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The map label for this gene is phoR [H]

Identifier: 51891887

GI number: 51891887

Start: 834120

End: 835454

Strand: Reverse

Name: phoR [H]

Synonym: STH749

Alternate gene names: 51891887

Gene position: 835454-834120 (Counterclockwise)

Preceding gene: 51891888

Following gene: 51891886

Centisome position: 23.43

GC content: 73.41

Gene sequence:

>1335_bases
GTGGCGCAGATGAGGCGTCCGTATCGCCCGGCGCTCCTCTGGTTCGCCCTGCCGCCGGCCGCGGGGGTGACCGTCGCCCT
GGCCTACGCGGCCTCCGGCCGCCTGGAGGCGGCGCTCGCCCGGGGGCCGAGGGCGCTGGATCTGGCCGTATGGCTGGCGC
TGCTGGCCGCCCTGCTGATCCCGCCGGTCTACGGATACCGGGAGGCCAGCGGGTTGGCGCGCACCGCCGAGCGCCGCGCG
GACGCCGCGCACCGTGAAGCCCGGCGGGCCGCCCAGGAACGGCTGGACCGGCTCCTGGCGGAGAAGGCCCAGATGGACCT
GATCCTCCAGCACATGGCCGACGGCATCCTGCTGCTGGACGAGCGCCGGCGCATCGTGCTCGTCAACCCCGCCGCCGAAC
GCATGCTGGGCGTCTCCCGGCACGAGGCGCTGGGGCGGGACCACCTGGAGGTCACCCACCACTTCGAGCTGGACGAGCGG
CTGGCCCGGGTGCTGGCCACCGGCCGGCCCGAGGCGCTGGAGATCCGCCGGGCGCACCCGCAGGAGCAGATCCTGGAGGC
CCGCCTCGCCCTGGCGCCCAGCGGGGGCGAGCGCGGCGTGCTGGTCATGCTTCGTGACATCACCCGGTCCCGCCAGCTGG
AGCAGATGCGCACGGAGTTCGTCGCCAACGTCACCCACGAGCTCCGCACCCCCCTCACCTCCATCCAGGGGTTTGCGGAA
ACGCTGCTGGAGGGCGCGCTGGACGAGCCGGAAACGGCCCGCCACTTCGTCGAGATCATGCTCCGGGAGAGCCGCCACCT
GGGCGCGTTGATCGACGAGCTCCTGGACCTCTCCCGGGTGGAGTCGGGCAAGTTCCGCATGCAGCGGCGGCCCACCGTCC
CGGCCGAACTCATCGCCGCCACCGCCGCGCGGTTCGCCCAGAAGGCCGAGCGGGCTGGGGTTCAGTTGGTGACCGAGGCG
CCCGATGGGCTGCCCCTGATCAACGGCGACCCCGACCGGCTGGTCCAGGTGCTGAGCAACCTGGTGGAGAACGCCATCAA
GTACACCCCGGCGGGTGGCCGCATCACCCTCTCTGCCCGGCGGGACGGGGACGGCGTCCGGATCGCGGTCGCGGACACGG
GCGCGGGCATCCCGCAGGCGGACCTGGGACGGATCTTCGAGCGGTTCTACCGGGTGGACAAGGCCCGCTCCCGGGCCACC
GGCGGCACCGGGCTGGGGCTGGCGATCGCCAAGCACATCGTGGAGGCCCACGGCGGCACCATCGGCGTGGAAAGCGAAGT
GGGCAAGGGCAGCACCTTCACCGTGATCCTGCCCGCCCTCACCGGGCCCGAGTAG

Upstream 100 bases:

>100_bases
CTCCGGGCCAAGCTGGAGGAAAACCCCTCCGAGCCCAGGCTGATCGAGACGGTGCGGGGCGTCGGCTACCGGTTCGCCGG
GCCGAGGCGCAGGTAGGGCG

Downstream 100 bases:

>100_bases
ACCGGGCAGACTGCGAAAAGGATATGACCACCGACGGAGGAGGGGTTCGATGGACCGGGTGCGCACCGCAGACCGGCTGG
CGCGGGCCGTGCTCACCGGC

Product: two-component sensor kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MAQMRRPYRPALLWFALPPAAGVTVALAYAASGRLEAALARGPRALDLAVWLALLAALLIPPVYGYREASGLARTAERRA
DAAHREARRAAQERLDRLLAEKAQMDLILQHMADGILLLDERRRIVLVNPAAERMLGVSRHEALGRDHLEVTHHFELDER
LARVLATGRPEALEIRRAHPQEQILEARLALAPSGGERGVLVMLRDITRSRQLEQMRTEFVANVTHELRTPLTSIQGFAE
TLLEGALDEPETARHFVEIMLRESRHLGALIDELLDLSRVESGKFRMQRRPTVPAELIAATAARFAQKAERAGVQLVTEA
PDGLPLINGDPDRLVQVLSNLVENAIKYTPAGGRITLSARRDGDGVRIAVADTGAGIPQADLGRIFERFYRVDKARSRAT
GGTGLGLAIAKHIVEAHGGTIGVESEVGKGSTFTVILPALTGPE

Sequences:

>Translated_444_residues
MAQMRRPYRPALLWFALPPAAGVTVALAYAASGRLEAALARGPRALDLAVWLALLAALLIPPVYGYREASGLARTAERRA
DAAHREARRAAQERLDRLLAEKAQMDLILQHMADGILLLDERRRIVLVNPAAERMLGVSRHEALGRDHLEVTHHFELDER
LARVLATGRPEALEIRRAHPQEQILEARLALAPSGGERGVLVMLRDITRSRQLEQMRTEFVANVTHELRTPLTSIQGFAE
TLLEGALDEPETARHFVEIMLRESRHLGALIDELLDLSRVESGKFRMQRRPTVPAELIAATAARFAQKAERAGVQLVTEA
PDGLPLINGDPDRLVQVLSNLVENAIKYTPAGGRITLSARRDGDGVRIAVADTGAGIPQADLGRIFERFYRVDKARSRAT
GGTGLGLAIAKHIVEAHGGTIGVESEVGKGSTFTVILPALTGPE
>Mature_443_residues
AQMRRPYRPALLWFALPPAAGVTVALAYAASGRLEAALARGPRALDLAVWLALLAALLIPPVYGYREASGLARTAERRAD
AAHREARRAAQERLDRLLAEKAQMDLILQHMADGILLLDERRRIVLVNPAAERMLGVSRHEALGRDHLEVTHHFELDERL
ARVLATGRPEALEIRRAHPQEQILEARLALAPSGGERGVLVMLRDITRSRQLEQMRTEFVANVTHELRTPLTSIQGFAET
LLEGALDEPETARHFVEIMLRESRHLGALIDELLDLSRVESGKFRMQRRPTVPAELIAATAARFAQKAERAGVQLVTEAP
DGLPLINGDPDRLVQVLSNLVENAIKYTPAGGRITLSARRDGDGVRIAVADTGAGIPQADLGRIFERFYRVDKARSRATG
GTGLGLAIAKHIVEAHGGTIGVESEVGKGSTFTVILPALTGPE

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=340, Percent_Identity=35.2941176470588, Blast_Score=178, Evalue=8e-46,
Organism=Escherichia coli, GI145693157, Length=384, Percent_Identity=30.2083333333333, Blast_Score=151, Evalue=7e-38,
Organism=Escherichia coli, GI1788393, Length=226, Percent_Identity=38.0530973451327, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1789149, Length=233, Percent_Identity=34.7639484978541, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1790436, Length=248, Percent_Identity=39.1129032258064, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI48994928, Length=312, Percent_Identity=29.8076923076923, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1788549, Length=349, Percent_Identity=30.6590257879656, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1786912, Length=269, Percent_Identity=34.5724907063197, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1788713, Length=271, Percent_Identity=29.520295202952, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1786783, Length=251, Percent_Identity=31.4741035856574, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI87081816, Length=229, Percent_Identity=33.1877729257642, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1790861, Length=221, Percent_Identity=35.2941176470588, Blast_Score=111, Evalue=8e-26,
Organism=Escherichia coli, GI1790346, Length=230, Percent_Identity=33.0434782608696, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI87082128, Length=230, Percent_Identity=30.8695652173913, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1790300, Length=365, Percent_Identity=26.5753424657534, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1787894, Length=232, Percent_Identity=30.1724137931034, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1790551, Length=212, Percent_Identity=29.2452830188679, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789808, Length=244, Percent_Identity=28.2786885245902, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1787374, Length=244, Percent_Identity=25.4098360655738, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1790567, Length=349, Percent_Identity=25.7879656160458, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1789403, Length=204, Percent_Identity=29.4117647058824, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48499; Mature: 48367

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQMRRPYRPALLWFALPPAAGVTVALAYAASGRLEAALARGPRALDLAVWLALLAALLI
CCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHC
PPVYGYREASGLARTAERRADAAHREARRAAQERLDRLLAEKAQMDLILQHMADGILLLD
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
ERRRIVLVNPAAERMLGVSRHEALGRDHLEVTHHFELDERLARVLATGRPEALEIRRAHP
CCCEEEEECCHHHHHHCCHHHHHCCCCCHHHHHCCCHHHHHHHHHHCCCCHHHHHHHCCC
QEQILEARLALAPSGGERGVLVMLRDITRSRQLEQMRTEFVANVTHELRTPLTSIQGFAE
HHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
TLLEGALDEPETARHFVEIMLRESRHLGALIDELLDLSRVESGKFRMQRRPTVPAELIAA
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHH
TAARFAQKAERAGVQLVTEAPDGLPLINGDPDRLVQVLSNLVENAIKYTPAGGRITLSAR
HHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCEEEEEEC
RDGDGVRIAVADTGAGIPQADLGRIFERFYRVDKARSRATGGTGLGLAIAKHIVEAHGGT
CCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCE
IGVESEVGKGSTFTVILPALTGPE
EECCCCCCCCCEEEEEEECCCCCC
>Mature Secondary Structure 
AQMRRPYRPALLWFALPPAAGVTVALAYAASGRLEAALARGPRALDLAVWLALLAALLI
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHC
PPVYGYREASGLARTAERRADAAHREARRAAQERLDRLLAEKAQMDLILQHMADGILLLD
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
ERRRIVLVNPAAERMLGVSRHEALGRDHLEVTHHFELDERLARVLATGRPEALEIRRAHP
CCCEEEEECCHHHHHHCCHHHHHCCCCCHHHHHCCCHHHHHHHHHHCCCCHHHHHHHCCC
QEQILEARLALAPSGGERGVLVMLRDITRSRQLEQMRTEFVANVTHELRTPLTSIQGFAE
HHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
TLLEGALDEPETARHFVEIMLRESRHLGALIDELLDLSRVESGKFRMQRRPTVPAELIAA
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHH
TAARFAQKAERAGVQLVTEAPDGLPLINGDPDRLVQVLSNLVENAIKYTPAGGRITLSAR
HHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCEEEEEEC
RDGDGVRIAVADTGAGIPQADLGRIFERFYRVDKARSRATGGTGLGLAIAKHIVEAHGGT
CCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCE
IGVESEVGKGSTFTVILPALTGPE
EECCCCCCCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]