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The map label for this gene is galM

Identifier: 51595512

GI number: 51595512

Start: 1394563

End: 1395633

Strand: Reverse

Name: galM

Synonym: YPTB1168

Alternate gene names: 51595512

Gene position: 1395633-1394563 (Counterclockwise)

Preceding gene: 51595513

Following gene: 51595511

Centisome position: 29.41

GC content: 51.73

Gene sequence:

>1071_bases
ATGCTGAAAAACGGCGCGGCATCACCAAACAGTGTTGACTCGTTAGCACCGGATGGTCACCCTTTTGAACTCACCAAATT
GCAGAATAAAACCGGTATGACCGTCACCTTTATGGATTGGGGTGCAACCTGGTTATCGGCCATATTACCGCTGAAAAATG
GTGAGCAACGTGAATTGCTGCTGGGCTGCCCGACACCGGCTGATTACCTGCATCAAGCCGCTTATCTCGGGGCAACGGTT
GGCCGTTATGCCAACCGGATAGCCAATGCGCAAATCACCTTGGATGGCGAAACAATCCAGTTGGTCCCGAACCAAGGCCC
TAACCAATTACACGGTGGCCCGGAGGGTTTCCATGCCCAGCGTTGGCAGAAAGTGACCCAAGATGACCACCAGGTTACCT
ATAAACTTGATTCACCAGATGGCGATCAAGGTTTCCCCGGTAATCTGACTGTTGAAGTACAGTACCTGCTAACCGAAGAT
AACCGGCTGGAAATTCATTATCAGGCACAGGTGGATAAAACCTGCCCGGTTAACCTGACCAATCATGCCTATTTCAACCT
TGACGGCGAAGGGCATGATGCCCGTTCACATCGTTTGCAACTGTTTGCAGACCGTTACCTGCCTGTCGACAGTGCGGGCA
TCCCAACCGGAGGACTCGCTGATGTCGAGAATACCGGTATGGATTTTCGCCAACCTAAAACATTGGCGCAGGATTTTCTA
CAAGATCGCTGCCAGCAACGAGTTAAAGGCTATGACCACGCTTATTTGCTGCACCGCACCTGTGGGGCCTTAGACTCTCC
GGCGGCACACTTGTGGTCATCCGATAACCAGGTGCAAATGAGTATGTTCACCTCAGCGCCTGCGTTGCAGCTTTACAGCG
GAAATTATCTTGCTGGCACACCCGCACGCAACGGCGGCACCTATGCCAGCTATGCGGGTGTGGCACTAGAAAGTGAATTT
TTGCCTGATAGCCCTAACCACCCTGAATGGCCACAGCCCGATTGTTGGCTAAAACCGGGGAAGACCTATCGCTCAACGAC
GGTTTATCACTTTATTGCGTTGCCTTTATAA

Upstream 100 bases:

>100_bases
TCGAGCAGGTTCGCACCACCGTTGCGCAGGAATACCCGGCACACAGCGGCGGCAAGAAAGAGACTTTTTATGTCTGTCAG
GCTTCACAAGGAGCGGGTTT

Downstream 100 bases:

>100_bases
ATGATGACGTTATGAATGATGACGTTATGAATGATGTATTACGAATACTCCTGGCGTAATACATCATGCCGCAACGGCCA
CCCGGTTCTCACTTCGGTAG

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MLKNGAASPNSVDSLAPDGHPFELTKLQNKTGMTVTFMDWGATWLSAILPLKNGEQRELLLGCPTPADYLHQAAYLGATV
GRYANRIANAQITLDGETIQLVPNQGPNQLHGGPEGFHAQRWQKVTQDDHQVTYKLDSPDGDQGFPGNLTVEVQYLLTED
NRLEIHYQAQVDKTCPVNLTNHAYFNLDGEGHDARSHRLQLFADRYLPVDSAGIPTGGLADVENTGMDFRQPKTLAQDFL
QDRCQQRVKGYDHAYLLHRTCGALDSPAAHLWSSDNQVQMSMFTSAPALQLYSGNYLAGTPARNGGTYASYAGVALESEF
LPDSPNHPEWPQPDCWLKPGKTYRSTTVYHFIALPL

Sequences:

>Translated_356_residues
MLKNGAASPNSVDSLAPDGHPFELTKLQNKTGMTVTFMDWGATWLSAILPLKNGEQRELLLGCPTPADYLHQAAYLGATV
GRYANRIANAQITLDGETIQLVPNQGPNQLHGGPEGFHAQRWQKVTQDDHQVTYKLDSPDGDQGFPGNLTVEVQYLLTED
NRLEIHYQAQVDKTCPVNLTNHAYFNLDGEGHDARSHRLQLFADRYLPVDSAGIPTGGLADVENTGMDFRQPKTLAQDFL
QDRCQQRVKGYDHAYLLHRTCGALDSPAAHLWSSDNQVQMSMFTSAPALQLYSGNYLAGTPARNGGTYASYAGVALESEF
LPDSPNHPEWPQPDCWLKPGKTYRSTTVYHFIALPL
>Mature_356_residues
MLKNGAASPNSVDSLAPDGHPFELTKLQNKTGMTVTFMDWGATWLSAILPLKNGEQRELLLGCPTPADYLHQAAYLGATV
GRYANRIANAQITLDGETIQLVPNQGPNQLHGGPEGFHAQRWQKVTQDDHQVTYKLDSPDGDQGFPGNLTVEVQYLLTED
NRLEIHYQAQVDKTCPVNLTNHAYFNLDGEGHDARSHRLQLFADRYLPVDSAGIPTGGLADVENTGMDFRQPKTLAQDFL
QDRCQQRVKGYDHAYLLHRTCGALDSPAAHLWSSDNQVQMSMFTSAPALQLYSGNYLAGTPARNGGTYASYAGVALESEF
LPDSPNHPEWPQPDCWLKPGKTYRSTTVYHFIALPL

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=339, Percent_Identity=35.693215339233, Blast_Score=196, Evalue=2e-50,
Organism=Escherichia coli, GI1786971, Length=344, Percent_Identity=61.046511627907, Blast_Score=445, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI17557428, Length=329, Percent_Identity=33.434650455927, Blast_Score=194, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI115533334, Length=329, Percent_Identity=33.434650455927, Blast_Score=194, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6319493, Length=334, Percent_Identity=30.8383233532934, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6322004, Length=359, Percent_Identity=27.8551532033426, Blast_Score=105, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6324399, Length=310, Percent_Identity=26.4516129032258, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24668278, Length=332, Percent_Identity=34.6385542168675, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24659048, Length=373, Percent_Identity=32.9758713136729, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24583720, Length=336, Percent_Identity=33.0357142857143, Blast_Score=177, Evalue=8e-45,
Organism=Drosophila melanogaster, GI24641876, Length=343, Percent_Identity=27.6967930029155, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24668282, Length=348, Percent_Identity=29.3103448275862, Blast_Score=137, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR013458
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 39324; Mature: 39324

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00545 ALDOSE_1_EPIMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKNGAASPNSVDSLAPDGHPFELTKLQNKTGMTVTFMDWGATWLSAILPLKNGEQRELL
CCCCCCCCCCCCHHCCCCCCCEEEEEECCCCCCEEEEECCCHHHHHHHHCCCCCCCCEEE
LGCPTPADYLHQAAYLGATVGRYANRIANAQITLDGETIQLVPNQGPNQLHGGPEGFHAQ
EECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEECCCCCCCCCCCCCCCCHHH
RWQKVTQDDHQVTYKLDSPDGDQGFPGNLTVEVQYLLTEDNRLEIHYQAQVDKTCPVNLT
HHHHHCCCCCEEEEEECCCCCCCCCCCCEEEEEEEEEECCCEEEEEEEEECCCCCCCEEC
NHAYFNLDGEGHDARSHRLQLFADRYLPVDSAGIPTGGLADVENTGMDFRQPKTLAQDFL
CCEEEEECCCCCCCHHHHEEEEHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
QDRCQQRVKGYDHAYLLHRTCGALDSPAAHLWSSDNQVQMSMFTSAPALQLYSGNYLAGT
HHHHHHHHCCCCCEEEEHHHHCCCCCCHHHHCCCCCEEEEEEECCCCEEEEECCCEEECC
PARNGGTYASYAGVALESEFLPDSPNHPEWPQPDCWLKPGKTYRSTTVYHFIALPL
CCCCCCCCHHCCCEEEECCCCCCCCCCCCCCCCCCEECCCCCCCCEEEEEEEEECC
>Mature Secondary Structure
MLKNGAASPNSVDSLAPDGHPFELTKLQNKTGMTVTFMDWGATWLSAILPLKNGEQRELL
CCCCCCCCCCCCHHCCCCCCCEEEEEECCCCCCEEEEECCCHHHHHHHHCCCCCCCCEEE
LGCPTPADYLHQAAYLGATVGRYANRIANAQITLDGETIQLVPNQGPNQLHGGPEGFHAQ
EECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEECCCCCCCCCCCCCCCCHHH
RWQKVTQDDHQVTYKLDSPDGDQGFPGNLTVEVQYLLTEDNRLEIHYQAQVDKTCPVNLT
HHHHHCCCCCEEEEEECCCCCCCCCCCCEEEEEEEEEECCCEEEEEEEEECCCCCCCEEC
NHAYFNLDGEGHDARSHRLQLFADRYLPVDSAGIPTGGLADVENTGMDFRQPKTLAQDFL
CCEEEEECCCCCCCHHHHEEEEHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
QDRCQQRVKGYDHAYLLHRTCGALDSPAAHLWSSDNQVQMSMFTSAPALQLYSGNYLAGT
HHHHHHHHCCCCCEEEEHHHHCCCCCCHHHHCCCCCEEEEEEECCCCEEEEECCCEEECC
PARNGGTYASYAGVALESEFLPDSPNHPEWPQPDCWLKPGKTYRSTTVYHFIALPL
CCCCCCCCHHCCCEEEECCCCCCCCCCCCCCCCCCEECCCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7966338; 8905232; 9278503 [H]