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The map label for this gene is gcvPB [H]

Identifier: 51893057

GI number: 51893057

Start: 2062270

End: 2063730

Strand: Reverse

Name: gcvPB [H]

Synonym: STH1919

Alternate gene names: 51893057

Gene position: 2063730-2062270 (Counterclockwise)

Preceding gene: 51893058

Following gene: 51893056

Centisome position: 57.87

GC content: 69.4

Gene sequence:

>1461_bases
ATGGCGCTCGTACCGCTGCTCTTCGAGAAGTCGACCCCCGGCAAGCGGGCGGTCACCTTCCCCGCGCCGGACGTGCCGAC
GGTGGAGCTGAGCGAGGCGATCCCGGCCGACCTCATCCGCCAGACGCCCGCGGCGCTGCCGGAGCTCTCCGAGGTCGAGG
TCGTCCGCCACTTCACGCAGCTGAGCAGGCTGAACCACGGCGTGGACGTGGACTTCTACCCGCTGGGCTCCTGCACGATG
AAGTACAACCCCAAGGTCAACGAGGAGGCGGCCCGCATCCCGGGGTTCGCCCTGACCCACCCGCTGCAGCCGGAGGAGAC
CGTGCAGGGCAACCTGCAGCTGCTGCACACCCTGGAGGGCTGGCTCTGCGAGGTCACCGGCATGGACCGGATGACCTTCC
AGCCGGCCGCGGGCGCGCACGGCGAGCTGACGGGCATCCTGCTGATCCGGGCGTACCATGAGTCCCGGGGGGACACCGAG
CGGAACGAGGTCATCGTGCCCGACTCGGCCCACGGTACCAACCCGGCCACCGCCGCCATGGCGGGTTACCGGGTGGTTCC
GGTGAAGTCCCGGCCCGACGGCTCCATCGACGTGGACGCCCTGCGGCAGATCGTCGGCCCCAAGACCGCCGCCCTGATGA
TGACCAACCCGTCCACCCTCGGGCTCTTCGATCCCCACGTCCGGGAGATCACGGAGATCGTCCACCAGGCGGGCGGGCTC
TGCTACTACGACGGCGCCAACCTCAACGCCATCATGGGCTACGCCCGCCCGGGCGACATGGGGTTTGACGTCGTCCACCT
GAACCTGCACAAGACCTTCTCCACGCCCCACGGCGGCGGCGGGCCCGGCAGCGGCCCGGTGGGCGTCAAGTCCCACCTGG
TGCCGTTCCTGCCGGTGCCGGTGGTGGAGAAGCAGGGCGACCGGTACGCGCTGGACTGGGACCGGCCGCAGTCCATCGGG
AAGATCCACGGCTTCTGGGGCAACTTCGGCGTCATCGTGCGGGCCTACGCGTATGTCCTGGCCCACGGGCCGGCGCTGAA
GGAGGTCTCCGAGCACGCGGTGCTCAACGCCAACTACGTCCTGGCCCGCCTGAAGCCTTACTACGAGCCCTACGTCGACC
GGTACTGCATGCACGAGTGCGTGCTGTCGGCCCGCACCCTGAAGCAGGAGACCGGCGTCAGGACGCTGGACGTGGCCAAG
CGGCTGCTGGACGAGGGGGTCCATCCGCCCACGATCTACTTCCCGCTGATCGTGGAGGAGGCCTTGATGATCGAGCCGAC
GGAGACGGAGGACAAGGCCACGCTGGACCGGTTCATCGAGGCGATGATCCGTATCCACGACGAGGCCCGGTCCAACCCCG
AGTACGTCAAGTCTGCCCCCCACAAGACGCCCGTGGGGCGGCTGGACGAGGCGCTGGCGGCCAGGCGGCCGAACCTGCGC
TACCGGGCGAACCCGAGCTGA

Upstream 100 bases:

>100_bases
GCCGGCGGCCCGGCGGCCGCGCTGAGCTTCGCGGTCACCGAAAAGCGGACGCGGGCGGAGATCGACCGGCTCGTGGCCGC
GCTCGGGGAGGTGAAGTAGG

Downstream 100 bases:

>100_bases
CGCAAGCGGGTGGGGGTGCCGCAGGGCACGCCCCACCCGTTTTCACGACGAGAGGGATGACGGTGACCGATGGCGCTGAT
GGAGACGAACTGGCGGCTGC

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MALVPLLFEKSTPGKRAVTFPAPDVPTVELSEAIPADLIRQTPAALPELSEVEVVRHFTQLSRLNHGVDVDFYPLGSCTM
KYNPKVNEEAARIPGFALTHPLQPEETVQGNLQLLHTLEGWLCEVTGMDRMTFQPAAGAHGELTGILLIRAYHESRGDTE
RNEVIVPDSAHGTNPATAAMAGYRVVPVKSRPDGSIDVDALRQIVGPKTAALMMTNPSTLGLFDPHVREITEIVHQAGGL
CYYDGANLNAIMGYARPGDMGFDVVHLNLHKTFSTPHGGGGPGSGPVGVKSHLVPFLPVPVVEKQGDRYALDWDRPQSIG
KIHGFWGNFGVIVRAYAYVLAHGPALKEVSEHAVLNANYVLARLKPYYEPYVDRYCMHECVLSARTLKQETGVRTLDVAK
RLLDEGVHPPTIYFPLIVEEALMIEPTETEDKATLDRFIEAMIRIHDEARSNPEYVKSAPHKTPVGRLDEALAARRPNLR
YRANPS

Sequences:

>Translated_486_residues
MALVPLLFEKSTPGKRAVTFPAPDVPTVELSEAIPADLIRQTPAALPELSEVEVVRHFTQLSRLNHGVDVDFYPLGSCTM
KYNPKVNEEAARIPGFALTHPLQPEETVQGNLQLLHTLEGWLCEVTGMDRMTFQPAAGAHGELTGILLIRAYHESRGDTE
RNEVIVPDSAHGTNPATAAMAGYRVVPVKSRPDGSIDVDALRQIVGPKTAALMMTNPSTLGLFDPHVREITEIVHQAGGL
CYYDGANLNAIMGYARPGDMGFDVVHLNLHKTFSTPHGGGGPGSGPVGVKSHLVPFLPVPVVEKQGDRYALDWDRPQSIG
KIHGFWGNFGVIVRAYAYVLAHGPALKEVSEHAVLNANYVLARLKPYYEPYVDRYCMHECVLSARTLKQETGVRTLDVAK
RLLDEGVHPPTIYFPLIVEEALMIEPTETEDKATLDRFIEAMIRIHDEARSNPEYVKSAPHKTPVGRLDEALAARRPNLR
YRANPS
>Mature_485_residues
ALVPLLFEKSTPGKRAVTFPAPDVPTVELSEAIPADLIRQTPAALPELSEVEVVRHFTQLSRLNHGVDVDFYPLGSCTMK
YNPKVNEEAARIPGFALTHPLQPEETVQGNLQLLHTLEGWLCEVTGMDRMTFQPAAGAHGELTGILLIRAYHESRGDTER
NEVIVPDSAHGTNPATAAMAGYRVVPVKSRPDGSIDVDALRQIVGPKTAALMMTNPSTLGLFDPHVREITEIVHQAGGLC
YYDGANLNAIMGYARPGDMGFDVVHLNLHKTFSTPHGGGGPGSGPVGVKSHLVPFLPVPVVEKQGDRYALDWDRPQSIGK
IHGFWGNFGVIVRAYAYVLAHGPALKEVSEHAVLNANYVLARLKPYYEPYVDRYCMHECVLSARTLKQETGVRTLDVAKR
LLDEGVHPPTIYFPLIVEEALMIEPTETEDKATLDRFIEAMIRIHDEARSNPEYVKSAPHKTPVGRLDEALAARRPNLRY
RANPS

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=456, Percent_Identity=41.4473684210526, Blast_Score=297, Evalue=1e-80,
Organism=Escherichia coli, GI1789269, Length=409, Percent_Identity=44.4987775061125, Blast_Score=300, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI17535605, Length=448, Percent_Identity=41.2946428571429, Blast_Score=287, Evalue=7e-78,
Organism=Caenorhabditis elegans, GI32564013, Length=390, Percent_Identity=43.0769230769231, Blast_Score=264, Evalue=7e-71,
Organism=Saccharomyces cerevisiae, GI6323843, Length=432, Percent_Identity=43.9814814814815, Blast_Score=314, Evalue=2e-86,
Organism=Drosophila melanogaster, GI24645648, Length=409, Percent_Identity=43.7652811735941, Blast_Score=293, Evalue=2e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 53439; Mature: 53308

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALVPLLFEKSTPGKRAVTFPAPDVPTVELSEAIPADLIRQTPAALPELSEVEVVRHFTQ
CCCCCEEECCCCCCCEEEECCCCCCCCEEHHHCCCHHHHHHCHHCCCCHHHHHHHHHHHH
LSRLNHGVDVDFYPLGSCTMKYNPKVNEEAARIPGFALTHPLQPEETVQGNLQLLHTLEG
HHHHCCCCCEEEEECCCEEEEECCCCCCHHHHCCCCEECCCCCCHHHHHCCHHHHHHHHC
WLCEVTGMDRMTFQPAAGAHGELTGILLIRAYHESRGDTERNEVIVPDSAHGTNPATAAM
CEEEECCCCCEEECCCCCCCCCEEEEEEEEEEHHCCCCCCCCEEECCCCCCCCCCHHHHH
AGYRVVPVKSRPDGSIDVDALRQIVGPKTAALMMTNPSTLGLFDPHVREITEIVHQAGGL
CCEEEEEECCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCE
CYYDGANLNAIMGYARPGDMGFDVVHLNLHKTFSTPHGGGGPGSGPVGVKSHLVPFLPVP
EEECCCCCEEEEEECCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCHHHCCCCCCCCC
VVEKQGDRYALDWDRPQSIGKIHGFWGNFGVIVRAYAYVLAHGPALKEVSEHAVLNANYV
CCCCCCCEEEECCCCCCCCCHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHEECCCCC
LARLKPYYEPYVDRYCMHECVLSARTLKQETGVRTLDVAKRLLDEGVHPPTIYFPLIVEE
EEHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEHHHHHH
ALMIEPTETEDKATLDRFIEAMIRIHDEARSNPEYVKSAPHKTPVGRLDEALAARRPNLR
HHEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHHCCCCCC
YRANPS
EECCCC
>Mature Secondary Structure 
ALVPLLFEKSTPGKRAVTFPAPDVPTVELSEAIPADLIRQTPAALPELSEVEVVRHFTQ
CCCCEEECCCCCCCEEEECCCCCCCCEEHHHCCCHHHHHHCHHCCCCHHHHHHHHHHHH
LSRLNHGVDVDFYPLGSCTMKYNPKVNEEAARIPGFALTHPLQPEETVQGNLQLLHTLEG
HHHHCCCCCEEEEECCCEEEEECCCCCCHHHHCCCCEECCCCCCHHHHHCCHHHHHHHHC
WLCEVTGMDRMTFQPAAGAHGELTGILLIRAYHESRGDTERNEVIVPDSAHGTNPATAAM
CEEEECCCCCEEECCCCCCCCCEEEEEEEEEEHHCCCCCCCCEEECCCCCCCCCCHHHHH
AGYRVVPVKSRPDGSIDVDALRQIVGPKTAALMMTNPSTLGLFDPHVREITEIVHQAGGL
CCEEEEEECCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCE
CYYDGANLNAIMGYARPGDMGFDVVHLNLHKTFSTPHGGGGPGSGPVGVKSHLVPFLPVP
EEECCCCCEEEEEECCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCHHHCCCCCCCCC
VVEKQGDRYALDWDRPQSIGKIHGFWGNFGVIVRAYAYVLAHGPALKEVSEHAVLNANYV
CCCCCCCEEEECCCCCCCCCHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHEECCCCC
LARLKPYYEPYVDRYCMHECVLSARTLKQETGVRTLDVAKRLLDEGVHPPTIYFPLIVEE
EEHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEHHHHHH
ALMIEPTETEDKATLDRFIEAMIRIHDEARSNPEYVKSAPHKTPVGRLDEALAARRPNLR
HHEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCHHHHHHHHHHCCCCCC
YRANPS
EECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA