Click here to switch to the map view.

The map label for this gene is ybdL

Identifier: 51595223

GI number: 51595223

Start: 1048356

End: 1049516

Strand: Reverse

Name: ybdL

Synonym: YPTB0873

Alternate gene names: 51595223

Gene position: 1049516-1048356 (Counterclockwise)

Preceding gene: 51595227

Following gene: 51595222

Centisome position: 22.12

GC content: 53.14

Gene sequence:

>1161_bases
ATGAGCACTTTATCTTTTATTCCAGACAGTAAATTGCCTGCGCAAGGCACCACCATCTTCACGCAAATGAGTGCATTGGC
CCAAAAGCACCAAGCGATCAATTTGTCACAGGGCTTCCCTGATTTTGATGGGCCGGATTACCTGAAGCAGCGGCTAGCCT
ATCATGTCGACCAAGGCGCAAACCAATATGCGCCGATGATCGGCGTCGCACCACTGCGTCATGCTATCGCGGAAAAAACG
GCCAATCTCTACGGGTGGCGGCCCGATGCCGAGCACGAAGTGACCGTGACCACCGGGGCCAGCGAAGCACTATTTGCTGC
CATCACCGCCCTCGTTCGTCCTGGTGATGAAGTGATCTGCTTTGACCCCAGCTACGACAGCTATGCACCGGCAGTCAAAC
TGGCGGGTGGCGTGCTCAAGCGGATCACACTAAAACCCCCTGCTTTTACCACTGATTGGGCTGAATTTACCCGTCTGCTC
TCTGAACGCACCCGTCTGGTTATCGTTAATACCCCCCATAACCCGTCGGCTACCGTTTGGTGTGCAGAAGATTTTGAACA
GCTTTGGCAGGTCATTGCAGAACGCAATATTTATGTTTTGAGTGATGAAGTTTACGAGCACATCTGCTTTAGCCGTTCAG
GTCATGCCAGTGTGTTGGCCCATCCGCAACTGCGTCAGCGAGCGATTGCCGTTTCTTCGTTCGGCAAAACCTTTCATATG
ACGGGCTGGAAAGTGGGTTATTGCATCGCACCCGCCGCCATCAGCGCCGAAGTGCGCAAAATTCACCAGTACCTGACCTT
CTCCGTCTGCACACCGGTCCAACTGGCATTGGCAGATATGCTTAATGCCGAGCCAGAACACTGGCAGCAGTTGCCTAAAT
TTTACCGTGCCCGCCGCGATCGTTTCGTCAAGGCACTGGCAGCCAGTCGCCTGAAAATTCTGCCAAGCGAGGGGACCTAT
TTCCTGTTGGCGGATTACAGCGGCATTTCAGATCTTGATGATGTTGAGTTCTGTCAATGGCTCACCGAGCACGTGGGCGT
TGCTGCAATACCGTTATCGGTATTTTGTGAAGCTCCGTTCCCCCATAAATTGATCCGGCTGTGCTTCGCCAAACAAGATG
CCACGCTGGACGCCGCCGCAGAGAGATTATGTCAACTTTAA

Upstream 100 bases:

>100_bases
TGCTGTTTTAGCCGTTTAAACATCTAAGCGTCTTGATTGCCAAATCTTAACATCGTGTTATATTTACGGCAACATACAGC
ACCAAGAGTCTTCATCCGCC

Downstream 100 bases:

>100_bases
AACTGACGTTATTGCAACAGCCGCTGGTCTGGTTGGATGCACCCGCTAACTTTCGCCATTTTGAGACGCTACTTGCGCCG
TTATCGTCGCGTGATGTGAT

Product: aminotransferase

Products: oxaloacetate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MSTLSFIPDSKLPAQGTTIFTQMSALAQKHQAINLSQGFPDFDGPDYLKQRLAYHVDQGANQYAPMIGVAPLRHAIAEKT
ANLYGWRPDAEHEVTVTTGASEALFAAITALVRPGDEVICFDPSYDSYAPAVKLAGGVLKRITLKPPAFTTDWAEFTRLL
SERTRLVIVNTPHNPSATVWCAEDFEQLWQVIAERNIYVLSDEVYEHICFSRSGHASVLAHPQLRQRAIAVSSFGKTFHM
TGWKVGYCIAPAAISAEVRKIHQYLTFSVCTPVQLALADMLNAEPEHWQQLPKFYRARRDRFVKALAASRLKILPSEGTY
FLLADYSGISDLDDVEFCQWLTEHVGVAAIPLSVFCEAPFPHKLIRLCFAKQDATLDAAAERLCQL

Sequences:

>Translated_386_residues
MSTLSFIPDSKLPAQGTTIFTQMSALAQKHQAINLSQGFPDFDGPDYLKQRLAYHVDQGANQYAPMIGVAPLRHAIAEKT
ANLYGWRPDAEHEVTVTTGASEALFAAITALVRPGDEVICFDPSYDSYAPAVKLAGGVLKRITLKPPAFTTDWAEFTRLL
SERTRLVIVNTPHNPSATVWCAEDFEQLWQVIAERNIYVLSDEVYEHICFSRSGHASVLAHPQLRQRAIAVSSFGKTFHM
TGWKVGYCIAPAAISAEVRKIHQYLTFSVCTPVQLALADMLNAEPEHWQQLPKFYRARRDRFVKALAASRLKILPSEGTY
FLLADYSGISDLDDVEFCQWLTEHVGVAAIPLSVFCEAPFPHKLIRLCFAKQDATLDAAAERLCQL
>Mature_385_residues
STLSFIPDSKLPAQGTTIFTQMSALAQKHQAINLSQGFPDFDGPDYLKQRLAYHVDQGANQYAPMIGVAPLRHAIAEKTA
NLYGWRPDAEHEVTVTTGASEALFAAITALVRPGDEVICFDPSYDSYAPAVKLAGGVLKRITLKPPAFTTDWAEFTRLLS
ERTRLVIVNTPHNPSATVWCAEDFEQLWQVIAERNIYVLSDEVYEHICFSRSGHASVLAHPQLRQRAIAVSSFGKTFHMT
GWKVGYCIAPAAISAEVRKIHQYLTFSVCTPVQLALADMLNAEPEHWQQLPKFYRARRDRFVKALAASRLKILPSEGTYF
LLADYSGISDLDDVEFCQWLTEHVGVAAIPLSVFCEAPFPHKLIRLCFAKQDATLDAAAERLCQL

Specific function: Shows aminotransferase activity with methionine and histidine as substrates, and to a lesser extent also with phenylalanine [H]

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI56713254, Length=409, Percent_Identity=33.2518337408313, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI56713256, Length=409, Percent_Identity=33.2518337408313, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI95147551, Length=399, Percent_Identity=32.3308270676692, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI169881279, Length=399, Percent_Identity=32.3308270676692, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI169881281, Length=399, Percent_Identity=27.0676691729323, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI4507369, Length=373, Percent_Identity=26.2734584450402, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1786816, Length=386, Percent_Identity=74.8704663212435, Blast_Score=608, Evalue=1e-175,
Organism=Escherichia coli, GI1788722, Length=333, Percent_Identity=23.7237237237237, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788627, Length=228, Percent_Identity=24.1228070175439, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1787710, Length=296, Percent_Identity=26.6891891891892, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71994472, Length=413, Percent_Identity=32.2033898305085, Blast_Score=222, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI71994476, Length=419, Percent_Identity=31.980906921241, Blast_Score=222, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17567369, Length=410, Percent_Identity=27.8048780487805, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17567663, Length=348, Percent_Identity=21.551724137931, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322401, Length=387, Percent_Identity=30.2325581395349, Blast_Score=191, Evalue=2e-49,
Organism=Drosophila melanogaster, GI28573069, Length=405, Percent_Identity=34.0740740740741, Blast_Score=232, Evalue=4e-61,
Organism=Drosophila melanogaster, GI24646114, Length=405, Percent_Identity=34.0740740740741, Blast_Score=232, Evalue=4e-61,
Organism=Drosophila melanogaster, GI28573067, Length=405, Percent_Identity=34.0740740740741, Blast_Score=232, Evalue=4e-61,
Organism=Drosophila melanogaster, GI28573065, Length=405, Percent_Identity=34.0740740740741, Blast_Score=232, Evalue=4e-61,
Organism=Drosophila melanogaster, GI18859735, Length=371, Percent_Identity=24.2587601078167, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.1

Molecular weight: Translated: 42974; Mature: 42842

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLSFIPDSKLPAQGTTIFTQMSALAQKHQAINLSQGFPDFDGPDYLKQRLAYHVDQGA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHCCCC
NQYAPMIGVAPLRHAIAEKTANLYGWRPDAEHEVTVTTGASEALFAAITALVRPGDEVIC
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEE
FDPSYDSYAPAVKLAGGVLKRITLKPPAFTTDWAEFTRLLSERTRLVIVNTPHNPSATVW
ECCCCCCCCCHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCEEEE
CAEDFEQLWQVIAERNIYVLSDEVYEHICFSRSGHASVLAHPQLRQRAIAVSSFGKTFHM
EHHHHHHHHHHHHHCCEEEECHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHCCCEEEE
TGWKVGYCIAPAAISAEVRKIHQYLTFSVCTPVQLALADMLNAEPEHWQQLPKFYRARRD
CCCEEEEEECCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RFVKALAASRLKILPSEGTYFLLADYSGISDLDDVEFCQWLTEHVGVAAIPLSVFCEAPF
HHHHHHHHHHHEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHCCEEEECHHHEECCCC
PHKLIRLCFAKQDATLDAAAERLCQL
HHHHHHHHHHCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
STLSFIPDSKLPAQGTTIFTQMSALAQKHQAINLSQGFPDFDGPDYLKQRLAYHVDQGA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHCCCC
NQYAPMIGVAPLRHAIAEKTANLYGWRPDAEHEVTVTTGASEALFAAITALVRPGDEVIC
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEE
FDPSYDSYAPAVKLAGGVLKRITLKPPAFTTDWAEFTRLLSERTRLVIVNTPHNPSATVW
ECCCCCCCCCHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCEEEE
CAEDFEQLWQVIAERNIYVLSDEVYEHICFSRSGHASVLAHPQLRQRAIAVSSFGKTFHM
EHHHHHHHHHHHHHCCEEEECHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHCCCEEEE
TGWKVGYCIAPAAISAEVRKIHQYLTFSVCTPVQLALADMLNAEPEHWQQLPKFYRARRD
CCCEEEEEECCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RFVKALAASRLKILPSEGTYFLLADYSGISDLDDVEFCQWLTEHVGVAAIPLSVFCEAPF
HHHHHHHHHHHEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHCCEEEECHHHEECCCC
PHKLIRLCFAKQDATLDAAAERLCQL
HHHHHHHHHHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate; 2-oxoglutarate

Specific reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]