCTGCTGGTGAGCGA
TGCGGCCCTGAAGGCGGCCGGCAGCGATGAGGAGCGGTTGGTGCTGCTGGCCGGCAAGGCCGAGCGGGCCGTGGCCTTCT
TCATGAACATCCACGCCCGGTTCCTGTTCGAGACCCGGTTCTACGCGGAGCGGGCGAAGGGGCTCGTGCCCGTGGCCCGG
CTCAACGAGCTCATGGTGCAGGCGCAGAAGGAGGCTTACCGGGACGCGCTCTCGGAGTATCACCCGCACTTCTGGGCGTC
GAAGCTGCACTTCTACTCCACGGGGCAGCCGTTCTACAACTTCCCCTACACCTTCGGCTTCCTGTTCAGCTCCGGCGTCT
ACGCCCGTGCGCTGGAGGAGGGCCCGGCCTTCGCGCAGCGGTACGTGGACCTGCTCCGCGACACCGGCCGGATGCGGGTC
GAGGACCTGGCGGCGAAGCACCTGGGCGTCGACCTGACCAAGCCCGACTTCTGGCAGGCCGCGGTGGACGTCTCGGTGGC
CGACGTCCGGCAGTTCCTGGCCCTCACGGAGAACCGCTGA

Upstream 100 bases:

>100_bases
ATTTACCGACCAATTTAGCCGCAGGGAATCGACGTGTCAAGTCCGAATCGCTATGAATCAGACCCTGTTCCATGCCATGC
CACAAAAGGAGGACCGATCC

Downstream 100 bases:

>100_bases
CTCTCCACGCGCCCGCCTTTGGCACGTTTGGACTATCCCGATTAGGGCGTATGCCCCTACGGCGGCGGACCGGGCCGTCG
TAGAATCAATGGCAGGGAAA

Product: oligoendopeptidase F

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 599; Mature: 598

Protein sequence:

>599_residues
MAQQPLNQTWDLDVFFPGGSSSPEFKRFLDALTEDVTAFGQRLEAAGVPGTAADLDGWMPLLDTFQDLTQRIRQAGAFVS
CLTAQDMADEGAKLLQGRVAQIRAALGNATTLLDHQLSAMPEEVFAALEARPECEAIAYPLRERRLRAAMRMDPQRESLA
GDLAVDGYHAWGQLYGELVARVQIPWEAGGRTVHLSAGQAANKLLDPDRAVRVRLWERWEKAWAEQADLIGAALNHLAGF
RIQLYKHRGWDSILSEPLENNRMKAETLEVMWDVIDRNKGIFVEFLNRKARLLGLDKLAWHDVDAPLGGADTKMTYDEAA
EFVVEHFGRFSPDMARFARKAFEERWIEAEDRPGKRPGGFCTSFPLTRQSRIFMTFGGNLDNVSTLAHELGHAYHQSVMN
DLPQLAQGYAMNVAETASTFAELLVSDAALKAAGSDEERLVLLAGKAERAVAFFMNIHARFLFETRFYAERAKGLVPVAR
LNELMVQAQKEAYRDALSEYHPHFWASKLHFYSTGQPFYNFPYTFGFLFSSGVYARALEEGPAFAQRYVDLLRDTGRMRV
EDLAAKHLGVDLTKPDFWQAAVDVSVADVRQFLALTENR

Sequences:

>Translated_599_residues
MAQQPLNQTWDLDVFFPGGSSSPEFKRFLDALTEDVTAFGQRLEAAGVPGTAADLDGWMPLLDTFQDLTQRIRQAGAFVS
CLTAQDMADEGAKLLQGRVAQIRAALGNATTLLDHQLSAMPEEVFAALEARPECEAIAYPLRERRLRAAMRMDPQRESLA
GDLAVDGYHAWGQLYGELVARVQIPWEAGGRTVHLSAGQAANKLLDPDRAVRVRLWERWEKAWAEQADLIGAALNHLAGF
RIQLYKHRGWDSILSEPLENNRMKAETLEVMWDVIDRNKGIFVEFLNRKARLLGLDKLAWHDVDAPLGGADTKMTYDEAA
EFVVEHFGRFSPDMARFARKAFEERWIEAEDRPGKRPGGFCTSFPLTRQSRIFMTFGGNLDNVSTLAHELGHAYHQSVMN
DLPQLAQGYAMNVAETASTFAELLVSDAALKAAGSDEERLVLLAGKAERAVAFFMNIHARFLFETRFYAERAKGLVPVAR
LNELMVQAQKEAYRDALSEYHPHFWASKLHFYSTGQPFYNFPYTFGFLFSSGVYARALEEGPAFAQRYVDLLRDTGRMRV
EDLAAKHLGVDLTKPDFWQAAVDVSVADVRQFLALTENR
>Mature_598_residues
AQQPLNQTWDLDVFFPGGSSSPEFKRFLDALTEDVTAFGQRLEAAGVPGTAADLDGWMPLLDTFQDLTQRIRQAGAFVSC
LTAQDMADEGAKLLQGRVAQIRAALGNATTLLDHQLSAMPEEVFAALEARPECEAIAYPLRERRLRAAMRMDPQRESLAG
DLAVDGYHAWGQLYGELVARVQIPWEAGGRTVHLSAGQAANKLLDPDRAVRVRLWERWEKAWAEQADLIGAALNHLAGFR
IQLYKHRGWDSILSEPLENNRMKAETLEVMWDVIDRNKGIFVEFLNRKARLLGLDKLAWHDVDAPLGGADTKMTYDEAAE
FVVEHFGRFSPDMARFARKAFEERWIEAEDRPGKRPGGFCTSFPLTRQSRIFMTFGGNLDNVSTLAHELGHAYHQSVMND
LPQLAQGYAMNVAETASTFAELLVSDAALKAAGSDEERLVLLAGKAERAVAFFMNIHARFLFETRFYAERAKGLVPVARL
NELMVQAQKEAYRDALSEYHPHFWASKLHFYSTGQPFYNFPYTFGFLFSSGVYARALEEGPAFAQRYVDLLRDTGRMRVE
DLAAKHLGVDLTKPDFWQAAVDVSVADVRQFLALTENR

Specific function: Has oligopeptidase activity and degrades a variety of small bioactive peptides, including bradykinin, neurotensin, and peptide fragments of substance P and adrenocorticotropin. Also hydrolyzes the synthetic collagen-like substrate N-(3-[2- furyl]acryloyl)

COG id: COG1164

COG function: function code E; Oligoendopeptidase F

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3B family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567
- InterPro:   IPR004438
- InterPro:   IPR013647 [H]

Pfam domain/function: PF01432 Peptidase_M3; PF08439 Peptidase_M3_N [H]

EC number: NA

Molecular weight: Translated: 67262; Mature: 67131

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQQPLNQTWDLDVFFPGGSSSPEFKRFLDALTEDVTAFGQRLEAAGVPGTAADLDGWMP
CCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCHH
LLDTFQDLTQRIRQAGAFVSCLTAQDMADEGAKLLQGRVAQIRAALGNATTLLDHQLSAM
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHC
PEEVFAALEARPECEAIAYPLRERRLRAAMRMDPQRESLAGDLAVDGYHAWGQLYGELVA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEECCHHHHHHHHHHHHH
RVQIPWEAGGRTVHLSAGQAANKLLDPDRAVRVRLWERWEKAWAEQADLIGAALNHLAGF
HEECCCCCCCCEEEEECCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RIQLYKHRGWDSILSEPLENNRMKAETLEVMWDVIDRNKGIFVEFLNRKARLLGLDKLAW
EEEEEECCCHHHHHHCHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHCHHHHHCCHHHHH
HDVDAPLGGADTKMTYDEAAEFVVEHFGRFSPDMARFARKAFEERWIEAEDRPGKRPGGF
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
CTSFPLTRQSRIFMTFGGNLDNVSTLAHELGHAYHQSVMNDLPQLAQGYAMNVAETASTF
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AELLVSDAALKAAGSDEERLVLLAGKAERAVAFFMNIHARFLFETRFYAERAKGLVPVAR
HHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LNELMVQAQKEAYRDALSEYHPHFWASKLHFYSTGQPFYNFPYTFGFLFSSGVYARALEE
HHHHHHHHHHHHHHHHHHHHCCCHHHHHEEEEECCCCCCCCCHHHHHHHCCCHHHHHHHC
GPAFAQRYVDLLRDTGRMRVEDLAAKHLGVDLTKPDFWQAAVDVSVADVRQFLALTENR
CHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
AQQPLNQTWDLDVFFPGGSSSPEFKRFLDALTEDVTAFGQRLEAAGVPGTAADLDGWMP
CCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCHH
LLDTFQDLTQRIRQAGAFVSCLTAQDMADEGAKLLQGRVAQIRAALGNATTLLDHQLSAM
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHC
PEEVFAALEARPECEAIAYPLRERRLRAAMRMDPQRESLAGDLAVDGYHAWGQLYGELVA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEECCHHHHHHHHHHHHH
RVQIPWEAGGRTVHLSAGQAANKLLDPDRAVRVRLWERWEKAWAEQADLIGAALNHLAGF
HEECCCCCCCCEEEEECCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RIQLYKHRGWDSILSEPLENNRMKAETLEVMWDVIDRNKGIFVEFLNRKARLLGLDKLAW
EEEEEECCCHHHHHHCHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHCHHHHHCCHHHHH
HDVDAPLGGADTKMTYDEAAEFVVEHFGRFSPDMARFARKAFEERWIEAEDRPGKRPGGF
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
CTSFPLTRQSRIFMTFGGNLDNVSTLAHELGHAYHQSVMNDLPQLAQGYAMNVAETASTF
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AELLVSDAALKAAGSDEERLVLLAGKAERAVAFFMNIHARFLFETRFYAERAKGLVPVAR
HHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LNELMVQAQKEAYRDALSEYHPHFWASKLHFYSTGQPFYNFPYTFGFLFSSGVYARALEE
HHHHHHHHHHHHHHHHHHHHCCCHHHHHEEEEECCCCCCCCCHHHHHHHCCCHHHHHHHC
GPAFAQRYVDLLRDTGRMRVEDLAAKHLGVDLTKPDFWQAAVDVSVADVRQFLALTENR
CHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757883; 12354221 [H]