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The map label for this gene is nth [H]

Identifier: 51892440

GI number: 51892440

Start: 1438281

End: 1438979

Strand: Reverse

Name: nth [H]

Synonym: STH1302

Alternate gene names: 51892440

Gene position: 1438979-1438281 (Counterclockwise)

Preceding gene: 51892441

Following gene: 51892439

Centisome position: 40.35

GC content: 69.1

Gene sequence:

>699_bases
GTGGACTGGGAAGGGCTAAGCCGAGCGCTGGCGGCGCGGTATGGCAGTCCCCGGCACGGCAACCCCACCGACCCGACCGA
CTGCCTGTTCTACCTGATGCTGAGCCGCAAGACCCCAATCCGGACAGCGGCGAGGGTCTATAAGCGGCTCCGCGCCACCG
TACGTGGCTGGGACGGCCTGCTCGGGCTGACGCAGGTGGAGCTCGTCCGGCTGCTCTGGGGGAGCGGGTTGGAGGAGATC
AGAGCTGGCCACCTGCTGGCGGTGGCCGGCCTGCTGCGCGACCGCTTCGGTGCCGTCACCCTTGAACCGCTCCGGCAGTG
GCCGGATGACGAGTGCCTGGCGTTCCTCATGTCGCTCCCCGGCATGGGGATGAAGACGGCCTTGTGCGTGATGCTCTACG
GCCTGGACCGGCCGGTGTTCCCGGCGGACGCCCACTGCATCCGGGTGCTAAAGCGCATGGGCGTCATCGACGCCCGGCTG
GCCCACCGCCCCGCACAGCGAGAGCTGGCCCGCATCGTCCCGGGCCACCTGGGGTACGTGCTGCACGTGAACCTGGTGGC
CCACGGTCAGCAGATCTGCACGGCCCGCTGCCCCAGATGTGCGGAGTGCGTGGTGGCCAACTACTGCCTGTTGGGAGAGG
CCGCCCAGCAGGCCGCGGAAGGTCAGCTGCCTTATGGTGAATCTCTGCGGCGGACTTGA

Upstream 100 bases:

>100_bases
CCTGGTGATCCTGCACCCGCGTCGGGCTCCTTCCCCCCTCATCGCCGAGCTGGAGGGACCCCACTGGACACTGGCGGGGC
AGCAGGCGGAGGGATGATCC

Downstream 100 bases:

>100_bases
CAGGACATTACTTCGGGGATGAGGGCCATGGCGATCTATCGAAAGTGCAAGTACTGCGGGGCACCACTGAGCCTGCGTGA
GATGCCGGCTGGGCAGTGGG

Product: endonuclease III

Products: NA

Alternate protein names: DNA-(apurinic or apyrimidinic site) lyase [H]

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MDWEGLSRALAARYGSPRHGNPTDPTDCLFYLMLSRKTPIRTAARVYKRLRATVRGWDGLLGLTQVELVRLLWGSGLEEI
RAGHLLAVAGLLRDRFGAVTLEPLRQWPDDECLAFLMSLPGMGMKTALCVMLYGLDRPVFPADAHCIRVLKRMGVIDARL
AHRPAQRELARIVPGHLGYVLHVNLVAHGQQICTARCPRCAECVVANYCLLGEAAQQAAEGQLPYGESLRRT

Sequences:

>Translated_232_residues
MDWEGLSRALAARYGSPRHGNPTDPTDCLFYLMLSRKTPIRTAARVYKRLRATVRGWDGLLGLTQVELVRLLWGSGLEEI
RAGHLLAVAGLLRDRFGAVTLEPLRQWPDDECLAFLMSLPGMGMKTALCVMLYGLDRPVFPADAHCIRVLKRMGVIDARL
AHRPAQRELARIVPGHLGYVLHVNLVAHGQQICTARCPRCAECVVANYCLLGEAAQQAAEGQLPYGESLRRT
>Mature_232_residues
MDWEGLSRALAARYGSPRHGNPTDPTDCLFYLMLSRKTPIRTAARVYKRLRATVRGWDGLLGLTQVELVRLLWGSGLEEI
RAGHLLAVAGLLRDRFGAVTLEPLRQWPDDECLAFLMSLPGMGMKTALCVMLYGLDRPVFPADAHCIRVLKRMGVIDARL
AHRPAQRELARIVPGHLGYVLHVNLVAHGQQICTARCPRCAECVVANYCLLGEAAQQAAEGQLPYGESLRRT

Specific function: Has both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. Incises damaged DNA at cytosines, thymines and guanines. Acts on a damaged strand, 5' from the damaged site [H]

COG id: COG0177

COG function: function code L; Predicted EndoIII-related endonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR005759
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: =4.2.99.18 [H]

Molecular weight: Translated: 25725; Mature: 25725

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
3.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDWEGLSRALAARYGSPRHGNPTDPTDCLFYLMLSRKTPIRTAARVYKRLRATVRGWDGL
CCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
LGLTQVELVRLLWGSGLEEIRAGHLLAVAGLLRDRFGAVTLEPLRQWPDDECLAFLMSLP
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCEEHHHHHCCCCHHHHHHHHHCC
GMGMKTALCVMLYGLDRPVFPADAHCIRVLKRMGVIDARLAHRPAQRELARIVPGHLGYV
CCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCHHHHHHHCCCHHHHHHHHCCCHHHHH
LHVNLVAHGQQICTARCPRCAECVVANYCLLGEAAQQAAEGQLPYGESLRRT
HHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCC
>Mature Secondary Structure
MDWEGLSRALAARYGSPRHGNPTDPTDCLFYLMLSRKTPIRTAARVYKRLRATVRGWDGL
CCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
LGLTQVELVRLLWGSGLEEIRAGHLLAVAGLLRDRFGAVTLEPLRQWPDDECLAFLMSLP
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCEEHHHHHCCCCHHHHHHHHHCC
GMGMKTALCVMLYGLDRPVFPADAHCIRVLKRMGVIDARLAHRPAQRELARIVPGHLGYV
CCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCHHHHHHHCCCHHHHHHHHCCCHHHHH
LHVNLVAHGQQICTARCPRCAECVVANYCLLGEAAQQAAEGQLPYGESLRRT
HHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]