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The map label for this gene is HasA

Identifier: 51594472

GI number: 51594472

Start: 134963

End: 135580

Strand: Direct

Name: HasA

Synonym: YPTB0114

Alternate gene names: 51594472

Gene position: 134963-135580 (Clockwise)

Preceding gene: 51594471

Following gene: 51594473

Centisome position: 2.84

GC content: 41.91

Gene sequence:

>618_bases
ATGAGTACAACTATTCAATATAACAGTAATTATGCCGATTACAGCATCTCCTCTTATCTTCGGGAATGGGCTAATAACTT
TGGTGATATTGATCAAGCTCCAGCTGAAACAAAAGATCGTGGGAGTTTCTCTGGTTCCTCAACCTTATTTAGCGGTACTC
AATATGCGATTGGTAGCTCGCATAGTAATCCAGAGGGAATGATTGCTGAGGGTGATTTGAAATACTCCTTTATGCCTCAG
CATACTTTCCATGGGCAAATAGACACCCTGCAGTTTGGTAAGGATTTAGCTACTAATGCGGGTGGCCCTAGTGCAGGTAA
ACATCTTGAAAAAATTGATATAACCTTTAACGAACTGGATCTTAGCGGTGAATTTGATTCTGGTAAATCAATGACAGAAA
ACCACCAAGGCGATATGCATAAATCCGTACGTGGTTTGATGAAAGGTAACCCAGATCCAATGCTGGAAGTGATGAAAGCC
AAAGGCATTAATGTCGATACTGCCTTTAAAGACCTGTCTATTGCCAGCCAATATCCTGACAGTGGTTATATGTCTGATGC
GCCAATGGTGGATACCGTTGGTGTGATGGATAGCAACGATATGCTGCTAGCCGCTTAA

Upstream 100 bases:

>100_bases
ACTTGAAGTATACGAGAATAATATATTTCACTTATGGAACCACATGGATTAATAATAATCCATGTTCACCGTAACAATTA
ATAATTAAAAGGACATTATC

Downstream 100 bases:

>100_bases
GAAAAACAGCCAGAAAATAACTTTCTGGCTGAGTCATTGATACCACCGCTAGGGCTTACTGGCCGGTTTGCTGTAGCGGT
GGTGCAGATTGTAGTTGTCC

Product: extracellular heme acquisition hemophore HasA

Products: NA

Alternate protein names: Heme acquisition system protein A [H]

Number of amino acids: Translated: 205; Mature: 204

Protein sequence:

>205_residues
MSTTIQYNSNYADYSISSYLREWANNFGDIDQAPAETKDRGSFSGSSTLFSGTQYAIGSSHSNPEGMIAEGDLKYSFMPQ
HTFHGQIDTLQFGKDLATNAGGPSAGKHLEKIDITFNELDLSGEFDSGKSMTENHQGDMHKSVRGLMKGNPDPMLEVMKA
KGINVDTAFKDLSIASQYPDSGYMSDAPMVDTVGVMDSNDMLLAA

Sequences:

>Translated_205_residues
MSTTIQYNSNYADYSISSYLREWANNFGDIDQAPAETKDRGSFSGSSTLFSGTQYAIGSSHSNPEGMIAEGDLKYSFMPQ
HTFHGQIDTLQFGKDLATNAGGPSAGKHLEKIDITFNELDLSGEFDSGKSMTENHQGDMHKSVRGLMKGNPDPMLEVMKA
KGINVDTAFKDLSIASQYPDSGYMSDAPMVDTVGVMDSNDMLLAA
>Mature_204_residues
STTIQYNSNYADYSISSYLREWANNFGDIDQAPAETKDRGSFSGSSTLFSGTQYAIGSSHSNPEGMIAEGDLKYSFMPQH
TFHGQIDTLQFGKDLATNAGGPSAGKHLEKIDITFNELDLSGEFDSGKSMTENHQGDMHKSVRGLMKGNPDPMLEVMKAK
GINVDTAFKDLSIASQYPDSGYMSDAPMVDTVGVMDSNDMLLAA

Specific function: Can bind free heme and also acquire it from hemoglobin. Conveys heme from hemoglobin to the HasR receptor which releases it into the bacterium. HasR alone can take up heme but the synergy between HasA and HasR increases heme uptake 100-fold [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010495 [H]

Pfam domain/function: PF06438 HasA [H]

EC number: NA

Molecular weight: Translated: 22224; Mature: 22093

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTIQYNSNYADYSISSYLREWANNFGDIDQAPAETKDRGSFSGSSTLFSGTQYAIGSS
CCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEECCCEEECCCC
HSNPEGMIAEGDLKYSFMPQHTFHGQIDTLQFGKDLATNAGGPSAGKHLEKIDITFNELD
CCCCCCEEECCCEEEEECCCCCCCCCCCHHHHCHHHHCCCCCCCCCCCEEEEEEEEEEEE
LSGEFDSGKSMTENHQGDMHKSVRGLMKGNPDPMLEVMKAKGINVDTAFKDLSIASQYPD
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCC
SGYMSDAPMVDTVGVMDSNDMLLAA
CCCCCCCCCEEEEEEECCCCEEEEC
>Mature Secondary Structure 
STTIQYNSNYADYSISSYLREWANNFGDIDQAPAETKDRGSFSGSSTLFSGTQYAIGSS
CCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEECCCEEECCCC
HSNPEGMIAEGDLKYSFMPQHTFHGQIDTLQFGKDLATNAGGPSAGKHLEKIDITFNELD
CCCCCCEEECCCEEEEECCCCCCCCCCCHHHHCHHHHCCCCCCCCCCCEEEEEEEEEEEE
LSGEFDSGKSMTENHQGDMHKSVRGLMKGNPDPMLEVMKAKGINVDTAFKDLSIASQYPD
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCC
SGYMSDAPMVDTVGVMDSNDMLLAA
CCCCCCCCCEEEEEEECCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7937909; 9188703; 9171402; 10360351; 10966573 [H]