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The map label for this gene is nhaB

Identifier: 51596397

GI number: 51596397

Start: 2437844

End: 2439418

Strand: Reverse

Name: nhaB

Synonym: YPTB2071

Alternate gene names: 51596397

Gene position: 2439418-2437844 (Counterclockwise)

Preceding gene: 51596399

Following gene: 51596396

Centisome position: 51.41

GC content: 46.6

Gene sequence:

>1575_bases
ATGGACATTACCAACAGACAAGCTGTACTCAAGAATTTTCTTGGTAACTCTCCGGATTGGTACAAACTAGCAATTATGGG
GTTCTTGATCATTAACCCTCTAGTCTTCTTCTTTGTCAGCCCCTTTGTCGCGGGCTGGATGCTGGTTATCGAGTTTATCT
TTACCTTAGCCATGGCGCTGAAATGTTACCCGCTGCAACCGGGGGGTTTGCTCGCTATTCAAGCCGTTGCCATCGGCATG
ACCAGCCCGCATCAAGTTGCAGAAGAGATCGCCAATAACCTGGAAGTCCTCTTGCTTTTAGTATTTATGGTGGCCGGCAT
CTACTTTATGAAACAGCTGCTGCTGTTTGTATTTACGAAATTGCTGTTGAATATTCGGTCAAAAACTATCCTTTCCCTGG
CCTTTTGTCTGGCGTCAGCCTTCCTATCAGCATTTTTGGATGCCTTAACCGTAATCGCGGTAGTTATCAGCGTATCCGTT
GGTTTTTATACTATTTATCATAACGTTACTTCAAATCACAGTGACAAAGATATTACTGATGACAGCGGAATCGATAATCA
GGACAGCCATGAAACATTAGAGCAATTCCGGGCATTTTTACGCAGTCTGATGATGCATGCTGGCGTGGGTACCGCTCTGG
GGGGCGTCATGACAATGGTTGGTGAGCCTCAGAATTTGATTATTGCCAAAAGCGCGGGTTGGAATTTTGCTGACTTCTTT
ATTCGCATGTTACCCGTCACCTTACCCGTCTTTATTTTCGGGTTATTGGTCTGCTTGCTGGTCGAAAAATTTAAACTGTT
TGGTTATGGTGCCCAGTTGCCAGAACGTGTGCGTCAGGTTCTGACCGAATACGATCAGCAAGCCAGTGCGAAACGGACCA
AGCAAGAGAAGATGAAGTTAATAGTACAAGCCATTATTGGTGTCTGGTTGGTATTGGCACTGGCACTCCATTTAGCTGAA
GTCGGTTTGGTCGGGCTATCCGTTATTATTCTCGCCACCTCATTTTGTGGTATCACAAATGAGCATTCATTGGGCAAAGC
CTTTCAGGAAGCCTTGCCGTTTACCGCGCTGCTAACCGTATTTTTTGCCGTGGTCGCGGTTATTATTGAACAAAGCCTCT
TTACCCCCATTATTCAGTTTGTTTTACAAGCCTCGCCTTCCGCTCAGCTATCGCTGTTTTATCTGTTTAATGGCTTGCTC
TCATCGGTGTCAGACAATGTTTTTGTCGGTACCGTGTATATCAATGAGGCCCGTTCTGCGTTTGAGCATGGTATTGTCTC
GTTACAACAATTTGAATTGTTGGCGGTCGCCATCAATACAGGGACCAACCTCCCCTCCGTGGCGACACCAAACGGCCAGG
CCGCTTTCTTGTTCCTGCTGACTTCGGCATTGGCACCACTAATTCGCCTTTCCTATGGGCGAATGGTATATATGGCTTTG
CCTTATACTCTAGTGATGACGATTGTTGGCCTGCTGGGTGTCGAGTTTTTATTGGTACCGATGACAGAGTGGCTGACTCA
GGCTGGATGGATCAGTTTGCCACACATCACAAACGGGGTTGCCATCCCACACTGA

Upstream 100 bases:

>100_bases
CAGAGAATACGTATTGCTTTTAACTGGATTACGTAAACTAAAATGTAACCTTTCGTCGTAATCGCATCATAATAATTTAT
TAAGGGAAAAATCATTCACA

Downstream 100 bases:

>100_bases
TCACTTGCATTATGGTTGGCCAGCCTTGGGGATAAGTGCGACAACTCAAGGTGGCACGAATGGGGGCTGGCAAAACCAAC
CAACATCTCACCCAAAGTAA

Product: sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaB

Number of amino acids: Translated: 524; Mature: 524

Protein sequence:

>524_residues
MDITNRQAVLKNFLGNSPDWYKLAIMGFLIINPLVFFFVSPFVAGWMLVIEFIFTLAMALKCYPLQPGGLLAIQAVAIGM
TSPHQVAEEIANNLEVLLLLVFMVAGIYFMKQLLLFVFTKLLLNIRSKTILSLAFCLASAFLSAFLDALTVIAVVISVSV
GFYTIYHNVTSNHSDKDITDDSGIDNQDSHETLEQFRAFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKSAGWNFADFF
IRMLPVTLPVFIFGLLVCLLVEKFKLFGYGAQLPERVRQVLTEYDQQASAKRTKQEKMKLIVQAIIGVWLVLALALHLAE
VGLVGLSVIILATSFCGITNEHSLGKAFQEALPFTALLTVFFAVVAVIIEQSLFTPIIQFVLQASPSAQLSLFYLFNGLL
SSVSDNVFVGTVYINEARSAFEHGIVSLQQFELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVYMAL
PYTLVMTIVGLLGVEFLLVPMTEWLTQAGWISLPHITNGVAIPH

Sequences:

>Translated_524_residues
MDITNRQAVLKNFLGNSPDWYKLAIMGFLIINPLVFFFVSPFVAGWMLVIEFIFTLAMALKCYPLQPGGLLAIQAVAIGM
TSPHQVAEEIANNLEVLLLLVFMVAGIYFMKQLLLFVFTKLLLNIRSKTILSLAFCLASAFLSAFLDALTVIAVVISVSV
GFYTIYHNVTSNHSDKDITDDSGIDNQDSHETLEQFRAFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKSAGWNFADFF
IRMLPVTLPVFIFGLLVCLLVEKFKLFGYGAQLPERVRQVLTEYDQQASAKRTKQEKMKLIVQAIIGVWLVLALALHLAE
VGLVGLSVIILATSFCGITNEHSLGKAFQEALPFTALLTVFFAVVAVIIEQSLFTPIIQFVLQASPSAQLSLFYLFNGLL
SSVSDNVFVGTVYINEARSAFEHGIVSLQQFELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVYMAL
PYTLVMTIVGLLGVEFLLVPMTEWLTQAGWISLPHITNGVAIPH
>Mature_524_residues
MDITNRQAVLKNFLGNSPDWYKLAIMGFLIINPLVFFFVSPFVAGWMLVIEFIFTLAMALKCYPLQPGGLLAIQAVAIGM
TSPHQVAEEIANNLEVLLLLVFMVAGIYFMKQLLLFVFTKLLLNIRSKTILSLAFCLASAFLSAFLDALTVIAVVISVSV
GFYTIYHNVTSNHSDKDITDDSGIDNQDSHETLEQFRAFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKSAGWNFADFF
IRMLPVTLPVFIFGLLVCLLVEKFKLFGYGAQLPERVRQVLTEYDQQASAKRTKQEKMKLIVQAIIGVWLVLALALHLAE
VGLVGLSVIILATSFCGITNEHSLGKAFQEALPFTALLTVFFAVVAVIIEQSLFTPIIQFVLQASPSAQLSLFYLFNGLL
SSVSDNVFVGTVYINEARSAFEHGIVSLQQFELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVYMAL
PYTLVMTIVGLLGVEFLLVPMTEWLTQAGWISLPHITNGVAIPH

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons

COG id: COG3067

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaB Na(+)/H(+) (TC 2.A.34) antiporter family

Homologues:

Organism=Escherichia coli, GI1787435, Length=513, Percent_Identity=75.6335282651072, Blast_Score=752, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAB_YERP3 (A7FI95)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001400973.1
- STRING:   A7FI95
- GeneID:   5387767
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_2000
- eggNOG:   COG3067
- HOGENOM:   HBG296776
- OMA:   CFLVEKF
- ProtClustDB:   PRK09547
- BioCyc:   YPSE349747:YPSIP31758_2000-MONOMER
- HAMAP:   MF_01599
- InterPro:   IPR004671
- TIGRFAMs:   TIGR00774

Pfam domain/function: PF06450 NhaB

EC number: NA

Molecular weight: Translated: 57450; Mature: 57450

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1b9b6464)-; HASH(0x1b66bf50)-; HASH(0x1bbc5a38)-; HASH(0x19002d9c)-; HASH(0x19ac5ae0)-; HASH(0x1aec64ac)-; HASH(0x1b5ac518)-; HASH(0x1bbb3c9c)-; HASH(0x1bbb3dd4)-; HASH(0x1b99bbf8)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCH
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3 Proton [Periplasm]; Na (I) [Cytoplasm] [C]

Specific reaction: 3 Proton [Periplasm] + 2 Na (I) [Cytoplasm] = 2 Na (I) [Periplasm] + 3 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA