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The map label for this gene is argD

Identifier: 51598021

GI number: 51598021

Start: 4425772

End: 4426989

Strand: Reverse

Name: argD

Synonym: YPTB3731

Alternate gene names: 51598021

Gene position: 4426989-4425772 (Counterclockwise)

Preceding gene: 51598022

Following gene: 51598018

Centisome position: 93.3

GC content: 53.04

Gene sequence:

>1218_bases
ATGACAGATAAGTTAGCAGTGAATCGCAACACATTCGATCAGGTCATTTTGCCTGTTTATGCACCCGCGCAGTTTATCCC
AGTAAAAGGGAAAGGCAGCCGAGTGTGGGATCAACAAGGTACGGAGTACATTGATTTCGCCGGTGGCATTGCGGTTACCG
CACTGGGCCATTGCCATCCGGCACTGGTATCCGCATTGCATCAGCAGGGTGAAACGTTGTGGCACACCAGTAATGTGTTT
ACCAATGAGCCAGCACTGCGTTTAGCACAGAAGCTGATTGCCGCAACCTTTGCTGACCGGGTTTTCTTTGCCAACTCGGG
TGCTGAAGCGAATGAAGCGGCATTTAAGTTAGCTCGCCATTACGCTATTGAGCGTCATAGCCCCTATAAAACCAAGATTA
TTGCTTTCCACAATGCGTTTCATGGCCGCACCCTGTTTACGGTCTCTGTCGGGGGGCAGCCAAAGTATTCCGATGGTTTT
GGCCCGAAACCTGCGGATATCATCCATGTCCCGTTTAATGATCTGGCGGCAGTGAAAGCGGTGATGGATGATCACACCTG
TGCCGTGGTACTGGAACCGATTCAGGGAGAGGGCGGGATCACTTCTGCCACGCCAGAGTTCCTACAAGGGGTGCGCGCGT
TGTGCGATCAACATAACGCCCTGCTGGTGTTTGATGAAGTGCAAAGCGGTATGGGGCGCAGTGGCAAGTTGTTTAGCTAT
ATGCATCATGGTGTGACGCCGGATATCCTTACCACGGCGAAGGCATTGGGCGGTGGCTTCCCAATCAGTGCGATGCTAAC
GACCGAAGAGATCGCTTCAGTGATGACGGTGGGTACCCACGGAACCACCTATGGGGGTAATCCTCTGGCCTGTGCGGTCG
CTGAGGCCGCGTTGGATGTGATTAATACCCCTGAGGTACTTAATGGTATTGAACAGCGCCATGGTCTGTTTGTGCAGGCG
CTACAAAGCATCAACAGCAAGTATGATGTTTTCAGTGATATTCGTGGTATGGGGTTGTTGATTGGCGCGGAGTTAACCGC
GAAATACCGGGGGCAGGCGCGTGAGTTCCTGGCCGCCGCTGCCGCTAACGGCTTGATGATCCTCAATGCGGGTCCAGATG
TTCTGCGGTTAGCGCCCTCGCTGGTGATTGAATTGGAGGATATCCAGCAAGGGATGGCGCGGTTGGAGAAAGCAATGGCG
AGTGTGATCAAAGGTTAA

Upstream 100 bases:

>100_bases
TTATCATTTGCTTGCGGATGATTTTTTATGCATATTTTGTGAGTATATTTTCACATGTCAATAAATAACAGCTTAGTGGT
TTATTAGGGTGGGCAGCGTA

Downstream 100 bases:

>100_bases
GCAGCCAATAACCGCGTTATGGAGAGGCGCTAGCCTCTCAGACTGCTGACAAACCCCGATGACGCGATCTTGAATGGTGA
GGATAGGCAGAGGAGTAAAG

Product: bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein

Products: NA

Alternate protein names: ACOAT; DapATase; Succinyldiaminopimelate transferase [H]

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MTDKLAVNRNTFDQVILPVYAPAQFIPVKGKGSRVWDQQGTEYIDFAGGIAVTALGHCHPALVSALHQQGETLWHTSNVF
TNEPALRLAQKLIAATFADRVFFANSGAEANEAAFKLARHYAIERHSPYKTKIIAFHNAFHGRTLFTVSVGGQPKYSDGF
GPKPADIIHVPFNDLAAVKAVMDDHTCAVVLEPIQGEGGITSATPEFLQGVRALCDQHNALLVFDEVQSGMGRSGKLFSY
MHHGVTPDILTTAKALGGGFPISAMLTTEEIASVMTVGTHGTTYGGNPLACAVAEAALDVINTPEVLNGIEQRHGLFVQA
LQSINSKYDVFSDIRGMGLLIGAELTAKYRGQAREFLAAAAANGLMILNAGPDVLRLAPSLVIELEDIQQGMARLEKAMA
SVIKG

Sequences:

>Translated_405_residues
MTDKLAVNRNTFDQVILPVYAPAQFIPVKGKGSRVWDQQGTEYIDFAGGIAVTALGHCHPALVSALHQQGETLWHTSNVF
TNEPALRLAQKLIAATFADRVFFANSGAEANEAAFKLARHYAIERHSPYKTKIIAFHNAFHGRTLFTVSVGGQPKYSDGF
GPKPADIIHVPFNDLAAVKAVMDDHTCAVVLEPIQGEGGITSATPEFLQGVRALCDQHNALLVFDEVQSGMGRSGKLFSY
MHHGVTPDILTTAKALGGGFPISAMLTTEEIASVMTVGTHGTTYGGNPLACAVAEAALDVINTPEVLNGIEQRHGLFVQA
LQSINSKYDVFSDIRGMGLLIGAELTAKYRGQAREFLAAAAANGLMILNAGPDVLRLAPSLVIELEDIQQGMARLEKAMA
SVIKG
>Mature_404_residues
TDKLAVNRNTFDQVILPVYAPAQFIPVKGKGSRVWDQQGTEYIDFAGGIAVTALGHCHPALVSALHQQGETLWHTSNVFT
NEPALRLAQKLIAATFADRVFFANSGAEANEAAFKLARHYAIERHSPYKTKIIAFHNAFHGRTLFTVSVGGQPKYSDGFG
PKPADIIHVPFNDLAAVKAVMDDHTCAVVLEPIQGEGGITSATPEFLQGVRALCDQHNALLVFDEVQSGMGRSGKLFSYM
HHGVTPDILTTAKALGGGFPISAMLTTEEIASVMTVGTHGTTYGGNPLACAVAEAALDVINTPEVLNGIEQRHGLFVQAL
QSINSKYDVFSDIRGMGLLIGAELTAKYRGQAREFLAAAAANGLMILNAGPDVLRLAPSLVIELEDIQQGMARLEKAMAS
VIKG

Specific function: Involved in both the arginine and lysine biosynthetic pathways [H]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=387, Percent_Identity=35.9173126614987, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI284507298, Length=301, Percent_Identity=36.5448504983389, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI13994255, Length=412, Percent_Identity=28.6407766990291, Blast_Score=168, Evalue=8e-42,
Organism=Homo sapiens, GI37574042, Length=413, Percent_Identity=28.3292978208232, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI24119277, Length=412, Percent_Identity=27.1844660194175, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI226442709, Length=386, Percent_Identity=28.7564766839378, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI226442705, Length=413, Percent_Identity=27.1186440677966, Blast_Score=131, Evalue=1e-30,
Organism=Escherichia coli, GI1789759, Length=401, Percent_Identity=77.3067331670823, Blast_Score=660, Evalue=0.0,
Organism=Escherichia coli, GI1788044, Length=392, Percent_Identity=63.0102040816327, Blast_Score=534, Evalue=1e-153,
Organism=Escherichia coli, GI1789016, Length=395, Percent_Identity=36.4556962025316, Blast_Score=231, Evalue=9e-62,
Organism=Escherichia coli, GI145693181, Length=389, Percent_Identity=35.73264781491, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1787560, Length=403, Percent_Identity=33.2506203473945, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI1786991, Length=315, Percent_Identity=32.3809523809524, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1786349, Length=302, Percent_Identity=31.1258278145695, Blast_Score=122, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI25144271, Length=376, Percent_Identity=37.5, Blast_Score=249, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI25144274, Length=260, Percent_Identity=38.4615384615385, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI32564660, Length=423, Percent_Identity=30.4964539007092, Blast_Score=184, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI71992977, Length=430, Percent_Identity=27.906976744186, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17541228, Length=439, Percent_Identity=25.0569476082005, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71981843, Length=165, Percent_Identity=32.7272727272727, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324432, Length=396, Percent_Identity=39.6464646464646, Blast_Score=290, Evalue=3e-79,
Organism=Saccharomyces cerevisiae, GI6323470, Length=402, Percent_Identity=35.3233830845771, Blast_Score=221, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6324386, Length=314, Percent_Identity=30.8917197452229, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6321456, Length=429, Percent_Identity=24.7086247086247, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21357415, Length=388, Percent_Identity=35.5670103092784, Blast_Score=232, Evalue=4e-61,
Organism=Drosophila melanogaster, GI161085790, Length=415, Percent_Identity=29.1566265060241, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI28574759, Length=404, Percent_Identity=29.4554455445545, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI21356575, Length=422, Percent_Identity=27.2511848341232, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI281366494, Length=438, Percent_Identity=22.8310502283105, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24667139, Length=438, Percent_Identity=22.8310502283105, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24667143, Length=438, Percent_Identity=22.8310502283105, Blast_Score=99, Evalue=7e-21,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR017652 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11; =2.6.1.17 [H]

Molecular weight: Translated: 43305; Mature: 43174

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDKLAVNRNTFDQVILPVYAPAQFIPVKGKGSRVWDQQGTEYIDFAGGIAVTALGHCHP
CCCCEECCCCCHHHEEEEEECCCEEEEECCCCCCCHHCCCCEEEECCCCHHHHHHHCCHH
ALVSALHQQGETLWHTSNVFTNEPALRLAQKLIAATFADRVFFANSGAEANEAAFKLARH
HHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHH
YAIERHSPYKTKIIAFHNAFHGRTLFTVSVGGQPKYSDGFGPKPADIIHVPFNDLAAVKA
HHHHCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEECCHHHHHHHH
VMDDHTCAVVLEPIQGEGGITSATPEFLQGVRALCDQHNALLVFDEVQSGMGRSGKLFSY
HHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCCHHHH
MHHGVTPDILTTAKALGGGFPISAMLTTEEIASVMTVGTHGTTYGGNPLACAVAEAALDV
HHCCCCHHHHHHHHHHCCCCCEEEEEEHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHH
INTPEVLNGIEQRHGLFVQALQSINSKYDVFSDIRGMGLLIGAELTAKYRGQAREFLAAA
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHH
AANGLMILNAGPDVLRLAPSLVIELEDIQQGMARLEKAMASVIKG
HCCCEEEEECCCHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TDKLAVNRNTFDQVILPVYAPAQFIPVKGKGSRVWDQQGTEYIDFAGGIAVTALGHCHP
CCCEECCCCCHHHEEEEEECCCEEEEECCCCCCCHHCCCCEEEECCCCHHHHHHHCCHH
ALVSALHQQGETLWHTSNVFTNEPALRLAQKLIAATFADRVFFANSGAEANEAAFKLARH
HHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHH
YAIERHSPYKTKIIAFHNAFHGRTLFTVSVGGQPKYSDGFGPKPADIIHVPFNDLAAVKA
HHHHCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEECCHHHHHHHH
VMDDHTCAVVLEPIQGEGGITSATPEFLQGVRALCDQHNALLVFDEVQSGMGRSGKLFSY
HHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCCHHHH
MHHGVTPDILTTAKALGGGFPISAMLTTEEIASVMTVGTHGTTYGGNPLACAVAEAALDV
HHCCCCHHHHHHHHHHCCCCCEEEEEEHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHH
INTPEVLNGIEQRHGLFVQALQSINSKYDVFSDIRGMGLLIGAELTAKYRGQAREFLAAA
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHH
AANGLMILNAGPDVLRLAPSLVIELEDIQQGMARLEKAMASVIKG
HCCCEEEEECCCHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]