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The map label for this gene is eif

Identifier: 51595227

GI number: 51595227

Start: 1051684

End: 1052724

Strand: Reverse

Name: eif

Synonym: YPTB0877

Alternate gene names: 51595227

Gene position: 1052724-1051684 (Counterclockwise)

Preceding gene: 51595233

Following gene: 51595223

Centisome position: 22.19

GC content: 55.43

Gene sequence:

>1041_bases
ATGCAGACGCTTAACACCCTCGACTTACAGACCACCAGCTTAAAAATTGTCAATGGTCAGCTTTGGATCCTTGACCAGCA
AGCACTGCCGCAGCGTCAAGAGTGGCTACTAGCCGATACCGTCGCCTCGTTGATTGAACATATTCAGGCGCTGCGGGTTC
GTGGTGCGCCACTTATTGGCTTGTCAGCCAGCCTGCTCTTGGCGCTACTGGCTGAACGTGGTTTATCGCAGGCTTTACTT
GAGCAAGCATTGATTGCCTTGCGTGAGTCACGCCCGACTGCCGTTAACCTCATGAATAATCTGGCACGGATGCAGCAAGC
GTTATTACAGCCCAATTGGGTTACGGCGATGGCCGCTGAAGCGCTACGATTAGTCGATGAAGACCGTGAGTTGTGTGAGC
GTATTGCCCAGCATGGGGCGGCACTGGTTAAACCCGGTAGCAACCTATTGACCCATTGCAATACTGGCGGGCTGGCCACT
GCCGGGATCGGCACCGCGATTGGCGTCTTACTGCGCGCCCATCAGCAGGGCAACCTCCGACAGGTTTGGGTTGATGAAAC
CCGGCCCTTATTACAAGGTGGGCGTTTAACCGCCTGGGAGTTAGGTGAATTGGGGATTCCCTATCAATTGATTTGCGATT
CGATGGCCGCCAGCCTGATGGCTCATGGCCAAGTGGATGCTATCTGGGTCGGCGCTGATCGCATTGCTGCCAACGGTGAT
GTGGCGAACAAAATTGGCACCTACAGCCTGGCGGTATTGGCGCATTATCACCGAATTCCGTTCTATGTTGCCGCACCGCA
CACCACCCACGATCCAGATTGCCCTGATGGAGCAGCGATCCCGATTGAACAACGTGCTGCCAGTGAGGTGACCGGTGTCT
CTGGCGGATTTGGTCATTGCCAGTGGGCACCAAAAGACACGGCGGTGTACAACCCAGCCTTTGATGTCACCCCTGCGGCA
TTGATCAGTGGTTGGGTGTTAGATAGCGGAGTGATCACACCTGAACAGGTCGCGGCAGGCTTTTTCCAGCCTCACCGCTA
G

Upstream 100 bases:

>100_bases
TGTATTTAGGCGTAAAAACATATGGACGTCTATACATCCGTAAAACATGTTGGCAGAATAAGAAACCAGATGCAATAACG
CAACATGGATTTAACTGACT

Downstream 100 bases:

>100_bases
CAATCAATACCCGATACTTAATATTTCTTAGTTTAGGCGAGGCGAGGATAGCCGTCGGCAATATTATCGCCGGTAGAACG
TGCTATCCAGCCTTCCGGGT

Product: translation initiation factor EIF-2B, GDP-GTP exchange factor (alpha subunit)

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MQTLNTLDLQTTSLKIVNGQLWILDQQALPQRQEWLLADTVASLIEHIQALRVRGAPLIGLSASLLLALLAERGLSQALL
EQALIALRESRPTAVNLMNNLARMQQALLQPNWVTAMAAEALRLVDEDRELCERIAQHGAALVKPGSNLLTHCNTGGLAT
AGIGTAIGVLLRAHQQGNLRQVWVDETRPLLQGGRLTAWELGELGIPYQLICDSMAASLMAHGQVDAIWVGADRIAANGD
VANKIGTYSLAVLAHYHRIPFYVAAPHTTHDPDCPDGAAIPIEQRAASEVTGVSGGFGHCQWAPKDTAVYNPAFDVTPAA
LISGWVLDSGVITPEQVAAGFFQPHR

Sequences:

>Translated_346_residues
MQTLNTLDLQTTSLKIVNGQLWILDQQALPQRQEWLLADTVASLIEHIQALRVRGAPLIGLSASLLLALLAERGLSQALL
EQALIALRESRPTAVNLMNNLARMQQALLQPNWVTAMAAEALRLVDEDRELCERIAQHGAALVKPGSNLLTHCNTGGLAT
AGIGTAIGVLLRAHQQGNLRQVWVDETRPLLQGGRLTAWELGELGIPYQLICDSMAASLMAHGQVDAIWVGADRIAANGD
VANKIGTYSLAVLAHYHRIPFYVAAPHTTHDPDCPDGAAIPIEQRAASEVTGVSGGFGHCQWAPKDTAVYNPAFDVTPAA
LISGWVLDSGVITPEQVAAGFFQPHR
>Mature_346_residues
MQTLNTLDLQTTSLKIVNGQLWILDQQALPQRQEWLLADTVASLIEHIQALRVRGAPLIGLSASLLLALLAERGLSQALL
EQALIALRESRPTAVNLMNNLARMQQALLQPNWVTAMAAEALRLVDEDRELCERIAQHGAALVKPGSNLLTHCNTGGLAT
AGIGTAIGVLLRAHQQGNLRQVWVDETRPLLQGGRLTAWELGELGIPYQLICDSMAASLMAHGQVDAIWVGADRIAANGD
VANKIGTYSLAVLAHYHRIPFYVAAPHTTHDPDCPDGAAIPIEQRAASEVTGVSGGFGHCQWAPKDTAVYNPAFDVTPAA
LISGWVLDSGVITPEQVAAGFFQPHR

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) [H]

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily [H]

Homologues:

Organism=Homo sapiens, GI72534748, Length=354, Percent_Identity=39.8305084745763, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI23943880, Length=333, Percent_Identity=37.5375375375375, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17557462, Length=341, Percent_Identity=39.5894428152493, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17557123, Length=191, Percent_Identity=27.2251308900524, Blast_Score=71, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6325375, Length=396, Percent_Identity=33.5858585858586, Blast_Score=167, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6322878, Length=207, Percent_Identity=29.951690821256, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357667, Length=356, Percent_Identity=38.4831460674157, Blast_Score=205, Evalue=3e-53,
Organism=Drosophila melanogaster, GI24651647, Length=356, Percent_Identity=38.4831460674157, Blast_Score=205, Evalue=3e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559 [H]

Pfam domain/function: PF01008 IF-2B [H]

EC number: =5.3.1.23 [H]

Molecular weight: Translated: 37153; Mature: 37153

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTLNTLDLQTTSLKIVNGQLWILDQQALPQRQEWLLADTVASLIEHIQALRVRGAPLIG
CCCCCCCCEEEEEEEEECCEEEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEC
LSASLLLALLAERGLSQALLEQALIALRESRPTAVNLMNNLARMQQALLQPNWVTAMAAE
HHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
ALRLVDEDRELCERIAQHGAALVKPGSNLLTHCNTGGLATAGIGTAIGVLLRAHQQGNLR
HHHHHHHHHHHHHHHHHCCCEEECCCCHHEEECCCCCCCHHHHHHHHHHHHHHHCCCCCE
QVWVDETRPLLQGGRLTAWELGELGIPYQLICDSMAASLMAHGQVDAIWVGADRIAANGD
EEECCCCCHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCEECCCC
VANKIGTYSLAVLAHYHRIPFYVAAPHTTHDPDCPDGAAIPIEQRAASEVTGVSGGFGHC
HHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCC
QWAPKDTAVYNPAFDVTPAALISGWVLDSGVITPEQVAAGFFQPHR
CCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHCCCCCCC
>Mature Secondary Structure
MQTLNTLDLQTTSLKIVNGQLWILDQQALPQRQEWLLADTVASLIEHIQALRVRGAPLIG
CCCCCCCCEEEEEEEEECCEEEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEC
LSASLLLALLAERGLSQALLEQALIALRESRPTAVNLMNNLARMQQALLQPNWVTAMAAE
HHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
ALRLVDEDRELCERIAQHGAALVKPGSNLLTHCNTGGLATAGIGTAIGVLLRAHQQGNLR
HHHHHHHHHHHHHHHHHCCCEEECCCCHHEEECCCCCCCHHHHHHHHHHHHHHHCCCCCE
QVWVDETRPLLQGGRLTAWELGELGIPYQLICDSMAASLMAHGQVDAIWVGADRIAANGD
EEECCCCCHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCEECCCC
VANKIGTYSLAVLAHYHRIPFYVAAPHTTHDPDCPDGAAIPIEQRAASEVTGVSGGFGHC
HHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCC
QWAPKDTAVYNPAFDVTPAALISGWVLDSGVITPEQVAAGFFQPHR
CCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA