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The map label for this gene is hemA

Identifier: 161760578

GI number: 161760578

Start: 2359815

End: 2361077

Strand: Direct

Name: hemA

Synonym: YPTB2004

Alternate gene names: 161760578

Gene position: 2359815-2361077 (Clockwise)

Preceding gene: 51596326

Following gene: 51596331

Centisome position: 49.74

GC content: 50.36

Gene sequence:

>1263_bases
ATGACTCTGCTTGCATTAGGCATTAATCACAAAACCGCACCTGTATCGTTACGTGAACGAGTGACGTTTTCACCGGAATC
GATGGATCAGGCGCTGAATAGCTTGCTCCAACAGCCGTTGGTGCAGGGCGGTGTCGTGTTGTCCACGTGCAACCGGACTG
AACTGTATCTCAGTGTGGAACAGCAAGAAAACCTACACGAACAATTAACCGCCTGGCTGTGTAACTATCATAAACTCAGC
CCGGATGACGTGAGACAAAGCCTGTACTGGCATCATGGTAATGACGCTGTCCGCCATTTGATGCGGGTCGCCAGTGGTTT
GGATTCCCAAGTTTTGGGTGAACCACAAATATTAGGCCAGGTGAAAAAAGCGTTTGCTGAATCTCAGCGCGGGCAATCTC
TGTCGAGTGAACTGGAACGGTTATTCCAGAAATCTTTTTCTGTCGCCAAACGTGTACGCACAGAAACTGAAATTGGAGCC
AGTGCGGTTTCGGTCGCTTTTGCTGCCTGTTCTCTGGCTCGGCAAATTTTCGAATCATTATCAGAACTGCATGTATTATT
GGTCGGGGCCGGTGAGACGATTGAATTGGTGGCGCGCCACCTGCGTGAACATCAGGTCAAACATATGATTATTGCCAACC
GCACCCGTGAACGTGCGCAATCTCTGGCAAGCGAGGTCGGTGCCGAAGTGATAACGTTGCCAGAAATTGATGCTCGTCTG
GCGGATGCTGATATTATTATCAGTTCTACCGCCAGCCCGTTACCTATTATTGGTAAGGGAATGGTCGAGCGGGCATTGAA
AACCCGTCGTAATCAGCCAATGTTATTTATTGATATTGCCGTACCCCGTGATATCGAACCGGAGGTCGGTAAGTTGTCGA
ACGCCTATTTATACAGTGTTGATGATTTGCAGGCGATCATTCAGCACAACATGGCTCAGCGGCAGGCTGCGGCTGTTCAG
GCTGAATCGATAGTACAACAGGAAAGCATGAACTTTATGACCTGGCTGCGGGCTCAGGGAGCGGTAGAAACGATCCGTGA
CTATCGCTCTCAAGCTGAGCAGGTCCGCAGTGAAATGACCGCTAAAGCCTTGGTAGCCATTGAGCAGGGCGCTAACGTGG
AACAGGTCATTAATGAGTTGGCCTATAAGCTGACCAACCGCCTTATTCATGCGCCTACCAAATCCCTCCAGCAAGCCGCC
AGCGATGGCGATATGGAGCGGTTGCAATTATTACGCGACAGCCTTGGGCTGGATCAGCATTAG

Upstream 100 bases:

>100_bases
CAGGATGATGCCGTGCGACTTTTATTGATCTCGCGCATCAAGTAGAATGCGCTTCAGACGAGAATCCATACTAACACCAG
TATTACTCGAAGCCGTTCCC

Downstream 100 bases:

>100_bases
TTTCCTCTAATTAATAGGGTTTAAAACCACGGATGAAGTCTTCTATTGTTGCCAAACTGGAAGCGTTACAAGAGCGCCAT
GAAGAAGTTCTGGCATATCT

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MTLLALGINHKTAPVSLRERVTFSPESMDQALNSLLQQPLVQGGVVLSTCNRTELYLSVEQQENLHEQLTAWLCNYHKLS
PDDVRQSLYWHHGNDAVRHLMRVASGLDSQVLGEPQILGQVKKAFAESQRGQSLSSELERLFQKSFSVAKRVRTETEIGA
SAVSVAFAACSLARQIFESLSELHVLLVGAGETIELVARHLREHQVKHMIIANRTRERAQSLASEVGAEVITLPEIDARL
ADADIIISSTASPLPIIGKGMVERALKTRRNQPMLFIDIAVPRDIEPEVGKLSNAYLYSVDDLQAIIQHNMAQRQAAAVQ
AESIVQQESMNFMTWLRAQGAVETIRDYRSQAEQVRSEMTAKALVAIEQGANVEQVINELAYKLTNRLIHAPTKSLQQAA
SDGDMERLQLLRDSLGLDQH

Sequences:

>Translated_420_residues
MTLLALGINHKTAPVSLRERVTFSPESMDQALNSLLQQPLVQGGVVLSTCNRTELYLSVEQQENLHEQLTAWLCNYHKLS
PDDVRQSLYWHHGNDAVRHLMRVASGLDSQVLGEPQILGQVKKAFAESQRGQSLSSELERLFQKSFSVAKRVRTETEIGA
SAVSVAFAACSLARQIFESLSELHVLLVGAGETIELVARHLREHQVKHMIIANRTRERAQSLASEVGAEVITLPEIDARL
ADADIIISSTASPLPIIGKGMVERALKTRRNQPMLFIDIAVPRDIEPEVGKLSNAYLYSVDDLQAIIQHNMAQRQAAAVQ
AESIVQQESMNFMTWLRAQGAVETIRDYRSQAEQVRSEMTAKALVAIEQGANVEQVINELAYKLTNRLIHAPTKSLQQAA
SDGDMERLQLLRDSLGLDQH
>Mature_419_residues
TLLALGINHKTAPVSLRERVTFSPESMDQALNSLLQQPLVQGGVVLSTCNRTELYLSVEQQENLHEQLTAWLCNYHKLSP
DDVRQSLYWHHGNDAVRHLMRVASGLDSQVLGEPQILGQVKKAFAESQRGQSLSSELERLFQKSFSVAKRVRTETEIGAS
AVSVAFAACSLARQIFESLSELHVLLVGAGETIELVARHLREHQVKHMIIANRTRERAQSLASEVGAEVITLPEIDARLA
DADIIISSTASPLPIIGKGMVERALKTRRNQPMLFIDIAVPRDIEPEVGKLSNAYLYSVDDLQAIIQHNMAQRQAAAVQA
ESIVQQESMNFMTWLRAQGAVETIRDYRSQAEQVRSEMTAKALVAIEQGANVEQVINELAYKLTNRLIHAPTKSLQQAAS
DGDMERLQLLRDSLGLDQH

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=418, Percent_Identity=79.6650717703349, Blast_Score=672, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_YERP3 (A7FIG2)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001401040.1
- ProteinModelPortal:   A7FIG2
- SMR:   A7FIG2
- STRING:   A7FIG2
- GeneID:   5386513
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_2067
- eggNOG:   COG0373
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- ProtClustDB:   PRK00045
- BioCyc:   YPSE349747:YPSIP31758_2067-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR003462
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR13812
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 46661; Mature: 46530

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 109-109 BINDING 120-120

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLLALGINHKTAPVSLRERVTFSPESMDQALNSLLQQPLVQGGVVLSTCNRTELYLSVE
CEEEEEECCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCEEEEEEEH
QQENLHEQLTAWLCNYHKLSPDDVRQSLYWHHGNDAVRHLMRVASGLDSQVLGEPQILGQ
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHCCCHHHHHH
VKKAFAESQRGQSLSSELERLFQKSFSVAKRVRTETEIGASAVSVAFAACSLARQIFESL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SELHVLLVGAGETIELVARHLREHQVKHMIIANRTRERAQSLASEVGAEVITLPEIDARL
HHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHH
ADADIIISSTASPLPIIGKGMVERALKTRRNQPMLFIDIAVPRDIEPEVGKLSNAYLYSV
CCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHCCCCCEEEEH
DDLQAIIQHNMAQRQAAAVQAESIVQQESMNFMTWLRAQGAVETIRDYRSQAEQVRSEMT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
AKALVAIEQGANVEQVINELAYKLTNRLIHAPTKSLQQAASDGDMERLQLLRDSLGLDQH
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TLLALGINHKTAPVSLRERVTFSPESMDQALNSLLQQPLVQGGVVLSTCNRTELYLSVE
EEEEEECCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCEEEEEEEH
QQENLHEQLTAWLCNYHKLSPDDVRQSLYWHHGNDAVRHLMRVASGLDSQVLGEPQILGQ
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHCCCHHHHHH
VKKAFAESQRGQSLSSELERLFQKSFSVAKRVRTETEIGASAVSVAFAACSLARQIFESL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SELHVLLVGAGETIELVARHLREHQVKHMIIANRTRERAQSLASEVGAEVITLPEIDARL
HHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHH
ADADIIISSTASPLPIIGKGMVERALKTRRNQPMLFIDIAVPRDIEPEVGKLSNAYLYSV
CCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHCCCCCEEEEH
DDLQAIIQHNMAQRQAAAVQAESIVQQESMNFMTWLRAQGAVETIRDYRSQAEQVRSEMT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
AKALVAIEQGANVEQVINELAYKLTNRLIHAPTKSLQQAASDGDMERLQLLRDSLGLDQH
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA