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The map label for this gene is thlA [H]

Identifier: 51891942

GI number: 51891942

Start: 901238

End: 902416

Strand: Reverse

Name: thlA [H]

Synonym: STH804

Alternate gene names: 51891942

Gene position: 902416-901238 (Counterclockwise)

Preceding gene: 51891943

Following gene: 51891941

Centisome position: 25.31

GC content: 73.11

Gene sequence:

>1179_bases
ATGCGGGAAGCGGTGATCGTGTCGGCGGTGCGCACCCCCATCGGCAGCCTGGGCGGCGCGCTGTCGACCGTGAAGTCTTA
CGAGCTGGGCGCGGCCGCCATCGCCGAGGCGCTGCGCCGGGCCGGGATCCGCGGCGAGCAGGTGGATGAGGTGATCATCG
GCCAGGTGCTGGAGGCCGGGGAGGGGCAACACCCTGCCCGGATCGCGAGCCTGAAGGCCGGGATCCCCTACACGGTGCCG
GTGACCGGCGTCAACAAGGTCTGCGGCTCCGGCCTGAAGGCGGTGGCCCTGGCCGCCCAGGCGATCATGCTCGGGGATGC
CGACGTGGTGGTGGCCGGCGGCCAGGAGTCGATGTCCGGGGCCCCCTACCTGGTGCCCCGGGCCCGGTTCGGCTACCGGA
TGGGCCACGGCCAGCTGGTGGACTCGATGATCGCGGACGCCCTGACCTGCGGCTGGGAGCACGTCCACATGGGGCTCACC
GCCGAGAACATCGCCGAGCAGTTCGGCATCAGCCGGGAGGACCAGGACGCCTTCGCCGCCGCCTCCCAGCAGAAGGCGGA
GGCGGCGATCAAGGCCGGCAGGTTCCGGGAGGAGATCGTGCCGGTGACCGTGCCCGGCCGCAAGGGCGACACGGTGGTGG
ACGCCGACGAGCACCCGCGCTTCGGCACCACGGTGGAGGCGCTGGCCAAACTCCGCCCGGCCTTCAAGGAGGGCGGCACC
GTGACGGCCGGCAACGCCTCCGGCATCAACGACGGCGCCGCGGCGGTGGTGGTGATGTCGGCGGAGAAGGCGGCGTCCCT
GGGGGTCAGGCCCATGGCGGTGATCCGCAGCTACGCCGCCGCCGGGGTGGAGCCCCGGATCATGGGCACCGGCCCCATCC
CGGCCACCCGGAAGGCCCTGGCCCGGGCGGGACTGACCATCGACCGGCTGGACCTGATCGAGGCCAACGAGGCCTTCGCC
GCCCAGGCCCTCGCGGTGGTCCGGGGGCTGGAACTGGACCCCGGCAAGGTCAACGTCAACGGCGGCGCCATCGCCCTGGG
CCATCCCGTAGGGGCCTCGGGCGCCCGCATCCTGGTCACGCTGCTTTACGAGATGCAGAGGCGGCGGAGCCGGTACGGCC
TGGCGACCCTCTGCATCGGCGGCGGCCAGGGCATCGCCATGGTGGTCGAGCGGGCCTGA

Upstream 100 bases:

>100_bases
CTGGGCGGGGGTGCTGGCCTCGCCCCGGGCCCACTACATGACCGGCGCCGTGATCGACTGCAACGGCGGCGTGTACATGT
AGCCCCGGGAGGTGCCGGCC

Downstream 100 bases:

>100_bases
CCGGTCCGCCTGCACCCTGCACGCATCTCCATCACAGATAGGGGGAGACAGACGTGAGACGTTGGTTCACTGCGATCCTC
GCCTGCGCGCTTTCCCTGGC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MREAVIVSAVRTPIGSLGGALSTVKSYELGAAAIAEALRRAGIRGEQVDEVIIGQVLEAGEGQHPARIASLKAGIPYTVP
VTGVNKVCGSGLKAVALAAQAIMLGDADVVVAGGQESMSGAPYLVPRARFGYRMGHGQLVDSMIADALTCGWEHVHMGLT
AENIAEQFGISREDQDAFAAASQQKAEAAIKAGRFREEIVPVTVPGRKGDTVVDADEHPRFGTTVEALAKLRPAFKEGGT
VTAGNASGINDGAAAVVVMSAEKAASLGVRPMAVIRSYAAAGVEPRIMGTGPIPATRKALARAGLTIDRLDLIEANEAFA
AQALAVVRGLELDPGKVNVNGGAIALGHPVGASGARILVTLLYEMQRRRSRYGLATLCIGGGQGIAMVVERA

Sequences:

>Translated_392_residues
MREAVIVSAVRTPIGSLGGALSTVKSYELGAAAIAEALRRAGIRGEQVDEVIIGQVLEAGEGQHPARIASLKAGIPYTVP
VTGVNKVCGSGLKAVALAAQAIMLGDADVVVAGGQESMSGAPYLVPRARFGYRMGHGQLVDSMIADALTCGWEHVHMGLT
AENIAEQFGISREDQDAFAAASQQKAEAAIKAGRFREEIVPVTVPGRKGDTVVDADEHPRFGTTVEALAKLRPAFKEGGT
VTAGNASGINDGAAAVVVMSAEKAASLGVRPMAVIRSYAAAGVEPRIMGTGPIPATRKALARAGLTIDRLDLIEANEAFA
AQALAVVRGLELDPGKVNVNGGAIALGHPVGASGARILVTLLYEMQRRRSRYGLATLCIGGGQGIAMVVERA
>Mature_392_residues
MREAVIVSAVRTPIGSLGGALSTVKSYELGAAAIAEALRRAGIRGEQVDEVIIGQVLEAGEGQHPARIASLKAGIPYTVP
VTGVNKVCGSGLKAVALAAQAIMLGDADVVVAGGQESMSGAPYLVPRARFGYRMGHGQLVDSMIADALTCGWEHVHMGLT
AENIAEQFGISREDQDAFAAASQQKAEAAIKAGRFREEIVPVTVPGRKGDTVVDADEHPRFGTTVEALAKLRPAFKEGGT
VTAGNASGINDGAAAVVVMSAEKAASLGVRPMAVIRSYAAAGVEPRIMGTGPIPATRKALARAGLTIDRLDLIEANEAFA
AQALAVVRGLELDPGKVNVNGGAIALGHPVGASGARILVTLLYEMQRRRSRYGLATLCIGGGQGIAMVVERA

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=389, Percent_Identity=54.7557840616967, Blast_Score=404, Evalue=1e-113,
Organism=Homo sapiens, GI167614485, Length=391, Percent_Identity=44.7570332480818, Blast_Score=336, Evalue=3e-92,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=45.8015267175573, Blast_Score=329, Evalue=3e-90,
Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=45.8227848101266, Blast_Score=291, Evalue=9e-79,
Organism=Homo sapiens, GI4504327, Length=426, Percent_Identity=33.5680751173709, Blast_Score=198, Evalue=8e-51,
Organism=Homo sapiens, GI194353979, Length=390, Percent_Identity=35.1282051282051, Blast_Score=174, Evalue=1e-43,
Organism=Escherichia coli, GI1788554, Length=392, Percent_Identity=60.7142857142857, Blast_Score=432, Evalue=1e-122,
Organism=Escherichia coli, GI87082165, Length=391, Percent_Identity=55.2429667519182, Blast_Score=429, Evalue=1e-121,
Organism=Escherichia coli, GI1787663, Length=407, Percent_Identity=49.3857493857494, Blast_Score=352, Evalue=3e-98,
Organism=Escherichia coli, GI48994986, Length=402, Percent_Identity=45.5223880597015, Blast_Score=288, Evalue=5e-79,
Organism=Escherichia coli, GI1788683, Length=423, Percent_Identity=35.4609929078014, Blast_Score=207, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI133906874, Length=387, Percent_Identity=46.2532299741602, Blast_Score=340, Evalue=5e-94,
Organism=Caenorhabditis elegans, GI25147385, Length=390, Percent_Identity=41.7948717948718, Blast_Score=298, Evalue=4e-81,
Organism=Caenorhabditis elegans, GI17535921, Length=393, Percent_Identity=39.440203562341, Blast_Score=263, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI17551802, Length=425, Percent_Identity=31.5294117647059, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17535917, Length=393, Percent_Identity=31.8066157760814, Blast_Score=181, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6325229, Length=397, Percent_Identity=45.8438287153652, Blast_Score=311, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6322031, Length=394, Percent_Identity=38.5786802030457, Blast_Score=236, Evalue=7e-63,
Organism=Drosophila melanogaster, GI24655093, Length=391, Percent_Identity=58.0562659846547, Blast_Score=452, Evalue=1e-127,
Organism=Drosophila melanogaster, GI17648125, Length=389, Percent_Identity=45.2442159383033, Blast_Score=329, Evalue=2e-90,
Organism=Drosophila melanogaster, GI24640423, Length=391, Percent_Identity=44.2455242966752, Blast_Score=301, Evalue=4e-82,
Organism=Drosophila melanogaster, GI17137578, Length=422, Percent_Identity=32.9383886255924, Blast_Score=193, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40342; Mature: 40342

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREAVIVSAVRTPIGSLGGALSTVKSYELGAAAIAEALRRAGIRGEQVDEVIIGQVLEAG
CCCCEEHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
EGQHPARIASLKAGIPYTVPVTGVNKVCGSGLKAVALAAQAIMLGDADVVVAGGQESMSG
CCCCCHHHHHHHCCCCEEEECCCHHHHHCCCHHHHHHHHHHHEECCCCEEEECCCCCCCC
APYLVPRARFGYRMGHGQLVDSMIADALTCGWEHVHMGLTAENIAEQFGISREDQDAFAA
CCEEEECHHHCEECCCHHHHHHHHHHHHHCCHHHEEECCCHHHHHHHHCCCCCCCHHHHH
ASQQKAEAAIKAGRFREEIVPVTVPGRKGDTVVDADEHPRFGTTVEALAKLRPAFKEGGT
HHHHHHHHHHHHHCHHHHCEEEEECCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCCE
VTAGNASGINDGAAAVVVMSAEKAASLGVRPMAVIRSYAAAGVEPRIMGTGPIPATRKAL
EEECCCCCCCCCCEEEEEEECHHHHHCCCCHHHHHHHHHHCCCCCEEEECCCCCHHHHHH
ARAGLTIDRLDLIEANEAFAAQALAVVRGLELDPGKVNVNGGAIALGHPVGASGARILVT
HHCCCEEEHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEECCCEEEECCCCCCCHHHHHHH
LLYEMQRRRSRYGLATLCIGGGQGIAMVVERA
HHHHHHHHHHHCCEEEEEEECCCCEEEEEECC
>Mature Secondary Structure
MREAVIVSAVRTPIGSLGGALSTVKSYELGAAAIAEALRRAGIRGEQVDEVIIGQVLEAG
CCCCEEHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
EGQHPARIASLKAGIPYTVPVTGVNKVCGSGLKAVALAAQAIMLGDADVVVAGGQESMSG
CCCCCHHHHHHHCCCCEEEECCCHHHHHCCCHHHHHHHHHHHEECCCCEEEECCCCCCCC
APYLVPRARFGYRMGHGQLVDSMIADALTCGWEHVHMGLTAENIAEQFGISREDQDAFAA
CCEEEECHHHCEECCCHHHHHHHHHHHHHCCHHHEEECCCHHHHHHHHCCCCCCCHHHHH
ASQQKAEAAIKAGRFREEIVPVTVPGRKGDTVVDADEHPRFGTTVEALAKLRPAFKEGGT
HHHHHHHHHHHHHCHHHHCEEEEECCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCCE
VTAGNASGINDGAAAVVVMSAEKAASLGVRPMAVIRSYAAAGVEPRIMGTGPIPATRKAL
EEECCCCCCCCCCEEEEEEECHHHHHCCCCHHHHHHHHHHCCCCCEEEECCCCCHHHHHH
ARAGLTIDRLDLIEANEAFAAQALAVVRGLELDPGKVNVNGGAIALGHPVGASGARILVT
HHCCCEEEHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEECCCEEEECCCCCCCHHHHHHH
LLYEMQRRRSRYGLATLCIGGGQGIAMVVERA
HHHHHHHHHHHCCEEEEEEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]