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The map label for this gene is pleC [H]

Identifier: 51891870

GI number: 51891870

Start: 815751

End: 817505

Strand: Reverse

Name: pleC [H]

Synonym: STH732

Alternate gene names: 51891870

Gene position: 817505-815751 (Counterclockwise)

Preceding gene: 51891876

Following gene: 51891869

Centisome position: 22.92

GC content: 68.38

Gene sequence:

>1755_bases
ATGTGGCACGAATGGTGCATGTCCCCCTGGTCACTTCGTGCACCCAAGGGGCAGGCTAGCCGCTTTATGGGCAAACATGT
CGCGGAGCCGTATGATTTAACCATGAACACCACGGCCCCCGGAGGTGAACCCGTGCACACCAGCATCGCGACCAAGTTCA
TGATCGGCGTCACCGCCGCGCTCGTGACCGTTCTGGGCGTCAACCTGGGGCTGGACATCCGGCAACAGCGGGCCCAGGCG
GAGGAGGATCTGCGGGAGCAGGCGCGGATGGTCGCGACCCAGGTCATCGCGATGCGGGAGTTCATCGCCCGCAACCAGGA
CCGGATCAACCGGGACAGCCACGGCCACTTTGAGTTCAAGTACCTGAACCCGGCTGCCGTCGGCCGGGGCGTCGGCCAGA
TCTTCGCCGAGATGTCCGACTACCAGTACAAGCAGACCCGCCTTCAGGTGCGTATGGCCGAGAACATGCCGGACGCCTTC
GAGGTGGAGGCCCTTCGCCGGTTTGCCAGCAATCCGGACCTGGCGGAGGTCGTCGGGTACACGGGATCCGGGCAGGACCG
GGTGTTCCGCTACATGGTGCCGCTGAAGATGGAGGCCTCCTGCCTGCCGTGTCACGGTCCCCCCGCCGGCGAACCGGACA
TCGCCGGCTACCCCAAGGAAGGGCTCCAGGTGGGAGAACTGGCCGGCGCCCTGTCGATCACGATCCCCACCGAGCGGTTC
GAGGCCCGGCTCACGCAATCTACCCGCAGCCGGGCGACGGTCATCGTCCTGGCGACCGGGCTCTCACTGGCCCTGATCGG
ATTCCTCAACCACCAGCTGGTGGCACGGCCCCTCGCCGCCCTGGCCGGGGTGACCCGGCGCATCGGACAGGGCCGGTGGG
AAGTGCCCGAGGAGGAGGTGCGGGACCTCAGGGCCCACCAGGAGACGTCGCCGCTGGTGGACGCCATCCAGGCCATGTCG
GATGAGCTGCAGGCGCTCTACCGGAACCTGGAGCGGAAGGTGGCGGAGCGCACCCGCCAGCTGCAGGAAGCCCACGCGGA
CCTGGAGGCGCTGCACCGGAGCCAGACAGAGTTTTACTCGGCGATGACCCACGAGTTCCGCACGCCGCTGACGTCCATCA
TCGGCTTCAGCCAGCTGCTCCTGAGCCCCGGGGGCGACCCCCTGACGCCCGGCCAGCGGGAGCATTTGAAGGACATCCTG
GAGAGCGCGCAGCGGCTGCTGCAGCTGGTGAACGATCTGCTGGACGCCTCCCGCCTGCAGGCCGGCCAGATGCCACTCCG
AATCGCCGCCGTCGACCTGGGCGAGGCGGTGCAGGAGGCGCTGGCGGTGGTCCGGCCCCTGGCCCAGCAGCGGGAGATCA
CGGTCACCTGCCACATCCCCGCCGATCTGCCGCTGGTGGCGGCCGACGACCTGCGGGTGCTCCAGATCCTGCTGAACCTG
CTCAGCAACGCGATCAAGTTCACCCAGGTCGGCGGCGAGGTTGCGCTGACGGCGGAGGCCCGGAGCGACCTGGTGCAGGT
ATCGGTCCGGGACAACGGCCCCGGCATTCCGCCCGAGGACCATGAGGTGATCTTCCAGCTGTTCCGCCGGGGATCCGCCC
ACGAACGGACCGGCGGGTCCGGTCTGGGCCTCGCTCTGGCCAAGCTCCTGGTGGAGCTGCACGGGGGCCGGATCTGGGTC
GAGAGCAGACCGGGATGCGGCTCCACGTTCCACTTCACCCTGCCCGTGCACGGAGGTGAACCGCGGTGTCCGTAG

Upstream 100 bases:

>100_bases
CTATGCACGCGCCCATCGACCGCCCGCCGCCGCGGCGGCGGGCTCGCCGCGCGCGCGGCGGGCGCTTCCATATAGGCGCG
CTCCGGAAGCAGGCGGCGAA

Downstream 100 bases:

>100_bases
CTCGCCGGATTCTGGTGGCCGACGACGACCCGAAGACCCTGAAGGTCCTGGAGCATGCGCTGACCGCCGAGGGGTTCGCG
GTGATCAAGGCCAGCGACGG

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 584; Mature: 584

Protein sequence:

>584_residues
MWHEWCMSPWSLRAPKGQASRFMGKHVAEPYDLTMNTTAPGGEPVHTSIATKFMIGVTAALVTVLGVNLGLDIRQQRAQA
EEDLREQARMVATQVIAMREFIARNQDRINRDSHGHFEFKYLNPAAVGRGVGQIFAEMSDYQYKQTRLQVRMAENMPDAF
EVEALRRFASNPDLAEVVGYTGSGQDRVFRYMVPLKMEASCLPCHGPPAGEPDIAGYPKEGLQVGELAGALSITIPTERF
EARLTQSTRSRATVIVLATGLSLALIGFLNHQLVARPLAALAGVTRRIGQGRWEVPEEEVRDLRAHQETSPLVDAIQAMS
DELQALYRNLERKVAERTRQLQEAHADLEALHRSQTEFYSAMTHEFRTPLTSIIGFSQLLLSPGGDPLTPGQREHLKDIL
ESAQRLLQLVNDLLDASRLQAGQMPLRIAAVDLGEAVQEALAVVRPLAQQREITVTCHIPADLPLVAADDLRVLQILLNL
LSNAIKFTQVGGEVALTAEARSDLVQVSVRDNGPGIPPEDHEVIFQLFRRGSAHERTGGSGLGLALAKLLVELHGGRIWV
ESRPGCGSTFHFTLPVHGGEPRCP

Sequences:

>Translated_584_residues
MWHEWCMSPWSLRAPKGQASRFMGKHVAEPYDLTMNTTAPGGEPVHTSIATKFMIGVTAALVTVLGVNLGLDIRQQRAQA
EEDLREQARMVATQVIAMREFIARNQDRINRDSHGHFEFKYLNPAAVGRGVGQIFAEMSDYQYKQTRLQVRMAENMPDAF
EVEALRRFASNPDLAEVVGYTGSGQDRVFRYMVPLKMEASCLPCHGPPAGEPDIAGYPKEGLQVGELAGALSITIPTERF
EARLTQSTRSRATVIVLATGLSLALIGFLNHQLVARPLAALAGVTRRIGQGRWEVPEEEVRDLRAHQETSPLVDAIQAMS
DELQALYRNLERKVAERTRQLQEAHADLEALHRSQTEFYSAMTHEFRTPLTSIIGFSQLLLSPGGDPLTPGQREHLKDIL
ESAQRLLQLVNDLLDASRLQAGQMPLRIAAVDLGEAVQEALAVVRPLAQQREITVTCHIPADLPLVAADDLRVLQILLNL
LSNAIKFTQVGGEVALTAEARSDLVQVSVRDNGPGIPPEDHEVIFQLFRRGSAHERTGGSGLGLALAKLLVELHGGRIWV
ESRPGCGSTFHFTLPVHGGEPRCP
>Mature_584_residues
MWHEWCMSPWSLRAPKGQASRFMGKHVAEPYDLTMNTTAPGGEPVHTSIATKFMIGVTAALVTVLGVNLGLDIRQQRAQA
EEDLREQARMVATQVIAMREFIARNQDRINRDSHGHFEFKYLNPAAVGRGVGQIFAEMSDYQYKQTRLQVRMAENMPDAF
EVEALRRFASNPDLAEVVGYTGSGQDRVFRYMVPLKMEASCLPCHGPPAGEPDIAGYPKEGLQVGELAGALSITIPTERF
EARLTQSTRSRATVIVLATGLSLALIGFLNHQLVARPLAALAGVTRRIGQGRWEVPEEEVRDLRAHQETSPLVDAIQAMS
DELQALYRNLERKVAERTRQLQEAHADLEALHRSQTEFYSAMTHEFRTPLTSIIGFSQLLLSPGGDPLTPGQREHLKDIL
ESAQRLLQLVNDLLDASRLQAGQMPLRIAAVDLGEAVQEALAVVRPLAQQREITVTCHIPADLPLVAADDLRVLQILLNL
LSNAIKFTQVGGEVALTAEARSDLVQVSVRDNGPGIPPEDHEVIFQLFRRGSAHERTGGSGLGLALAKLLVELHGGRIWV
ESRPGCGSTFHFTLPVHGGEPRCP

Specific function: Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator pleD, leading to its activation [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=353, Percent_Identity=32.2946175637394, Blast_Score=158, Evalue=8e-40,
Organism=Escherichia coli, GI87081816, Length=412, Percent_Identity=29.126213592233, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI145693157, Length=247, Percent_Identity=33.6032388663968, Blast_Score=128, Evalue=1e-30,
Organism=Escherichia coli, GI1786912, Length=267, Percent_Identity=32.2097378277154, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1788713, Length=231, Percent_Identity=33.3333333333333, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI48994928, Length=251, Percent_Identity=34.6613545816733, Blast_Score=122, Evalue=8e-29,
Organism=Escherichia coli, GI1790436, Length=244, Percent_Identity=33.1967213114754, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1788549, Length=222, Percent_Identity=31.981981981982, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1786600, Length=255, Percent_Identity=31.3725490196078, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1788393, Length=248, Percent_Identity=28.6290322580645, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI87082128, Length=250, Percent_Identity=31.2, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1790346, Length=232, Percent_Identity=30.1724137931034, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1786783, Length=234, Percent_Identity=31.6239316239316, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1790300, Length=241, Percent_Identity=30.7053941908714, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1787894, Length=241, Percent_Identity=28.6307053941909, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1788279, Length=272, Percent_Identity=24.6323529411765, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1790861, Length=230, Percent_Identity=33.0434782608696, Blast_Score=73, Evalue=6e-14,
Organism=Escherichia coli, GI1789808, Length=244, Percent_Identity=25, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789403, Length=218, Percent_Identity=28.8990825688073, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 64286; Mature: 64286

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWHEWCMSPWSLRAPKGQASRFMGKHVAEPYDLTMNTTAPGGEPVHTSIATKFMIGVTAA
CCHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHH
LVTVLGVNLGLDIRQQRAQAEEDLREQARMVATQVIAMREFIARNQDRINRDSHGHFEFK
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCEEEE
YLNPAAVGRGVGQIFAEMSDYQYKQTRLQVRMAENMPDAFEVEALRRFASNPDLAEVVGY
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHCC
TGSGQDRVFRYMVPLKMEASCLPCHGPPAGEPDIAGYPKEGLQVGELAGALSITIPTERF
CCCCHHHHEEEECCCEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCEEEEEECHHHH
EARLTQSTRSRATVIVLATGLSLALIGFLNHQLVARPLAALAGVTRRIGQGRWEVPEEEV
HHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
RDLRAHQETSPLVDAIQAMSDELQALYRNLERKVAERTRQLQEAHADLEALHRSQTEFYS
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMTHEFRTPLTSIIGFSQLLLSPGGDPLTPGQREHLKDILESAQRLLQLVNDLLDASRLQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGQMPLRIAAVDLGEAVQEALAVVRPLAQQREITVTCHIPADLPLVAADDLRVLQILLNL
CCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEECCHHHHHHHHHHH
LSNAIKFTQVGGEVALTAEARSDLVQVSVRDNGPGIPPEDHEVIFQLFRRGSAHERTGGS
HHHHHHHHCCCCCEEEEEHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCC
GLGLALAKLLVELHGGRIWVESRPGCGSTFHFTLPVHGGEPRCP
HHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEEECCCCCCCC
>Mature Secondary Structure
MWHEWCMSPWSLRAPKGQASRFMGKHVAEPYDLTMNTTAPGGEPVHTSIATKFMIGVTAA
CCHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHH
LVTVLGVNLGLDIRQQRAQAEEDLREQARMVATQVIAMREFIARNQDRINRDSHGHFEFK
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCEEEE
YLNPAAVGRGVGQIFAEMSDYQYKQTRLQVRMAENMPDAFEVEALRRFASNPDLAEVVGY
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHCC
TGSGQDRVFRYMVPLKMEASCLPCHGPPAGEPDIAGYPKEGLQVGELAGALSITIPTERF
CCCCHHHHEEEECCCEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCEEEEEECHHHH
EARLTQSTRSRATVIVLATGLSLALIGFLNHQLVARPLAALAGVTRRIGQGRWEVPEEEV
HHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
RDLRAHQETSPLVDAIQAMSDELQALYRNLERKVAERTRQLQEAHADLEALHRSQTEFYS
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMTHEFRTPLTSIIGFSQLLLSPGGDPLTPGQREHLKDILESAQRLLQLVNDLLDASRLQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGQMPLRIAAVDLGEAVQEALAVVRPLAQQREITVTCHIPADLPLVAADDLRVLQILLNL
CCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEECCHHHHHHHHHHH
LSNAIKFTQVGGEVALTAEARSDLVQVSVRDNGPGIPPEDHEVIFQLFRRGSAHERTGGS
HHHHHHHHCCCCCEEEEEHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCC
GLGLALAKLLVELHGGRIWVESRPGCGSTFHFTLPVHGGEPRCP
HHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8421698; 11259647 [H]