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The map label for this gene is hisD

Identifier: 51595898

GI number: 51595898

Start: 1878899

End: 1880230

Strand: Reverse

Name: hisD

Synonym: YPTB1561

Alternate gene names: 51595898

Gene position: 1880230-1878899 (Counterclockwise)

Preceding gene: 51595899

Following gene: 51595897

Centisome position: 39.63

GC content: 53.38

Gene sequence:

>1332_bases
ATGCAGCCGACGAATTTCAATACCCTGATCAATTGGCAACAATGCAGCGAAGAACAGCAAAAAGCGCTGTTGAGCCGCCC
GGCCATCAATGCATCCGAGAGGATCACTGCGACGGTCAGTGACATCCTGGACCGGGTGAAAGCGGAAGGCGATAGCGCCC
TGCGTGATTTTAGCCAGCGTTTTGACCATGTGCAGGTCGCGGATATCCGTATCACTGCATCAGAGATCGCTGCGGCCTCG
GCGCGCCTGAGTGACGATGTCAAGCACGCCATGGCACAGGCGGTACGTAATATTGAAATCTTCCACAATGCGCAGAAAAT
GCCGGTGGTGGATGTTGAAACTCAGCCGGGTGTGCGTTGTCAGCAAATCACGCGTCCGATTGCTTCCGTCGGCTTGTATA
TTCCCGGTGGTTCTGCACCGTTGCCATCAACCGTACTGATGCTCGGCACCCCAGCACGTATTGCCGGTTGTCAGCGGGTC
GTTTTATGTTCTCCACCGCCTATTGCCGATGAAATTTTGTATGCCGCTCAACTGTGCGGTATTCAGGAAGTATTCCAGAT
CGGCGGGGCACAAGCGATCGCCGCCATGGCATTCGGCAGTGAATCAGTACCTAAAGTGCACAAAATTTTTGGGCCGGGCA
ACGCTTATGTCACTGAAGCAAAACGTCAGGTTAGCCAGCGCCTGGACGGTGCTGCCATCGATATGCCCGCAGGCCCATCA
GAGGTGTTGGTGATCGCCGACAGCGGTGCTACACCTGCGTTTATCGCGGCGGATTTACTCTCACAAGCGGAACACGGGCC
TGATTCTCAAGTGATCTTACTGACACCTGATGCCGCTATCGCACAAGCGGTGGCAGTCGAAGTTGAGCAACAACTCGCGC
TGTTATCCCGAGCCGATATTGCCCGTCAGGCACTGGAAAGCAGCCGTTTGATCGTGACCAACGATTTACAGCAATGCATT
GATATCAGTAATGCATACGGCCCTGAGCATTTGATTCTACAAATTCGTCAACCAGAAGAAATCATTGACCAGATTGATAA
CGCTGGCTCCGTGTTTATGGGCGATTGGTCACCGGAATCGGCTGGGGATTACGCCTCGGGCACCAACCACGTACTGCCAA
CCTACGGTTATACCTCAACCTATTCCAGTTTAGGTTTGGCTGACTTTGTTAAGCGTATGACCGTACAGCAATTGACACCA
CAGGGTTTGTTAGGGCTGGCCTCCACCATCGAAACACTGGCACAGGCCGAACAACTGACCGCACACAAAAATGCAGTTAC
CCTGCGCGTTACCGCCTTGAATAACGCCCTGACCGCCGTGAATAAGGAGTAA

Upstream 100 bases:

>100_bases
CAGCAGCGAAACGTTGTTCTGGGAAACCATGGAGAAATTGAAGGCGCTGGGTGCCAGCTCCATTCTGGTATTACCGATTG
AAAAAATGATGGAGTAACCC

Downstream 100 bases:

>100_bases
GCATGAGCCAATCTAATAACGTCACGGACCTGGCCCGTGCCAACATCCGTGCTCTGACTCCCTATATGTCCGCACGTCGG
TTAGGCGGTAATGGCGATGT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MQPTNFNTLINWQQCSEEQQKALLSRPAINASERITATVSDILDRVKAEGDSALRDFSQRFDHVQVADIRITASEIAAAS
ARLSDDVKHAMAQAVRNIEIFHNAQKMPVVDVETQPGVRCQQITRPIASVGLYIPGGSAPLPSTVLMLGTPARIAGCQRV
VLCSPPPIADEILYAAQLCGIQEVFQIGGAQAIAAMAFGSESVPKVHKIFGPGNAYVTEAKRQVSQRLDGAAIDMPAGPS
EVLVIADSGATPAFIAADLLSQAEHGPDSQVILLTPDAAIAQAVAVEVEQQLALLSRADIARQALESSRLIVTNDLQQCI
DISNAYGPEHLILQIRQPEEIIDQIDNAGSVFMGDWSPESAGDYASGTNHVLPTYGYTSTYSSLGLADFVKRMTVQQLTP
QGLLGLASTIETLAQAEQLTAHKNAVTLRVTALNNALTAVNKE

Sequences:

>Translated_443_residues
MQPTNFNTLINWQQCSEEQQKALLSRPAINASERITATVSDILDRVKAEGDSALRDFSQRFDHVQVADIRITASEIAAAS
ARLSDDVKHAMAQAVRNIEIFHNAQKMPVVDVETQPGVRCQQITRPIASVGLYIPGGSAPLPSTVLMLGTPARIAGCQRV
VLCSPPPIADEILYAAQLCGIQEVFQIGGAQAIAAMAFGSESVPKVHKIFGPGNAYVTEAKRQVSQRLDGAAIDMPAGPS
EVLVIADSGATPAFIAADLLSQAEHGPDSQVILLTPDAAIAQAVAVEVEQQLALLSRADIARQALESSRLIVTNDLQQCI
DISNAYGPEHLILQIRQPEEIIDQIDNAGSVFMGDWSPESAGDYASGTNHVLPTYGYTSTYSSLGLADFVKRMTVQQLTP
QGLLGLASTIETLAQAEQLTAHKNAVTLRVTALNNALTAVNKE
>Mature_443_residues
MQPTNFNTLINWQQCSEEQQKALLSRPAINASERITATVSDILDRVKAEGDSALRDFSQRFDHVQVADIRITASEIAAAS
ARLSDDVKHAMAQAVRNIEIFHNAQKMPVVDVETQPGVRCQQITRPIASVGLYIPGGSAPLPSTVLMLGTPARIAGCQRV
VLCSPPPIADEILYAAQLCGIQEVFQIGGAQAIAAMAFGSESVPKVHKIFGPGNAYVTEAKRQVSQRLDGAAIDMPAGPS
EVLVIADSGATPAFIAADLLSQAEHGPDSQVILLTPDAAIAQAVAVEVEQQLALLSRADIARQALESSRLIVTNDLQQCI
DISNAYGPEHLILQIRQPEEIIDQIDNAGSVFMGDWSPESAGDYASGTNHVLPTYGYTSTYSSLGLADFVKRMTVQQLTP
QGLLGLASTIETLAQAEQLTAHKNAVTLRVTALNNALTAVNKE

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=430, Percent_Identity=76.046511627907, Blast_Score=683, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319819, Length=424, Percent_Identity=45.0471698113208, Blast_Score=364, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 47263; Mature: 47263

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPTNFNTLINWQQCSEEQQKALLSRPAINASERITATVSDILDRVKAEGDSALRDFSQR
CCCCCCCCEECHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
FDHVQVADIRITASEIAAASARLSDDVKHAMAQAVRNIEIFHNAQKMPVVDVETQPGVRC
CCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHH
QQITRPIASVGLYIPGGSAPLPSTVLMLGTPARIAGCQRVVLCSPPPIADEILYAAQLCG
HHHHHHHHHCEEECCCCCCCCCCEEEEECCCHHHHCCCEEEEECCCCHHHHHHHHHHHHC
IQEVFQIGGAQAIAAMAFGSESVPKVHKIFGPGNAYVTEAKRQVSQRLDGAAIDMPAGPS
HHHHHHCCCHHHHHHHHCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCEEECCCCCC
EVLVIADSGATPAFIAADLLSQAEHGPDSQVILLTPDAAIAQAVAVEVEQQLALLSRADI
CEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
ARQALESSRLIVTNDLQQCIDISNAYGPEHLILQIRQPEEIIDQIDNAGSVFMGDWSPES
HHHHHHCCCEEEEHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHCCCCCEEECCCCCCC
AGDYASGTNHVLPTYGYTSTYSSLGLADFVKRMTVQQLTPQGLLGLASTIETLAQAEQLT
CCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
AHKNAVTLRVTALNNALTAVNKE
HCCCEEEEEEEECCCHHHHCCCC
>Mature Secondary Structure
MQPTNFNTLINWQQCSEEQQKALLSRPAINASERITATVSDILDRVKAEGDSALRDFSQR
CCCCCCCCEECHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
FDHVQVADIRITASEIAAASARLSDDVKHAMAQAVRNIEIFHNAQKMPVVDVETQPGVRC
CCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHH
QQITRPIASVGLYIPGGSAPLPSTVLMLGTPARIAGCQRVVLCSPPPIADEILYAAQLCG
HHHHHHHHHCEEECCCCCCCCCCEEEEECCCHHHHCCCEEEEECCCCHHHHHHHHHHHHC
IQEVFQIGGAQAIAAMAFGSESVPKVHKIFGPGNAYVTEAKRQVSQRLDGAAIDMPAGPS
HHHHHHCCCHHHHHHHHCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCEEECCCCCC
EVLVIADSGATPAFIAADLLSQAEHGPDSQVILLTPDAAIAQAVAVEVEQQLALLSRADI
CEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
ARQALESSRLIVTNDLQQCIDISNAYGPEHLILQIRQPEEIIDQIDNAGSVFMGDWSPES
HHHHHHCCCEEEEHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHCCCCCEEECCCCCCC
AGDYASGTNHVLPTYGYTSTYSSLGLADFVKRMTVQQLTPQGLLGLASTIETLAQAEQLT
CCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
AHKNAVTLRVTALNNALTAVNKE
HCCCEEEEEEEECCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]