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The map label for this gene is gcvPA [H]

Identifier: 51893058

GI number: 51893058

Start: 2063732

End: 2065108

Strand: Reverse

Name: gcvPA [H]

Synonym: STH1920

Alternate gene names: 51893058

Gene position: 2065108-2063732 (Counterclockwise)

Preceding gene: 51893059

Following gene: 51893057

Centisome position: 57.91

GC content: 70.15

Gene sequence:

>1377_bases
ATGCGATACGTCCCGATTACGCAGGCCGACAAGGCGGCCATGCTGCGGGAGATCGGCGTCAGTTCCACCGAGGAGCTCTT
TGCTGCCAACATCCCGGCGGAGGTACGCCTGAACCGGCCGCTCAACCTGCCCCCGGCGCTCACCGAGATGGAGCTGCTCG
CGCACCTCAGGGAGCTGGCTGCGCAGAACGCGCACACGGGGGAGTATGCCTGCTTCCTGGGCGGCGGCGCGTACGACCAC
TACGTGCCCGCCGCGGTGGACGCGGTGATTCGCCGGGGGGAGTTCCTCACCGCGTATACTCCGTATCAGCCTGAGATCTC
TCAGGGCGTACTGCAGGCCATCTACGAGTACCAGTCGCTGATGTGCGAGCTGACGGGCATGGACCTGTCCAACGCCTCCA
TGTACGACGGCGCCTCGGCCCTGGCCGAGGCCGCGGGCATGGTGGTGAACCAGACCGGCCGGTCCAAGCTCCTGGTCGCA
CGGTCCGTGAGCCCGCTGTACCGCCGGGTCGTGCAGACCTACATGCACGGCATCGGCGTCGAGCTCATCGAGGTGCCGCT
GGATGGCGTGACGCTGGACCTGAACCGGCTCGAGGCCCTGATGACCGAGGAGGTCGGCGGCCTCCTGCTCCAGACGCCCA
ACTACCTGGGCTACCTGGAGAAGGTGCGGGAGATCGAGGCGCTGGTGCACGCGAAGAACGGGCTCTTCGTCGTAGCCGTC
GACCCCATCTCCCTGGGCCTCCTGGAGGCCCCGGGCAGCTACGGCGCAGACATCGTCGTGGCGGAGGGCCAGGGGCTCGG
CGTGCCCCTCTCCTACGGCGGCCCGTACCTGGGCGTTCTGGCCACCCGCGACCGGTTCGCCCGCCGCATGCCCGGCCGCA
TCGCCGGCGCCACGGTGGACAACCGCGGCCAGCGGGGCTTCGTGCTGACCATGCAGGCCCGTGAGCAGCACATCCGGCGT
GAGAAGGCCACGTCCAACATCTGCACCAACCAGGCCCTGATCGCCCTCGCGGCCACCGTCTACCTGGCCCTGGTGGGCAA
GGAGGGCCTCCGGGAGGTCGCCAACCTCTCGCTGCAGAAGGCGCACTACGCGGCGCAACAGATCGCCAGGCTGCCCGGTT
GGCGGCTGGCCGGCGACGCGCCCTTCTTTAAGGAGTTCACCGTGCTGGCCCCCGCGGCCGCGGCGGAGGTCAGCCGTCGC
CTGGTGGATCGGAAGATCCTGGGCGGCCTGGACGTGGGCGCGGACTATCCGGAGCTGCTGGGCGGCGCGGCCGGTTCCGC
CGGCGGCCCGGCGGCCGCGCTGAGCTTCGCGGTCACCGAAAAGCGGACGCGGGCGGAGATCGACCGGCTCGTGGCCGCGC
TCGGGGAGGTGAAGTAG

Upstream 100 bases:

>100_bases
CGGCGAGGGCTGGATTCTGAAGCTGGAGCTCTCGAACCCGGCCGAACTGGACAACCTGCTGGATGCGGCGGCTTACGACG
CGTTTACCAAGGAGGGCTAA

Downstream 100 bases:

>100_bases
GATGGCGCTCGTACCGCTGCTCTTCGAGAAGTCGACCCCCGGCAAGCGGGCGGTCACCTTCCCCGCGCCGGACGTGCCGA
CGGTGGAGCTGAGCGAGGCG

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1 [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MRYVPITQADKAAMLREIGVSSTEELFAANIPAEVRLNRPLNLPPALTEMELLAHLRELAAQNAHTGEYACFLGGGAYDH
YVPAAVDAVIRRGEFLTAYTPYQPEISQGVLQAIYEYQSLMCELTGMDLSNASMYDGASALAEAAGMVVNQTGRSKLLVA
RSVSPLYRRVVQTYMHGIGVELIEVPLDGVTLDLNRLEALMTEEVGGLLLQTPNYLGYLEKVREIEALVHAKNGLFVVAV
DPISLGLLEAPGSYGADIVVAEGQGLGVPLSYGGPYLGVLATRDRFARRMPGRIAGATVDNRGQRGFVLTMQAREQHIRR
EKATSNICTNQALIALAATVYLALVGKEGLREVANLSLQKAHYAAQQIARLPGWRLAGDAPFFKEFTVLAPAAAAEVSRR
LVDRKILGGLDVGADYPELLGGAAGSAGGPAAALSFAVTEKRTRAEIDRLVAALGEVK

Sequences:

>Translated_458_residues
MRYVPITQADKAAMLREIGVSSTEELFAANIPAEVRLNRPLNLPPALTEMELLAHLRELAAQNAHTGEYACFLGGGAYDH
YVPAAVDAVIRRGEFLTAYTPYQPEISQGVLQAIYEYQSLMCELTGMDLSNASMYDGASALAEAAGMVVNQTGRSKLLVA
RSVSPLYRRVVQTYMHGIGVELIEVPLDGVTLDLNRLEALMTEEVGGLLLQTPNYLGYLEKVREIEALVHAKNGLFVVAV
DPISLGLLEAPGSYGADIVVAEGQGLGVPLSYGGPYLGVLATRDRFARRMPGRIAGATVDNRGQRGFVLTMQAREQHIRR
EKATSNICTNQALIALAATVYLALVGKEGLREVANLSLQKAHYAAQQIARLPGWRLAGDAPFFKEFTVLAPAAAAEVSRR
LVDRKILGGLDVGADYPELLGGAAGSAGGPAAALSFAVTEKRTRAEIDRLVAALGEVK
>Mature_458_residues
MRYVPITQADKAAMLREIGVSSTEELFAANIPAEVRLNRPLNLPPALTEMELLAHLRELAAQNAHTGEYACFLGGGAYDH
YVPAAVDAVIRRGEFLTAYTPYQPEISQGVLQAIYEYQSLMCELTGMDLSNASMYDGASALAEAAGMVVNQTGRSKLLVA
RSVSPLYRRVVQTYMHGIGVELIEVPLDGVTLDLNRLEALMTEEVGGLLLQTPNYLGYLEKVREIEALVHAKNGLFVVAV
DPISLGLLEAPGSYGADIVVAEGQGLGVPLSYGGPYLGVLATRDRFARRMPGRIAGATVDNRGQRGFVLTMQAREQHIRR
EKATSNICTNQALIALAATVYLALVGKEGLREVANLSLQKAHYAAQQIARLPGWRLAGDAPFFKEFTVLAPAAAAEVSRR
LVDRKILGGLDVGADYPELLGGAAGSAGGPAAALSFAVTEKRTRAEIDRLVAALGEVK

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=409, Percent_Identity=35.2078239608802, Blast_Score=243, Evalue=2e-64,
Organism=Escherichia coli, GI1789269, Length=362, Percent_Identity=35.9116022099448, Blast_Score=194, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17535605, Length=360, Percent_Identity=35.2777777777778, Blast_Score=218, Evalue=5e-57,
Organism=Saccharomyces cerevisiae, GI6323843, Length=362, Percent_Identity=33.9779005524862, Blast_Score=220, Evalue=3e-58,
Organism=Drosophila melanogaster, GI24645648, Length=355, Percent_Identity=38.3098591549296, Blast_Score=245, Evalue=5e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 49073; Mature: 49073

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00285 POTATO_INHIBITOR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYVPITQADKAAMLREIGVSSTEELFAANIPAEVRLNRPLNLPPALTEMELLAHLRELA
CCCCCCCCCHHHHHHHHHCCCCHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHH
AQNAHTGEYACFLGGGAYDHYVPAAVDAVIRRGEFLTAYTPYQPEISQGVLQAIYEYQSL
HCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHH
MCELTGMDLSNASMYDGASALAEAAGMVVNQTGRSKLLVARSVSPLYRRVVQTYMHGIGV
HHHHCCCCCCCCCCCCCHHHHHHHHHHHEECCCCCEEEEECCCCHHHHHHHHHHHHHCCC
ELIEVPLDGVTLDLNRLEALMTEEVGGLLLQTPNYLGYLEKVREIEALVHAKNGLFVVAV
EEEEECCCCEEECHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHCCCCEEEEEE
DPISLGLLEAPGSYGADIVVAEGQGLGVPLSYGGPYLGVLATRDRFARRMPGRIAGATVD
CCCEEEEEECCCCCCCEEEEECCCCCCEEECCCCCEEEEEEHHHHHHHHCCCCEECCCCC
NRGQRGFVLTMQAREQHIRREKATSNICTNQALIALAATVYLALVGKEGLREVANLSLQK
CCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
AHYAAQQIARLPGWRLAGDAPFFKEFTVLAPAAAAEVSRRLVDRKILGGLDVGADYPELL
HHHHHHHHHHCCCCEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
GGAAGSAGGPAAALSFAVTEKRTRAEIDRLVAALGEVK
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRYVPITQADKAAMLREIGVSSTEELFAANIPAEVRLNRPLNLPPALTEMELLAHLRELA
CCCCCCCCCHHHHHHHHHCCCCHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHH
AQNAHTGEYACFLGGGAYDHYVPAAVDAVIRRGEFLTAYTPYQPEISQGVLQAIYEYQSL
HCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHH
MCELTGMDLSNASMYDGASALAEAAGMVVNQTGRSKLLVARSVSPLYRRVVQTYMHGIGV
HHHHCCCCCCCCCCCCCHHHHHHHHHHHEECCCCCEEEEECCCCHHHHHHHHHHHHHCCC
ELIEVPLDGVTLDLNRLEALMTEEVGGLLLQTPNYLGYLEKVREIEALVHAKNGLFVVAV
EEEEECCCCEEECHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHCCCCEEEEEE
DPISLGLLEAPGSYGADIVVAEGQGLGVPLSYGGPYLGVLATRDRFARRMPGRIAGATVD
CCCEEEEEECCCCCCCEEEEECCCCCCEEECCCCCEEEEEEHHHHHHHHCCCCEECCCCC
NRGQRGFVLTMQAREQHIRREKATSNICTNQALIALAATVYLALVGKEGLREVANLSLQK
CCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
AHYAAQQIARLPGWRLAGDAPFFKEFTVLAPAAAAEVSRRLVDRKILGGLDVGADYPELL
HHHHHHHHHHCCCCEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
GGAAGSAGGPAAALSFAVTEKRTRAEIDRLVAALGEVK
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA