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The map label for this gene is clcB

Identifier: 161760573

GI number: 161760573

Start: 2581709

End: 2582953

Strand: Reverse

Name: clcB

Synonym: YPTB2192

Alternate gene names: 161760573

Gene position: 2582953-2581709 (Counterclockwise)

Preceding gene: 51596519

Following gene: 51596514

Centisome position: 54.44

GC content: 52.37

Gene sequence:

>1245_bases
ATGCTGCGTCGATTAGTGATCTCCATCATGCTCGGCATGGTATCCGCGCTCATCGTTTGGCTGTTTCATCAGGCGATGCT
GGGGCTGGAGTGGCTGCTCTTCTCACGAACAGATGGTAGCCTGGTTGCTGCTGCGGCCTCTATTACTGGGTGGCGGCGGG
CATTAACTCCTGCTTTGGGGGGATTGGCGGCAGGTTTGCTGTTATGGGCATACCAACGTTATCAACACCGTAAACCCAGT
GCGCCCACTGATTATATGGAAGCCATTGAAATCGGTGATGGCCGATTAGATGTTTCCGCCAGCCTAGTGAAGTCCCTCGC
CTCTTTGTTAGTCGTATCCAGCGGCAGTGCCATTGGTCGTGAAGGCGCTATGGTATTGTTGGCCGCCCTGTTCGCTTCGG
TTTTCGCTCAACGCTATGCAAAACCTAAAGAGTGGAAGTTGTGGGTCGCCTGTGGGGCCGCTGCGGGAATGGCAAGTGCT
TACCATGCTCCGTTGGCTGGCAGCCTGTTTATTGCAGAAATTCTATTTGGAACACTGATGTTGGCTTCACTCGGCCCGGT
AGTGATCGCCGCGGTCAGTGCGTTATTGACGACCAACTTGCTACAAGGTGGTCAGGAAACCCTTTATCAAGTGCAGACAC
TCCCTTCTCCTTGGCCGGTACAATATTTCCTGATGGCGCTTCTAGGATTAATGGCGGGCTTCAGCGGCCCTTTATTTTTA
AAAGCGATGGCGGCTAGCAGTCATGCTTTCCGCTCCCTGAATTTATTGCCACCTCTGCAATTGGCGCTGGGGGGGATAAT
TGTTGGTTTACTATCATTGATATTTCCAGAGGTCTGGGGCAATGGCTACAGCGTAGTGCAATCACTCCTCACCACGCCGC
CGGGGGTGTTACTGATAGGCGGCATATTGATCTGTAAGTTATTGGCCGTGCTTGCCAGTAGTGGGTCCGGCGCTCCGGGA
GGGGTATTTACACCTACATTGTTTGTCGGTGCCGCACTCGGCATGTTATGTGGGCAGATATTTTCTTTGTGGCCCGTGCT
GGGCGACAATATTGGGTTATTAATGGCACTGACCGGCATGGCAACATTATTGGCAGCAACGACCCATGCGCCCATTATGG
CCGCTTTAATGGTTTGTGAAATGACCGGCGAGTACACCTTATTGCCAGGGCTATTATTATCTTGTGTTATCGCGACAACA
ATAGCCCGCTGGTTGCGCCCAATATCGGTATATCGGTCTCACTAA

Upstream 100 bases:

>100_bases
CAAGTAACAATGTCCTTATCTAAAAGAACAGAGTTTACTTCAACATGTCAGTCAGTTGTCTTGCATGAAACGGCCAATCC
ATCTCTATTACTACCGTGCG

Downstream 100 bases:

>100_bases
ATGATGGGCCGAGTAACGAAAGCAGCCAACATACATTCAGCTTGAAACACACATTCCAGCTTGAAACACACATTCAGCTT
GAAATAGGATGGATATAAAT

Product: voltage-gated ClC-type chloride channel ClcB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MLRRLVISIMLGMVSALIVWLFHQAMLGLEWLLFSRTDGSLVAAAASITGWRRALTPALGGLAAGLLLWAYQRYQHRKPS
APTDYMEAIEIGDGRLDVSASLVKSLASLLVVSSGSAIGREGAMVLLAALFASVFAQRYAKPKEWKLWVACGAAAGMASA
YHAPLAGSLFIAEILFGTLMLASLGPVVIAAVSALLTTNLLQGGQETLYQVQTLPSPWPVQYFLMALLGLMAGFSGPLFL
KAMAASSHAFRSLNLLPPLQLALGGIIVGLLSLIFPEVWGNGYSVVQSLLTTPPGVLLIGGILICKLLAVLASSGSGAPG
GVFTPTLFVGAALGMLCGQIFSLWPVLGDNIGLLMALTGMATLLAATTHAPIMAALMVCEMTGEYTLLPGLLLSCVIATT
IARWLRPISVYRSH

Sequences:

>Translated_414_residues
MLRRLVISIMLGMVSALIVWLFHQAMLGLEWLLFSRTDGSLVAAAASITGWRRALTPALGGLAAGLLLWAYQRYQHRKPS
APTDYMEAIEIGDGRLDVSASLVKSLASLLVVSSGSAIGREGAMVLLAALFASVFAQRYAKPKEWKLWVACGAAAGMASA
YHAPLAGSLFIAEILFGTLMLASLGPVVIAAVSALLTTNLLQGGQETLYQVQTLPSPWPVQYFLMALLGLMAGFSGPLFL
KAMAASSHAFRSLNLLPPLQLALGGIIVGLLSLIFPEVWGNGYSVVQSLLTTPPGVLLIGGILICKLLAVLASSGSGAPG
GVFTPTLFVGAALGMLCGQIFSLWPVLGDNIGLLMALTGMATLLAATTHAPIMAALMVCEMTGEYTLLPGLLLSCVIATT
IARWLRPISVYRSH
>Mature_414_residues
MLRRLVISIMLGMVSALIVWLFHQAMLGLEWLLFSRTDGSLVAAAASITGWRRALTPALGGLAAGLLLWAYQRYQHRKPS
APTDYMEAIEIGDGRLDVSASLVKSLASLLVVSSGSAIGREGAMVLLAALFASVFAQRYAKPKEWKLWVACGAAAGMASA
YHAPLAGSLFIAEILFGTLMLASLGPVVIAAVSALLTTNLLQGGQETLYQVQTLPSPWPVQYFLMALLGLMAGFSGPLFL
KAMAASSHAFRSLNLLPPLQLALGGIIVGLLSLIFPEVWGNGYSVVQSLLTTPPGVLLIGGILICKLLAVLASSGSGAPG
GVFTPTLFVGAALGMLCGQIFSLWPVLGDNIGLLMALTGMATLLAATTHAPIMAALMVCEMTGEYTLLPGLLLSCVIATT
IARWLRPISVYRSH

Specific function: Probably acts as an electrical shunt for an outwardly- directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily

Homologues:

Organism=Escherichia coli, GI87081943, Length=414, Percent_Identity=63.5265700483092, Blast_Score=438, Evalue=1e-124,
Organism=Escherichia coli, GI1786350, Length=252, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLCB_YERP3 (A7FHW4)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001400842.1
- ProteinModelPortal:   A7FHW4
- SMR:   A7FHW4
- STRING:   A7FHW4
- GeneID:   5387387
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_1867
- eggNOG:   COG0038
- HOGENOM:   HBG437193
- OMA:   SAPFAYA
- ProtClustDB:   PRK01610
- BioCyc:   YPSE349747:YPSIP31758_1867-MONOMER
- HAMAP:   MF_01203
- InterPro:   IPR014743
- InterPro:   IPR001807
- Gene3D:   G3DSA:1.10.3080.10
- PANTHER:   PTHR11689
- PRINTS:   PR00762

Pfam domain/function: PF00654 Voltage_CLC; SSF81340 Cl-channel_core

EC number: NA

Molecular weight: Translated: 43478; Mature: 43478

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1afe1108)-; HASH(0x1aeb8ee4)-; HASH(0x1baa99d4)-; HASH(0x1b5c98dc)-; HASH(0x18268fa0)-; HASH(0x18978278)-; HASH(0x176bcb88)-; HASH(0x1be18da0)-; HASH(0x1b5a2a70)-; HASH(0x1bbb1c1c)-; HASH(0x1b660398)-;

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRRLVISIMLGMVSALIVWLFHQAMLGLEWLLFSRTDGSLVAAAASITGWRRALTPALG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
GLAAGLLLWAYQRYQHRKPSAPTDYMEAIEIGDGRLDVSASLVKSLASLLVVSSGSAIGR
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
EGAMVLLAALFASVFAQRYAKPKEWKLWVACGAAAGMASAYHAPLAGSLFIAEILFGTLM
CHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LASLGPVVIAAVSALLTTNLLQGGQETLYQVQTLPSPWPVQYFLMALLGLMAGFSGPLFL
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHH
KAMAASSHAFRSLNLLPPLQLALGGIIVGLLSLIFPEVWGNGYSVVQSLLTTPPGVLLIG
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHH
GILICKLLAVLASSGSGAPGGVFTPTLFVGAALGMLCGQIFSLWPVLGDNIGLLMALTGM
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
ATLLAATTHAPIMAALMVCEMTGEYTLLPGLLLSCVIATTIARWLRPISVYRSH
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure
MLRRLVISIMLGMVSALIVWLFHQAMLGLEWLLFSRTDGSLVAAAASITGWRRALTPALG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
GLAAGLLLWAYQRYQHRKPSAPTDYMEAIEIGDGRLDVSASLVKSLASLLVVSSGSAIGR
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
EGAMVLLAALFASVFAQRYAKPKEWKLWVACGAAAGMASAYHAPLAGSLFIAEILFGTLM
CHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LASLGPVVIAAVSALLTTNLLQGGQETLYQVQTLPSPWPVQYFLMALLGLMAGFSGPLFL
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHH
KAMAASSHAFRSLNLLPPLQLALGGIIVGLLSLIFPEVWGNGYSVVQSLLTTPPGVLLIG
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHH
GILICKLLAVLASSGSGAPGGVFTPTLFVGAALGMLCGQIFSLWPVLGDNIGLLMALTGM
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
ATLLAATTHAPIMAALMVCEMTGEYTLLPGLLLSCVIATTIARWLRPISVYRSH
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA