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The map label for this gene is macA [H]

Identifier: 51892947

GI number: 51892947

Start: 1952698

End: 1954287

Strand: Reverse

Name: macA [H]

Synonym: STH1809

Alternate gene names: 51892947

Gene position: 1954287-1952698 (Counterclockwise)

Preceding gene: 51892948

Following gene: 51892946

Centisome position: 54.8

GC content: 72.01

Gene sequence:

>1590_bases
ATGGGGCCCGAGGGCGCCCCGGTGGTGCAGGTGCAGCGGGTCAGCCGGGGGATGCTGATCCAGGAGATCTACTCCCCCGG
CACGGTGCAGGCCGGGAACCTGCAGGAGTACAAGGCCCCGCTGACAAGCCCGCGCGTCACGGTCTACGTGGAGGCCGGTC
AGCAGGTGGAGGAGGGGCAGTTGCTGGTGGAGCTGGACGCCACCGAGCTGCAGGAGGAGGTCAAGACCAAGGAGCGCGAC
CTCCTGCAGGCGCAGCGGGAGCTGGAGGAGCTGCTGCGCCAGATGGAGAGCGCGCCGCTGCAGCTGGAGCGGAACCTGCA
GGAGGCCCGCCAGCAGCTGGCCGAGGCCCAGAGCAACCTGGCGCGGGTGAAGGCAGGCGGCGGGGAGAGCAGCGACGTGG
AGCGGCTGCGGGCGCAGATCGACCAGCTCCGCAGCCAGGTGGCCGCCGCACAGCAGCCGGTGGAGGAGGCCCGGGAGAAC
CTGGCCGCCGCGGAGGCGGCCTACCTCGCCAACCCCTCCGACTCCCAGGCCGCGCAGGCGTATCGCGCGGCTGAGGAGGC
CTACCGCGAGGCGGTGCGCAAGAGCCAGGCGACGGTGCAGGAGGCCGCGGAGAAGCTCGCGGAGGCCGAGGCGGAGCTGG
CCGCGCTGCTGGAGGGCAGCCAGGACGGGGCTAGCCGCGAGTTGAACGTGCGGCTGGCGGAGATCCAGGTGAGCCTGGCG
GAGGTGGCGGTGAAGGAGGCCGAGGAGGCGGTGCGCCGCGGCCCCGACATGGGCCAGGTGGAGCTGGCCCGGGCCCGGGT
CGAGGCCGCCCAGGCGACCCTGGACAAACTGCGCGCCAATCTGGAGGCGACCCGGATCGTCGCCGCCGCACCGGGGACGG
TGCTGAGCGTGCACGTGAAGGACGGCGACCCGGTGCAGCAGGGCGCTTCCCTGTTGCGGGTCGGCGACATGGAGCGGATG
GAGCTGATCGGCCAGGTGGAGGCCGTGGACCTGGACAGCCTGGAGCCCGGCCAGCCGATCATGGTCACCTCGTCGTTGCT
GCCGCTGGCCAGCTTCGAGGGCACCGTGACCCGCATCAGCCAGCAGACCGCGCAGAGCAACGACGGGTTCTACGGCGGCC
CGATCTACTACATGGGTGACACCGTCACCTTCGAGGTGCGGGGCGAGGTCATGAACGCCGACGGCCGGCTGAAGAGCGGC
ATGTCGGTGGAGATGCGCATCCAGACCGCCCAGCTGGAGGACGTGATCGTGGTGCCGCTCCTCGCCGTGCGTGAGGAAGC
CGGGCAGGCCTTCGTGCTCGTGGTCCACGAGGACTACACCGTGGAGGTGCGGCCCATCCAGACCGGCCTGGTCACCAACC
GCGAGGTGGAGGTCGTCGCGGGGCTGGAGGAGGGGGAGATGATCGTCACCGGCCCCTTCGGCCTGATCGAGACGCTGCAG
GACGGTGACCCGGTGCAGATCGAGGCGATGCCCGGGATGGATCCCTTCATGGGCGGCCCCACGGGCCCGGGCGGCGGGCG
GATGCGGACGGTGCCCGGGGGTGTCCGGGCTGTTCCGCTGGGGCTCGCGACGGGGGGCGCAGCGCGATGA

Upstream 100 bases:

>100_bases
GGTCATCGTGATCCTTCTCGTGCTTGCGGTGCTGGGCGCCGGCGGTTGGTTCGGCTACCAGCGCTTCTTCGGCGGGCGTT
CGGCCGTCACCGTGACGGCC

Downstream 100 bases:

>100_bases
ACCTGCTGGAAACCTTCAGCGTCGCGCTTTCGGCCCTGTGGGCCAACAAGCTGCGCTCGGCGCTGACCATGCTGGGGCTG
ATCATCGGGGTCGGCTCGGT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 529; Mature: 528

Protein sequence:

>529_residues
MGPEGAPVVQVQRVSRGMLIQEIYSPGTVQAGNLQEYKAPLTSPRVTVYVEAGQQVEEGQLLVELDATELQEEVKTKERD
LLQAQRELEELLRQMESAPLQLERNLQEARQQLAEAQSNLARVKAGGGESSDVERLRAQIDQLRSQVAAAQQPVEEAREN
LAAAEAAYLANPSDSQAAQAYRAAEEAYREAVRKSQATVQEAAEKLAEAEAELAALLEGSQDGASRELNVRLAEIQVSLA
EVAVKEAEEAVRRGPDMGQVELARARVEAAQATLDKLRANLEATRIVAAAPGTVLSVHVKDGDPVQQGASLLRVGDMERM
ELIGQVEAVDLDSLEPGQPIMVTSSLLPLASFEGTVTRISQQTAQSNDGFYGGPIYYMGDTVTFEVRGEVMNADGRLKSG
MSVEMRIQTAQLEDVIVVPLLAVREEAGQAFVLVVHEDYTVEVRPIQTGLVTNREVEVVAGLEEGEMIVTGPFGLIETLQ
DGDPVQIEAMPGMDPFMGGPTGPGGGRMRTVPGGVRAVPLGLATGGAAR

Sequences:

>Translated_529_residues
MGPEGAPVVQVQRVSRGMLIQEIYSPGTVQAGNLQEYKAPLTSPRVTVYVEAGQQVEEGQLLVELDATELQEEVKTKERD
LLQAQRELEELLRQMESAPLQLERNLQEARQQLAEAQSNLARVKAGGGESSDVERLRAQIDQLRSQVAAAQQPVEEAREN
LAAAEAAYLANPSDSQAAQAYRAAEEAYREAVRKSQATVQEAAEKLAEAEAELAALLEGSQDGASRELNVRLAEIQVSLA
EVAVKEAEEAVRRGPDMGQVELARARVEAAQATLDKLRANLEATRIVAAAPGTVLSVHVKDGDPVQQGASLLRVGDMERM
ELIGQVEAVDLDSLEPGQPIMVTSSLLPLASFEGTVTRISQQTAQSNDGFYGGPIYYMGDTVTFEVRGEVMNADGRLKSG
MSVEMRIQTAQLEDVIVVPLLAVREEAGQAFVLVVHEDYTVEVRPIQTGLVTNREVEVVAGLEEGEMIVTGPFGLIETLQ
DGDPVQIEAMPGMDPFMGGPTGPGGGRMRTVPGGVRAVPLGLATGGAAR
>Mature_528_residues
GPEGAPVVQVQRVSRGMLIQEIYSPGTVQAGNLQEYKAPLTSPRVTVYVEAGQQVEEGQLLVELDATELQEEVKTKERDL
LQAQRELEELLRQMESAPLQLERNLQEARQQLAEAQSNLARVKAGGGESSDVERLRAQIDQLRSQVAAAQQPVEEARENL
AAAEAAYLANPSDSQAAQAYRAAEEAYREAVRKSQATVQEAAEKLAEAEAELAALLEGSQDGASRELNVRLAEIQVSLAE
VAVKEAEEAVRRGPDMGQVELARARVEAAQATLDKLRANLEATRIVAAAPGTVLSVHVKDGDPVQQGASLLRVGDMERME
LIGQVEAVDLDSLEPGQPIMVTSSLLPLASFEGTVTRISQQTAQSNDGFYGGPIYYMGDTVTFEVRGEVMNADGRLKSGM
SVEMRIQTAQLEDVIVVPLLAVREEAGQAFVLVVHEDYTVEVRPIQTGLVTNREVEVVAGLEEGEMIVTGPFGLIETLQD
GDPVQIEAMPGMDPFMGGPTGPGGGRMRTVPGGVRAVPLGLATGGAAR

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=287, Percent_Identity=29.2682926829268, Blast_Score=94, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 56704; Mature: 56572

Theoretical pI: Translated: 4.21; Mature: 4.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGPEGAPVVQVQRVSRGMLIQEIYSPGTVQAGNLQEYKAPLTSPRVTVYVEAGQQVEEGQ
CCCCCCCCHHHHHHHCCHHHHHHCCCCCEECCCCHHHCCCCCCCCEEEEEECCCCCCCCC
LLVELDATELQEEVKTKERDLLQAQRELEELLRQMESAPLQLERNLQEARQQLAEAQSNL
EEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
ARVKAGGGESSDVERLRAQIDQLRSQVAAAQQPVEEARENLAAAEAAYLANPSDSQAAQA
HEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
YRAAEEAYREAVRKSQATVQEAAEKLAEAEAELAALLEGSQDGASRELNVRLAEIQVSLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEHHHHHHH
EVAVKEAEEAVRRGPDMGQVELARARVEAAQATLDKLRANLEATRIVAAAPGTVLSVHVK
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCEEEEEEC
DGDPVQQGASLLRVGDMERMELIGQVEAVDLDSLEPGQPIMVTSSLLPLASFEGTVTRIS
CCCCHHHCCHHHHCCCHHHHHHHHCCEEECCCCCCCCCCEEEECCCCCHHCCCCHHHHHH
QQTAQSNDGFYGGPIYYMGDTVTFEVRGEVMNADGRLKSGMSVEMRIQTAQLEDVIVVPL
HHHHHCCCCCCCCCEEEECCEEEEEEECEEECCCCCCCCCCEEEEEEEECCCCCCHHHHH
LAVREEAGQAFVLVVHEDYTVEVRPIQTGLVTNREVEVVAGLEEGEMIVTGPFGLIETLQ
HHHHHCCCCEEEEEEECCEEEEEEEEEECCCCCCCEEEEEECCCCCEEEECCHHHHHHHC
DGDPVQIEAMPGMDPFMGGPTGPGGGRMRTVPGGVRAVPLGLATGGAAR
CCCCEEEEECCCCCCCCCCCCCCCCCEEEECCCCCEEEEEEECCCCCCC
>Mature Secondary Structure 
GPEGAPVVQVQRVSRGMLIQEIYSPGTVQAGNLQEYKAPLTSPRVTVYVEAGQQVEEGQ
CCCCCCCHHHHHHHCCHHHHHHCCCCCEECCCCHHHCCCCCCCCEEEEEECCCCCCCCC
LLVELDATELQEEVKTKERDLLQAQRELEELLRQMESAPLQLERNLQEARQQLAEAQSNL
EEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
ARVKAGGGESSDVERLRAQIDQLRSQVAAAQQPVEEARENLAAAEAAYLANPSDSQAAQA
HEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
YRAAEEAYREAVRKSQATVQEAAEKLAEAEAELAALLEGSQDGASRELNVRLAEIQVSLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEHHHHHHH
EVAVKEAEEAVRRGPDMGQVELARARVEAAQATLDKLRANLEATRIVAAAPGTVLSVHVK
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCEEEEEEC
DGDPVQQGASLLRVGDMERMELIGQVEAVDLDSLEPGQPIMVTSSLLPLASFEGTVTRIS
CCCCHHHCCHHHHCCCHHHHHHHHCCEEECCCCCCCCCCEEEECCCCCHHCCCCHHHHHH
QQTAQSNDGFYGGPIYYMGDTVTFEVRGEVMNADGRLKSGMSVEMRIQTAQLEDVIVVPL
HHHHHCCCCCCCCCEEEECCEEEEEEECEEECCCCCCCCCCEEEEEEEECCCCCCHHHHH
LAVREEAGQAFVLVVHEDYTVEVRPIQTGLVTNREVEVVAGLEEGEMIVTGPFGLIETLQ
HHHHHCCCCEEEEEEECCEEEEEEEEEECCCCCCCEEEEEECCCCCEEEECCHHHHHHHC
DGDPVQIEAMPGMDPFMGGPTGPGGGRMRTVPGGVRAVPLGLATGGAAR
CCCCEEEEECCCCCCCCCCCCCCCCCEEEECCCCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]