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The map label for this gene is lysA [H]

Identifier: 51892948

GI number: 51892948

Start: 1954557

End: 1955888

Strand: Reverse

Name: lysA [H]

Synonym: STH1810

Alternate gene names: 51892948

Gene position: 1955888-1954557 (Counterclockwise)

Preceding gene: 51892949

Following gene: 51892947

Centisome position: 54.85

GC content: 71.17

Gene sequence:

>1332_bases
ATGCACTTCTACGGCACCGCATCCCGCAACGGGCAGGGGCACCTGACCATCGGCGGCGTCGACGTGGTGGACCTGGCGAG
GGAGTTCGGCACGCCGCTGTACGTCATGGATGAGGAGCTCATCCGGCAGAACTGCCGCGCCTACGTCGCGGCGTTCCGGG
ACCATTATCCGGATTTCGATGTGGCATACGCCTCGAAGGCGTTCCTGTGCACGGCCATGGCCGCCCTCGTCGCCCAGGAG
GGGCTGTCGCTGGACGTCGTCTCCGGCGGCGAGATCGCCACGGCCCTGCAGGCGGGGTTCCCGATGGACCGCACCTACTT
CCACGGCAACAACAAGACGGCCGAGGAGATCCGGCTCGCCCTGGAGGCCGGGGTCGGCCGCTTCGTGGTGGACTCCCTCC
ACGAGCTGGAGCTCCTGAACCGGCTCGCCGGGGAGCGGGGCACGACGGCGCGCGCCCTGCTGCGGGTGACGCCGGGCGTG
GAGGCGCACACGCACGAGTACATCAGTACCGGACAGCTGGATTCCAAGTTCGGGATCCCCATCGAGGGCGGCCAGGCCCT
CGACGCCGCGCGGGCCGCCCTGCAGGCGGACCACGTGGAGCTGTTGGGCTTCCACTGCCACATCGGGTCGCAGATCTTCG
ACCTGACCGGCTACCGGGTGGCTGCCGACAGGATGCTGGCCTTCGCCGCGGCGGTCCGGGAGGAGACCGGGTTCACGCCG
TCGGAGCTGAGCCTGGGCGGCGGGCTGGGCGTGCGCTACGTGGAGGGCGACCGTCCCTTGCCGCCGGCCGATCTGGTGGC
CTGCCTTGCCGAGGCCGTGCGCAGCGGGGCGGCCGAGCGCGCCCTGCCCCTGCCGAAGCTGATCGTCGAGCCCGGCCGGT
CCATCGTGGCCGAGGCGGGCACCACGCTGTACACGGTGGGCACGATCAAGGAGATCCCCGGCGTGCGCACGTACCTCTCC
GTGGACGGCGGCATGGGCGACAACATCCGCCCGGCGCTCTACCACGCCCGGTACGAGTGCGCCGTCGCCAACAAGCTGGA
CAGCGAACGGACCCGGATCGTCACCGTCGTCGGCCGCTATTGCGAATCGGGGGACGTGCTGCTGACCGACGCGGCCGTGG
CAGCGGATGTCGCCCCGGGCGACCTGCTGGCGGTCTTCGCCACCGGCGCTTACAACTACAGCATGGCGTCCCGCTACAAC
CGCTTCCCCACGCCGGCCGTGGTGTTCGTGCGGGACGGCCGGGCGGACCTGGTGGTCCGGCGCGAGACCTTTGCCGACAT
GGCCGCCTGCGACGTCCTGCCTCCCCGGTTTCGCCCCCGGGCGGAGGCGTAG

Upstream 100 bases:

>100_bases
CCTGTGCCGTTGACAGTCGACCGCGCGGGATGCTATTGTGGGGACAATTTCGGGGACGGTCATGTGGACCGGCTACGGCC
CGCGGAAGGAGTTGTGGACG

Downstream 100 bases:

>100_bases
TGCGCAGGGGCCCGTTCCTCCGGCGGTGCGGCCCGCATCGGGGGACGGGCCCTGTTTCGCGCCTGTTTTTTCTGCGGCGT
TGGGGGAGGAAAGTGGAACC

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MHFYGTASRNGQGHLTIGGVDVVDLAREFGTPLYVMDEELIRQNCRAYVAAFRDHYPDFDVAYASKAFLCTAMAALVAQE
GLSLDVVSGGEIATALQAGFPMDRTYFHGNNKTAEEIRLALEAGVGRFVVDSLHELELLNRLAGERGTTARALLRVTPGV
EAHTHEYISTGQLDSKFGIPIEGGQALDAARAALQADHVELLGFHCHIGSQIFDLTGYRVAADRMLAFAAAVREETGFTP
SELSLGGGLGVRYVEGDRPLPPADLVACLAEAVRSGAAERALPLPKLIVEPGRSIVAEAGTTLYTVGTIKEIPGVRTYLS
VDGGMGDNIRPALYHARYECAVANKLDSERTRIVTVVGRYCESGDVLLTDAAVAADVAPGDLLAVFATGAYNYSMASRYN
RFPTPAVVFVRDGRADLVVRRETFADMAACDVLPPRFRPRAEA

Sequences:

>Translated_443_residues
MHFYGTASRNGQGHLTIGGVDVVDLAREFGTPLYVMDEELIRQNCRAYVAAFRDHYPDFDVAYASKAFLCTAMAALVAQE
GLSLDVVSGGEIATALQAGFPMDRTYFHGNNKTAEEIRLALEAGVGRFVVDSLHELELLNRLAGERGTTARALLRVTPGV
EAHTHEYISTGQLDSKFGIPIEGGQALDAARAALQADHVELLGFHCHIGSQIFDLTGYRVAADRMLAFAAAVREETGFTP
SELSLGGGLGVRYVEGDRPLPPADLVACLAEAVRSGAAERALPLPKLIVEPGRSIVAEAGTTLYTVGTIKEIPGVRTYLS
VDGGMGDNIRPALYHARYECAVANKLDSERTRIVTVVGRYCESGDVLLTDAAVAADVAPGDLLAVFATGAYNYSMASRYN
RFPTPAVVFVRDGRADLVVRRETFADMAACDVLPPRFRPRAEA
>Mature_443_residues
MHFYGTASRNGQGHLTIGGVDVVDLAREFGTPLYVMDEELIRQNCRAYVAAFRDHYPDFDVAYASKAFLCTAMAALVAQE
GLSLDVVSGGEIATALQAGFPMDRTYFHGNNKTAEEIRLALEAGVGRFVVDSLHELELLNRLAGERGTTARALLRVTPGV
EAHTHEYISTGQLDSKFGIPIEGGQALDAARAALQADHVELLGFHCHIGSQIFDLTGYRVAADRMLAFAAAVREETGFTP
SELSLGGGLGVRYVEGDRPLPPADLVACLAEAVRSGAAERALPLPKLIVEPGRSIVAEAGTTLYTVGTIKEIPGVRTYLS
VDGGMGDNIRPALYHARYECAVANKLDSERTRIVTVVGRYCESGDVLLTDAAVAADVAPGDLLAVFATGAYNYSMASRYN
RFPTPAVVFVRDGRADLVVRRETFADMAACDVLPPRFRPRAEA

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=427, Percent_Identity=30.9133489461358, Blast_Score=146, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 47585; Mature: 47585

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHFYGTASRNGQGHLTIGGVDVVDLAREFGTPLYVMDEELIRQNCRAYVAAFRDHYPDFD
CCEECCCCCCCCEEEEECCCHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHCCCCCC
VAYASKAFLCTAMAALVAQEGLSLDVVSGGEIATALQAGFPMDRTYFHGNNKTAEEIRLA
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHCCCCCCCEEEECCCCCHHHHHHH
LEAGVGRFVVDSLHELELLNRLAGERGTTARALLRVTPGVEAHTHEYISTGQLDSKFGIP
HHHCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCC
IEGGQALDAARAALQADHVELLGFHCHIGSQIFDLTGYRVAADRMLAFAAAVREETGFTP
CCCCCHHHHHHHHHHCCCEEEEEEEEECCCCEECCCCCHHHHHHHHHHHHHHHHHCCCCC
SELSLGGGLGVRYVEGDRPLPPADLVACLAEAVRSGAAERALPLPKLIVEPGRSIVAEAG
CCEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCHHHCCCCCHHHHCCCCHHHHHCC
TTLYTVGTIKEIPGVRTYLSVDGGMGDNIRPALYHARYECAVANKLDSERTRIVTVVGRY
CEEEEECCHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHEEEEEEHHH
CESGDVLLTDAAVAADVAPGDLLAVFATGAYNYSMASRYNRFPTPAVVFVRDGRADLVVR
CCCCCEEEECHHHHHCCCCCCEEEEEECCCCCHHHHHHCCCCCCCEEEEEECCCCEEEEE
RETFADMAACDVLPPRFRPRAEA
HHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MHFYGTASRNGQGHLTIGGVDVVDLAREFGTPLYVMDEELIRQNCRAYVAAFRDHYPDFD
CCEECCCCCCCCEEEEECCCHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHCCCCCC
VAYASKAFLCTAMAALVAQEGLSLDVVSGGEIATALQAGFPMDRTYFHGNNKTAEEIRLA
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHCCCCCCCEEEECCCCCHHHHHHH
LEAGVGRFVVDSLHELELLNRLAGERGTTARALLRVTPGVEAHTHEYISTGQLDSKFGIP
HHHCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCC
IEGGQALDAARAALQADHVELLGFHCHIGSQIFDLTGYRVAADRMLAFAAAVREETGFTP
CCCCCHHHHHHHHHHCCCEEEEEEEEECCCCEECCCCCHHHHHHHHHHHHHHHHHCCCCC
SELSLGGGLGVRYVEGDRPLPPADLVACLAEAVRSGAAERALPLPKLIVEPGRSIVAEAG
CCEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCHHHCCCCCHHHHCCCCHHHHHCC
TTLYTVGTIKEIPGVRTYLSVDGGMGDNIRPALYHARYECAVANKLDSERTRIVTVVGRY
CEEEEECCHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHEEEEEEHHH
CESGDVLLTDAAVAADVAPGDLLAVFATGAYNYSMASRYNRFPTPAVVFVRDGRADLVVR
CCCCCEEEECHHHHHCCCCCCEEEEEECCCCCHHHHHHCCCCCCCEEEEEECCCCEEEEE
RETFADMAACDVLPPRFRPRAEA
HHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]