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The map label for this gene is phoP [H]

Identifier: 51891888

GI number: 51891888

Start: 835459

End: 836166

Strand: Reverse

Name: phoP [H]

Synonym: STH750

Alternate gene names: 51891888

Gene position: 836166-835459 (Counterclockwise)

Preceding gene: 51891889

Following gene: 51891887

Centisome position: 23.45

GC content: 69.49

Gene sequence:

>708_bases
GTGTTCCCTGTGCCCGAGCGGATTCTCGTCGTCGATGATGAGCCCTCGATCCTCGAACTGGTCGCGTACAACTTGCGCCG
GGCGGGCTTCGAAGTGCTGACCGCGGACAACGGCGAGGACGGGCTGCGCATCGCCCGGGAGGAAGAGATCGACCTGGTGA
TCCTGGACGTGATGCTGCCCGGGATCGACGGATTCGAGGTCCTGCGCGCCCTCCGCCGCCACTCCGAACTGCCGGTGCTG
ATGCTCACCGCCCGGGGCGAGGAGATCGACCGGGTGGTGGGGTTCGAGATCGGCGCCGACGACTACGTGACCAAGCCGTT
CAGCCCCCGGGAGCTGACCGGGCGGGTGAAGGCGATCCTCCGCCGGGCGCGCAGAAGTGCGGAACCCCAGGACCAGGACA
CGCTGGTCCTCGGGCCGCTCACCATCAACTTCGCAAGCTACGAGGTCCTGCGCGACGGCCGGCGCGTGGACCTCACCCCC
ACCGAGTTCCAGATCCTGGGCGTCCTTGCCCGGTCCCCGGGCCGGGTGTTCACCCGGGACGAGCTGGTGGACCGGGTGAT
GGGCCCGGACTTCTACGGCGACGTCCGCACCGTGGACGTGCACATCCGGCACCTCCGGGCCAAGCTGGAGGAAAACCCCT
CCGAGCCCAGGCTGATCGAGACGGTGCGGGGCGTCGGCTACCGGTTCGCCGGGCCGAGGCGCAGGTAG

Upstream 100 bases:

>100_bases
GAGCCCCGAGTTCCAGGAGGAGTACGTGGCGGAGCTGGGCTTCGTGCCCATCACCCGGGAGACTGCCCGCTGAGCCGACC
GCGGCCCCTGTGCGTCGGAG

Downstream 100 bases:

>100_bases
GGCGGTGGCGCAGATGAGGCGTCCGTATCGCCCGGCGCTCCTCTGGTTCGCCCTGCCGCCGGCCGCGGGGGTGACCGTCG
CCCTGGCCTACGCGGCCTCC

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MFPVPERILVVDDEPSILELVAYNLRRAGFEVLTADNGEDGLRIAREEEIDLVILDVMLPGIDGFEVLRALRRHSELPVL
MLTARGEEIDRVVGFEIGADDYVTKPFSPRELTGRVKAILRRARRSAEPQDQDTLVLGPLTINFASYEVLRDGRRVDLTP
TEFQILGVLARSPGRVFTRDELVDRVMGPDFYGDVRTVDVHIRHLRAKLEENPSEPRLIETVRGVGYRFAGPRRR

Sequences:

>Translated_235_residues
MFPVPERILVVDDEPSILELVAYNLRRAGFEVLTADNGEDGLRIAREEEIDLVILDVMLPGIDGFEVLRALRRHSELPVL
MLTARGEEIDRVVGFEIGADDYVTKPFSPRELTGRVKAILRRARRSAEPQDQDTLVLGPLTINFASYEVLRDGRRVDLTP
TEFQILGVLARSPGRVFTRDELVDRVMGPDFYGDVRTVDVHIRHLRAKLEENPSEPRLIETVRGVGYRFAGPRRR
>Mature_235_residues
MFPVPERILVVDDEPSILELVAYNLRRAGFEVLTADNGEDGLRIAREEEIDLVILDVMLPGIDGFEVLRALRRHSELPVL
MLTARGEEIDRVVGFEIGADDYVTKPFSPRELTGRVKAILRRARRSAEPQDQDTLVLGPLTINFASYEVLRDGRRVDLTP
TEFQILGVLARSPGRVFTRDELVDRVMGPDFYGDVRTVDVHIRHLRAKLEENPSEPRLIETVRGVGYRFAGPRRR

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=43.5555555555556, Blast_Score=188, Evalue=2e-49,
Organism=Escherichia coli, GI1786599, Length=227, Percent_Identity=43.1718061674009, Blast_Score=181, Evalue=5e-47,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=40.9691629955947, Blast_Score=176, Evalue=1e-45,
Organism=Escherichia coli, GI87082012, Length=228, Percent_Identity=39.4736842105263, Blast_Score=162, Evalue=1e-41,
Organism=Escherichia coli, GI1790860, Length=229, Percent_Identity=43.2314410480349, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1786784, Length=228, Percent_Identity=40.7894736842105, Blast_Score=160, Evalue=8e-41,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=40.2654867256637, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=38.5650224215247, Blast_Score=150, Evalue=5e-38,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=35.2173913043478, Blast_Score=147, Evalue=8e-37,
Organism=Escherichia coli, GI1787229, Length=236, Percent_Identity=36.0169491525424, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI1790552, Length=225, Percent_Identity=35.1111111111111, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=34.6846846846847, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=31.6017316017316, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=32.4444444444444, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1788550, Length=168, Percent_Identity=29.1666666666667, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1790299, Length=175, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=8e-14,
Organism=Escherichia coli, GI1788905, Length=107, Percent_Identity=35.5140186915888, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI145693157, Length=120, Percent_Identity=31.6666666666667, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1788191, Length=120, Percent_Identity=33.3333333333333, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1790437, Length=128, Percent_Identity=32.8125, Blast_Score=61, Evalue=7e-11,
Organism=Escherichia coli, GI1788713, Length=108, Percent_Identity=35.1851851851852, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26698; Mature: 26698

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPVPERILVVDDEPSILELVAYNLRRAGFEVLTADNGEDGLRIAREEEIDLVILDVMLP
CCCCCCEEEEECCCCCHHHHHHHHHHHCCEEEEECCCCCCCCEEECCCCCCEEEEEECCC
GIDGFEVLRALRRHSELPVLMLTARGEEIDRVVGFEIGADDYVTKPFSPRELTGRVKAIL
CCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHCCEEECCCCCCCCCCCCHHHHHHHHHHH
RRARRSAEPQDQDTLVLGPLTINFASYEVLRDGRRVDLTPTEFQILGVLARSPGRVFTRD
HHHHHCCCCCCCCEEEECCEEEEHHHHHHHHCCCEECCCCCHHHEEEHHHCCCCCEECHH
ELVDRVMGPDFYGDVRTVDVHIRHLRAKLEENPSEPRLIETVRGVGYRFAGPRRR
HHHHHHHCCCCCCCEEEEHHHHHHHHHHHHCCCCCCHHHHHHHHCCEECCCCCCC
>Mature Secondary Structure
MFPVPERILVVDDEPSILELVAYNLRRAGFEVLTADNGEDGLRIAREEEIDLVILDVMLP
CCCCCCEEEEECCCCCHHHHHHHHHHHCCEEEEECCCCCCCCEEECCCCCCEEEEEECCC
GIDGFEVLRALRRHSELPVLMLTARGEEIDRVVGFEIGADDYVTKPFSPRELTGRVKAIL
CCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHCCEEECCCCCCCCCCCCHHHHHHHHHHH
RRARRSAEPQDQDTLVLGPLTINFASYEVLRDGRRVDLTPTEFQILGVLARSPGRVFTRD
HHHHHCCCCCCCCEEEECCEEEEHHHHHHHHCCCEECCCCCHHHEEEHHHCCCCCEECHH
ELVDRVMGPDFYGDVRTVDVHIRHLRAKLEENPSEPRLIETVRGVGYRFAGPRRR
HHHHHHHCCCCCCCEEEEHHHHHHHHHHHHCCCCCCHHHHHHHHCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]