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The map label for this gene is yycF [H]

Identifier: 51891869

GI number: 51891869

Start: 815065

End: 815760

Strand: Reverse

Name: yycF [H]

Synonym: STH731

Alternate gene names: 51891869

Gene position: 815760-815065 (Counterclockwise)

Preceding gene: 51891870

Following gene: 51891868

Centisome position: 22.88

GC content: 68.82

Gene sequence:

>696_bases
GTGTCCGTAGCTCGCCGGATTCTGGTGGCCGACGACGACCCGAAGACCCTGAAGGTCCTGGAGCATGCGCTGACCGCCGA
GGGGTTCGCGGTGATCAAGGCCAGCGACGGCCAGGAGGCCCTGGACCTCGCCCTGTCGCAACGGCCGGACCTGGTCATCC
TCGACGTCATGATGCCGAAAGTGGACGGCTTCGCGGTCTGTGGCCGCATTCGCGCCGCCTCGGCGGTGCCGATCCTCCTG
CTCACCGCCAGGGGCGACAGCGTCGACAAGGTCGTCGGCTTCCGGCTGGGGGCCGACGACTACGTGACCAAACCCTTCGA
CCTGAACGAGCTGGTGCTGCGGGTGCACGCCATCCTGCGCCGGATGCCCACCCTGCCCGAGAGCCGCACCCTGCGCTTCG
GCCACCTGGAGATCAACAAGAGCACGCGCACGGTGCACGTGGGCGACCGGAACCCGGAGCTCACCCCCAGGGAGTTCGAC
CTGCTCTGGCTGATGGCCAGCCACCCGGGCCACCCCTTCACCCGGGAGTCCCTCCTGGCCCGCGTGTGGCACGGCGACGC
ACCCACCGACCAGTCCACCGTCACCGTCTGCATCCGCCGGCTCCGGGAGAAGATCGAGGACAACCCCGCTCAGCCCCGGT
GGATCAAGACGGTCTGGGGAATCGGCTACAAGTTCGATCCGGCGGGCGCCGAATGA

Upstream 100 bases:

>100_bases
TCCTGGTGGAGCTGCACGGGGGCCGGATCTGGGTCGAGAGCAGACCGGGATGCGGCTCCACGTTCCACTTCACCCTGCCC
GTGCACGGAGGTGAACCGCG

Downstream 100 bases:

>100_bases
AGGCGCCCGCCGGTTTTCTTCTGATTCACCAAAACCCAAGGACCGTGTAAGCCTTGTGTAATCAATGGCTGATACGCTGA
GGGTGAGGAGAAAGGGGGTG

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 230

Protein sequence:

>231_residues
MSVARRILVADDDPKTLKVLEHALTAEGFAVIKASDGQEALDLALSQRPDLVILDVMMPKVDGFAVCGRIRAASAVPILL
LTARGDSVDKVVGFRLGADDYVTKPFDLNELVLRVHAILRRMPTLPESRTLRFGHLEINKSTRTVHVGDRNPELTPREFD
LLWLMASHPGHPFTRESLLARVWHGDAPTDQSTVTVCIRRLREKIEDNPAQPRWIKTVWGIGYKFDPAGAE

Sequences:

>Translated_231_residues
MSVARRILVADDDPKTLKVLEHALTAEGFAVIKASDGQEALDLALSQRPDLVILDVMMPKVDGFAVCGRIRAASAVPILL
LTARGDSVDKVVGFRLGADDYVTKPFDLNELVLRVHAILRRMPTLPESRTLRFGHLEINKSTRTVHVGDRNPELTPREFD
LLWLMASHPGHPFTRESLLARVWHGDAPTDQSTVTVCIRRLREKIEDNPAQPRWIKTVWGIGYKFDPAGAE
>Mature_230_residues
SVARRILVADDDPKTLKVLEHALTAEGFAVIKASDGQEALDLALSQRPDLVILDVMMPKVDGFAVCGRIRAASAVPILLL
TARGDSVDKVVGFRLGADDYVTKPFDLNELVLRVHAILRRMPTLPESRTLRFGHLEINKSTRTVHVGDRNPELTPREFDL
LWLMASHPGHPFTRESLLARVWHGDAPTDQSTVTVCIRRLREKIEDNPAQPRWIKTVWGIGYKFDPAGAE

Specific function: Member of the two-component regulatory system YycG/YycF involved in the regulation of the ftsAZ operon, the yocH, ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Probably phosphorylates YycF. Binds to the ftsAZ P1 promoter seque

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=238, Percent_Identity=37.8151260504202, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=36.8181818181818, Blast_Score=146, Evalue=9e-37,
Organism=Escherichia coli, GI1786599, Length=226, Percent_Identity=35.3982300884956, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=36.4864864864865, Blast_Score=142, Evalue=1e-35,
Organism=Escherichia coli, GI1786911, Length=221, Percent_Identity=35.2941176470588, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1788394, Length=222, Percent_Identity=34.2342342342342, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=36.1990950226244, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=32.5991189427313, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI2367329, Length=225, Percent_Identity=37.3333333333333, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1790552, Length=219, Percent_Identity=36.5296803652968, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1787229, Length=224, Percent_Identity=33.0357142857143, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI145693140, Length=236, Percent_Identity=31.7796610169492, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=32.7354260089686, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1789402, Length=219, Percent_Identity=32.4200913242009, Blast_Score=104, Evalue=4e-24,
Organism=Escherichia coli, GI1788550, Length=193, Percent_Identity=31.0880829015544, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790437, Length=208, Percent_Identity=30.2884615384615, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790299, Length=107, Percent_Identity=35.5140186915888, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1787487, Length=130, Percent_Identity=32.3076923076923, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788905, Length=106, Percent_Identity=36.7924528301887, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1788713, Length=136, Percent_Identity=32.3529411764706, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25772; Mature: 25641

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVARRILVADDDPKTLKVLEHALTAEGFAVIKASDGQEALDLALSQRPDLVILDVMMPK
CCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCEEEEEEECCC
VDGFAVCGRIRAASAVPILLLTARGDSVDKVVGFRLGADDYVTKPFDLNELVLRVHAILR
CCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHEEEECCCCCCCCCCCHHHHHHHHHHHHH
RMPTLPESRTLRFGHLEINKSTRTVHVGDRNPELTPREFDLLWLMASHPGHPFTRESLLA
HCCCCCCCCCEEEEEEEECCCCEEEEECCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHH
RVWHGDAPTDQSTVTVCIRRLREKIEDNPAQPRWIKTVWGIGYKFDPAGAE
HHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCEEECCCCCC
>Mature Secondary Structure 
SVARRILVADDDPKTLKVLEHALTAEGFAVIKASDGQEALDLALSQRPDLVILDVMMPK
CCCCEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCEEEEEEECCC
VDGFAVCGRIRAASAVPILLLTARGDSVDKVVGFRLGADDYVTKPFDLNELVLRVHAILR
CCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHEEEECCCCCCCCCCCHHHHHHHHHHHHH
RMPTLPESRTLRFGHLEINKSTRTVHVGDRNPELTPREFDLLWLMASHPGHPFTRESLLA
HCCCCCCCCCEEEEEEEECCCCEEEEECCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHH
RVWHGDAPTDQSTVTVCIRRLREKIEDNPAQPRWIKTVWGIGYKFDPAGAE
HHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 9829949; 10878122 [H]