Click here to switch to the map view.

The map label for this gene is galK

Identifier: 51595513

GI number: 51595513

Start: 1395627

End: 1396778

Strand: Reverse

Name: galK

Synonym: YPTB1169

Alternate gene names: 51595513

Gene position: 1396778-1395627 (Counterclockwise)

Preceding gene: 51595514

Following gene: 51595512

Centisome position: 29.44

GC content: 51.39

Gene sequence:

>1152_bases
ATGAGTTTAAAACAACATACCCAGACTATTTTCCGCCAACAGTTTGACCGCGAGTCTGACATCACCATTAAAGCGCCGGG
CCGCGTCAATCTGATTGGCGAACATACCGACTATAACGATGGCTTTGTTCTGCCCTGCGCCATTAATTATGAAACGGTGA
TCAGTTGTGGCAAACGCGGCGATCGCCAGATTCGTGTTATTGCCGCCGACTATGAAAACCAGCAGGATATATTCTCTCTT
GATGCACCGATTGTCCCGCATCCTGAATATCGCTGGGCTGACTACGTGCGTGGTGTGGTGAAACATCTACAAATGCGCAA
CGCTGATTTTGGTGGGGCCGATCTGGTTATCTGTGGCAATGTCCCGCAGGGTGCTGGCCTCAGTTCCTCTGCATCGTTGG
AAGTGGCCGTGGGCCAAGCCCTGCAATCACTCTATCAACTCCCTCTTAGCGGTGTAGAACTGGCGCTGAATGGGCAAGAG
GCAGAAAACCAATTTGTCGGCTGTAACTGCGGCATTATGGATCAGTTAATCTCAGCATTGGGTAAAAAAGACCATGCGTT
GCTGATTGATTGTCGGACCTTGGAAACCCGTGCCGTGCCAATGCCGGAAAACATGGCCGTCGTTATTATCAACTCAAACA
TTCAACGTGGCCTGGTTGACAGCGAATACAATACTCGCCGCCAACAGTGTGAAGCTGCCGCCCGTTTCTTTGGCGTCAAA
GCATTGCGTGATGTCGAACCGAGCCTCTTCTTCTCAATACAAGACGAGCTAGATCCGGTCGTCGCTAAACGCGCCCGCCA
TGTGATCAGCGAGAATGCACGCACGCTAGCAGCCGCAGATGCCTTGGCCGCCGGGAACTTGAAATTGATGGGGCAATTGA
TGCAAGAGTCTCATATTTCTATGCGTGATGACTTTGAGATCACGGTTCCGCCAATAGATAGACTCGTCGAGATTGTGAAA
TCAGTGATTGGTGATCAAGGTGGGGTGCGCATGACGGGTGGCGGTTTTGGCGGTTGTATTGTCGCCTTAATGCCACTTGA
ATTAGTCGAGCAGGTTCGCACCACCGTTGCGCAGGAATACCCGGCACACAGCGGCGGCAAGAAAGAGACTTTTTATGTCT
GTCAGGCTTCACAAGGAGCGGGTTTATGCTGA

Upstream 100 bases:

>100_bases
AACTGCTGGCCGAAACCCAGCGAGACCTTACAGCAGAACAGGCGGCAGCACTCCTGCGGGCAGTAAGTGATGTTCACTAT
AAAGAGGCCGGAGCCAAATC

Downstream 100 bases:

>100_bases
AAAACGGCGCGGCATCACCAAACAGTGTTGACTCGTTAGCACCGGATGGTCACCCTTTTGAACTCACCAAATTGCAGAAT
AAAACCGGTATGACCGTCAC

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MSLKQHTQTIFRQQFDRESDITIKAPGRVNLIGEHTDYNDGFVLPCAINYETVISCGKRGDRQIRVIAADYENQQDIFSL
DAPIVPHPEYRWADYVRGVVKHLQMRNADFGGADLVICGNVPQGAGLSSSASLEVAVGQALQSLYQLPLSGVELALNGQE
AENQFVGCNCGIMDQLISALGKKDHALLIDCRTLETRAVPMPENMAVVIINSNIQRGLVDSEYNTRRQQCEAAARFFGVK
ALRDVEPSLFFSIQDELDPVVAKRARHVISENARTLAAADALAAGNLKLMGQLMQESHISMRDDFEITVPPIDRLVEIVK
SVIGDQGGVRMTGGGFGGCIVALMPLELVEQVRTTVAQEYPAHSGGKKETFYVCQASQGAGLC

Sequences:

>Translated_383_residues
MSLKQHTQTIFRQQFDRESDITIKAPGRVNLIGEHTDYNDGFVLPCAINYETVISCGKRGDRQIRVIAADYENQQDIFSL
DAPIVPHPEYRWADYVRGVVKHLQMRNADFGGADLVICGNVPQGAGLSSSASLEVAVGQALQSLYQLPLSGVELALNGQE
AENQFVGCNCGIMDQLISALGKKDHALLIDCRTLETRAVPMPENMAVVIINSNIQRGLVDSEYNTRRQQCEAAARFFGVK
ALRDVEPSLFFSIQDELDPVVAKRARHVISENARTLAAADALAAGNLKLMGQLMQESHISMRDDFEITVPPIDRLVEIVK
SVIGDQGGVRMTGGGFGGCIVALMPLELVEQVRTTVAQEYPAHSGGKKETFYVCQASQGAGLC
>Mature_382_residues
SLKQHTQTIFRQQFDRESDITIKAPGRVNLIGEHTDYNDGFVLPCAINYETVISCGKRGDRQIRVIAADYENQQDIFSLD
APIVPHPEYRWADYVRGVVKHLQMRNADFGGADLVICGNVPQGAGLSSSASLEVAVGQALQSLYQLPLSGVELALNGQEA
ENQFVGCNCGIMDQLISALGKKDHALLIDCRTLETRAVPMPENMAVVIINSNIQRGLVDSEYNTRRQQCEAAARFFGVKA
LRDVEPSLFFSIQDELDPVVAKRARHVISENARTLAAADALAAGNLKLMGQLMQESHISMRDDFEITVPPIDRLVEIVKS
VIGDQGGVRMTGGGFGGCIVALMPLELVEQVRTTVAQEYPAHSGGKKETFYVCQASQGAGLC

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=382, Percent_Identity=43.979057591623, Blast_Score=280, Evalue=1e-75,
Organism=Homo sapiens, GI48527957, Length=440, Percent_Identity=27.2727272727273, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI4503897, Length=440, Percent_Identity=27.2727272727273, Blast_Score=133, Evalue=3e-31,
Organism=Escherichia coli, GI1786972, Length=383, Percent_Identity=72.5848563968668, Blast_Score=572, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI71989053, Length=404, Percent_Identity=28.960396039604, Blast_Score=107, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319494, Length=252, Percent_Identity=30.1587301587302, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320212, Length=249, Percent_Identity=28.5140562248996, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24661292, Length=433, Percent_Identity=27.2517321016166, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI21355577, Length=433, Percent_Identity=27.2517321016166, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24661285, Length=433, Percent_Identity=27.2517321016166, Blast_Score=108, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 41794; Mature: 41663

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKQHTQTIFRQQFDRESDITIKAPGRVNLIGEHTDYNDGFVLPCAINYETVISCGKRG
CCHHHHHHHHHHHHCCCCCCEEEECCCEEEEEECCCCCCCCEEEEEECCHHHHHHHCCCC
DRQIRVIAADYENQQDIFSLDAPIVPHPEYRWADYVRGVVKHLQMRNADFGGADLVICGN
CCEEEEEEECCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECC
VPQGAGLSSSASLEVAVGQALQSLYQLPLSGVELALNGQEAENQFVGCNCGIMDQLISAL
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEECCCCCHHHHHHHHH
GKKDHALLIDCRTLETRAVPMPENMAVVIINSNIQRGLVDSEYNTRRQQCEAAARFFGVK
CCCCCEEEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
ALRDVEPSLFFSIQDELDPVVAKRARHVISENARTLAAADALAAGNLKLMGQLMQESHIS
HHHHCCCHHEEEEHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHCCC
MRDDFEITVPPIDRLVEIVKSVIGDQGGVRMTGGGFGGCIVALMPLELVEQVRTTVAQEY
CCCCCEEECCCHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHC
PAHSGGKKETFYVCQASQGAGLC
CCCCCCCCCEEEEEECCCCCCCC
>Mature Secondary Structure 
SLKQHTQTIFRQQFDRESDITIKAPGRVNLIGEHTDYNDGFVLPCAINYETVISCGKRG
CHHHHHHHHHHHHCCCCCCEEEECCCEEEEEECCCCCCCCEEEEEECCHHHHHHHCCCC
DRQIRVIAADYENQQDIFSLDAPIVPHPEYRWADYVRGVVKHLQMRNADFGGADLVICGN
CCEEEEEEECCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECC
VPQGAGLSSSASLEVAVGQALQSLYQLPLSGVELALNGQEAENQFVGCNCGIMDQLISAL
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEECCCCCHHHHHHHHH
GKKDHALLIDCRTLETRAVPMPENMAVVIINSNIQRGLVDSEYNTRRQQCEAAARFFGVK
CCCCCEEEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
ALRDVEPSLFFSIQDELDPVVAKRARHVISENARTLAAADALAAGNLKLMGQLMQESHIS
HHHHCCCHHEEEEHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHCCC
MRDDFEITVPPIDRLVEIVKSVIGDQGGVRMTGGGFGGCIVALMPLELVEQVRTTVAQEY
CCCCCEEECCCHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHC
PAHSGGKKETFYVCQASQGAGLC
CCCCCCCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA