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The map label for this gene is folE [H]

Identifier: 51892128

GI number: 51892128

Start: 1108756

End: 1109319

Strand: Reverse

Name: folE [H]

Synonym: STH990

Alternate gene names: 51892128

Gene position: 1109319-1108756 (Counterclockwise)

Preceding gene: 51892130

Following gene: 51892127

Centisome position: 31.11

GC content: 68.26

Gene sequence:

>564_bases
GTGGACAAGGCAAAGATTGAGCAGGCGGTGCGGATGATCCTGGAAGCGGTCGGCGAGGATCCGGACCGCGAGGGGCTGCT
GGAGACGCCCCGCCGCGTGGCGGACTTCTACGAGGAGGTGTTCGCCGGGCTCCACCGGGACCCGGCTGAAAGGCTCACCG
CGATCTTCAACGAGGACCACGAGGAGCTGGTGATCGTCCGCGACATCTCCTTCGAGTCCATGTGCGAGCATCACCTGCTG
CCCTTCTTCGGCAAGGCGCACGTCGCCTACATCCCCCGCAGCGGCCGGGTGGTCGGGCTCTCCAAGCTGGCCCGGGTGGT
CGAGGACTTCTCCCGGCGGCCACAGCTGCAGGAGCGGCTCACCGCCCAGATCGCCGACCTGCTGATGGAGAAGCTGAACC
CCCTCGGCGTGCTGGTGGTCGTGGAAGCCGAGCACATGTGCATGACCATGCGCGGCGTGCGCAAGCCCGGATCCTCCACC
ATCACCTCCGCGGTGCGGGGCGTCTTCCAGACCAGCGAGGCGACCCGGGCCGAGGCCATGGCCCTCATCCGCGGCGTCAG
GTAG

Upstream 100 bases:

>100_bases
GCGGTCCGTCCAAAGAGGGGTGGACCCCCGGCGGTCCGCCCCCTCGCGCCCCGGCGGGCTGCGAAGTCGTGACACGGAAA
GGCGGTGACCACGGTTGTCC

Downstream 100 bases:

>100_bases
CGAAGCCTCCGCAACCCCAGGGTTGCGGAGGCTTTCTCCTTCCACCAAGACCCTCCGCAAGTCGTGGAACCCTGTAATGG
CAAGCCCCGTCCAATCTCAT

Product: GTP cyclohydrolase

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MDKAKIEQAVRMILEAVGEDPDREGLLETPRRVADFYEEVFAGLHRDPAERLTAIFNEDHEELVIVRDISFESMCEHHLL
PFFGKAHVAYIPRSGRVVGLSKLARVVEDFSRRPQLQERLTAQIADLLMEKLNPLGVLVVVEAEHMCMTMRGVRKPGSST
ITSAVRGVFQTSEATRAEAMALIRGVR

Sequences:

>Translated_187_residues
MDKAKIEQAVRMILEAVGEDPDREGLLETPRRVADFYEEVFAGLHRDPAERLTAIFNEDHEELVIVRDISFESMCEHHLL
PFFGKAHVAYIPRSGRVVGLSKLARVVEDFSRRPQLQERLTAQIADLLMEKLNPLGVLVVVEAEHMCMTMRGVRKPGSST
ITSAVRGVFQTSEATRAEAMALIRGVR
>Mature_187_residues
MDKAKIEQAVRMILEAVGEDPDREGLLETPRRVADFYEEVFAGLHRDPAERLTAIFNEDHEELVIVRDISFESMCEHHLL
PFFGKAHVAYIPRSGRVVGLSKLARVVEDFSRRPQLQERLTAQIADLLMEKLNPLGVLVVVEAEHMCMTMRGVRKPGSST
ITSAVRGVFQTSEATRAEAMALIRGVR

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=177, Percent_Identity=54.2372881355932, Blast_Score=182, Evalue=1e-46,
Organism=Homo sapiens, GI4503949, Length=177, Percent_Identity=54.2372881355932, Blast_Score=182, Evalue=1e-46,
Organism=Homo sapiens, GI66932970, Length=154, Percent_Identity=48.7012987012987, Blast_Score=140, Evalue=5e-34,
Organism=Homo sapiens, GI66932972, Length=136, Percent_Identity=54.4117647058823, Blast_Score=139, Evalue=1e-33,
Organism=Escherichia coli, GI1788476, Length=174, Percent_Identity=41.9540229885057, Blast_Score=127, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17560486, Length=178, Percent_Identity=52.247191011236, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6321706, Length=181, Percent_Identity=51.3812154696133, Blast_Score=180, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24656782, Length=177, Percent_Identity=49.1525423728814, Blast_Score=165, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24656796, Length=179, Percent_Identity=48.6033519553073, Blast_Score=163, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24656791, Length=179, Percent_Identity=48.6033519553073, Blast_Score=163, Evalue=6e-41,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 21040; Mature: 21040

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKAKIEQAVRMILEAVGEDPDREGLLETPRRVADFYEEVFAGLHRDPAERLTAIFNEDH
CCHHHHHHHHHHHHHHHCCCCCCCCHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
EELVIVRDISFESMCEHHLLPFFGKAHVAYIPRSGRVVGLSKLARVVEDFSRRPQLQERL
CCEEEEECCCHHHHHHHHCCCHHCCCEEEEECCCCCEECHHHHHHHHHHHHHCCHHHHHH
TAQIADLLMEKLNPLGVLVVVEAEHMCMTMRGVRKPGSSTITSAVRGVFQTSEATRAEAM
HHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHH
ALIRGVR
HHHHCCC
>Mature Secondary Structure
MDKAKIEQAVRMILEAVGEDPDREGLLETPRRVADFYEEVFAGLHRDPAERLTAIFNEDH
CCHHHHHHHHHHHHHHHCCCCCCCCHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
EELVIVRDISFESMCEHHLLPFFGKAHVAYIPRSGRVVGLSKLARVVEDFSRRPQLQERL
CCEEEEECCCHHHHHHHHCCCHHCCCEEEEECCCCCEECHHHHHHHHHHHHHCCHHHHHH
TAQIADLLMEKLNPLGVLVVVEAEHMCMTMRGVRKPGSSTITSAVRGVFQTSEATRAEAM
HHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHH
ALIRGVR
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA